-
1
-
-
77950365906
-
Nonresolving inflammation
-
Nathan C, Ding A (2010) Nonresolving inflammation. Cell 140: 871-882.
-
(2010)
Cell
, vol.140
, pp. 871-882
-
-
Nathan, C.1
Ding, A.2
-
2
-
-
56849125235
-
Aging is associated with greater nuclear NFkappaB, reduced IkappaBalpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans
-
DOI 10.1111/j.1474-9726.2008.00438.x
-
Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR (2008) Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell 7: 805-812. (Pubitemid 352749435)
-
(2008)
Aging Cell
, vol.7
, Issue.6
, pp. 805-812
-
-
Donato, A.J.1
Black, A.D.2
Jablonski, K.L.3
Gano, L.B.4
Seals, D.R.5
-
3
-
-
77953669656
-
Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults
-
Seidler S, Zimmermann HW, Bartneck M, Trautwein C, Tacke F (2010) Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunol 11: 30.
-
(2010)
BMC Immunol
, vol.11
, pp. 30
-
-
Seidler, S.1
Zimmermann, H.W.2
Bartneck, M.3
Trautwein, C.4
Tacke, F.5
-
4
-
-
77952105389
-
Inflammatory networks during cellular senescence: Causes and consequences
-
Freund A, Orjalo AV, Desprez PY, Campisi J (2010) Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 16: 238-246.
-
(2010)
Trends Mol Med
, vol.16
, pp. 238-246
-
-
Freund, A.1
Orjalo, A.V.2
Desprez, P.Y.3
Campisi, J.4
-
5
-
-
33846121333
-
Vascular cell senescence: Contribution to atherosclerosis
-
DOI 10.1161/01.RES.0000256837.40544.4a, PII 0000301220070105000006
-
Minamino T, Komuro I (2007) Vascular cell senescence: contribution to atherosclerosis. Circ Res 100: 15-26. (Pubitemid 46074968)
-
(2007)
Circulation Research
, vol.100
, Issue.1
, pp. 15-26
-
-
Minamino, T.1
Komuro, I.2
-
6
-
-
80855128461
-
Cellular senescence: A link between cancer and age-related degenerative disease?
-
Campisi J, Andersen JK, Kapahi P, Melov S (2011) Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol 21: 354-359.
-
(2011)
Semin Cancer Biol
, vol.21
, pp. 354-359
-
-
Campisi, J.1
Andersen, J.K.2
Kapahi, P.3
Melov, S.4
-
7
-
-
68249096784
-
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
-
Rodier F, Coppe JP, Patil CK, Hoeijmakers WA, Munoz DP, et al. (2009) Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 11: 973-979.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 973-979
-
-
Rodier, F.1
Coppe, J.P.2
Patil, C.K.3
Hoeijmakers, W.A.4
Munoz, D.P.5
-
8
-
-
79952281150
-
Klotho suppresses RIG-I-mediated senescence-associated inflammation
-
Liu F, Wu S, Ren H, Gu J (2011) Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat Cell Biol 13: 254-262.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 254-262
-
-
Liu, F.1
Wu, S.2
Ren, H.3
Gu, J.4
-
9
-
-
81855169964
-
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
-
Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, et al. (2011) Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479: 547-551.
-
(2011)
Nature
, vol.479
, pp. 547-551
-
-
Kang, T.W.1
Yevsa, T.2
Woller, N.3
Hoenicke, L.4
Wuestefeld, T.5
-
10
-
-
84876291823
-
Non-cell-autonomous tumor suppression by p53
-
Lujambio A, Akkari L, Simon J, Grace D, Tschaharganeh DF, et al. (2013) Non-cell-autonomous tumor suppression by p53. Cell 153: 449-460.
-
(2013)
Cell
, vol.153
, pp. 449-460
-
-
Lujambio, A.1
Akkari, L.2
Simon, J.3
Grace, D.4
Tschaharganeh, D.F.5
-
11
-
-
84879888338
-
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
-
Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, et al. (2013) Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature.
-
(2013)
Nature
-
-
Yoshimoto, S.1
Loo, T.M.2
Atarashi, K.3
Kanda, H.4
Sato, S.5
-
12
-
-
80855138775
-
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
-
Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, et al. (2011) Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479: 232-236.
