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Volumn 46, Issue 8, 2014, Pages 1971-1979

Leucine facilitates the insulin-stimulated glucose uptake and insulin signaling in skeletal muscle cells: Involving mTORC1 and mTORC2

Author keywords

Glucose uptake; Insulin signaling; Leucine; Mammalian target of rapamycin

Indexed keywords

INSULIN; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN KINASE B; RAPAMYCIN; SMALL INTERFERING RNA; WORTMANNIN; ANDROSTANE DERIVATIVE; CARRIER PROTEIN; GLUCOSE; HYPERGLYCEMIC AGENT; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; RICTOR PROTEIN, RAT; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

EID: 84904751608     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-014-1752-9     Document Type: Article
Times cited : (39)

References (41)
  • 2
    • 79951673619 scopus 로고    scopus 로고
    • Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance
    • doi:10.1016/j.jnutbio.2010.02.001
    • Balage M, Dupont J, Mothe-Satney I, Tesseraud S, Mosoni L, Dardevet D (2011) Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance. J Nutr Biochem 22(3):219-226. doi:10.1016/j.jnutbio.2010.02.001
    • (2011) J Nutr Biochem , vol.22 , Issue.3 , pp. 219-226
    • Balage, M.1    Dupont, J.2    Mothe-Satney, I.3    Tesseraud, S.4    Mosoni, L.5    Dardevet, D.6
  • 3
    • 79955165505 scopus 로고    scopus 로고
    • An amino acid mixture improves glucose tolerance and insulin signaling in Sprague-Dawley rats
    • doi:10.1152/ajpendo.00643.2010
    • Bernard JR, Liao YH, Hara D, Ding Z, Chen CY, Nelson JL, Ivy JL (2011) An amino acid mixture improves glucose tolerance and insulin signaling in Sprague-Dawley rats. Am J Physiol Endocrinol Metab 300(4):E752-E760. doi:10.1152/ajpendo.00643.2010
    • (2011) Am J Physiol Endocrinol Metab , vol.300 , Issue.4
    • Bernard, J.R.1    Liao, Y.H.2    Hara, D.3    Ding, Z.4    Chen, C.Y.5    Nelson, J.L.6    Ivy, J.L.7
  • 4
    • 84863320065 scopus 로고    scopus 로고
    • An amino acid mixture is essential to optimize insulin-stimulated glucose uptake and GLUT4 translocation in perfused rodent hindlimb muscle
    • doi:10.1152/japplphysiol.01484.2011
    • Bernard JR, Liao YH, Doerner PG 3rd, Ding Z, Hsieh M, Wang W, Nelson JL, Ivy JL (2012) An amino acid mixture is essential to optimize insulin-stimulated glucose uptake and GLUT4 translocation in perfused rodent hindlimb muscle. J Appl Physiol 113(1):97-104. doi:10.1152/japplphysiol.01484.2011
    • (2012) J Appl Physiol , vol.113 , Issue.1 , pp. 97-104
    • Bernard, J.R.1    Liao, Y.H.2    Doerner III, P.G.3    Ding, Z.4    Hsieh, M.5    Wang, W.6    Nelson, J.L.7    Ivy, J.L.8
  • 5
    • 84879225162 scopus 로고    scopus 로고
    • An amino acid mixture improves glucose tolerance and lowers insulin resistance in the obese Zucker rat
    • doi:10.1007/s00726-013-1488-y
    • Bernard JR, Liao YH, Ding Z, Hara D, Kleinert M, Nelson JL, Ivy JL (2013) An amino acid mixture improves glucose tolerance and lowers insulin resistance in the obese Zucker rat. Amino Acids 45(1):191-203. doi:10.1007/s00726-013-1488- y
    • (2013) Amino Acids , vol.45 , Issue.1 , pp. 191-203
    • Bernard, J.R.1    Liao, Y.H.2    Ding, Z.3    Hara, D.4    Kleinert, M.5    Nelson, J.L.6    Ivy, J.L.7
