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Volumn 123, Issue , 2014, Pages 67-94

Aberrant posttranscriptional processing of hyaluronan synthase 1 in malignant transformation and tumor progression

Author keywords

Aberrant splicing; Alternative splicing; B cell malignancies; Hyaluronan synthase 1; Intracellular hyaluronan; Mitotic catastrophe; Oncogenic events; RHAMM

Indexed keywords

HYALURONATE SYNTHETASE; SYNTHETASE; UNCLASSIFIED DRUG; GLUCURONOSYLTRANSFERASE; GREEN FLUORESCENT PROTEIN; HYALURONAN SYNTHASE; MESSENGER RNA;

EID: 84904862424     PISSN: 0065230X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800092-2.00003-4     Document Type: Chapter
Times cited : (9)

References (88)
  • 3
    • 84895817817 scopus 로고    scopus 로고
    • A genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets
    • Adamia S., Haibe-Kains B., Pilarski P.M., Bar-Natan M., Pevzner S., Avet-Loiseau H., et al. A genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets. Clinical Cancer Research 2014, 20(5):1135-1145.
    • (2014) Clinical Cancer Research , vol.20 , Issue.5 , pp. 1135-1145
    • Adamia, S.1    Haibe-Kains, B.2    Pilarski, P.M.3    Bar-Natan, M.4    Pevzner, S.5    Avet-Loiseau, H.6
  • 7
    • 84878641955 scopus 로고    scopus 로고
    • Aberrant splicing, hyaluronan synthases and intracellular hyaluronan as drivers of oncogenesis and potential drug targets
    • Adamia S., Pilarski P.M., Belch A.R., Pilarski L.M. Aberrant splicing, hyaluronan synthases and intracellular hyaluronan as drivers of oncogenesis and potential drug targets. Current Cancer Drug Targets 2013, 13:347-361.
    • (2013) Current Cancer Drug Targets , vol.13 , pp. 347-361
    • Adamia, S.1    Pilarski, P.M.2    Belch, A.R.3    Pilarski, L.M.4
  • 8
    • 58149374579 scopus 로고    scopus 로고
    • Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia
    • Adamia S., Reichert A.A., Kuppusamy H., Kriangkum J., Ghosh A., Hodges J.J., et al. Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia. Blood 2008, 112:5111-5121.
    • (2008) Blood , vol.112 , pp. 5111-5121
    • Adamia, S.1    Reichert, A.A.2    Kuppusamy, H.3    Kriangkum, J.4    Ghosh, A.5    Hodges, J.J.6
  • 9
    • 18144417341 scopus 로고    scopus 로고
    • Intronic splicing of hyaluronan synthase 1 (HAS1): A biologically relevant indicator of poor outcome in multiple myeloma
    • Adamia S., Reiman T., Crainie M., Mant M.J., Belch A.R., Pilarski L.M. Intronic splicing of hyaluronan synthase 1 (HAS1): A biologically relevant indicator of poor outcome in multiple myeloma. Blood 2005, 105:4836-4844.
    • (2005) Blood , vol.105 , pp. 4836-4844
    • Adamia, S.1    Reiman, T.2    Crainie, M.3    Mant, M.J.4    Belch, A.R.5    Pilarski, L.M.6
  • 10
    • 18144410210 scopus 로고    scopus 로고
    • Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia
    • Adamia S., Treon S.P., Reiman T., Tournilhac O., McQuarrie C., Mant M.J., et al. Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia. Clinical Lymphoma 2005, 5:253-256.
    • (2005) Clinical Lymphoma , vol.5 , pp. 253-256
    • Adamia, S.1    Treon, S.P.2    Reiman, T.3    Tournilhac, O.4    McQuarrie, C.5    Mant, M.J.6
  • 11
    • 0032988728 scopus 로고    scopus 로고
    • Immunophenotypic and DNA content characteristics of plasma cells in multiple myeloma and monoclonal gammopathy of undetermined significance
    • Almeida J., Orfao A., Mateo G., Ocqueteau M., Garcia-Sanz R., Moro M.J., et al. Immunophenotypic and DNA content characteristics of plasma cells in multiple myeloma and monoclonal gammopathy of undetermined significance. Pathologie Biologie (Paris) 1999, 47:119-127.
    • (1999) Pathologie Biologie (Paris) , vol.47 , pp. 119-127
    • Almeida, J.1    Orfao, A.2    Mateo, G.3    Ocqueteau, M.4    Garcia-Sanz, R.5    Moro, M.J.6
  • 12
    • 0029934319 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 stimulates multiple protein interactions at a unique cis-element in the 3'-untranslated region of the hyaluronan receptor RHAMM mRNA
    • Amara F.M., Entwistle J., Kuschak T.I., Turley E.A., Wright J.A. Transforming growth factor-beta1 stimulates multiple protein interactions at a unique cis-element in the 3'-untranslated region of the hyaluronan receptor RHAMM mRNA. Journal of Biological Chemistry 1996, 271:15279-15284.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 15279-15284
    • Amara, F.M.1    Entwistle, J.2    Kuschak, T.I.3    Turley, E.A.4    Wright, J.A.5
  • 13
    • 0033490051 scopus 로고    scopus 로고
    • The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments
    • Assmann V., Jenkinson D., Marshall J.F., Hart I.R. The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments. Journal of Cell Science 1999, 112(Pt. 22):3943-3954.