-
(2011)
Nature
, vol.479
, pp. 232-236
-
-
Baker, D.J.1
Wijshake, T.2
Tchkonia, T.3
LeBrasseur, N.K.4
Childs, B.G.5
-
13
-
-
0033552883
-
Atherosclerosis - an inflammatory disease
-
Ross R (1999) Atherosclerosis - an inflammatory disease. N Engl J Med 340: 115-126.
-
(1999)
N Engl J Med
, vol.340
, pp. 115-126
-
-
Ross, R.1
-
15
-
-
0037022910
-
Inflammation and atherosclerosis
-
DOI 10.1161/hc0902.104353
-
Libby P, Ridker PM, Maseri A (2002) Inflammation and atherosclerosis. Circulation 105: 1135-1143. (Pubitemid 34212626)
-
(2002)
Circulation
, vol.105
, Issue.9
, pp. 1135-1143
-
-
Libby, P.1
Ridker, P.M.2
Maseri, A.3
-
16
-
-
54849382700
-
Vascular aging: Insights from studies on cellular senescence, stem cell aging, and progeroid syndromes
-
Minamino T, Komuro I (2008) Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes. Nat Clin Pract Cardiovasc Med 5: 637-648.
-
(2008)
Nat Clin Pract Cardiovasc Med
, vol.5
, pp. 637-648
-
-
Minamino, T.1
Komuro, I.2
-
17
-
-
1442274703
-
Cdc42: New roads to travel
-
Cerione RA (2004) Cdc42: new roads to travel. Trends Cell Biol 14: 127-132.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 127-132
-
-
Cerione, R.A.1
-
18
-
-
52149106669
-
Cellular signaling for activation of Rho GTPase Cdc42
-
Sinha S, Yang W (2008) Cellular signaling for activation of Rho GTPase Cdc42. Cell Signal 20: 1927-1934.
-
(2008)
Cell Signal
, vol.20
, pp. 1927-1934
-
-
Sinha, S.1
Yang, W.2
-
19
-
-
84860634046
-
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation
-
Florian MC, Dorr K, Niebel A, Daria D, Schrezenmeier H, et al. (2012) Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 10: 520-530.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 520-530
-
-
Florian, M.C.1
Dorr, K.2
Niebel, A.3
Daria, D.4
Schrezenmeier, H.5
-
20
-
-
66149165914
-
Gene expression profiles associated with aging and mortality in humans
-
Kerber RA, O'Brien E, Cawthon RM (2009) Gene expression profiles associated with aging and mortality in humans. Aging Cell 8: 239-250.
-
(2009)
Aging Cell
, vol.8
, pp. 239-250
-
-
Kerber, R.A.1
O'Brien, E.2
Cawthon, R.M.3
-
21
-
-
33846604728
-
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes
-
DOI 10.1073/pnas.0609149104
-
Wang L, Yang L, Debidda M, Witte D, Zheng Y (2007) Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Proc Natl Acad Sci U S A 104: 1248-1253. (Pubitemid 46183990)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.4
, pp. 1248-1253
-
-
Wang, L.1
Yang, L.2
Debidda, M.3
Witte, D.4
Zheng, Y.5
-
22
-
-
0028086441
-
Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
-
Luo L, Liao YJ, Jan LY, Jan YN (1994) Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev 8: 1787-1802. (Pubitemid 24265785)
-
(1994)
Genes and Development
, vol.8
, Issue.15
, pp. 1787-1802
-
-
Luo, L.1
Joyce, L.Y.2
Jan, L.Y.3
Jan, Y.N.4
-
23
-
-
0036781052
-
NF-kappaB regulation in the immune system
-
Li Q, Verma IM (2002) NF-kappaB regulation in the immune system. Nat Rev Immunol 2: 725-734.
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 725-734
-
-
Li, Q.1
Verma, I.M.2
-
24
-
-
0033972422
-
Synergistic action of pro-inflammatory agents: Cellular and molecular aspects
-
Paludan SR (2000) Synergistic action of pro-inflammatory agents: cellular and molecular aspects. J Leukoc Biol 67: 18-25.
