Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death

Brain, Behavior, and Immunity

Volumn 24, Issue 5, 2010, Pages 831-838

  Grohm, Julia ^a   Plesnila, Nikolaus ^b   Culmsee, Carsten ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

Apoptosis; Apoptosis inducing factor; Bcl 2; Bid; Fission and fusion; Glutamate; Mitochodondrial fission; Mitochondria; Mitochondrial membrane potential; Neurodegeneration; Neuronal cell death; Oxidative stress

Indexed keywords

GLUTAMIC ACID; GLUTATHIONE; PROTEIN BID; PROTEIN INHIBITOR; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL IMMORTALIZATION; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE TRANSPORT; CELL NUCLEUS MEMBRANE; CELL ORGANELLE; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN CELL; MEMBRANE FUSION; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL NECROSIS; NEUROPROTECTION; OUTER MEMBRANE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CELL LINE; CELL NUCLEUS; CELLS, CULTURED; GENE TRANSFER TECHNIQUES; GLUTAMIC ACID; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MITOCHONDRIA; NEURONS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 77953610930     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2009.11.015     Document Type: Article

References (42)

1. Arnoult D. Mitochondrial fragmentation in apoptosis. Trends Cell Biol. 2007, 17:6-12.
2. Becattini B., Culmsee C., Leone M., Zhai D.Y., Zhang X.Y., Crowell K.J., Rega M.F., Landshamer S., Reed J.C., Plesnila N., Pellecchia M. Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid. Proc. Natl. Acad. Sci. USA 2006, 103:12602-12606.
3. Bereiter-Hahn J., Voth M. Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria. Microsc. Res. Tech. 1994, 27:198-219.
4. Bermpohl D., You Z., Lo E.H., Kim H.H., Whalen M.J. TNF alpha and Fas mediate tissue damage and functional outcome after traumatic brain injury in mice. J. Cereb. Blood Flow Metab. 2007, 27:1806-1818.
5. Billen L.P., Kokoski C.L., Lovell J.F., Leber B., Andrews D.W. Bcl-XL inhibits membrane permeabilization by competing with Bax. PLoS Biol. 2008, 6:e147.
6. Bossy-Wetzel E., Barsoum M.J., Godzik A., Schwarzenbacher R., Lipton S.A. Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr. Opin. Cell Biol. 2003, 15:706-716.
7. Brooks C., Dong Z. Regulation of mitochondrial morphological dynamics during apoptosis by Bcl-2 family proteins: a key in Bak?. Cell Cycle 2007, 6:3043-3047.
8. Chan D.C. Mitochondrial fusion and fission in mammals. Annu. Rev. Cell Dev. Biol. 2006, 22:79-99.
9. Cheung E.C., McBride H.M., Slack R.S. Mitochondrial dynamics in the regulation of neuronal cell death. Apoptosis 2007, 12:979-992.
10. Chipuk J.E., Green D.R. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?. Trends Cell Biol. 2008, 18:157-164.
11. Culmsee C., Gerling N., Landshamer S., Rickerts B., Duchstein H.J., Umezawa K., Klumpp S., Krieglstein J. Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis. Mol. Pharmacol. 2005, 68:1006-1017.
12. Culmsee C., Plesnila N. Targeting Bid to prevent programmed cell death in neurons. Biochem. Soc. Trans. 2006, 34:1334-1340.
13. Culmsee C., Zhu C., Landshamer S., Becattini B., Wagner E., Pellecchia M., Blomgren K., Plesnila N. Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J. Neurosci. 2005, 25:10262-10272.
14. Danial N.N., Korsmeyer S.J. Cell death: critical control points. Cell 2004, 116:205-219.
15. Desagher S., Martinou J.C. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 2000, 10:369-377.
16. Duvezin-Caubet S., Jagasia R., Wagener J., Hofmann S., Trifunovic A., Hansson A., Chomyn A., Bauer M.F., Attardi G., Larsson N.G., Neupert W., Reichert A.S. Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology. J. Biol. Chem. 2006, 281:37972-37979.
