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Volumn 87, Issue 2, 2000, Pages 236-240

Methylation of specific CpG sites in the promoter region could significantly down-regulate p16(INK4a) expression in gastric adenocarcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GENETICS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DNA DETERMINATION; DNA METHYLATION; DOWN REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROMOTER REGION; STOMACH ADENOCARCINOMA;

EID: 0034662110     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000715)87:2<236::AID-IJC14>3.0.CO;2-M     Document Type: Article
Times cited : (69)

References (19)
  • 2
    • 0029967152 scopus 로고    scopus 로고
    • Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation
    • COSTELLO, J.F., BERGER, M.S., HUANG, H.-J.S. and CAVENEE, W.K., Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res., 56, 2405-2410 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 2405-2410
    • Costello, J.F.1    Berger, M.S.2    Huang, H.-J.S.3    Cavenee, W.K.4
  • 4
    • 0028875205 scopus 로고
    • Methylation of the 5′ cpg island of the p16/CDKn2 tumor-suppressor gene in normal and transformed human tissues correlates with gene silencing
    • GONZALEZ-ZULUETA, M., BENDER, C.M., YANG, A.S., NGUYEN, T., BEART, R.W., VAN TORNOUT, J.M. and JONES, P.A., Methylation of the 5′ CpG island of the p16/CDKN2 tumor-suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res., 55, 4531-4535 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 4531-4535
    • Gonzalez-Zulueta, M.1    Bender, C.M.2    Yang, A.S.3    Nguyen, T.4    Beart, R.W.5    Van Tornout, J.M.6    Jones, P.A.7
  • 6
  • 7
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • HERMAN, J.G., MERLO, A., MAO, L., LAPIDUS, R.G., ISSA, J-P.J., DAVIDSON, N.E., SIDRANSKY, D. and BAYLIN, S.B., Inactivation of the CDKN2/p16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res., 55, 4525-4530 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.-P.J.5    Davidson, N.E.6    Sidransky, D.7    Baylin, S.B.8
  • 9
    • 0033566898 scopus 로고    scopus 로고
    • Up-regulation of human telomerase catalytic sub-unit during gastric carcinogenesis
    • JONG, H.-S., PARK, Y.I., KIM, S., SOHN, J.H., KANG, S.H., SONG, S.H., BANG, Y-J. and KIM, N.K., Up-regulation of human telomerase catalytic sub-unit during gastric carcinogenesis. Cancer, 86, 559-565 (1999).
    • (1999) Cancer , vol.86 , pp. 559-565
    • Jong, H.-S.1    Park, Y.I.2    Kim, S.3    Sohn, J.H.4    Kang, S.H.5    Song, S.H.6    Bang, Y.-J.7    Kim, N.K.8
  • 11
    • 0033590404 scopus 로고    scopus 로고
    • High frequency of p16INK4A-gene alterations in hepatocellular carcinoma
    • LIEW, C.T. and 12 OTHERS, High frequency of p16INK4A-gene alterations in hepatocellular carcinoma. Oncogene, 18, 789-795 (1999).
    • (1999) Oncogene , vol.18 , pp. 789-795
    • Liew, C.T.1
  • 13
    • 0032924622 scopus 로고    scopus 로고
    • P16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma
    • MATSUDA, Y., ICHIDA, T., MATSUZAWA, J., SUGIMURA, K. and ASAKURA, H., p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma. Gastroenterology, 116, 394-400 (1999).
    • (1999) Gastroenterology , vol.116 , pp. 394-400
    • Matsuda, Y.1    Ichida, T.2    Matsuzawa, J.3    Sugimura, K.4    Asakura, H.5
  • 14
    • 0029011539 scopus 로고
    • 5′CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/ MTS1 in human cancers
    • MERLO, A., HERMAN, J.G., MAO, L., LEE, D.J., GABRIELSON, E., BURGER, P.C., BAYLIN, S.B. and SIDRANSKY, D., 5′CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/ MTS1 in human cancers. Nature Med., 1, 686-692 (1995).
    • (1995) Nature Med. , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 16
    • 0031771497 scopus 로고    scopus 로고
    • The human ARF cell-cycle-regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53
    • ROBERTSON, K.D. and JONES, P.A., The human ARF cell-cycle-regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol. cell. Biol., 18, 6457-6473 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 6457-6473
    • Robertson, K.D.1    Jones, P.A.2
  • 17
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • SERRANO, M., HANNON, G.J. and BEACH, D., A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (Lond.), 366, 704-707 (1993).
    • (1993) Nature (Lond.) , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 18
    • 0032585651 scopus 로고    scopus 로고
    • Re-expression of endogenous p16ink4a in oral-squamous-cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescence-like state
    • TIMMERMANN, S., HINDS, P.W. and MUNGER, K., Re-expression of endogenous p16ink4a in oral-squamous-cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescence-like state. Oncogene, 17, 3445-3453 (1998).
    • (1998) Oncogene , vol.17 , pp. 3445-3453
    • Timmermann, S.1    Hinds, P.W.2    Munger, K.3
  • 19
    • 0031945061 scopus 로고    scopus 로고
    • Over-expression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: With respect to histological sub-types and stages
    • WU, M.S., SHUN, C.T., SHEU, J.C., WANG, H.P., WANG, J.T., LEE, W.J., CHEN, C.J., WANG, T.H. and LIN, J.T., Over-expression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: with respect to histological sub-types and stages. J. Gastroenterol. Hepatol., 13, 305-310 (1998).
    • (1998) J. Gastroenterol. Hepatol. , vol.13 , pp. 305-310
    • Wu, M.S.1    Shun, C.T.2    Sheu, J.C.3    Wang, H.P.4    Wang, J.T.5    Lee, W.J.6    Chen, C.J.7    Wang, T.H.8    Lin, J.T.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.