Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: Regulation of Treg/Th17 cells

Journal of Gastroenterology and Hepatology (Australia)

Volumn 29, Issue 8, 2014, Pages 1620-1628

  Xu, Lanman ^a   Gong, Yuewen ^c   Wang, Benfu ^b   Shi, Keqing ^a   Hou, Yijun ^a   Wang, Liping ^a   Lin, Zuo ^a   Han, Yixiang ^b   Lu, Lu ^b   Chen, Dazhi ^a   Lin, Xiuli ^a   Zeng, Qiqiang ^b   Feng, Wenke ^a,d   Chen, Yongping ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF MANITOBA   (Canada)

^d University of Louisville School of Medicine   (United States)

Author keywords

Bone marrow mesenchymal stem cells; Hepatitis B virus; Liver cirrhosis; Stem cell transplantation; Treg Th17 cells

Indexed keywords

ENTECAVIR; INTERLEUKIN 17; INTERLEUKIN 6; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; ANTIVIRUS AGENT; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; GUANINE; RETINOID RELATED ORPHAN RECEPTOR GAMMA;

ADULT; ARTICLE; AUTOLOGOUS BONE MARROW MESENCHYMAL STEM CELL TRANSPLANTATION; AUTOLOGOUS STEM CELL TRANSPLANTATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; FOLLOW UP; HEMATOPOIETIC STEM CELL; HEPATITIS B; HEPATITIS B VIRUS LIVER CIRRHOSIS; HUMAN; HUMAN CELL; LIVER CIRRHOSIS; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MODEL FOR END STAGE LIVER DISEASE SCORE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; REGULATORY T LYMPHOCYTE; TH17 CELL; ANALOGS AND DERIVATIVES; AUTOGRAFT; BLOOD; COMPLICATION; IMMUNOLOGY; LYMPHOCYTE COUNT; MIDDLE AGED; MULTIMODALITY CANCER THERAPY;

ADULT; ANTIVIRAL AGENTS; AUTOGRAFTS; COMBINED MODALITY THERAPY; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GUANINE; HEPATITIS B; HUMANS; INTERLEUKIN-17; INTERLEUKIN-6; LIVER CIRRHOSIS; LYMPHOCYTE COUNT; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MIDDLE AGED; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PROSPECTIVE STUDIES; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84904893413     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12653     Document Type: Article

References (40)