  • 6
    • 34047095297 scopus 로고    scopus 로고
    • The Two TORCs and Akt
    • DOI 10.1016/j.devcel.2007.03.020, PII S1534580707001207
    • Bhaskar PT, Hay N (2007) The two TORCs and AKT. Dev Cell 12(4):487-502. doi:10.1016/j.devcel.2007.03.020 (Pubitemid 46523652)
    • (2007) Developmental Cell , vol.12 , Issue.4 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 7
    • 33646582664 scopus 로고    scopus 로고
    • Hypothalamic mTOR signaling regulates food intake
    • DOI 10.1126/science.1124147
    • Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ (2006) Hypothalamic mTOR signaling regulates food intake. Science 312(5775):927-930. doi:10.1126/science.1124147 (Pubitemid 43727328)
    • (2006) Science , vol.312 , Issue.5775 , pp. 927-930
    • Cota, D.1    Proulx, K.2    Blake, S.K.A.3    Kozma, S.C.4    Thomas, G.5    Woods, S.C.6    Seeley, R.J.7
  • 8
    • 84861840965 scopus 로고    scopus 로고
    • Leucine and mTORC1: A complex relationship
    • doi:10.1152/ajpendo.00525.2011
    • Dodd KM, Tee AR (2012) Leucine and mTORC1: a complex relationship. Am J Physiol Endocrinol Metab 302(11):E1329-E1342. doi:10.1152/ajpendo.00525.2011
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , Issue.11
    • Dodd, K.M.1    Tee, A.R.2
  • 10
    • 34447574828 scopus 로고    scopus 로고
    • Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis
    • DOI 10.1152/ajpendo.00609.2006
    • Doi M, Yamaoka I, Nakayama M, Sugahara K, Yoshizawa F (2007) Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis. Am J Physiol Endocrinol Metab 292(6):E1683-E1693. doi:10.1152/ajpendo.00609.2006 (Pubitemid 47084704)
    • (2007) American Journal of Physiology - Endocrinology and Metabolism , vol.292 , Issue.6
    • Doi, M.1    Yamaoka, I.2    Nakayama, M.3    Sugahara, K.4    Yoshizawa, F.5
  • 11
    • 0013953978 scopus 로고
    • Stimulation of insulin secretion by amino acids
    • doi:10.1172/JCI105456
    • Floyd JC Jr, Fajans SS, Conn JW, Knopf RF, Rull J (1966) Stimulation of insulin secretion by amino acids. J Clin Invest 45(9):1487-1502. doi:10.1172/JCI105456
    • (1966) J Clin Invest , vol.45 , Issue.9 , pp. 1487-1502
    • Floyd Jr., J.C.1    Fajans, S.S.2    Conn, J.W.3    Knopf, R.F.4    Rull, J.5
  • 13
    • 0034830022 scopus 로고    scopus 로고
    • Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle
    • Greiwe JS, Kwon G, McDaniel ML, Semenkovich CF (2001) Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle. Am J Physiol Endocrinol Metab 281(3):E466-E471
    • (2001) Am J Physiol Endocrinol Metab , vol.281 , Issue.3
    • Greiwe, J.S.1    Kwon, G.2    McDaniel, M.L.3    Semenkovich, C.F.4
  • 14
    • 14544271905 scopus 로고    scopus 로고
    • Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
    • DOI 10.1016/j.biochi.2004.10.019
    • Gual P, Le Marchand-Brustel Y, Tanti JF (2005) Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87:99-109. doi:10.1016/j.biochi.2004.10.019 (Pubitemid 40298772)
    • (2005) Biochimie , vol.87 , Issue.1 SPEC. ISS. , pp. 99-109
    • Gual, P.1    Le M.-Brustel, Y.2    Tanti, J.-F.3
  • 15
    • 77954395002 scopus 로고    scopus 로고
    • Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus
