Essential oil of Pinus koraiensis inhibits cell proliferation and migration via inhibition of p21-activated kinase 1 pathway in HCT116 colorectal cancer cells

BMC Complementary and Alternative Medicine

Volumn 14, Issue 1, 2014, Pages

  Cho, Sun Mi ^a   Lee, Eun Ok ^a   Kim, Sung Hoon ^a   Lee, Hyo Jeong ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Colorectal cancer; EOPK; Migration; PAK1; Proliferation

Indexed keywords

BETA CATENIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; ESSENTIAL OIL; MITOGEN ACTIVATED PROTEIN KINASE; P21 ACTIVATED KINASE 1; PROTEIN KINASE B; P21 ACTIVATED KINASE; PLANT EXTRACT; SMALL INTERFERING RNA;

ACTIN FILAMENT; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL MIGRATION ASSAY; CELL PROLIFERATION ASSAY; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DOSE RESPONSE; DRUG ISOLATION; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HCT116 CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MIGRATION INHIBITION; NONHUMAN; PINE; PINUS KORAIENSIS; PLANT LEAF; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CELL MOTION; CELL PROLIFERATION; CHEMISTRY; COLORECTAL TUMOR; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; HCT116 CELLS; HUMANS; MICE; OILS, VOLATILE; P21-ACTIVATED KINASES; PINUS; PLANT EXTRACTS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84904845628     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-275     Document Type: Article

References (34)

