Systemic lipopolysaccharide induces cochlear inflammation and exacerbates the synergistic ototoxicity of kanamycin and furosemide

JARO - Journal of the Association for Research in Otolaryngology

Volumn 15, Issue 4, 2014, Pages 555-570

  Hirose, Keiko ^a   Li, Song Zhe ^a   Ohlemiller, Kevin K ^a   Ransohoff, Richard M ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

cochlea; inflammation; LPS; macrophage; monocyte; ototoxicity

Indexed keywords

FUROSEMIDE; KANAMYCIN; LIPOPOLYSACCHARIDE; ANTIINFECTIVE AGENT; CHEMOKINE RECEPTOR; CX3CR1 PROTEIN, MOUSE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; COCHLEA INFLAMMATION; CONTROLLED STUDY; HAIR CELL; HEARING IMPAIRMENT; HUMAN; INFLAMMATION; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; SPIRAL LIGAMENT; SYSTEMATIC REVIEW; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; COCHLEA; DISEASE MODEL; DRUG EFFECTS; DRUG POTENTIATION; EVOKED BRAIN STEM AUDITORY RESPONSE; GENETICS; HETEROZYGOTE; INBRED MOUSE STRAIN; INNER EAR; INNER EAR DISEASE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANTI-BACTERIAL AGENTS; COCHLEA; COCHLEAR DISEASES; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; EAR, INNER; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FUROSEMIDE; HAIR CELLS, AUDITORY, OUTER; HETEROZYGOTE; INFLAMMATION; KANAMYCIN; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; RECEPTORS, CHEMOKINE;

EID: 84904764859     PISSN: 15253961     EISSN: 14387573     Source Type: Journal    
DOI: 10.1007/s10162-014-0458-8     Document Type: Article

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