SCP, a polysaccharide from Schisandra chinensis, induces apoptosis in human renal cell carcinoma Caki-1 cells through mitochondrial-dependent pathway via inhibition of ERK activation

Tumor Biology

Volumn 35, Issue 6, 2014, Pages 5369-5374

  Liu, Shi Jian ^a   Qu, Hai Ming ^a   Ren, Ye Ping ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Caspase; ERK; Human renal cell carcinoma; Mitochondrial dependent pathway; Polysaccharide; Schisandra chinensis

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; SCHISANDRA CHINENSIS EXTRACT; SCHISANDRA CHINENSIS POLYSACCHARIDE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENAL CANCER CELL LINE; SCHISANDRA CHINENSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

APOPTOSIS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; KIDNEY NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; POLYSACCHARIDES; SCHISANDRA;

EID: 84904767695     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-1699-1     Document Type: Article

References (25)

1. Motzer RJ, Bander NH, Nanus DM. Renal-cell carcinoma. N Engl J Med. 1996;335:865-75.
2. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, et al. Cancer statistics, 2006. CA Cancer J Clin. 2006;56:106-30.
3. Rini BI, Rathmell WK, Godley P. Renal cell carcinoma. Curr Opin Oncol. 2008;20:300-6. (Pubitemid 351507551)
4. Janzen NK, Kim HL, Figlin RA, Belldegrun AS. Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol Clin North Am. 2003;30:843-52. (Pubitemid 37485197)
5. Cheng L, Zhang S, MacLennan GT, Lopez-Beltran A, Montironi R. Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms. Hum Pathol. 2009;40:10-29.
6. Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod. 2003;66:1022-37. (Pubitemid 36909859)
7. Liu GT. Pharmacological actions and clinical use of Fructus schizandrae. Chin Med J. 1989;102:740-9.
8. Choi YW, Takamatsu S, Khan SI, Srinivas PV, Ferreira D, Zhao J, et al. Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. J Nat Prod. 2006;69:356-9.
9. Panossian A, Wikman G. Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine. J Ethnopharmacol. 2008;118:183-212.
10. Ikeya Y, Miki E, Okada M, Mitsuhashi H, Chai JG, Benzoylgomisin Q, et al. Two new lignans from Schisandra sphenanthera Rehd. et Wils. Chem Pharm Bull. 1990;38:1408-11.
11. Ikeya Y, Taguchi H, Yosioka I, Kobayashi H. The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, Gomisin A, B, C, F, and G, and the absolute structure of schizandrin. Chem Pharm Bull. 1979;27:1383-94. (Pubitemid 9237109)
12. He XG, Lian LZ, Lin LZ. Analysis of lignan constituents from Schisandra chinensis by liquid chromatography-electrospray mass spectrometry. J Chromatogr A. 1997;757:81-7.
13. Yan S, Yang LQ, Zhao T, Zhao JL, Zou YM. Latest research progress on polysaccharide from Schisandra chinensis (Turcz.) Baill. J Jiangsu Univ. 2009;19:366-8.
14. Cummings BS, Kinsey GR, Bolchoz LJ, Schnellmann RG. Identification of caspase-independent apoptosis in epithelial and cancer cells. J Pharmacol Exp Ther. 2004;310:126-34. (Pubitemid 38812703)
15. Bai XC, Ma DZ, Liu AL, Shen XY, Wang QMJ, Liu YJ, et al. Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science. 2007;318:977-80.
16. Li M, Zhao L, Liu J, Liu AL, Zeng WS, Luo SQ, et al. Hydrogen peroxide induces G2 cell cycle arrest and inhibits cell proliferation in osteoblasts. Anat Rec (Hoboken). 2009;292:1107-13.
17. Yang J, Xiao YL, He XR, Qiu GF, Hu XM. Aesculetin-induced apoptosis through a ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells. J Asian Nat Prod Res. 2010;12:185-93.
18. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309-12. (Pubitemid 28406816)
19. Cheung HY, Cheung SH, Li J, Cheung CS, Lai WP, Fong WF, et al. Andrographolide isolated from Andrographis paniculata induces cell cycle arrest and mitochondrial-mediated apoptosis in human leukemic HL-60 cells. Planta Med. 2005;71:1106-11. (Pubitemid 43107055)
20. Green DR. Kroemer GThe pathophysiology of mitochondrial cell death. Science. 2004;305:626-9. (Pubitemid 39006738)
21. Xie CY, Yang W, Li M, Ying J, Tao SJ, Li K, et al. Cell apoptosis induced by delta-elemene in colorectal adenocarcinoma cells via a mitochondrial- mediated pathway. Yakugaku Zasshi. 2009;129:1403-13.
22. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol. 1999;15:269-90. (Pubitemid 32250377)
23. Lowe SW, Lin AW. Apoptosis in cancer. Carcinogenesis. 2000;21:485-95. (Pubitemid 30137934)
24. Tang XL, Yang XY, Jung HJ, Kim SY, Jung SY, Choi DY, et al. Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade. Biol Pharm Bull. 2009;32:1399-405.
25. Petrache I, Choi ME, Otterbein LE, Chin BY, Mantell LL, Horowitz S, et al. Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells. Am J Physiol. 1999;277:L589-95. (Pubitemid 29459679)