A practical synthesis of 2-((1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino)-5- fluoronicotinic acid

Journal of Organic Chemistry

Volumn 71, Issue 10, 2006, Pages 4021-4023

  Wang, Xin ^a   Zhi, Ben ^a   Baum, Jean ^a   Chen, Ying ^a   Crockett, Richard ^a   Huang, Liang ^a   Eisenberg, Shawn ^a   Ng, John ^a   Larsen, Robert ^a   Martinelli, Mike ^a   Reider, Paul ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOMETHYL MOIETY; NICOTINIC ACID 3; REGIOSELECTIVE CHLORINATION;

CATALYSIS; CHLORINATION; REDUCTION; SYNTHESIS (CHEMICAL);

ORGANIC ACIDS;

1 [(1H PYRROLO[2,3 B]PYRIDIN 4 YL)METHYLAMINO] 5 FLUORONICOTINIC ACID; 2,6 DICHLORO 5 FLUORONICOTINIC ACID; 7 AZAINDOLE; AMINOMETHYL GROUP; FUNCTIONAL GROUP; INDOLE DERIVATIVE; NICOTINIC ACID; NICOTINIC ACID DERIVATIVE; NITROGEN; OXIDE; PALLADIUM; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHLORINATION; CYANATION; DECHLORINATION; MONODECHLORINATION; REDUCTION; STEREOCHEMISTRY; SYNTHESIS;

MOLECULAR STRUCTURE; NIACIN; PYRIDINES; PYRROLES;

EID: 33646497023     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0602571     Document Type: Article

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27. Preliminary reaction parameters were established during the preparation of a structurally similar compound, AMG 706, and details of those results will be published elsewhere.