    • (1999) Journal of Cell Science , vol.112 , Issue.PART 22 , pp. 3943-3954
    • Assmann, V.1    Jenkinson, D.2    Marshall, J.F.3    Hart, I.R.4
  • 14
    • 0031850550 scopus 로고    scopus 로고
    • The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells
    • Assmann V., Marshall J.F., Fieber C., Hofmann M., Hart I.R. The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells. Journal of Cell Science 1998, 111(Pt. 12):1685-1694.
    • (1998) Journal of Cell Science , vol.111 , Issue.PART 12 , pp. 1685-1694
    • Assmann, V.1    Marshall, J.F.2    Fieber, C.3    Hofmann, M.4    Hart, I.R.5
  • 15
    • 5044222204 scopus 로고    scopus 로고
    • How did alternative splicing evolve? Nature reviews
    • Ast G. How did alternative splicing evolve? Nature reviews. Genetics 2004, 5:773-782.
    • (2004) Genetics , vol.5 , pp. 773-782
    • Ast, G.1
  • 16
    • 0030957791 scopus 로고    scopus 로고
    • Molecular cytogenetic abnormalities in multiple myeloma and plasma cell leukemia measured using comparative genomic hybridization
    • Avet-Loiseau H., Andree-Ashley L.E., Moore D., Mellerin M.P., Feusner J., Bataille R., et al. Molecular cytogenetic abnormalities in multiple myeloma and plasma cell leukemia measured using comparative genomic hybridization. Genes, Chromosomes & Cancer 1997, 19:124-133.
    • (1997) Genes, Chromosomes & Cancer , vol.19 , pp. 124-133
    • Avet-Loiseau, H.1    Andree-Ashley, L.E.2    Moore, D.3    Mellerin, M.P.4    Feusner, J.5    Bataille, R.6
  • 17
    • 84864570434 scopus 로고    scopus 로고
    • Darwinian evolution and tiding clones in multiple myeloma
    • Bahlis N.J. Darwinian evolution and tiding clones in multiple myeloma. Blood 2012, 120:927-928.
    • (2012) Blood , vol.120 , pp. 927-928
    • Bahlis, N.J.1
  • 18
    • 0022506233 scopus 로고
    • Evidence for rapid metabolic turnover of hyaluronate synthetase in Swarm rat chondrosarcoma chondrocytes
    • Bansal M.K., Mason R.M. Evidence for rapid metabolic turnover of hyaluronate synthetase in Swarm rat chondrosarcoma chondrocytes. The Biochemical Journal 1986, 236:515-519.
    • (1986) The Biochemical Journal , vol.236 , pp. 515-519
    • Bansal, M.K.1    Mason, R.M.2
  • 19
    • 79953104675 scopus 로고    scopus 로고
    • Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling
    • Bharadwaj A.G., Goodrich N.P., McAtee C.O., Haferbier K., Oakley G.G., Wahl J.K., et al. Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling. Experimental Cell Research 2011, 317:1214-1225.
    • (2011) Experimental Cell Research , vol.317 , pp. 1214-1225
    • Bharadwaj, A.G.1    Goodrich, N.P.2    McAtee, C.O.3    Haferbier, K.4    Oakley, G.G.5    Wahl, J.K.6
  • 20
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms of alternative pre-messenger RNA splicing
    • Black D.L. Mechanisms of alternative pre-messenger RNA splicing. Annual Review of Biochemistry 2003, 72:291-336.
    • (2003) Annual Review of Biochemistry , vol.72 , pp. 291-336
    • Black, D.L.1
  • 21
    • 79952227361 scopus 로고    scopus 로고
    • CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression
    • Brown R.L., Reinke L.M., Damerow M.S., Perez D., Chodosh L.A., Yang J., et al. CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. The Journal of Clinical Investigation 2011, 121:1064-1074.
    • (2011) The Journal of Clinical Investigation , vol.121 , pp. 1064-1074
    • Brown, R.L.1    Reinke, L.M.2    Damerow, M.S.3    Perez, D.4    Chodosh, L.A.5    Yang, J.6
  • 22
    • 33748286796 scopus 로고    scopus 로고
    • A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
    • Carter S.L., Eklund A.C., Kohane I.S., Harris L.N., Szallasi Z. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nature Genetics 2006, 38:1043-1048.
    • (2006) Nature Genetics , vol.38 , pp. 1043-1048
    • Carter, S.L.1    Eklund, A.C.2    Kohane, I.S.3    Harris, L.N.4    Szallasi, Z.5
  • 23
    • 84872303004 scopus 로고    scopus 로고
    • Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms
    • Cazzola M., Rossi M., Malcovati L. Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms. Blood 2013, 121:260-269.
    • (2013) Blood , vol.121 , pp. 260-269
    • Cazzola, M.1    Rossi, M.2    Malcovati, L.3
  • 24
    • 79953766254 scopus 로고    scopus 로고
    • Cancer-associated splicing variant of tumor suppressor AIMP2/p38: Pathological implication in tumorigenesis
    • Choi J.W., Kim D.G., Lee A.-E., Kim H.R., Lee J.Y., Kwon N.H., et al. Cancer-associated splicing variant of tumor suppressor AIMP2/p38: Pathological implication in tumorigenesis. PLoS Genetics 2011, 7:e1001351.
