Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity

Journal of Pharmacology and Experimental Therapeutics

Volumn 350, Issue 2, 2014, Pages 273-289

  Oppermann, Sina ^a   Schrader, Florian C ^a   Elsässer, Katharina ^a   Dolga, Amalia M ^a   Kraus, Anna Lena ^a   Doti, Nunzianna ^b   Wegscheid Gerlach, Christof ^a   Schlitzer, Martin ^a   Culmsee, Carsten ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b Institute of Biostructure and Bioimaging   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 (3,4 DIMETHOXYPHENYL)THIAZOLIDINE 2,4 DIONE; 3 (3,4 DIMETHYLPHENYL)THIAZOLIDINE 2,4 DIONE; 3 (4 BENZYLPHENYL)THIAZOLIDINE 2,4 DIONE; 3 (4 METHOXYPHENYL)THIAZOLIDINE 2,4 DIONE; 3 (4 PHENOXYPHENYL)THIAZOLIDINE 2,4 DIONE; 3 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)TIAZOLIDINE 2,4 DIONE; 3 2 TOLYLTHIAZOLIDINE 2,4 DIONE; 3 4 TOLYLTHIAZOLIDINE 2,4 DIONE; 3 PHENYLTHIAZOLIDINE 2,4 DIONE; 3 [4 (METHYLSULFONYL)PHENYL]THIAZOLIDINE 2,4 DIONE; 5 (2,4 DIOXOTHIAZOLIDIN 3 YL) 2 METHYLBENZONITRILE; ADENOSINE TRIPHOSPHATE; BI 2A1; BI 2A7; BI 6C9; GLUTAMIC ACID; N [3 (2,4 DIOXOTHIAZOLIDIN 3 YL)PHENYL]ACETAMIDE; PROTEIN BID; PROTEIN INHIBITOR; TRUNCATED PROTEIN BID; UNCLASSIFIED DRUG; [N [4 [(4 AMINOPHENYL)THIO]PHENYL] 4 [[(4 METHOXYPHENYL)SULFONYL]AMINO]BUTANAMIDE];

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; EXCITOTOXICITY; GENE OVEREXPRESSION; GENE TRANSFER; HIPPOCAMPUS; HUMAN; HUMAN CELL; MEDIAN EFFECTIVE CONCENTRATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXYGEN CONSUMPTION; PLASMID; PRIORITY JOURNAL; PROTEIN DEPLETION; STRUCTURE ACTIVITY RELATION;

ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CELLS, CULTURED; GLUTAMIC ACID; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEURONS; NEUROPROTECTIVE AGENTS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 84904992419     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.213777     Document Type: Article

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