    • doi:10.1186/1743-7075-7-57
    • Guo K, Yu YH, Hou J, Zhang Y (2010) Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus. Nutr Metab (Lond) 7:57. doi:10.1186/1743-7075-7-57
    • (2010) Nutr Metab (Lond) , vol.7 , pp. 57
    • Guo, K.1    Yu, Y.H.2    Hou, J.3    Zhang, Y.4
  • 16
    • 10044219517 scopus 로고    scopus 로고
    • Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice
    • DOI 10.1096/fj.03-1409fje
    • Hinault C, Mothe-Satney I, Gautier N, Lawrence JC Jr, Van Obberghen E (2004) Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with Wortmannin and in adipocytes from db/db mice. FASEB J 18(15):1894-1896. doi:10.1096/fj.03-1409fje (Pubitemid 39602275)
    • (2004) FASEB Journal , vol.18 , Issue.15 , pp. 1894-1896
    • Hinault, C.1    Mothe-Satney, I.2    Gautier, N.3    Lawrence Jr., J.C.4    Van Obberghen, E.5
  • 17
    • 33646559999 scopus 로고    scopus 로고
    • Role of amino acids in insulin signaling in adipocytes and their potential to decrease insulin resistance of adipose tissue
    • DOI 10.1016/j.jnutbio.2006.02.008, PII S0955286306000520
    • Hinault C, Van Obberghen E, Mothe-Satney I (2006) Role of amino acids in insulin signaling in adipocytes and their potential to decrease insulin resistance of adipose tissue. J Nutr Biochem 17(6):374-378. doi:10.1016/j. jnutbio.2006.02.008 (Pubitemid 43729348)
    • (2006) Journal of Nutritional Biochemistry , vol.17 , Issue.6 , pp. 374-378
    • Hinault, C.1    Van Obberghen, E.2    Mothe-Satney, I.3
  • 18
    • 77953218866 scopus 로고    scopus 로고
    • Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
    • doi:10.2337/db09-1324
    • Houde VP, Brule S, Festuccia WT, Blanchard PG, Bellmann K, Deshaies Y, Marette A (2010) Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes 59(6):1338-1348. doi:10.2337/db09-1324
    • (2010) Diabetes , vol.59 , Issue.6 , pp. 1338-1348
    • Houde, V.P.1    Brule, S.2    Festuccia, W.T.3    Blanchard, P.G.4    Bellmann, K.5    Deshaies, Y.6    Marette, A.7
  • 19
    • 28844434558 scopus 로고    scopus 로고
    • 473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
    • DOI 10.1074/jbc.M508361200
    • Hresko RC, Mueckler M (2005) mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J Biol Chem 280:40406-40416. doi:10.1074/jbc.M508361200 (Pubitemid 41780527)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.49 , pp. 40406-40416
    • Hresko, R.C.1    Mueckler, M.2
  • 20
    • 75749105049 scopus 로고    scopus 로고
    • mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
    • doi:10.1128/MCB.00601-09
    • Julien LA, Carriere A, Moreau J, Roux PP (2010) mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol 30(4):908-921. doi:10.1128/MCB.00601-09
    • (2010) Mol Cell Biol , vol.30 , Issue.4 , pp. 908-921
    • Julien, L.A.1    Carriere, A.2    Moreau, J.3    Roux, P.P.4
  • 21
    • 55649124531 scopus 로고    scopus 로고
    • Leucine, when ingested with glucose, synergistically stimulates insulin secretion and lowers blood glucose
    • doi:10.1016/j.metabol.2008.09.001
    • Kalogeropoulou D, Lafave L, Schweim K, Gannon MC, Nuttall FQ (2008) Leucine, when ingested with glucose, synergistically stimulates insulin secretion and lowers blood glucose. Metabolism 57(12):1747-1752. doi:10.1016/j.metabol.2008.09.001