    • (2011) PLoS Genetics , vol.7
    • Choi, J.W.1    Kim, D.G.2    Lee, A.-E.3    Kim, H.R.4    Lee, J.Y.5    Kwon, N.H.6
  • 25
    • 0033104710 scopus 로고    scopus 로고
    • Overexpression of the receptor for hyaluronan-mediated motility (RHAMM) characterizes the malignant clone in multiple myeloma: Identification of three distinct RHAMM variants
    • Crainie M., Belch A.R., Mant M.J., Pilarski L.M. Overexpression of the receptor for hyaluronan-mediated motility (RHAMM) characterizes the malignant clone in multiple myeloma: Identification of three distinct RHAMM variants. Blood 1999, 93:1684-1696.
    • (1999) Blood , vol.93 , pp. 1684-1696
    • Crainie, M.1    Belch, A.R.2    Mant, M.J.3    Pilarski, L.M.4
  • 26
    • 18544370896 scopus 로고    scopus 로고
    • Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins
    • David A., Mabjeesh N., Azar I., Biton S., Engel S., Bernstein J., et al. Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins. Journal of Biological Chemistry 2002, 277:18084-18090.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 18084-18090
    • David, A.1    Mabjeesh, N.2    Azar, I.3    Biton, S.4    Engel, S.5    Bernstein, J.6
  • 27
    • 33747466753 scopus 로고    scopus 로고
    • Methotrexate resistance in vitro is achieved by a dynamic selection process of tumor cell variants emerging during treatment
    • de Anta J.M., Mayo C., Sole F., Salido M., Espinet B., Corzo C., et al. Methotrexate resistance in vitro is achieved by a dynamic selection process of tumor cell variants emerging during treatment. International Journal of Cancer 2006, 119:1607-1615.
    • (2006) International Journal of Cancer , vol.119 , pp. 1607-1615
    • de Anta, J.M.1    Mayo, C.2    Sole, F.3    Salido, M.4    Espinet, B.5    Corzo, C.6
  • 28
    • 84861341484 scopus 로고    scopus 로고
    • In multiple myeloma, bone-marrow lymphocytes harboring the same chromosomal abnormalities as autologous plasma cells predict poor survival
    • Debes Marun C.S., Belch A.R., Pilarski L.M. In multiple myeloma, bone-marrow lymphocytes harboring the same chromosomal abnormalities as autologous plasma cells predict poor survival. American Journal of Hematology 2012, 87:579-587.
    • (2012) American Journal of Hematology , vol.87 , pp. 579-587
    • Debes Marun, C.S.1    Belch, A.R.2    Pilarski, L.M.3
  • 29
    • 70450280545 scopus 로고    scopus 로고
    • The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells
    • Farina A.R., Tacconelli A., Cappabianca L., Cea G., Chioda A., Romanelli A., et al. The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells. Oncogene 2009, 28:4075-4094.
    • (2009) Oncogene , vol.28 , pp. 4075-4094
    • Farina, A.R.1    Tacconelli, A.2    Cappabianca, L.3    Cea, G.4    Chioda, A.5    Romanelli, A.6
  • 30
    • 0033989262 scopus 로고    scopus 로고
    • Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations
    • Ghadimi B.M., Sackett D.L., Difilippantonio M.J., Schrock E., Neumann T., Jauho A., et al. Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes, Chromosomes & Cancer 2000, 27:183-190.
    • (2000) Genes, Chromosomes & Cancer , vol.27 , pp. 183-190
    • Ghadimi, B.M.1    Sackett, D.L.2    Difilippantonio, M.J.3    Schrock, E.4    Neumann, T.5    Jauho, A.6
  • 31
    • 67650514337 scopus 로고    scopus 로고
    • Aberrant splice variants of HAS1 (Hyaluronan Synthase 1) multimerize with and modulate normally spliced HAS1 protein: A potential mechanism promoting human cancer
    • Ghosh A., Kuppusamy H., Pilarski L.M. Aberrant splice variants of HAS1 (Hyaluronan Synthase 1) multimerize with and modulate normally spliced HAS1 protein: A potential mechanism promoting human cancer. Journal of Biological Chemistry 2009, 284:18840-18850.
    • (2009) Journal of Biological Chemistry , vol.284 , pp. 18840-18850
    • Ghosh, A.1    Kuppusamy, H.2    Pilarski, L.M.3
  • 33
    • 7244234267 scopus 로고    scopus 로고
    • Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma
    • Gutierrez N.C., Garcia J.L., Hernandez J.M., Lumbreras E., Castellanos M., Rasillo A., et al. Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma. Blood 2004, 104:2661-2666.
    • (2004) Blood , vol.104 , pp. 2661-2666
    • Gutierrez, N.C.1    Garcia, J.L.2    Hernandez, J.M.3    Lumbreras, E.4    Castellanos, M.5    Rasillo, A.6
  • 34
    • 34447530390 scopus 로고    scopus 로고
    • The hyaluronan receptors CD44 and RHAMM (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells
    • Hamilton S.R., Fard S.F., Paiwand F.F., Tolg C., Veiseh M., Wang C., et al. The hyaluronan receptors CD44 and RHAMM (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. Journal of Biological Chemistry 2007, 282:16667-16680.