-
(2000)
J Leukoc Biol
, vol.67
, pp. 18-25
-
-
Paludan, S.R.1
-
25
-
-
31544457877
-
p53 ubiquitination: Mdm2 and beyond
-
DOI 10.1016/j.molcel.2006.01.020, PII S1097276506000402
-
Brooks CL, Gu W (2006) p53 ubiquitination: Mdm2 and beyond. Mol Cell 21: 307-315. (Pubitemid 43163526)
-
(2006)
Molecular Cell
, vol.21
, Issue.3
, pp. 307-315
-
-
Brooks, C.L.1
Gu, W.2
-
26
-
-
39549098360
-
Efficient, inducible cre-recombinase activation in vascular endothelium
-
DOI 10.1002/dvg.20367
-
Claxton S, Kostourou V, Jadeja S, Chambon P, Hodivala-Dilke K, et al. (2008) Efficient, inducible Cre-recombinase activation in vascular endothelium. Genesis 46: 74-80. (Pubitemid 351498176)
-
(2008)
Genesis
, vol.46
, Issue.2
, pp. 74-80
-
-
Claxton, S.1
Kostourou, V.2
Jadeja, S.3
Chambon, P.4
Hodivala-Dilke, K.5
Fruttiger, M.6
-
27
-
-
54849412805
-
Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis
-
Gareus R, Kotsaki E, Xanthoulea S, van der Made I, Gijbels MJ, et al. (2008) Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. Cell Metab 8: 372-383.
-
(2008)
Cell Metab
, vol.8
, pp. 372-383
-
-
Gareus, R.1
Kotsaki, E.2
Xanthoulea, S.3
Van Der Made, I.4
Gijbels, M.J.5
-
28
-
-
33748351173
-
Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway
-
DOI 10.1161/CIRCULATIONAHA.106.626606, PII 0000301720060829000014
-
Kunieda T, Minamino T, Nishi J, Tateno K, Oyama T, et al. (2006) Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 114: 953-960. (Pubitemid 44337139)
-
(2006)
Circulation
, vol.114
, Issue.9
, pp. 953-960
-
-
Kunieda, T.1
Minamino, T.2
Nishi, J.-I.3
Tateno, K.4
Oyama, T.5
Katsuno, T.6
Miyauchi, H.7
Orimo, M.8
Okada, S.9
Takamura, M.10
Nagai, T.11
Kaneko, S.12
Komuro, I.13
-
29
-
-
70349668990
-
Nucleolar proteins suppress Caenorhabditis elegans innate immunity by inhibiting p53/CEP-1
-
Fuhrman LE, Goel AK, Smith J, Shianna KV, Aballay A (2009) Nucleolar proteins suppress Caenorhabditis elegans innate immunity by inhibiting p53/CEP-1. PLoS Genet 5: e1000657.
-
(2009)
PLoS Genet
, vol.5
-
-
Fuhrman, L.E.1
Goel, A.K.2
Smith, J.3
Shianna, K.V.4
Aballay, A.5
-
30
-
-
84863667325
-
Aging and atherosclerosis: Mechanisms, functional consequences, and potential therapeutics for cellular senescence
-
Wang JC, Bennett M (2012) Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ Res 111: 245-259.
-
(2012)
Circ Res
, vol.111
, pp. 245-259
-
-
Wang, J.C.1
Bennett, M.2
-
31
-
-
67650266902
-
Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake
-
Choi SH, Harkewicz R, Lee JH, Boullier A, Almazan F, et al. (2009) Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ Res 104: 1355-1363.
-
(2009)
Circ Res
, vol.104
, pp. 1355-1363
-
-
Choi, S.H.1
Harkewicz, R.2
Lee, J.H.3
Boullier, A.4
Almazan, F.5
-
32
-
-
4744371424
-
Morphological adjustment of senescent cells by modulating caveolin-1 status
-
DOI 10.1074/jbc.M402352200
-
Cho KA, Ryu SJ, Oh YS, Park JH, Lee JW, et al. (2004) Morphological adjustment of senescent cells by modulating caveolin-1 status. J Biol Chem 279: 42270-42278. (Pubitemid 39313676)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.40
, pp. 42270-42278
-
-
Cho, K.A.1
Sung, J.R.2
Yoon, S.O.3
Ji, H.P.4
Jung, W.L.5
Kim, H.-P.6
Kyung, T.K.7
Ik, S.J.8
Sang, C.P.9
-
33
-
-
84876282419
-
Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1
-
Keestra AM, Winter MG, Auburger JJ, Frassle SP, Xavier MN, et al. (2013) Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1. Nature 496: 233-237.
