A systemic evaluation of cardiac differentiation from mRNA reprogrammed human induced pluripotent stem cells

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Mehta, Ashish ^a   Verma, Vinod ^a   Nandihalli, Manasi ^a   Ramachandra, Chrishan J A ^a   Sequiera, Glen L ^a   Sudibyo, Yuliansa ^a   Chung, Yingying ^a   Sun, William ^b   Shim, Winston ^a,c  

^a DEPARTMENT OF CARDIOLOGY   (Singapore)

^b Agency for Science   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; ADRENERGIC RECEPTOR; CALCIUM CHANNEL; ISOPRENALINE; MESSENGER RNA; NIFEDIPINE; POTASSIUM CHANNEL; SODIUM CHANNEL; SODIUM ION; SOTALOL; TETRODOTOXIN; CARBACHOL; CARDIOTONIC AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; ION CHANNEL; OCTAMER TRANSCRIPTION FACTOR 4; STAGE SPECIFIC EMBRYO ANTIGEN; STAGE-SPECIFIC EMBRYONIC ANTIGEN-4;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; HEART; HEART CONTRACTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MESODERM; MIDDLE AGED; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; QT PROLONGATION; SKIN FIBROBLAST; SODIUM TRANSPORT; TISSUE DIFFERENTIATION; CELL CULTURE; CELL REPROGRAMMING TECHNIQUE; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECTS; EVALUATION STUDY; FIBROBLAST; GENETICS; MEMBRANE POTENTIAL; METABOLISM; PHYSIOLOGY; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CARBACHOL; CARDIOTONIC AGENTS; CELL DIFFERENTIATION; CELLS, CULTURED; CELLULAR REPROGRAMMING; CELLULAR REPROGRAMMING TECHNIQUES; CHOLINERGIC AGONISTS; FIBROBLASTS; GENE EXPRESSION; HUMANS; INDUCED PLURIPOTENT STEM CELLS; ION CHANNELS; ISOPROTERENOL; MALE; MEMBRANE POTENTIALS; MICROSCOPY, CONFOCAL; MIDDLE AGED; MYOCYTES, CARDIAC; OCTAMER TRANSCRIPTION FACTOR-3; PLURIPOTENT STEM CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STAGE-SPECIFIC EMBRYONIC ANTIGENS;

EID: 84904901587     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103485     Document Type: Article

References (50)

1. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872. (Pubitemid 350138099)
2. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676. (Pubitemid 44233629)
3. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318: 1917-1920.
4. Okita K, Ichisaka T, Yamanaka S (2007) Generation of germline-competent induced pluripotent stem cells. Nature 448: 313-317. (Pubitemid 47080336)
5. Sun N, Longaker MT, Wu JC (2010) Human iPS cell-based therapy: considerations before clinical applications. Cell Cycle 9: 880-885.
6. Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, et al. (2012) Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis Model Mech 5: 220-230.
7. Moretti A, Bellin M, Welling A, Jung CB, Lam JT, et al. (2010) Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med 363: 1397-1409.
8. Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, et al. (2011) Modelling schizophrenia using human induced pluripotent stem cells. Nature 473: 221-225.
9. Kim C, Wong J, Wen J, Wang S, Wang C, et al. (2013) Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature 494: 105-110.
10. Pasca SP, Portmann T, Voineagu I, Yazawa M, Shcheglovitov A, et al. (2011) Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nat Med 17: 1657-1662.
11. Somers A, Jean JC, Sommer CA, Omari A, Ford CC, et al. (2010) Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells 28: 1728-1740.
12. Sommer CA, Stadtfeld M, Murphy GJ, Hochedlinger K, Kotton DN, et al. (2009) Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells 27: 543-549.
13. Carey BW, Markoulaki S, Hanna J, Saha K, Gao Q, et al. (2009) Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A 106: 157-162.
14. Chang CW, Lai YS, Pawlik KM, Liu K, Sun CW, et al. (2009) Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells. Stem Cells 27: 1042-1049.
15. Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, et al. (2009) piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 458: 766-770.
16. Yusa K, Rad R, Takeda J, Bradley A (2009) Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods 6: 363-369.
17. Yu J, Hu K, Smuga-Otto K, Tian S, Stewart R, et al. (2009) Human induced pluripotent stem cells free of vector and transgene sequences. Science 324: 797-801.
18. Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S (2008) Generation of mouse induced pluripotent stem cells without viral vectors. Science 322: 949-953.
19. Jia F, Wilson KD, Sun N, Gupta DM, Huang M, et al. (2010) A nonviral minicircle vector for deriving human iPS cells. Nat Methods 7: 197-199.
20. Yu J, Chau KF, Vodyanik MA, Jiang J, Jiang Y (2011) Efficient feeder-free episomal reprogramming with small molecules. PLOS One 6: e17557.
21. Sequiera GL, Mehta A, Ooi TH, Shim W (2013) Ontogenic development of cardiomyocytes derived from transgene-free human induced pluripotent stem cells and its homology with human heart. Life Sci 92: 63-71.
22. Zhou H, Wu S, Joo JY, Zhu S, Han DW, et al. (2009) Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4: 381-384.
23. Ban H, Nishishita N, Fusaki N, Tabata T, Saeki K, et al. (2011) Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors. Proc Natl Acad Sci U S A 108: 14234-14239.
24. Ono M, Hamada Y, Horiuchi Y, Matsuo-Takasaki M, Imoto Y, et al. (2012) Generation of induced pluripotent stem cells from human nasal epithelial cells using a Sendai virus vector. PLOS One 7: e42855.
25. Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, et al. (2010) Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7: 618-630.
26. Warren L, Ni Y, Wang J, Guo X (2012) Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA. Sci Rep 2.
27. Plews JR, Li J, Jones M, Moore HD, Mason C, et al. (2010) Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach. PLOS One 5: e14397.
28. Goh PA, Caxaria S, Casper C, Rosales C, Warner TT, et al. (2013) A Systematic Evaluation of Integration Free Reprogramming Methods for Deriving Clinically Relevant Patient Specific Induced Pluripotent Stem (iPS) Cells. PLOS ONE 8: e81622.
29. Mehta A, Chung YY, Ng A, Iskandar F, Atan S, et al. (2011) Pharmacological Response of Human Cardiomyocytes Derived from Viral-Free Induced Pluripotent Stem Cells. Cardiovascular Research.
30. Mehta A, Konala VB, Khanna A, Majumdar AS (2008) Assessment of drug induced developmental toxicity using human embryonic stem cells. Cell Biol Int 32: 1412-1424.
31. Mehta A, Sequiera GL, Ramachandra CJ, Sudibyo Y, Chung Y, et al. (2014) Re-trafficking of hERG reverses long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes. Cardiovasc Res 102: 497-506.
32. Mehta A, Chung Y, Sequiera GL, Wong P, Liew R, et al. (2013) Pharmacoelectrophysiology of Viral-Free Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes. Toxicological Sciences 131: 458-469.
33. Mehta A, Mathew S, Viswanathan C, Sen Majumdar A (2010) Intrinsic properties and external factors determine the differentiation bias of human embryonic stem cell lines. Cell Biol Int 34: 1021-1031.
34. Ritner C, Bernstein HS (2010) Fate mapping of human embryonic stem cells by teratoma formation. J Vis Exp.
35. Zwi L, Caspi O, Arbel G, Huber I, Gepstein A, et al. (2009) Cardiomyocyte differentiation of human induced pluripotent stem cells. Circulation 120: 1513-1523.
36. Zhu WZ, Santana LF, Laflamme MA (2009) Local control of excitation-contraction coupling in human embryonic stem cell-derived cardiomyocytes. PLOS One 4: e5407.
37. Kehat I, Gepstein A, Spira A, Itskovitz-Eldor J, Gepstein L (2002) High-Resolution Electrophysiological Assessment of Human Embryonic Stem Cell-Derived Cardiomyocytes: A Novel In Vitro Model for the Study of Conduction. Circulation Research 91: 659-661. (Pubitemid 35204947)
38. Burridge PW, Thompson S, Millrod MA, Weinberg S, Yuan X, et al. (2011) A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability. PLOS One 6: e18293.
39. Flora SJ, Mehta A (2009) Monoisoamyl dimercaptosuccinic acid abrogates arsenic-induced developmental toxicity in human embryonic stem cell-derived embryoid bodies: comparison with in vivo studies. Biochem Pharmacol 78: 1340-1349.
40. Ng KM, Lee YK, Lai WH, Chan YC, Fung ML, et al. (2011) Exogenous expression of human apoA-I enhances cardiac differentiation of pluripotent stem cells. PLOS One 6: e19787.
41. Dahlmann J, Kensah G, Kempf H, Skvorc D, Gawol A, et al. (2013) The use of agarose microwells for scalable embryoid body formation and cardiac differentiation of human and murine pluripotent stem cells. Biomaterials 34: 2463-2471.
42. Mummery CL, Zhang J, Ng ES, Elliott DA, Elefanty AG, et al. (2012) Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview. Circ Res 111: 344-358.
43. Pekkanen-Mattila M, Kerkela E, Tanskanen JM, Pietila M, Pelto-Huikko M, et al. (2009) Substantial variation in the cardiac differentiation of human embryonic stem cell lines derived and propagated under the same conditions - a comparison of multiple cell lines. Ann Med 41: 360-370.
44. Mehta A, Ramachandra CJ, Sequiera GL, Sudibyo Y, Nandihalli M, et al. (2014) Phasic Modulation of Wnt Signaling Enhances Cardiac Differentiation in Human Pluripotent Stem Cells by Recapitulating Developmental Ontogeny. BBA - Molecular Cell Research In Press.
45. Mummery C, Ward-van Oostwaard D, Doevendans P, Spijker R, van den Brink S, et al. (2003) Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation 107: 2733-2740. (Pubitemid 36667249)
46. Knollmann BC (2013) Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model? Circ Res 112: 969-976; discussion 976.
47. Itzhaki I, Rapoport S, Huber I, Mizrahi I, Zwi-Dantsis L, et al. (2011) Calcium handling in human induced pluripotent stem cell derived cardiomyocytes. PLOS One 6: e18037.
48. Escobar AL, Perez CG, Reyes ME, Lucero SG, Kornyeyev D, et al. (2012) Role of inositol 1,4,5-trisphosphate in the regulation of ventricular Ca(2+) signaling in intact mouse heart. J Mol Cell Cardiol 53: 768-779.
49. Lundy SD, Zhu WZ, Regnier M, Laflamme MA (2013) Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells. Stem Cells Dev 22: 1991-2002.
50. Yamanaka S (2007) Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 1: 39-49.