Novel signaling axis for ROS generation during k-ras-induced cellular transformation

Cell Death and Differentiation

Volumn 21, Issue 8, 2014, Pages 1185-1197

  Park, M T ^a,b   Kim, M J ^a,c   Suh, Y ^a   Kim, R K ^a   Kim, H ^a   Lim, E J ^a   Yoo, K C ^a   Lee, G H ^a   Kim, Y H ^a   Hwang, S G ^c   Yi, J M ^b   Lee, S J ^a  

^a Hanyang University   (South Korea)

^b Dongnam Institute of Radiological and Medical Science   (South Korea)

^c Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE C DELTA; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; STRESS ACTIVATED PROTEIN KINASE; KRAS PROTEIN, HUMAN; KRAS PROTEIN, RAT; NOX1 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; OXIDOREDUCTASE; P37 PROTEIN, HUMAN; PROTEIN P21; RAS PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; XY40 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CATALYSIS; CELL TRANSFORMATION; COLONY FORMATION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; FIBROBLAST; GENETIC TRANSFECTION; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; XENOGRAFT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; FIBROBLASTS; HETEROGRAFTS; NADH, NADPH OXIDOREDUCTASES; NADPH OXIDASE; NUCLEAR PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS P21(RAS); RAS PROTEINS; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84904961903     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.34     Document Type: Article

References (43)

1. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 1995; 270: 296-299.
2. Bae YS, Kang SW, Seo MS, Baines IC, Tekle E, Chock PB et al. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation. J Biol Chem 1997; 272: 217-221.
3. Leto TL, Geiszt M. Role of Nox family NADPH oxidases in host defense. Antioxid Redox Signal 2006; 8: 1549-1561.
4. Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 2000; 279: L1005-L1028.
5. Orient A, Donko A, Szabo A, Leto TL, Geiszt M. Novel sources of reactive oxygen species in the human body. Nephrol Dial Transplant 2007; 22: 1281-1288.
6. Halliwell B, Gutteridge JM, Cross CE. Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med 1992; 119: 598-620.
7. Cross CE, Halliwell B, Borish ET, Pryor WA, Ames BN, Saul RL et al. Oxygen radicals and human disease. Ann Intern Med 1987; 107: 526-545.
8. Kim C, Kim JY, Kim JH. Cytosolic phospholipase A(2), lipoxygenase metabolites, and reactive oxygen species. BMB Rep 2008; 41: 555-559.
9. Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM et al. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell 2002; 9: 1031-1044.
10. Gianni D, Taulet N, DerMardirossian C, Bokoch GM. c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells. Mol Biol Cell 2010; 21: 4287-4298.
11. Ferro E, Goitre L, Retta SF, Trabalzini L. The interplay between ROS and Ras GTPases: physiological and pathological implications. J Signal Transduct 2012; 2012: 365769.
12. Yang JQ, Li S, Huang Y, Zhang HJ, Domann FE, Buettner GR et al. V-Ha-Ras overexpression induces superoxide production and alters levels of primary antioxidant enzymes. Antioxid Redox Signal 2001; 3: 697-709.
13. Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989; 49: 4682-4689.
14. Adjei AA. Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst 2001; 93: 1062-1074.
15. Yang JQ, Li S, Domann FE, Buettner GR, Oberley LW. Superoxide generation in v-Ha-ras-transduced human keratinocyte HaCaT cells. Mol Carcinog 1999; 26: 180-188.
16. Yang JQ, Buettner GR, Domann FE, Li Q, Engelhardt JF, Weydert CD et al. v-Ha-ras mitogenic signaling through superoxide and derived reactive oxygen species. Mol Carcinog 2002; 33: 206-218.
17. Cullen JJ, Weydert C, Hinkhouse MM, Ritchie J, Domann FE, Spitz D et al. The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma. Cancer Res 2003; 63: 1297-1303.
18. Ang KK, Peters LJ, Weber RS, Morrison WH, Frankenthaler RA, Garden AS et al. Postoperative radiotherapy for cutaneous melanoma of the head and neck region. Int J Radiat Oncol Biol Phys 1994; 30: 795-798.
19. Maciag A, Sithanandam G, Anderson LM. Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells. Carcinogenesis 2004; 25: 2231-2237.
20. Ralph SJ, Rodriguez-Enriquez S, Neuzil J, Saavedra E, Moreno-Sanchez R. The causes of cancer revisited: 'mitochondrial malignancy' and ROS-induced oncogenic transformation- why mitochondria are targets for cancer therapy. Mol Aspects Med 2010; 31: 145-170.
21. Mitsushita J, Lambeth JD, Kamata T. The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation. Cancer Res 2004; 64: 3580-3585.
22. Cheng G, Lambeth JD. NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. J Biol Chem 2004; 279: 4737-4742.
23. Ago T, Kuribayashi F, Hiroaki H, Takeya R, Ito T, Kohda D et al. Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation. Proc Natl Acad Sci USA 2003; 100: 4474-4479.
24. Yuzawa S, Suzuki NN, Fujioka Y, Ogura K, Sumimoto H, Inagaki F. A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidase. Genes Cells 2004; 9: 443-456.
25. Symonds JM, Ohm AM, Carter CJ, Heasley LE, Boyle TA, Franklin WA et al. Protein kinase C delta is a downstream effector of oncogenic K-ras in lung tumors. Cancer Res 2011; 71: 2087-2097.
26. Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D. RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer 2011; 11: 761-774.
27. Avruch J, Khokhlatchev A, Kyriakis JM, Luo Z, Tzivion G, Vavvas D et al. Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res 2001; 56: 127-155.
28. Welman A, Griffiths JR, Whetton AD, Dive C. Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells. Protein Sci 2007; 16: 2711-2715.
29. Parekh DB, Ziegler W, Parker PJ. Multiple pathways control protein kinase C phosphorylation. Embo J 2000; 19: 496-503.
30. Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB et al. Protein kinase B kinases that mediate phosphatidylinositol 3, 4, 5-trisphosphate-dependent activation of protein kinase B. Science 1998; 279: 710-714.
31. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 1997; 7: 261-269.
32. Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF et al. Dual role of phosphatidylinositol-3, 4, 5-trisphosphate in the activation of protein kinase B. Science 1997; 277: 567-570.
33. Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 1998; 281: 2042-2045.
34. Hata K, Ito T, Takeshige K, Sumimoto H. Anionic amphiphile-independent activation of the phagocyte NADPH oxidase in a cell-free system by p47phox and p67phox, both in C terminally truncated forms. Implication for regulatory Src homology 3 domain-mediated interactions. J Biol Chem 1998; 273: 4232-4236.
35. Nitti M, Furfaro AL, Cevasco C, Traverso N, Marinari UM, Pronzato MA et al. PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation. Cell Signal 2010; 22: 828-835.
36. Nitti M, Furfaro AL, Traverso N, Odetti P, Storace D, Cottalasso D et al. PKC delta and NADPH oxidase in AGE-induced neuronal death. Neurosci Lett 2007; 416: 261-265.
37. Cai W, Torreggiani M, Zhu L, Chen X, He JC, Striker GE et al. AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-delta: implications for vascular disease. AmJ Physiol Cell Physiol 2010; 298: C624-C634.
38. Raimondi C, Falasca M. Targeting PDK1 in cancer. Curr Med Chem 2011; 18: 2763-2769.
39. Xie Z, Yuan H, Yin Y, Zeng X, Bai R, Glazer RI. 3-phosphoinositide- dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases. BMC Cancer 2006; 6: 77.
40. Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M et al. Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. Cancer Cell 2013; 23: 406-420.
41. Aoki Y, Niihori T, Narumi Y, Kure S, Matsubara Y. The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders. Hum Mutat 2008; 29: 992-1006.
42. Molina JR, Adjei AA. The Ras/Raf/MAPK pathway. J Thorac Oncol 2006; 1: 7-9.
43. Kim RK, Suh Y, Lim EJ, Yoo KC, Lee GH, Cui YH et al. A novel 2-pyrone derivative, BHP, impedes oncogenic KRAS-driven malignant progression in breast cancer. Cancer Lett 2013; 337: 49-57.