-
(2013)
Nature
, vol.496
, pp. 233-237
-
-
Keestra, A.M.1
Winter, M.G.2
Auburger, J.J.3
Frassle, S.P.4
Xavier, M.N.5
-
34
-
-
0035854826
-
Dbl and the Rho GTPases activate NF kappa B by I kappa B kinase (IKK)-dependent and IKK-independent pathways
-
Cammarano MS, Minden A (2001) Dbl and the Rho GTPases activate NF kappa B by I kappa B kinase (IKK)-dependent and IKK-independent pathways. J Biol Chem 276: 25876-25882.
-
(2001)
J Biol Chem
, vol.276
, pp. 25876-25882
-
-
Cammarano, M.S.1
Minden, A.2
-
35
-
-
0032841725
-
Activation of the small GTPase Cdc42 by the inflammatory cytokines TNF(alpha) and IL-1, and by the Epstein-Barr virus transforming protein LMP1
-
Puls A, Eliopoulos AG, Nobes CD, Bridges T, Young LS, et al. (1999) Activation of the small GTPase Cdc42 by the inflammatory cytokines TNF(alpha) and IL-1, and by the Epstein-Barr virus transforming protein LMP1. J Cell Sci 112 (Pt 17): 2983-2992. (Pubitemid 29430043)
-
(1999)
Journal of Cell Science
, vol.112
, Issue.17
, pp. 2983-2992
-
-
Puls, A.1
Eliopoulos, A.G.2
Nobes, C.D.3
Bridges, T.4
Young, L.S.5
Hall, A.6
-
36
-
-
0842263745
-
Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway
-
DOI 10.1038/sj.emboj.7600045
-
Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H, et al. (2004) Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J 23: 212-220. (Pubitemid 38165761)
-
(2004)
EMBO Journal
, vol.23
, Issue.1
, pp. 212-220
-
-
Miyauchi, H.1
Minamino, T.2
Tateno, K.3
Kunieda, T.4
Toko, H.5
Komuro, I.6
-
37
-
-
0035861968
-
Reactive oxygen species in mechanical stress-induced cardiac hypertrophy
-
DOI 10.1006/bbrc.2001.6068
-
Aikawa R, Nagai T, Tanaka M, Zou Y, Ishihara T, et al. (2001) Reactive oxygen species in mechanical stress-induced cardiac hypertrophy. Biochem Biophys Res Commun 289: 901-907. (Pubitemid 34060090)
-
(2001)
Biochemical and Biophysical Research Communications
, vol.289
, Issue.4
, pp. 901-907
-
-
Aikawa, R.1
Nagai, T.2
Tanaka, M.3
Zou, Y.4
Ishihara, T.5
Takano, H.6
Hasegawa, H.7
Akazawa, H.8
Mizukami, M.9
Nagai, R.10
Komuro, I.11
-
38
-
-
84861344070
-
Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development
-
Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, et al. (2012) Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development. Mech Dev 129: 38-50.
-
(2012)
Mech Dev
, vol.129
, pp. 38-50
-
-
Aizawa, R.1
Yamada, A.2
Suzuki, D.3
Iimura, T.4
Kassai, H.5
-
39
-
-
33644772395
-
Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4
-
Grier JD, Xiong S, Elizondo-Fraire AC, Parant JM, Lozano G (2006) Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Mol Cell Biol 26: 192-198.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 192-198
-
-
Grier, J.D.1
Xiong, S.2
Elizondo-Fraire, A.C.3
Parant, J.M.4
Lozano, G.5
-
40
-
-
66449123068
-
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
-
Benedito R, Roca C, Sorensen I, Adams S, Gossler A, et al. (2009) The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell 137: 1124-1135.
-
(2009)
Cell
, vol.137
, pp. 1124-1135
-
-
Benedito, R.1
Roca, C.2
Sorensen, I.3
Adams, S.4
Gossler, A.5
-
41
-
-
80052756899
-
Insulin/IGF-1 receptor signaling enhances biosynthetic activity and fat mobilization in the initial phase of starvation in adult male C. Elegans
-
Tan KT, Luo SC, Ho WZ, Lee YH (2011) Insulin/IGF-1 receptor signaling enhances biosynthetic activity and fat mobilization in the initial phase of starvation in adult male C. elegans. Cell Metab 14: 390-402.
-
(2011)
Cell Metab
, vol.14
, pp. 390-402
-
-
Tan, K.T.1
Luo, S.C.2
Ho, W.Z.3
Lee, Y.H.4
|