    • (2007) Journal of Biological Chemistry , vol.282 , pp. 16667-16680
    • Hamilton, S.R.1    Fard, S.F.2    Paiwand, F.F.3    Tolg, C.4    Veiseh, M.5    Wang, C.6
  • 35
    • 0026645557 scopus 로고
    • Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility
    • Hardwick C., Hoare K., Owens R., Hohn H.P., Hook M., Moore D., et al. Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility. Journal of Cell Biology 1992, 117:1343-1350.
    • (1992) Journal of Cell Biology , vol.117 , pp. 1343-1350
    • Hardwick, C.1    Hoare, K.2    Owens, R.3    Hohn, H.P.4    Hook, M.5    Moore, D.6
  • 36
    • 84900426582 scopus 로고    scopus 로고
    • Beneficial effects of raf inhibitor in mutant BRAF splice variant-expressing melanoma
    • Hartsough E.J., Basile K., Aplin A.E. Beneficial effects of raf inhibitor in mutant BRAF splice variant-expressing melanoma. Molecular Cancer Research 2014, 12(5):795-802.
    • (2014) Molecular Cancer Research , vol.12 , Issue.5 , pp. 795-802
    • Hartsough, E.J.1    Basile, K.2    Aplin, A.E.3
  • 37
    • 55749102434 scopus 로고    scopus 로고
    • Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: Implications for a new mechanism of resistance
    • Iacobucci I., Lonetti A., Messa F., Cilloni D., Arruga F., Ottaviani E., et al. Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: Implications for a new mechanism of resistance. Blood 2008, 112:3847-3855.
    • (2008) Blood , vol.112 , pp. 3847-3855
    • Iacobucci, I.1    Lonetti, A.2    Messa, F.3    Cilloni, D.4    Arruga, F.5    Ottaviani, E.6
  • 38
    • 20844463416 scopus 로고    scopus 로고
    • Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients
    • Keats J.J., Maxwell C.A., Taylor B.J., Hendzel M.J., Chesi M., Bergsagel P.L., et al. Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients. Blood 2005, 105:4060-4069.
    • (2005) Blood , vol.105 , pp. 4060-4069
    • Keats, J.J.1    Maxwell, C.A.2    Taylor, B.J.3    Hendzel, M.J.4    Chesi, M.5    Bergsagel, P.L.6
  • 39
    • 53449085087 scopus 로고    scopus 로고
    • A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma
    • Kirshner J., Thulien K.J., Martin L.D., Debes Marun C., Reiman T., Belch A.R., et al. A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma. Blood 2008, 112:2935-2945.
    • (2008) Blood , vol.112 , pp. 2935-2945
    • Kirshner, J.1    Thulien, K.J.2    Martin, L.D.3    Debes Marun, C.4    Reiman, T.5    Belch, A.R.6
  • 40
    • 33244477005 scopus 로고    scopus 로고
    • BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells
    • Klein F., Feldhahn N., Herzog S., Sprangers M., Mooster J.L., Jumaa H., et al. BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells. Oncogene 2006, 25:1118-1124.
    • (2006) Oncogene , vol.25 , pp. 1118-1124
    • Klein, F.1    Feldhahn, N.2    Herzog, S.3    Sprangers, M.4    Mooster, J.L.5    Jumaa, H.6
  • 42
    • 84871905869 scopus 로고    scopus 로고
    • Alteration of introns in a hyaluronan synthase 1 (HAS1) minigene convert Pre-mRNA [corrected] splicing to the aberrant pattern in multiple myeloma (MM): MM patients harbor similar changes
    • Kriangkum J., Warkentin A., Belch A.R., Pilarski L.M. Alteration of introns in a hyaluronan synthase 1 (HAS1) minigene convert Pre-mRNA [corrected] splicing to the aberrant pattern in multiple myeloma (MM): MM patients harbor similar changes. PLoS One 2013, 8:e53469.
    • (2013) PLoS One , vol.8
    • Kriangkum, J.1    Warkentin, A.2    Belch, A.R.3    Pilarski, L.M.4
  • 43
    • 0027982007 scopus 로고
    • Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells
    • Kuo M.T., Vyas R.C., Jiang L.X., Hittelman W.N. Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells. Molecular and Cellular Biology 1994, 14:5202-5211.
    • (1994) Molecular and Cellular Biology , vol.14 , pp. 5202-5211
    • Kuo, M.T.1    Vyas, R.C.2    Jiang, L.X.3    Hittelman, W.N.4
  • 45
    • 68649105674 scopus 로고    scopus 로고
    • Inactivation of SHIP1 in T-cell acute lymphoblastic leukemia due to mutation and extensive alternative splicing
    • Lo T.C., Barnhill L.M., Kim Y., Nakae E.A., Yu A.L., Diccianni M.B. Inactivation of SHIP1 in T-cell acute lymphoblastic leukemia due to mutation and extensive alternative splicing. Leukemia Research 2009, 33:1562-1566.
    • (2009) Leukemia Research , vol.33 , pp. 1562-1566
    • Lo, T.C.1    Barnhill, L.M.2    Kim, Y.3    Nakae, E.A.4    Yu, A.L.5    Diccianni, M.B.6
  • 46
    • 66149186859 scopus 로고    scopus 로고
    • Aberrant splicing of Hugl-1 is associated with hepatocellular carcinoma progression
    • Lu X., Feng X., Man X., Yang G., Tang L., Du D., et al. Aberrant splicing of Hugl-1 is associated with hepatocellular carcinoma progression. Clinical Cancer Research 2009, 15:3287-3296.