1. Kharaziha P, Hellstrom PM, Noorinayer B etal. Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial. Eur. J. Gastroenterol. Hepatol. 2009; 21: 1199-1205.
2. Lyra AC, Soares MB, da Silva LF etal. Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. World J. Gastroenterol. 2007; 13: 1067-1073.
3. Peng L, Xie DY, Lin BL etal. Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes. Hepatology 2011; 54: 820-828.
4. Terai S, Ishikawa T, Omori K etal. Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy. Stem Cells 2006; 24: 2292-2298.
5. Le Blanc K, Ringden O. Immunomodulation by mesenchymal stem cells and clinical experience. J. Intern. Med. 2007; 262: 509-525.
6. Ozaki K, Sato K, Oh I etal. Mechanisms of immunomodulation by mesenchymal stem cells. Int. J. Hematol. 2007; 86: 5-7.
7. Rasmusson I. Immune modulation by mesenchymal stem cells. Exp. Cell Res. 2006; 312: 2169-2179.
8. Le Blanc K, Rasmusson I, Sundberg B etal. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004; 363: 1439-1441.
9. Wu Y, Ren M, Yang R etal. Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4+CCR6+ Th/Treg cell subset imbalance in ankylosing spondylitis. Arthritis Res. Ther. 2011; 13: R29.
10. Wang L, Li J, Liu H etal. A pilot study of umbilical cord-derived mesenchymal stem cell transfusion in patients with primary biliary cirrhosis. J. Gastroenterol. Hepatol. 2013; 28(Suppl. 1): 85-92.
11. Madec AM, Mallone R, Afonso G etal. Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells. Diabetologia 2009; 52: 1391-1399.
12. Park MJ, Park HS, Cho ML etal. Transforming growth factor beta-transduced mesenchymal stem cells ameliorate experimental autoimmune arthritis through reciprocal regulation of Treg/Th17 cells and osteoclastogenesis. Arthritis Rheum. 2011; 63: 1668-1680.
13. Wang Y, Zhang A, Ye Z, Xie H, Zheng S. Bone marrow-derived mesenchymal stem cells inhibit acute rejection of rat liver allografts in association with regulatory T-cell expansion. Transplant. Proc. 2009; 41: 4352-4356.
14. Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008; 133: 775-787.
15. Zhu J, Paul WE. Heterogeneity and plasticity of T helper cells. Cell Res. 2010; 20: 4-12.
16. Rong G, Zhou Y, Xiong Y etal. Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population. Clin. Exp. Immunol. 2009; 156: 217-225.
17. Wang W, Shao S, Jiao Z, Guo M, Xu H, Wang S. The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis. Rheumatol. Int. 2012; 32: 887-893.
18. Yang J, Yang X, Zou H, Chu Y, Li M. Recovery of the immune balance between Th17 and regulatory T cells as a treatment for systemic lupus erythematosus. Rheumatology 2011; 50: 1366-1372.
19. Li J, Qiu SJ, She WM etal. Significance of the balance between regulatory T (Treg) and T helper 17 (Th17) cells during hepatitis B virus related liver fibrosis. PLoS ONE 2012; 7: e39307.
20. Niu Y, Liu H, Yin D etal. The balance between intrahepatic IL-17(+) T cells and Foxp3(+) regulatory T cells plays an important role in HBV-related end-stage liver disease. BMC Immunol. 2011; 12: 47.
21. Zhao L, Qiu K, Ma X. Th17 cells: the emerging reciprocal partner of regulatory T cells in the liver. J. Dig. Dis. 2010; 11: 126-133.
22. Li J, Tao R, Wu W etal. 3D PLGA scaffolds improve differentiation and function of bone marrow mesenchymal stem cell-derived hepatocytes. Stem Cells Dev. 2010; 19: 1427-1436.
23. Higgs ZC, Macafee DA, Braithwaite BD, Maxwell-Armstrong CA. The Seldinger technique: 50 years on. Lancet 2005; 366: 1407-1409.
24. Salama H, Zekri AR, Zern M etal. Autologous hematopoietic stem cell transplantation in 48 patients with end-stage chronic liver diseases. Cell Transplant. 2010; 19: 1475-1486.
25. Longhi MS, Meda F, Wang P etal. Expansion and de novo generation of potentially therapeutic regulatory T cells in patients with autoimmune hepatitis. Hepatology 2008; 47: 581-591.
26. Zhang JY, Zhang Z, Lin F etal. Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology 2010; 51: 81-91.
27. Lemmers A, Moreno C, Gustot T etal. The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology 2009; 49: 646-657.
28. Almeida-Porada G, Zanjani ED, Porada CD. Bone marrow stem cells and liver regeneration. Exp. Hematol. 2010; 38: 574-580.
29. Gilchrist ES, Plevris JN. Bone marrow-derived stem cells in liver repair: 10 years down the line. Liver Transpl. 2010; 16: 118-129.
30. Terai S, Sakaida I, Yamamoto N etal. An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes. J. Biochem. 2003; 134: 551-558.
31. Chen Z, Qi LZ, Zeng R, Li HY, Dai LJ. Stem cells and hepatic cirrhosis. Panminerva Med. 2010; 52: 149-165.
32. Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood 2007; 110: 3499-3506.
33. Tatara R, Ozaki K, Kikuchi Y etal. Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation. Cytotherapy 2011; 13: 686-694.
34. Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur. J. Immunol. 2010; 40: 1830-1835.
35. Augello A, Tasso R, Negrini SM, Cancedda R, Pennesi G. Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis. Arthritis Rheum. 2007; 56: 1175-1186.
36. Ye C, Li WY, Zheng MH, Chen YP. T-helper 17 cell: a distinctive cell in liver diseases. Hepatol. Res. 2011; 41: 22-29.
37. Bettelli E, Carrier Y, Gao W etal. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441: 235-238.
38. Mangan PR, Harrington LE, O'Quinn DB etal. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441: 231-234.
39. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006; 24: 179-189.
40. Zhou L, Lopes JE, Chong MM etal. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 2008; 453: 236-240.