A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex

Metallomics

Volumn 6, Issue 8, 2014, Pages 1491-1501

  Novohradsky, Vojtech ^a,b   Zerzankova, Lenka ^a   Stepankova, Jana ^a   Kisova, Anna ^a   Kostrhunova, Hana ^a   Liu, Zhe ^c   Sadler, Peter J ^c   Kasparkova, Jana ^b   Brabec, Viktor ^a  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b PALACKÝ UNIVERSITY   (Czech Republic)

^c UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL DEATH; CHLORINE COMPOUNDS; GENES; IRIDIUM; ORGANOMETALLICS; PLATINUM COMPOUNDS;

ACQUIRED RESISTANCE; APOPTOTIC EFFECTS; CELLULAR MECHANISMS; CELLULAR RESPONSE; HALF-SANDWICH COMPLEXES; HUMAN TUMOR CELL LINES; MITOCHONDRIAL DYSFUNCTION; NONTUMORIGENIC CELLS;

IRIDIUM COMPOUNDS;

ANTINEOPLASTIC METAL COMPLEX; CELL NUCLEUS DNA; CISPLATIN; FLUORESCEIN ISOTHIOCYANATE; GENOMIC DNA; IRIDIUM COMPLEX; ORGANOMETALLIC COMPOUND; PROTEIN P53; TRANSITION ELEMENT; ANTINEOPLASTIC AGENT; IRIDIUM; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL LINE; CELL CYCLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA DAMAGE; DNA FRAGMENTATION ASSAY; FLOW CYTOMETRY; HL 60 CELL LINE; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; OVARY CARCINOMA; PRIORITY JOURNAL; DRUG EFFECTS; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CISPLATIN; FLOW CYTOMETRY; HUMANS; IRIDIUM; REACTIVE OXYGEN SPECIES;

EID: 84904802196     PISSN: 17565901     EISSN: 1756591X     Source Type: Journal    
DOI: 10.1039/c4mt00112e     Document Type: Article

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