메뉴 건너뛰기




Volumn 168, Issue 2, 2013, Pages 335-338

Small molecular glucokinase activators: Has another new anti-diabetic therapeutic lost favour?

Author keywords

glucokinase; glucokinase activator; glucokinase regulatory protein; hepatic steatosis; hepatopharmacology; triglycerides; type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; GLUCOKINASE; GLUCOKINASE ACTIVATOR; GLUCOKINASE REGULATORY PROTEIN; GLUCOSE; HEMOGLOBIN A1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84871586858     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02201.x     Document Type: Review
Times cited : (26)

References (16)
  • 1
    • 70349980881 scopus 로고    scopus 로고
    • The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
    • Beer NL, Tribble ND, McCulloch LJ, Roos C, Johnson PR, Orho-Melander M, et al,. (2009). The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Hum Mol Genet 18: 4081-4088.
    • (2009) Hum Mol Genet , vol.18 , pp. 4081-4088
    • Beer, N.L.1    Tribble, N.D.2    McCulloch, L.J.3    Roos, C.4    Johnson, P.R.5    Orho-Melander, M.6
  • 2
    • 78049512890 scopus 로고    scopus 로고
    • Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: A mechanistic study
    • Bonadonna RC, Heise T, Arbet-Engels C, Kapitza C, Avogaro A, Grimsby J, et al,. (2010). Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: a mechanistic study. J Clin Endocrinol Metab 95: 5028-5036.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 5028-5036
    • Bonadonna, R.C.1    Heise, T.2    Arbet-Engels, C.3    Kapitza, C.4    Avogaro, A.5    Grimsby, J.6
  • 3
    • 84871604441 scopus 로고    scopus 로고
    • Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: A warning for therapeutic applications in humans
    • De Ceuninck F, Kargar C, Ilic C, Caliez A, Rolin JO, Umbdenstock T, et al,. (2012). Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans. Brit J Pharmacol 168: 339-353.
    • (2012) Brit J Pharmacol , vol.168 , pp. 339-353
    • De Ceuninck, F.1    Kargar, C.2    Ilic, C.3    Caliez, A.4    Rolin, J.O.5    Umbdenstock, T.6
  • 4
    • 75749086085 scopus 로고    scopus 로고
    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    • Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, et al,. (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42: 105-116.
    • (2010) Nat Genet , vol.42 , pp. 105-116
    • Dupuis, J.1    Langenberg, C.2    Prokopenko, I.3    Saxena, R.4    Soranzo, N.5    Jackson, A.U.6
  • 5
    • 0347477364 scopus 로고    scopus 로고
    • Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance
    • Ferre T, Riu E, Franckhauser S, Agudo J, Bosch F, (2003). Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance. Diabetologia 46: 1662-1668.
    • (2003) Diabetologia , vol.46 , pp. 1662-1668
    • Ferre, T.1    Riu, E.2    Franckhauser, S.3    Agudo, J.4    Bosch, F.5
  • 9
    • 81555210580 scopus 로고    scopus 로고
    • Effects of MK-0941, a novel glucokinase activator, on glycemic control in insulin-treated patients with type 2 diabetes
    • Meininger GE, Scott R, Alba M, Shentu Y, Luo E, Amin H, et al,. (2011). Effects of MK-0941, a novel glucokinase activator, on glycemic control in insulin-treated patients with type 2 diabetes. Diabetes Care 34: 2560-2566.
    • (2011) Diabetes Care , vol.34 , pp. 2560-2566
    • Meininger, G.E.1    Scott, R.2    Alba, M.3    Shentu, Y.4    Luo, E.5    Amin, H.6
  • 10
    • 84862215515 scopus 로고    scopus 로고
    • Effects of a glucokinase activator on hepatic intermediary metabolism: Study with (13)C-isotopomer-based metabolomics
    • Nissim I, Horyn O, Daikhin Y, Wehrli SL, Yudkoff M, Matschinsky FM, (2012). Effects of a glucokinase activator on hepatic intermediary metabolism: study with (13)C-isotopomer-based metabolomics. Biochem J 444: 537-551.
    • (2012) Biochem J , vol.444 , pp. 537-551
    • Nissim, I.1    Horyn, O.2    Daikhin, Y.3    Wehrli, S.L.4    Yudkoff, M.5    Matschinsky, F.M.6
  • 11
    • 0032884829 scopus 로고    scopus 로고
    • Metabolic impact of glucokinase overexpression in liver: Lowering of blood glucose in fed rats is accompanied by hyperlipidemia
    • O'Doherty RM, Lehman DL, Telemaque-Potts S, Newgard CB, (1999). Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. Diabetes 48: 2022-2027.
    • (1999) Diabetes , vol.48 , pp. 2022-2027
    • O'Doherty, R.M.1    Lehman, D.L.2    Telemaque-Potts, S.3    Newgard, C.B.4
  • 12
    • 70350741368 scopus 로고    scopus 로고
    • Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia
    • Osbak KK, Colclough K, Saint-Martin C, Beer NL, Bellanne-Chantelot C, Ellard S, et al,. (2009). Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia. Hum Mutat 30: 1512-1526.
    • (2009) Hum Mutat , vol.30 , pp. 1512-1526
    • Osbak, K.K.1    Colclough, K.2    Saint-Martin, C.3    Beer, N.L.4    Bellanne-Chantelot, C.5    Ellard, S.6
  • 13
  • 14
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Saxena R, Voight BF, Lyssenko V, Burtt NP, de, Bakker PI, Chen H, et al,. (2007). Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316: 1331-1336.
    • (2007) Science , vol.316 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2    Lyssenko, V.3    Burtt De, N.P.4    Bakker, P.I.5    Chen, H.6
  • 15
    • 79953745343 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
    • Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, et al,. (2011). Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet 7: e1001324.
    • (2011) PLoS Genet , vol.7
    • Speliotes, E.K.1    Yerges-Armstrong, L.M.2    Wu, J.3    Hernaez, R.4    Kim, L.J.5    Palmer, C.D.6
  • 16


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.