    • (2009) Clinical Cancer Research , vol.15 , pp. 3287-3296
    • Lu, X.1    Feng, X.2    Man, X.3    Yang, G.4    Tang, L.5    Du, D.6
  • 47
    • 33748846786 scopus 로고    scopus 로고
    • Overexpression of the receptor for hyaluronic acid mediated motility is an independent adverse prognostic factor in colorectal cancer
    • Lugli A., Zlobec I., Gunthert U., Minoo P., Baker K., Tornillo L., et al. Overexpression of the receptor for hyaluronic acid mediated motility is an independent adverse prognostic factor in colorectal cancer. Modern Pathology 2006, 19:1302-1309.
    • (2006) Modern Pathology , vol.19 , pp. 1302-1309
    • Lugli, A.1    Zlobec, I.2    Gunthert, U.3    Minoo, P.4    Baker, K.5    Tornillo, L.6
  • 48
    • 0030045099 scopus 로고    scopus 로고
    • Hyaluronan-dependent motility of B cells and leukemic plasma cells in blood, but not of bone marrow plasma cells, in multiple myeloma: Alternate use of receptor for hyaluronan-mediated motility (RHAMM) and CD44
    • Masellis-Smith A., Belch A.R., Mant M.J., Turley E.A., Pilarski L.M. Hyaluronan-dependent motility of B cells and leukemic plasma cells in blood, but not of bone marrow plasma cells, in multiple myeloma: Alternate use of receptor for hyaluronan-mediated motility (RHAMM) and CD44. Blood 1996, 87:1891-1899.
    • (1996) Blood , vol.87 , pp. 1891-1899
    • Masellis-Smith, A.1    Belch, A.R.2    Mant, M.J.3    Turley, E.A.4    Pilarski, L.M.5
  • 51
    • 13444294239 scopus 로고    scopus 로고
    • Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity
    • Maxwell C.A., Keats J.J., Belch A.R., Pilarski L.M., Reiman T. Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity. Cancer Research 2005, 65:850-860.
    • (2005) Cancer Research , vol.65 , pp. 850-860
    • Maxwell, C.A.1    Keats, J.J.2    Belch, A.R.3    Pilarski, L.M.4    Reiman, T.5
  • 52
    • 0037632929 scopus 로고    scopus 로고
    • RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability
    • Maxwell C.A., Keats J.J., Crainie M., Sun X., Yen T., Shibuya E., et al. RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability. Molecular Biology of the Cell 2003, 14:2262-2276.
    • (2003) Molecular Biology of the Cell , vol.14 , pp. 2262-2276
    • Maxwell, C.A.1    Keats, J.J.2    Crainie, M.3    Sun, X.4    Yen, T.5    Shibuya, E.6
  • 53
    • 43149106462 scopus 로고    scopus 로고
    • Cell-surface and mitotic-spindle RHAMM: Moonlighting or dual oncogenic functions?
    • Maxwell C.A., McCarthy J., Turley E. Cell-surface and mitotic-spindle RHAMM: Moonlighting or dual oncogenic functions?. Journal of Cell Science 2008, 121:925-932.
    • (2008) Journal of Cell Science , vol.121 , pp. 925-932
    • Maxwell, C.A.1    McCarthy, J.2    Turley, E.3
  • 54
    • 3843096002 scopus 로고    scopus 로고
    • RHAMM expression and isoform balance predict aggressive disease and poor survival in multiple myeloma
    • Maxwell C.A., Rasmussen E., Zhan F., Keats J.J., Adamia S., Strachan E., et al. RHAMM expression and isoform balance predict aggressive disease and poor survival in multiple myeloma. Blood 2004, 104:1151-1158.
    • (2004) Blood , vol.104 , pp. 1151-1158
    • Maxwell, C.A.1    Rasmussen, E.2    Zhan, F.3    Keats, J.J.4    Adamia, S.5    Strachan, E.6
  • 55
    • 0022477191 scopus 로고
    • Analysis of cell-growth-phase-related variations in hyaluronate synthase activity of isolated plasma-membrane fractions of cultured human skin fibroblasts
    • Mian N. Analysis of cell-growth-phase-related variations in hyaluronate synthase activity of isolated plasma-membrane fractions of cultured human skin fibroblasts. The Biochemical Journal 1986, 237:333-342.
    • (1986) The Biochemical Journal , vol.237 , pp. 333-342
    • Mian, N.1
  • 56
    • 0029935148 scopus 로고    scopus 로고
    • Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression
    • Mohapatra S., Yang X., Wright J.A., Turley E.A., Greenberg A.H. Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression. Journal of Experimental Medicine 1996, 183:1663-1668.
    • (1996) Journal of Experimental Medicine , vol.183 , pp. 1663-1668
    • Mohapatra, S.1    Yang, X.2    Wright, J.A.3    Turley, E.A.4    Greenberg, A.H.5
  • 57
    • 71249122797 scopus 로고    scopus 로고
    • Coexpression of CD44 variant isoforms and receptor for hyaluronic acid-mediated motility (RHAMM, CD168) is an International Prognostic Index and C-MYC gene status-independent predictor of poor outcome in diffuse large B-cell lymphomas
    • Nagel S., Hirschmann P., Dirnhofer S., Gunthert U., Tzankov A. Coexpression of CD44 variant isoforms and receptor for hyaluronic acid-mediated motility (RHAMM, CD168) is an International Prognostic Index and C-MYC gene status-independent predictor of poor outcome in diffuse large B-cell lymphomas. Experimental Hematology 2010, 38:38-45.