    • (2008) Metabolism , vol.57 , Issue.12 , pp. 1747-1752
    • Kalogeropoulou, D.1    Lafave, L.2    Schweim, K.3    Gannon, M.C.4    Nuttall, F.Q.5
  • 22
    • 79959409830 scopus 로고    scopus 로고
    • Amino acid signaling in TOR activation
    • doi:10.1146/annurev-biochem-062209-094414
    • Kim J, Guan KL (2011) Amino acid signaling in TOR activation. Annu Rev Biochem 80:1001-1032. doi:10.1146/annurev-biochem-062209-094414
    • (2011) Annu Rev Biochem , vol.80 , pp. 1001-1032
    • Kim, J.1    Guan, K.L.2
  • 23
    • 84894486696 scopus 로고    scopus 로고
    • Nutrient regulation of the mTOR complex 1 signaling pathway
    • doi:10.1007/s10059-013-0138-2
    • Kim SG, Buel GR, Blenis J (2013) Nutrient regulation of the mTOR complex 1 signaling pathway. Mol Cells 35(6):463-473. doi:10.1007/s10059-013-0138-2
    • (2013) Mol Cells , vol.35 , Issue.6 , pp. 463-473
    • Kim, S.G.1    Buel, G.R.2    Blenis, J.3
  • 24
    • 79960264780 scopus 로고    scopus 로고
    • An amino acid mixture enhances insulin-stimulated glucose uptake in isolated rat epitrochlearis muscle
    • doi:10.1152/japplphysiol.01368.2010
    • Kleinert M, Liao YH, Nelson JL, Bernard JR, Wang W, Ivy JL (2011) An amino acid mixture enhances insulin-stimulated glucose uptake in isolated rat epitrochlearis muscle. J Appl Physiol 111(1):163-169. doi:10.1152/japplphysiol. 01368.2010
    • (2011) J Appl Physiol , vol.111 , Issue.1 , pp. 163-169
    • Kleinert, M.1    Liao, Y.H.2    Nelson, J.L.3    Bernard, J.R.4    Wang, W.5    Ivy, J.L.6
  • 25
    • 77952650736 scopus 로고    scopus 로고
    • Computational model of cellular metabolic dynamics: Effect of insulin on glucose disposal in human skeletal muscle
    • doi:10.1152/ajpendo.00713.2009
    • Li Y, Solomon TP, Haus JM, Saidel GM, Cabrera ME, Kirwan JP (2010) Computational model of cellular metabolic dynamics: effect of insulin on glucose disposal in human skeletal muscle. Am J Physiol Endocrinol Metab 298(6):E1198-E1209. doi:10.1152/ajpendo.00713.2009
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , Issue.6
    • Li, Y.1    Solomon, T.P.2    Haus, J.M.3    Saidel, G.M.4    Cabrera, M.E.5    Kirwan, J.P.6
  • 26
    • 84878940048 scopus 로고    scopus 로고
    • Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues
    • doi:10.1002/mnfr.201200311
    • Li X, Wang X, Liu R, Ma Y, Guo H, Hao L, Yao P, Liu L, Sun X, He K, Cao W, Yang X (2013) Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues. Mol Nutr Food Res 57(6):1067-1079. doi:10.1002/mnfr.201200311
    • (2013) Mol Nutr Food Res , vol.57 , Issue.6 , pp. 1067-1079
    • Li, X.1    Wang, X.2    Liu, R.3    Ma, Y.4    Guo, H.5    Hao, L.6    Yao, P.7    Liu, L.8    Sun, X.9    He, K.10    Cao, W.11    Yang, X.12
  • 27
    • 79959453305 scopus 로고    scopus 로고
    • Dietary leucine - An environmental modifier of insulin resistance acting on multiple levels of metabolism
    • doi:10.1371/journal.pone.0021187
    • Macotela Y, Emanuelli B, Bang AM, Espinoza DO, Boucher J, Beebe K, Gall W, Kahn CR (2011) Dietary leucine - an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One 6(6):e21187. doi:10.1371/journal.pone.0021187
