Mechanisms of immunomodulation by mesenchymal stem cells

International Journal of Hematology

Volumn 86, Issue 1, 2007, Pages 5-7

  Ozaki, Katsutoshi ^a   Sato, Kazuya ^a   Oh, Iekuni ^a   Meguro, Akiko ^a   Tatara, Raine ^a   Muroi, Kazuo ^a   Ozawa, Keiya ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

GVHD; Immunomodulation; Mesenchymal stem cells

Indexed keywords

CYTOKINE; INDOLEAMINE 2,3 DIOXYGENASE; INDOMETACIN; NITRIC OXIDE; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; SCATTER FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TRYPTOPHAN;

ANTIGEN PRESENTING CELL; BONE MARROW; CELL ADHESION; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME INHIBITION; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOMODULATION; MESENCHYMAL STEM CELL; MOLECULAR DYNAMICS; MONOCYTE; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW; T LYMPHOCYTE; TH1 CELL;

GRAFT VS HOST DISEASE; HUMANS; IMMUNOLOGIC FACTORS; MESENCHYMAL STEM CELLS; NITRIC OXIDE;

EID: 34547626083     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.07003     Document Type: Review

References (20)

1. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143-147.
2. Horwitz EM, Gordon PL, Koo WK, et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci U S A. 2002;99:8932-8937.
3. Di Nicola M, Carlo-Stella C, Magni M, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood. 2002;99:3838-3843.
4. Le Blanc K, Rasmusson I, Sundberg B, et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet. 2004;363:1439-1441.
5. Ringden O, Uzunel M, Rasmusson I, et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation. 2006;81:1390-1397.
6. Le Blanc K, Frassoni F, Ball L, et al. Mesenchymal stem cells for treatment of severe acute graft-versus-host disease [abstract]. Blood. 2006;108:226a.
7. Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation. 2003;75: 389-397.
8. Krampera M, Glennie S, Dyson J, et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood. 2003;101:3722-3729.
9. Djouad F, Plence P, Bony C, et al. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood. 2003;102:3837-3844.
10. Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood. 2004;103:4619-4621.
11. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005;105:1815-1822.
12. Beyth S, Borovsky Z, Mevorach D, et al. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood. 2005;105:2214-2219.
13. Glennie S, Soeiro I, Dyson PJ, Lam EW, Dazzi F. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood. 2005;105:2821-2827.
14. Sato K, Ozaki K, Oh I, et al. Nitric oxide plays a critical role in sup pression of T cell proliferation by mesenchymal stem cells. Blood. 2007;109:228-234.
15. Kim SF, Huri DA, Snyder SH. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science. 2005;310:1966-1970.
16. Moriggl R, Topham DJ, Teglund S, et al. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity. 1999;10:249-259.
17. Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells: the International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315-317.
18. Sudres M, Norol F, Trenado A, et al. Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro but fail to prevent graft-versus-host disease in mice. J Immunol. 2006;176: 7761-7767.
19. Yanez R, Lamana ML, Garcia-Castro J, Colmenero I, Ramirez M, Bueren JA. Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease. Stem Cells. 2006;24:2582-2591.
20. Lazarus HM, Koc ON, Devine SM, et al. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant. 2005;11:389-398.