Ontogenic development of cardiomyocytes derived from transgene-free human induced pluripotent stem cells and its homology with human heart

Life Sciences

Volumn 92, Issue 1, 2013, Pages 63-71

  Sequiera, Glen Lester ^a   Mehta, Ashish ^a   Ooi, Ting Huay ^a   Shim, Winston ^a  

^a DEPARTMENT OF CARDIOLOGY   (Singapore)

Author keywords

Cardiomyocytes; Differentiation; Gene expression; Induced pluripotent stem cells

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; ACTININ; ION CHANNEL; MYOSIN LIGHT CHAIN; POTASSIUM CHANNEL KCNQ1; TROPONIN; VERAPAMIL;

ARTICLE; CELL DIFFERENTIATION; CHRONOTROPISM; CONTROLLED STUDY; EMBRYOID BODY; FIBROBLAST; GENE EXPRESSION; HEART DEVELOPMENT; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROELECTRODE; ONTOGENY; PHARMACOGENOMICS; PLURIPOTENT STEM CELL; REAL TIME POLYMERASE CHAIN REACTION; REGENERATIVE MEDICINE; STRUCTURAL GENE;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HUMANS; INDUCED PLURIPOTENT STEM CELLS; ISOPROTERENOL; MICE; MICE, SCID; MICROELECTRODES; MYOCYTES, CARDIAC; QUINIDINE; REAL-TIME POLYMERASE CHAIN REACTION; SODIUM; VERAPAMIL;

EID: 84871921267     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.10.020     Document Type: Article

References (30)

1. J. Asp, D. Steel, M. Jonsson, C. Ameen, K. Dahlenborg, and A. Jeppsson Cardiomyocyte clusters derived from human embryonic stem cells share similarities with human heart tissue J Mol Cell Biol 2 2010 276 283
2. A. Beqqali, J. Kloots, D. Ward-van Oostwaard, C. Mummery, and R. Passier Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes Stem Cells 24 2006 1956 1967
3. F. Cao, R.A. Wagner, K.D. Wilson, X. Xie, J.D. Fu, and M. Drukker Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes PLoS One 3 2008 e3474
4. X. Carvajal-Vergara, A. Sevilla, S.L. D'Souza, Y.S. Ang, C. Schaniel, and D.F. Lee Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome Nature 465 2010 808 812
5. S.J. Flora, and A. Mehta Monoisoamyl dimercaptosuccinic acid abrogates arsenic-induced developmental toxicity in human embryonic stem cell-derived embryoid bodies: comparison with in vivo studies Biochem Pharmacol 78 2009 1340 1349
6. J.Q. He, Y. Ma, Y. Lee, J.A. Thomson, and T.J. Kamp Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization Circ Res 93 2003 32 39
7. I. Itzhaki, L. Maizels, I. Huber, L. Zwi-Dantsis, O. Caspi, and A. Winterstern Modelling the long QT syndrome with induced pluripotent stem cells Nature 471 2011 225 229
8. I. Kola, and J. Landis Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3 2004 711 715
9. D. Malan, S. Friedrichs, B.K. Fleischmann, and P. Sasse Cardiomyocytes obtained from induced pluripotent stem cells with long-QT syndrome 3 recapitulate typical disease-specific features in vitro Circ Res 109 2011 841 847
10. E. Matsa, D. Rajamohan, E. Dick, L. Young, I. Mellor, and A. Staniforth Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation Eur Heart J 32 2011 952 962
11. A. Mehta, V.B. Konala, A. Khanna, and A.S. Majumdar Assessment of drug induced developmental toxicity using human embryonic stem cells Cell Biol Int 32 2008 1412 1424
12. A. Mehta, S. Mathew, C. Viswanathan, and A. Sen Majumdar Intrinsic properties and external factors determine the differentiation bias of human embryonic stem cell lines Cell Biol Int 34 2010 1021 1031
13. A. Mehta, Y.Y. Chung, A. Ng, F. Iskandar, S. Atan, and H. Wei Pharmacological response of human cardiomyocytes derived from virus-free induced pluripotent stem cells Cardiovasc Res 91 2011 577 586
14. A. Moretti, M. Bellin, A. Welling, C.B. Jung, J.T. Lam, and L. Bott-Flugel Patient-specific induced pluripotent stem-cell models for long-QT syndrome N Engl J Med 363 2010 1397 1409
15. C. Mummery, D. Ward-van Oostwaard, P. Doevendans, R. Spijker, S. van den Brink, and R. Hassink Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells Circulation 107 2003 2733 2740
16. T.J. Nelson, A. Martinez-Fernandez, and A. Terzic Induced pluripotent stem cells: developmental biology to regenerative medicine Nat Rev Cardiol 7 2010 700 710
17. H. Niwa, J. Miyazaki, and A.G. Smith Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells Nat Genet 24 2000 372 376
18. K. Osafune, L. Caron, M. Borowiak, R.J. Martinez, C.S. Fitz-Gerald, and Y. Sato Marked differences in differentiation propensity among human embryonic stem cell lines Nat Biotechnol 26 2008 313 315
19. C. Ritner, and H.S. Bernstein Fate mapping of human embryonic stem cells by teratoma formation J Vis Exp 42 2010 e2036
20. D.M. Roden Drug-induced prolongation of the QT interval N Engl J Med 350 2004 1013 1022
21. L. Sartiani, E. Bettiol, F. Stillitano, A. Mugelli, E. Cerbai, and M.E. Jaconi Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach Stem Cells 25 2007 1136 1144
22. M. Snir, I. Kehat, A. Gepstein, R. Coleman, J. Itskovitz-Eldor, and E. Livne Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes Am J Physiol Heart Circ Physiol 285 2003 H2355 H2363
23. J. Synnergren, K. Akesson, K. Dahlenborg, H. Vidarsson, C. Ameen, and D. Steel Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells Stem Cells 26 2008 1831 1840
24. K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, and K. Tomoda Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 2007 861 872
25. A. Tomescot, J. Leschik, V. Bellamy, G. Dubois, E. Messas, and P. Bruneval Differentiation in vivo of cardiac committed human embryonic stem cells in postmyocardial infarcted rats Stem Cells 25 2007 2200 2205
26. L. Warren, P.D. Manos, T. Ahfeldt, Y.H. Loh, H. Li, and F. Lau Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA Cell Stem Cell 7 2010 618 630
27. L. Yang, M.H. Soonpaa, E.D. Adler, T.K. Roepke, S.J. Kattman, and M. Kennedy Human cardiovascular progenitor cells develop from a KDR + embryonic-stem-cell-derived population Nature 453 2008 524 528
28. J. Yu, K. Hu, K. Smuga-Otto, S. Tian, R. Stewart, and I.I. Slukvin Human induced pluripotent stem cells free of vector and transgene sequences Science 324 2009 797 801
29. J. Zhang, G.F. Wilson, A.G. Soerens, C.H. Koonce, J. Yu, and S.P. Palecek Functional cardiomyocytes derived from human induced pluripotent stem cells Circ Res 104 2009 e30 e41
30. L. Zwi, O. Caspi, G. Arbel, I. Huber, A. Gepstein, and I.H. Park Cardiomyocyte differentiation of human induced pluripotent stem cells Circulation 120 2009 1513 1523