Aberrant DNA methylation of integrin α4 in human breast cancer

Tumor Biology

Volumn 35, Issue 7, 2014, Pages 7079-7084

  Do, Sung Im ^a   Ko, Eunkyung ^b   Kang, So Young ^b   Lee, Jeong Eon ^b   Nam, Seok Jin ^b   Cho, Eun Yoon ^b   Kim, Duk Hwan ^b  

^a School of Medicine   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Breast cancer; DNA methylation; HER2; Integrin; MIB1

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ALPHA4 INTEGRIN; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR;

ADULT; AGED; ALPHA4 INTEGRIN GENE; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER PROGNOSIS; CANCER STAGING; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; GENE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INVASIVE CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; METASTASIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CPG ISLANDS; DNA METHYLATION; FEMALE; HUMANS; INTEGRIN ALPHA4; LYMPHATIC METASTASIS; MCF-7 CELLS; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROMOTER REGIONS, GENETIC; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; TUMOR MARKERS, BIOLOGICAL;

EID: 84904958086     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-1952-7     Document Type: Article

References (28)

1. Giancotti FG, Tarone G. Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu Rev Cell Dev Biol. 2003;19:173-206. (Pubitemid 37487347)
2. van der Flier A, Sonnenberg A. Function and interactions of integrins. Cell Tissue Res. 2001;305(3):285-98. (Pubitemid 34212122)
3. Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 1992;69(1):11-25.
4. Miranti CK, Brugge JS. Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol. 2002;4(4):E83-90. (Pubitemid 34308848)
5. Aplin AE, Howe AK, Juliano RL. Cell adhesion molecules, signal transduction and cell growth. Curr Opin Cell Biol. 1999;11(6):737-44.
6. Chan BM, Kassner PD, Schiro JA, Byers HR, Kupper TS, Hemler ME. Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains. Cell. 1992;68(6):1051-60.
7. Hamann A, Andrew DP, Jablonski-Westrich D, Holzmann B, Butcher EC. Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol. 1994;152(7):3282-93.
8. Michetti M, Kelly CP, Kraehenbuhl JP, Bouzourene H, Michetti P. Gastric mucosal alpha(4)beta(7)-integrin-positive CD4 T lymphocytes and immune protection against helicobacter infection in mice. Gastroenterology. 2000;119(1):109-18. (Pubitemid 30452584)
9. Holzmann B, Gosslar U, Bittner M. alpha 4 integrins and tumor metastasis. Curr Top Microbiol Immunol. 1998;231:125-41.
10. Rincon J, Prieto J, Patarroyo M. Expression of integrins and other adhesion molecules in Epstein-Barr virus-transformed B lymphoblastoid cells and Burkitt's lymphoma cells. Int J Cancer. 1992;51(3):452-8.
11. Gosslar U, Jonas P, Luz A, Lifka A, Naor D, Hamann A, et al. Predominant role of alpha 4-integrins for distinct steps of lymphoma metastasis. Proc Natl Acad Sci U S A. 1996;93(10):4821-6. (Pubitemid 26162835)
12. Qian F, Vaux DL, Weissman IL. Expression of the integrin alpha 4 beta 1 on melanoma cells can inhibit the invasive stage of metastasis formation. Cell. 1994;77(3):335-47.
13. Herman JG, Jen J, Merlo A, Baylin SB. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res. 1996;56(4):722-7.
14. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A. 1998;95(12):6870-5. (Pubitemid 28278073)
15. Kang SH, Bang YJ, Im YH, Yang HK, Lee DA, Lee HY, et al. Transcriptional repression of the transforming growth factor-beta type I receptor gene by DNA methylation results in the development of TGF-beta resistance in human gastric cancer. Oncogene. 1999;18(51):7280-6. (Pubitemid 30032107)
16. Song SH, Jong HS, Choi HH, Kang SH, Ryu MH, Kim NK, et al. Methylation of specific CpG sites in the promoter region could significantly down-regulate p16(INK4a) expression in gastric adenocarcinoma. Int J Cancer. 2000;87(2):236-40. (Pubitemid 30434352)
17. Stirzaker C, Millar DS, Paul CL, Warnecke PM, Harrison J, Vincent PC, et al. Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors. Cancer Res. 1997;57(11):2229-37. (Pubitemid 27247043)
18. Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 2000;16(4):168-74. (Pubitemid 30169152)
19. Gao Y, Guan M, Su B, Liu W, Xu M, Lu Y. Hypermethylation of the RASSF1A gene in gliomas. Clin Chim Acta. 2004;349(1-2):173-9. (Pubitemid 39312003)
20. Goel A, Arnold CN, Tassone P, Chang DK, Niedzwiecki D, Dowell JM, et al. Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers. Int J Cancer. 2004;112(5):754-9. (Pubitemid 39435259)
21. Lindsey JC, Lusher ME, Strathdee G, Brown R, Gilbertson RJ, Bailey S, et al. Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours. Int J Cancer. 2006;118(2):346-52. (Pubitemid 41779073)
22. Maruyama R, Shoji F, Okamoto T, Miyamoto T, Miyake T, Nakamura T, et al. Prognostic value of visceral pleural invasion in resected non-small cell lung cancer diagnosed by using a jet stream of saline solution. J Thorac Cardiovasc Surg. 2004;127(6):1587-92. (Pubitemid 38725435)
23. Maruyama R, Sugio K, Yoshino I, Maehara Y, Gazdar AF. Hypermethylation of FHIT as a prognostic marker in nonsmall cell lung carcinoma. Cancer. 2004;100(7):1472-7. (Pubitemid 38366850)
24. Park J, Song SH, Kim TY, Choi MC, Jong HS, Lee JW, et al. Aberrant methylation of integrin alpha4 gene in human gastric cancer cells. Oncogene. 2004;23(19):3474-80. (Pubitemid 38669837)
25. Uhm KO, Lee JO, Lee YM, Lee ES, Kim HS, Park SH. Aberrant DNA methylation of integrin alpha4: a potential novel role for metastasis of cholangiocarcinoma. J Cancer Res Clin Oncol. 2010;136(2):187-94.
26. Gonzalo S. Epigenetic alterations in aging. J Appl Physiol. 2010;109(2):586-97.
27. Rathinam R, Alahari SK. Important role of integrins in the cancer biology. Cancer Metastasis Rev. 2010;29(1):223-37.
28. Yoon SO, Shin S, Lipscomb EA. A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: the alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling. Cancer Res. 2006;66(5):2732-9.