    • (2010) Experimental Hematology , vol.38 , pp. 38-45
    • Nagel, S.1    Hirschmann, P.2    Dirnhofer, S.3    Gunthert, U.4    Tzankov, A.5
  • 58
    • 0031778022 scopus 로고    scopus 로고
    • Immunophenotypic characterization of plasma cells from monoclonal gammopathy of undetermined significance patients. Implications for the differential diagnosis between MGUS and multiple myeloma
    • Ocqueteau M., Orfao A., Almeida J., Blade J., Gonzalez M., Garcia-Sanz R., et al. Immunophenotypic characterization of plasma cells from monoclonal gammopathy of undetermined significance patients. Implications for the differential diagnosis between MGUS and multiple myeloma. The American Journal of Pathology 1998, 152:1655-1665.
    • (1998) The American Journal of Pathology , vol.152 , pp. 1655-1665
    • Ocqueteau, M.1    Orfao, A.2    Almeida, J.3    Blade, J.4    Gonzalez, M.5    Garcia-Sanz, R.6
  • 59
    • 34447094967 scopus 로고    scopus 로고
    • A census of mitotic cancer genes: New insights into tumor cell biology and cancer therapy
    • Perez de Castro I., de Carcer G., Malumbres M. A census of mitotic cancer genes: New insights into tumor cell biology and cancer therapy. Carcinogenesis 2007, 28:899-912.
    • (2007) Carcinogenesis , vol.28 , pp. 899-912
    • Perez de Castro, I.1    de Carcer, G.2    Malumbres, M.3
  • 61
    • 0036794974 scopus 로고    scopus 로고
    • Clonotypic myeloma cells able to xenograft myeloma to nonobese diabetic severe combined immunodeficient mice copurify with CD34 (+) hematopoietic progenitors
    • Pilarski L.M., Belch A.R. Clonotypic myeloma cells able to xenograft myeloma to nonobese diabetic severe combined immunodeficient mice copurify with CD34 (+) hematopoietic progenitors. Clinical Cancer Research 2002, 8:3198-3204.
    • (2002) Clinical Cancer Research , vol.8 , pp. 3198-3204
    • Pilarski, L.M.1    Belch, A.R.2
  • 63
    • 0033977906 scopus 로고    scopus 로고
    • In multiple myeloma, circulating hyperdiploid B cells have clonotypic immunoglobulin heavy chain rearrangements and may mediate spread of disease
    • Pilarski L.M., Giannakopoulos N.V., Szczepek A.J., Masellis A.M., Mant M.J., Belch A.R. In multiple myeloma, circulating hyperdiploid B cells have clonotypic immunoglobulin heavy chain rearrangements and may mediate spread of disease. Clinical Cancer Research 2000, 6:585-596.
    • (2000) Clinical Cancer Research , vol.6 , pp. 585-596
    • Pilarski, L.M.1    Giannakopoulos, N.V.2    Szczepek, A.J.3    Masellis, A.M.4    Mant, M.J.5    Belch, A.R.6
  • 64
    • 0034142369 scopus 로고    scopus 로고
    • Myeloma progenitors in the blood of patients with aggressive or minimal disease: Engraftment and self-renewal of primary human myeloma in the bone marrow of NOD SCID mice
    • Pilarski L.M., Hipperson G., Seeberger K., Pruski E., Coupland R.W., Belch A.R. Myeloma progenitors in the blood of patients with aggressive or minimal disease: Engraftment and self-renewal of primary human myeloma in the bone marrow of NOD SCID mice. Blood 2000, 95:1056-1065.
    • (2000) Blood , vol.95 , pp. 1056-1065
    • Pilarski, L.M.1    Hipperson, G.2    Seeberger, K.3    Pruski, E.4    Coupland, R.W.5    Belch, A.R.6
  • 65
    • 0343309958 scopus 로고
    • Circulating monoclonal multi-drug resistant B cells may comprise the malignant stem cells population in multiple myeloma
    • Ares Serono Symposia, Rome, Italy, F. Dammaco, B. Barlogie (Eds.)
    • Pilarski L.M., Mant M.J., Belch A.R. Circulating monoclonal multi-drug resistant B cells may comprise the malignant stem cells population in multiple myeloma. Challenges in modern medicine 1994, Vol 4:31-39. Ares Serono Symposia, Rome, Italy. F. Dammaco, B. Barlogie (Eds.).
    • (1994) Challenges in modern medicine , vol.4 , pp. 31-39
    • Pilarski, L.M.1    Mant, M.J.2    Belch, A.R.3
  • 66
    • 0028168180 scopus 로고
    • RHAMM, a receptor for hyaluronan-mediated motility, on normal human lymphocytes, thymocytes and malignant B cells: A mediator in B cell malignancy?
    • Pilarski L.M., Masellis-Smith A., Belch A.R., Yang B., Savani R.C., Turley E.A. RHAMM, a receptor for hyaluronan-mediated motility, on normal human lymphocytes, thymocytes and malignant B cells: A mediator in B cell malignancy?. Leukemia and Lymphoma 1994, 14:363-374.