    • (2011) PLoS One , vol.6 , Issue.6
    • Macotela, Y.1    Emanuelli, B.2    Bang, A.M.3    Espinoza, D.O.4    Boucher, J.5    Beebe, K.6    Gall, W.7    Kahn, C.R.8
  • 28
    • 84866128888 scopus 로고    scopus 로고
    • Leucine signaling in the pathogenesis of type 2 diabetes and obesity
    • doi:10.4239/wjd.v3.i3.38
    • Melnik BC (2012) Leucine signaling in the pathogenesis of type 2 diabetes and obesity. World J Diabetes 3(3):38-53. doi:10.4239/wjd.v3.i3.38
    • (2012) World J Diabetes , vol.3 , Issue.3 , pp. 38-53
    • Melnik, B.C.1
  • 30
    • 0037026745 scopus 로고    scopus 로고
    • Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus
    • PII S0002914902025547
    • Petersen KF, Shulman GI (2002) Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. Am J Cardiol 90(5A):11G-18G (Pubitemid 35266676)
    • (2002) American Journal of Cardiology , vol.90 , Issue.5 SUPPL.
    • Petersen, K.F.1    Shulman, G.I.2
  • 31
    • 0034283186 scopus 로고    scopus 로고
    • L-Leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: Evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport
    • Peyrollier K, Hajduch E, Blair AS, Hyde R, Hundal HS (2000) L-Leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport. Biochem J 350(Pt 2):361-368
    • (2000) Biochem J , vol.350 , Issue.PART 2 , pp. 361-368
    • Peyrollier, K.1    Hajduch, E.2    Blair, A.S.3    Hyde, R.4    Hundal, H.S.5
  • 32
    • 76449100739 scopus 로고    scopus 로고
    • mTOR phosphorylated at S2448 binds to raptor and rictor
    • doi:10.1007/s00726-008-0230-7
    • Rosner M, Siegel N, Valli A, Fuchs C, Hengstschlager M (2010) mTOR phosphorylated at S2448 binds to raptor and rictor. Amino Acids 38(1):223-228. doi:10.1007/s00726-008-0230-7
    • (2010) Amino Acids , vol.38 , Issue.1 , pp. 223-228
    • Rosner, M.1    Siegel, N.2    Valli, A.3    Fuchs, C.4    Hengstschlager, M.5
  • 33
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • DOI 10.1126/science.1106148
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex. Science 307(5712):1098-1101. doi:10.1126/science.1106148 (Pubitemid 40262113)
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 34
    • 35248820393 scopus 로고    scopus 로고
    • Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation
    • DOI 10.1016/j.metabol.2006.08.002, PII S0026049506002824
    • Sipula IJ, Brown NF, Perdomo G (2006) Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation. Metabolism 55(12):1637-1644. doi:10.1016/j.metabol.2006.08.002 (Pubitemid 44827130)
    • (2006) Metabolism: Clinical and Experimental , vol.55 , Issue.12 , pp. 1637-1644
    • Sipula, I.J.1    Brown, N.F.2    Perdomo, G.3
  • 35
    • 77952965080 scopus 로고    scopus 로고
    • Embryonic skeletal muscle microexplant culture and isolation of skeletal muscle stem cells
    • doi:10.1007/978-1-59745-019-5-3
    • Smith J, Merrick D (2010) Embryonic skeletal muscle microexplant culture and isolation of skeletal muscle stem cells. Methods Mol Biol 633:29-56. doi:10.1007/978-1-59745-019-5-3
    • (2010) Methods Mol Biol , vol.633 , pp. 29-56
    • Smith, J.1    Merrick, D.2
  • 36
    • 79953211540 scopus 로고    scopus 로고
    • Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling
    • doi:10.1074/jbc.M110.166991
    • Tato I, Bartrons R, Ventura F, Luis RJ (2011) Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling. J Biol Chem 286(8):6128-6142. doi:10.1074/jbc.M110.166991
    • (2011) J Biol Chem , vol.286 , Issue.8 , pp. 6128-6142
    • Tato, I.1    Bartrons, R.2    Ventura, F.3    Luis, R.J.4
  • 37
    • 24144446404 scopus 로고    scopus 로고
    • Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
    • DOI 10.2337/diabetes.54.9.2674
    • Tremblay F, Krebs M, Dombrowski L, Brehm A, Bernroider E, Roth E, Nowotny P, Waldhausl W, Marette A, Roden M (2005) Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 54(9):2674-2684 (Pubitemid 41233590)
    • (2005) Diabetes , vol.54 , Issue.9 , pp. 2674-2684
    • Tremblay, F.1    Krebs, M.2    Dombrowski, L.3    Brehm, A.4    Bernroider, E.5    Roth, E.6    Nowotny, P.7    Waldhausl, W.8    Marette, A.9    Roden, M.10
  • 38
    • 33644943399 scopus 로고    scopus 로고
    • A nonradioisotope, enzymatic assay for 2-deoxyglucose uptake in L6 skeletal muscle cells cultured in a 96-well microplate
    • doi:10.1016/j.ab.2005.12.011
    • Yamamoto N, Sato T, Kawasaki K, Murosaki S, Yamamoto Y (2006) A nonradioisotope, enzymatic assay for 2-deoxyglucose uptake in L6 skeletal muscle cells cultured in a 96-well microplate. Anal Biochem 351(1):139-145. doi:10.1016/j.ab.2005.12.011
    • (2006) Anal Biochem , vol.351 , Issue.1 , pp. 139-145
    • Yamamoto, N.1    Sato, T.2    Kawasaki, K.3    Murosaki, S.4    Yamamoto, Y.5
  • 39
    • 84876004166 scopus 로고    scopus 로고
    • Leucine facilitates insulin signaling through a Galphai protein-dependent signaling pathway in hepatocytes
    • doi:10.1074/jbc.M112.409409
    • Yang X, Mei S, Wang X, Li X, Liu R, Ma Y, Hao L, Yao P, Liu L, Sun X, Gu H, Liu Z, Cao W (2013) Leucine facilitates insulin signaling through a Galphai protein-dependent signaling pathway in hepatocytes. J Biol Chem 288(13):9313-9320. doi:10.1074/jbc.M112.409409
    • (2013) J Biol Chem , vol.288 , Issue.13 , pp. 9313-9320
    • Yang, X.1    Mei, S.2    Wang, X.3    Li, X.4    Liu, R.5    Ma, Y.6    Hao, L.7    Yao, P.8    Liu, L.9    Sun, X.10    Gu, H.11    Liu, Z.12    Cao, W.13
  • 40
    • 84857522436 scopus 로고    scopus 로고
    • New therapeutic strategy for amino acid medicine: Notable functions of branched chain amino acids as biological regulators
    • doi:10.1254/jphs.11R05FM
    • Yoshizawa F (2012) New therapeutic strategy for amino acid medicine: notable functions of branched chain amino acids as biological regulators. J Pharmacol Sci 118(2):149-155. doi:10.1254/jphs.11R05FM
    • (2012) J Pharmacol Sci , vol.118 , Issue.2 , pp. 149-155
    • Yoshizawa, F.1
  • 41
    • 34249680883 scopus 로고    scopus 로고
    • Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms
    • DOI 10.2337/db07-0123
    • Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH (2007) Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multi-mechanisms. Diabetes 56(6):1647-1654. doi:10.2337/db07-0123 (Pubitemid 46842599)
    • (2007) Diabetes , vol.56 , Issue.6 , pp. 1647-1654
    • Zhang, Y.1    Guo, K.2    LeBlanc, R.E.3    Loh, D.4    Schwartz, G.J.5    Yu, Y.-H.6


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