1. Sala-Vila A, Folkes J, Calder PC. The effect of three lipid emulsions differing in fatty acid composition on growth, apoptosis and cell cycle arrest in the HT-29 colorectal cancer cell line. Clin Nutr 2010, 29(4):519-524. 10.1016/j.clnu.2009.11.004, 19945772.
2. Calvert PM, Frucht H. The genetics of colorectal cancer. Ann Intern Med 2002, 137(7):603-612.
3. Yuen ST, Davies H, Chan TL, Ho JW, Bignell GR, Cox C, Stephens P, Edkins S, Tsui WW, Chan AS, Futreal PA, Stratton MR, Wooster R, Leung SY. Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res 2002, 62(22):6451-6455.
4. Baldus SE, Schaefer KL, Engers R, Hartleb D, Stoecklein NH, Gabbert HE. Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases. Clin Cancer Res 2010, 16(3):790-799. 10.1158/1078-0432.CCR-09-2446, 20103678.
5. Fransen K, Klintenas M, Osterstrom A, Dimberg J, Monstein HJ, Soderkvist P. Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. Carcinogenesis 2004, 25(4):527-533.
6. Huynh N, Liu KH, Baldwin GS, He H. P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways. Biochim Biophys Acta 2010, 1803(9):1106-1113. 10.1016/j.bbamcr.2010.05.007, 20595063.
7. Arias-Romero LE, Chernoff J. A tale of two Paks. Biol Cell 2008, 100(2):97-108. 10.1042/BC20070109, 18199048.
8. Bokoch GM. Biology of the p21-activated kinases. Annu Rev Biochem 2003, 72:743-781. 10.1146/annurev.biochem.72.121801.161742, 12676796.
9. Eswaran J, Soundararajan M, Kumar R, Knapp S. UnPAKing the class differences among p21-activated kinases. Trends Biochem Sci 2008, 33(8):394-403. 10.1016/j.tibs.2008.06.002, 18639460.
10. Zhu G, Wang Y, Huang B, Liang J, Ding Y, Xu A, Wu W. A Rac1/PAK1 cascade controls beta-catenin activation in colon cancer cells. Oncogene 2012, 31(8):1001-1012. 10.1038/onc.2011.294, 21822311.
11. Carter JH, Douglass LE, Deddens JA, Colligan BM, Bhatt TR, Pemberton JO, Konicek S, Hom J, Marshall M, Graff JR. Pak-1 expression increases with progression of colorectal carcinomas to metastasis. Clin Cancer Res 2004, 10(10):3448-3456. 10.1158/1078-0432.CCR-03-0210, 15161701.
12. Coniglio SJ, Zavarella S, Symons MH. Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Mol Cell Biol 2008, 28(12):4162-4172. 10.1128/MCB.01532-07, 2423138, 18411304.
13. Schurmann A, Mooney AF, Sanders LC, Sells MA, Wang HG, Reed JC, Bokoch GM. p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol 2000, 20(2):453-461. 10.1128/MCB.20.2.453-461.2000, 85099, 10611223.
14. Whale A, Hashim FN, Fram S, Jones GE, Wells CM. Signalling to cancer cell invasion through PAK family kinases. Front Biosci (Landmark Ed) 2011, 16:849-864. 10.2741/3724, 21196207.
15. Kim JH, Lee HJ, Jeong SJ, Lee MH, Kim SH. Essential oil of Pinus koraiensis leaves exerts antihyperlipidemic effects via up-regulation of low-density lipoprotein receptor and inhibition of acyl-coenzyme A: cholesterol acyltransferase. Phytother Res 26(9):1314-1319.
16. Ko HS, Lee HJ, Sohn EJ, Yun M, Lee MH, Kim SH. Essential Oil of Pinus koraiensis Exerts Antiobesic and Hypolipidemic Activity via Inhibition of Peroxisome Proliferator-Activated Receptors Gamma Signaling. Evid Based Complement Alternat Med 2013, 2013:947037. 3753736, 23997801.
17. Joo HE, Lee HJ, Sohn EJ, Lee MH, Ko HS, Jeong SJ, Kim SH. Anti-Diabetic Potential of the Essential Oil of Pinus koraiensis Leaves toward Streptozotocin-Treated Mice and HIT-T15 Pancreatic beta Cells. Biosci Biotechnol Biochem 2013, 77(10):1997-2001. 10.1271/bbb.130254, 24096647.
18. Chen X, Zhang Y, Wang Z, Zu Y. In vivo antioxidant activity of Pinus koraiensis nut oil obtained by optimised supercritical carbon dioxide extraction. Nat Prod Res 25(19):1807-1816.
19. Park S, Lim Y, Shin S, Han SN. Impact of Korean pine nut oil on weight gain and immune responses in high-fat diet-induced obese mice. Nutr Res Pract 2013, 7(5):352-358. 10.4162/nrp.2013.7.5.352, 3796659, 24133613.
20. Pasman WJ, Heimerikx J, Rubingh CM, van den Berg R, O'Shea M, Gambelli L, Hendriks HF, Einerhand AW, Scott C, Keizer HG, Mennen LI. The effect of Korean pine nut oil on in vitro CCK release, on appetite sensations and on gut hormones in post-menopausal overweight women. Lipids Health Dis 2008, 7:10. 10.1186/1476-511X-7-10, 2322999, 18355411.
21. Hong EJ, Na KJ, Choi IG, Choi KC, Jeung EB. Antibacterial and antifungal effects of essential oils from coniferous trees. Biol Pharm Bull 2004, 27(6):863-866.
22. Higuchi M, Onishi K, Kikuchi C, Gotoh Y. Scaffolding function of PAK in the PDK1-Akt pathway. Nat Cell Biol 2008, 10(11):1356-1364.
23. Mao K, Kobayashi S, Jaffer ZM, Huang Y, Volden P, Chernoff J, Liang Q. Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. J Mol Cell Cardiol 2008, 44(2):429-434. 10.1016/j.yjmcc.2007.10.016, 2278035, 18054038.
24. Kichina JV, Goc A, Al-Husein B, Somanath PR, Kandel ES. PAK1 as a therapeutic target. Expert Opin Ther Targets 2010, 14(7):703-725. 10.1517/14728222.2010.492779, 3137287, 20507214.
25. Ong CC, Jubb AM, Zhou W, Haverty PM, Harris AL, Belvin M, Friedman LS, Koeppen H, Hoeflich KP. p21-activated kinase 1: PAK'ed with potential. Oncotarget 2011, 2(6):491-496. 3248206, 21653999.
26. Edwards DC, Sanders LC, Bokoch GM, Gill GN. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol 1999, 1(5):253-259.
27. Suzuki-Inoue K, Yatomi Y, Asazuma N, Kainoh M, Tanaka T, Satoh K, Ozaki Y. Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1). Blood 2001, 98(13):3708-3716. 10.1182/blood.V98.13.3708, 11739176.
28. Royce ME, Medgyesy D, Zukowski TH, Dwivedy S, Hoff PM, Pazdur R. Colorectal cancer: chemotherapy treatment overview. Oncology (Williston Park) 2000, 14(12 Suppl 14):40-46.
29. Chen XQ, Wu JB, Yang XQ, Song YG, Li MS. Effects of epigallocatechin-3-gallate on the proliferation of colonic cancer cell line SW620 and PAK1 gene expression. Nan Fang Yi Ke Da Xue Xue Bao 2009, 29(8):1568-1570.
30. Deepa M, Sureshkumar T, Satheeshkumar PK, Priya S. Antioxidant rich Morus alba leaf extract induces apoptosis in human colon and breast cancer cells by the downregulation of nitric oxide produced by inducible nitric oxide synthase. Nutr Cancer 2013, 65(2):305-310. 10.1080/01635581.2013.748924, 23441618.
31. Sugano M, Ikeda I, Wakamatsu K, Oka T. Influence of Korean pine (Pinus koraiensis)-seed oil containing cis-5, cis-9, cis-12-octadecatrienoic acid on polyunsaturated fatty acid metabolism, eicosanoid production and blood pressure of rats. Br J Nutr 1994, 72(5):775-783. 10.1079/BJN19940079, 7826999.
32. Speijers GJ, Dederen LH, Keizer H. A sub-chronic (13 weeks) oral toxicity study in rats and an in vitro genotoxicity study with Korean pine nut oil (PinnoThin TG). Regul Toxicol Pharmacol 2009, 55(2):158-165. 10.1016/j.yrtph.2009.06.010, 19559745.
33. Abdel-Magid AF. PAK1: A Therapeutic Target for Cancer Treatment. ACS Med Chem Lett 2013, 4(5):431-432. 10.1021/ml400101g, 4027248, 24900689.
34. Smith SD, Jaffer ZM, Chernoff J, Ridley AJ. PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J Cell Sci 2008, 121(Pt 22):3729-3736. 2702775, 18940914.