    • (1994) Leukemia and Lymphoma , vol.14 , pp. 363-374
    • Pilarski, L.M.1    Masellis-Smith, A.2    Belch, A.R.3    Yang, B.4    Savani, R.C.5    Turley, E.A.6
  • 67
    • 0033135255 scopus 로고    scopus 로고
    • Potential role for hyaluronan and the hyaluronan receptor RHAMM in mobilization and trafficking of hematopoietic progenitor cells
    • Pilarski L.M., Pruski E., Wizniak J., Paine D., Seeberger K., Mant M.J., et al. Potential role for hyaluronan and the hyaluronan receptor RHAMM in mobilization and trafficking of hematopoietic progenitor cells. Blood 1999, 93:2918-2927.
    • (1999) Blood , vol.93 , pp. 2918-2927
    • Pilarski, L.M.1    Pruski, E.2    Wizniak, J.3    Paine, D.4    Seeberger, K.5    Mant, M.J.6
  • 68
    • 26244446325 scopus 로고    scopus 로고
    • The malignant hierarchy in multiple myeloma: Relationships between malignant cells and bone disease
    • Kluwer Academic Publishers, The Netherlands, G. Singh, F.W. Orr (Eds.)
    • Pilarski L.M., Reiman T., Pilarski P.M., Orr F.W., Belch A.R. The malignant hierarchy in multiple myeloma: Relationships between malignant cells and bone disease. Bone metastasis and molecular mechanisms: Pathophysiology 2004, 109-138. Kluwer Academic Publishers, The Netherlands. G. Singh, F.W. Orr (Eds.).
    • (2004) Bone metastasis and molecular mechanisms: Pathophysiology , pp. 109-138
    • Pilarski, L.M.1    Reiman, T.2    Pilarski, P.M.3    Orr, F.W.4    Belch, A.R.5
  • 70
    • 84878638708 scopus 로고    scopus 로고
    • Review: Alternative splicing (AS) of genes as an approach for generating protein complexity
    • Roy B., Haupt L.M., Griffiths L.R. Review: Alternative splicing (AS) of genes as an approach for generating protein complexity. Current Genomics 2013, 14:182-194.
    • (2013) Current Genomics , vol.14 , pp. 182-194
    • Roy, B.1    Haupt, L.M.2    Griffiths, L.R.3
  • 71
    • 34247393658 scopus 로고    scopus 로고
    • Targeting aurora kinases as therapy in multiple myeloma
    • Shi Y., Reiman T., Li W., Maxwell C.A., Sen S., Pilarski L., et al. Targeting aurora kinases as therapy in multiple myeloma. Blood 2007, 109:3915-3921.
    • (2007) Blood , vol.109 , pp. 3915-3921
    • Shi, Y.1    Reiman, T.2    Li, W.3    Maxwell, C.A.4    Sen, S.5    Pilarski, L.6
  • 74
    • 84904873734 scopus 로고    scopus 로고
    • Identification of novel point mutations in splicing sites integrating whole-exome and RNA-seq data in myeloproliferative diseases
    • Spinelli R., Pirola A., Redaelli S., Sharma N., Raman H., Valletta S., et al. Identification of novel point mutations in splicing sites integrating whole-exome and RNA-seq data in myeloproliferative diseases. Molecular Genetics and Genomic Medicine 2013, 1:246-259.
    • (2013) Molecular Genetics and Genomic Medicine , vol.1 , pp. 246-259
    • Spinelli, R.1    Pirola, A.2    Redaelli, S.3    Sharma, N.4    Raman, H.5    Valletta, S.6
  • 75
    • 66049102881 scopus 로고    scopus 로고
    • Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia
    • Stark M., Wichman C., Avivi I., Assaraf Y.G. Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia. Blood 2009, 113:4362-4369.
    • (2009) Blood , vol.113 , pp. 4362-4369
    • Stark, M.1    Wichman, C.2    Avivi, I.3    Assaraf, Y.G.4
  • 76
    • 33746609814 scopus 로고    scopus 로고
    • Chromosomal instability, colorectal cancer and taxane resistance
    • Swanton C., Tomlinson I., Downward J. Chromosomal instability, colorectal cancer and taxane resistance. Cell Cycle 2006, 5:818-823.
    • (2006) Cell Cycle , vol.5 , pp. 818-823
    • Swanton, C.1    Tomlinson, I.2    Downward, J.3
  • 77
    • 80155136185 scopus 로고    scopus 로고
    • How does a protein with dual mitotic spindle and extracellular matrix receptor functions affect tumor susceptibility and progression?
    • Telmer P.G., Tolg C., McCarthy J.B., Turley E.A. How does a protein with dual mitotic spindle and extracellular matrix receptor functions affect tumor susceptibility and progression?. Communicative and Integrative Biology 2011, 4:182-185.
    • (2011) Communicative and Integrative Biology , vol.4 , pp. 182-185
    • Telmer, P.G.1    Tolg, C.2    McCarthy, J.B.3    Turley, E.A.4
  • 78
    • 0033198501 scopus 로고    scopus 로고
    • The role of hyaluronan and interleukin 8 in the migration of chronic lymphocytic leukemia cells within lymphoreticular tissues
    • Till K.J., Zuzel M., Cawley J.C. The role of hyaluronan and interleukin 8 in the migration of chronic lymphocytic leukemia cells within lymphoreticular tissues. Cancer Research 1999, 59:4419-4426.