17. Green D.R. Apoptotic pathways: ten minutes to dead. Cell 2005, 121:671-674.
18. Ishihara N., Jofuku A., Eura Y., Mihara K. Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cells. Biochem. Biophys. Res. Commun. 2003, 301:891-898.
19. Karbowski M., Jeong S.Y., Youle R.J. Endophilin B1 is required for the maintenance of mitochondrial morphology. J. Cell Biol. 2004, 166:1027-1039.
20. Karbowski M., Youle R.J. Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death Differ. 2003, 10:870-880.
21. Kazhdan I., Long L., Montellano R., Cavazos D.A., Marciniak R.A. Targeted gene therapy for breast cancer with truncated Bid. Cancer Gene Ther. 2006, 13:141-149.
22. Kluck R.M., Bossy-Wetzel E., Green D.R., Newmeyer D.D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 1997, 275:1132-1136.
23. Knott A.B., Bossy-Wetzel E. Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration. Ann. NY Acad. Sci. 2008, 1147:283-292.
24. Knott A.B., Perkins G., Schwarzenbacher R., Bossy-Wetzel E. Mitochondrial fragmentation in neurodegeneration. Nat. Rev. Neurosci. 2008, 9:505-518.
25. Kroemer G., Galluzzi L., Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 2007, 87:99-163.
26. Lackner L.L., Nunnari J.M. The molecular mechanism and cellular functions of mitochondrial division. Biochim. Biophys. Acta 2008.
27. Landshamer S., Hoehn M., Barth N., Duvezin-Caubet S., Schwake G., Tobaben S., Kazhdan I., Becattini B., Zahler S., Vollmar A., Pellecchia M., Reichert A., Plesnila N., Wagner E., Culmsee C. Bid-induced release of AIF from mitochondria causes immediate neuronal cell death. Cell Death Differ. 2008, 15:1553-1563.
28. Liesa M., Palacín M., Zorzano A. Mitochondrial dynamics in mammalian health and disease. Physiol. Rev. 2009, 89:799-845.
29. Liu Y., Peterson D.A., Kimura H., Schubert D. Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) reduction. J. Neurochem. 1997, 69:581-593.
30. Lovell J.F., Billen L.P., Bindner S., Shamas-Din A., Fradin C., Leber B., Andrews D.W. Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell 2008, 135:1074-1084.
31. Okamoto K., Shaw J.M. Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. Annu. Rev. Genet. 2005, 39:503-536.
32. Parone P.A., Da C.S., Tondera D., Mattenberger Y., James D.I., Maechler P., Barja F., Martinou J.C. Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS ONE 2008, 3:e3257.
33. Plesnila N., Zinkel S., Le D.A., min-Hanjani S., Wu Y., Qiu J., Chiarugi A., Thomas S.S., Kohane D.S., Korsmeyer S.J., Moskowitz M.A. BID mediates neuronal cell death after oxygen/glucose deprivation and focal cerebral ischemia. Proc. Natl. Acad. Sci. USA 2001, 98:15318-15323.
34. Rube D.A., van der Bliek A.M. Mitochondrial morphology is dynamic and varied. Mol. Cell. Biochem. 2004, 331-339.
35. Santel A., Frank S. Shaping mitochondria: the complex posttranslational regulation of the mitochondrial fission protein DRP1. IUBMB Life 2008, 60:448-455.
36. Seiler A., Schneider M., Forster H., Roth S., Wirth E.K., Culmsee C., Plesnila N., Kremmer E., Radmark O., Wurst W., Bornkamm G.W., Schweizer U., Conrad M. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 2008, 8:237-248.
37. Suen D.F., Norris K.L., Youle R.J. Mitochondrial dynamics and apoptosis. Genes Dev. 2008, 22:1577-1590.
38. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev. 2001, 15:2922-2933.
39. Wasiak S., Zunino R., McBride H.M. Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J. Cell Biol. 2007, 177:439-450.
40. Wasilewski M., Scorrano L. The changing shape of mitochondrial apoptosis. Trends Endocrinol. Metab. 2009, 20:287-294.
41. Youle R.J., Karbowski M. Mitochondrial fission in apoptosis. Nat. Rev. Mol. Cell Biol. 2005, 6:657-663.
42. Youle R.J., Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9:47-59.