    • (1999) Cancer Research , vol.59 , pp. 4419-4426
    • Till, K.J.1    Zuzel, M.2    Cawley, J.C.3
  • 79
    • 0033548172 scopus 로고    scopus 로고
    • Purification and lipid dependence of the recombinant hyaluronan synthases from Streptococcus pyogenes and Streptococcus equisimilis
    • Tlapak-Simmons V.L., Baggenstoss B.A., Clyne T., Weigel P.H. Purification and lipid dependence of the recombinant hyaluronan synthases from Streptococcus pyogenes and Streptococcus equisimilis. Journal of Biological Chemistry 1999, 274:4239-4245.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 4239-4245
    • Tlapak-Simmons, V.L.1    Baggenstoss, B.A.2    Clyne, T.3    Weigel, P.H.4
  • 80
    • 77956210930 scopus 로고    scopus 로고
    • RHAMM promotes interphase microtubule instability and mitotic spindle integrity through MEK1/ERK1/2 activity
    • Tolg C., Hamilton S.R., Morningstar L., Zhang J., Zhang S., Esguerra K.V., et al. RHAMM promotes interphase microtubule instability and mitotic spindle integrity through MEK1/ERK1/2 activity. Journal of Biological Chemistry 2010, 285:26461-26474.
    • (2010) Journal of Biological Chemistry , vol.285 , pp. 26461-26474
    • Tolg, C.1    Hamilton, S.R.2    Morningstar, L.3    Zhang, J.4    Zhang, S.5    Esguerra, K.V.6
  • 81
    • 0027390635 scopus 로고
    • Expression and function of a receptor for hyaluronan-mediated motility on normal and malignant B lymphocytes
    • Turley E.A., Belch A.J., Poppema S., Pilarski L.M. Expression and function of a receptor for hyaluronan-mediated motility on normal and malignant B lymphocytes. Blood 1993, 81:446-453.
    • (1993) Blood , vol.81 , pp. 446-453
    • Turley, E.A.1    Belch, A.J.2    Poppema, S.3    Pilarski, L.M.4
  • 82
    • 79960257171 scopus 로고    scopus 로고
    • In situ RHAMM protein expression in acute myeloid leukemia blasts suggests poor overall survival
    • Tzankov A., Strasser U., Dirnhofer S., Menter T., Arber C., Jotterand M., et al. In situ RHAMM protein expression in acute myeloid leukemia blasts suggests poor overall survival. Annals of Hematology 2011, 90:901-909.
    • (2011) Annals of Hematology , vol.90 , pp. 901-909
    • Tzankov, A.1    Strasser, U.2    Dirnhofer, S.3    Menter, T.4    Arber, C.5    Jotterand, M.6
  • 83
    • 67449164508 scopus 로고    scopus 로고
    • Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia
    • Vassen L., Khandanpour C., Ebeling P., van der Reijden B.A., Jansen J.H., Mahlmann S., et al. Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia. International Journal of Hematology 2009, 89:422-430.
    • (2009) International Journal of Hematology , vol.89 , pp. 422-430
    • Vassen, L.1    Khandanpour, C.2    Ebeling, P.3    van der Reijden, B.A.4    Jansen, J.H.5    Mahlmann, S.6
  • 84
    • 84871137013 scopus 로고    scopus 로고
    • Analysis of 30 putative BRCA1 splicing mutations in hereditary breast and ovarian cancer families identifies exonic splice site mutations that escape in silico prediction
    • Wappenschmidt B., Becker A.A., Hauke J., Weber U., Engert S., Kohler J., et al. Analysis of 30 putative BRCA1 splicing mutations in hereditary breast and ovarian cancer families identifies exonic splice site mutations that escape in silico prediction. PLoS One 2012, 7:e50800.
    • (2012) PLoS One , vol.7
    • Wappenschmidt, B.1    Becker, A.A.2    Hauke, J.3    Weber, U.4    Engert, S.5    Kohler, J.6
  • 86
    • 0024497416 scopus 로고
    • Mutation rates differ among regions of the mammalian genome
    • Wolfe K.H., Sharp P.M., Li W.H. Mutation rates differ among regions of the mammalian genome. Nature 1989, 337:283-285.
    • (1989) Nature , vol.337 , pp. 283-285
    • Wolfe, K.H.1    Sharp, P.M.2    Li, W.H.3
  • 87
    • 38049134885 scopus 로고    scopus 로고
    • Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation
    • Yang G., Huang S.C., Wu J.Y., Benz E.J. Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation. Blood 2008, 111:392-401.
    • (2008) Blood , vol.111 , pp. 392-401
    • Yang, G.1    Huang, S.C.2    Wu, J.Y.3    Benz, E.J.4
  • 88
    • 52449083217 scopus 로고    scopus 로고
    • RHAMM, p21 combined phenotype identifies microsatellite instability-high colorectal cancers with a highly adverse prognosis
    • Zlobec I., Baker K., Terracciano L.M., Lugli A. RHAMM, p21 combined phenotype identifies microsatellite instability-high colorectal cancers with a highly adverse prognosis. Clinical Cancer Research 2008, 14:3798-3806.
    • (2008) Clinical Cancer Research , vol.14 , pp. 3798-3806
    • Zlobec, I.1    Baker, K.2    Terracciano, L.M.3    Lugli, A.4


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