High glucose increases Cdk5 activity in podocytes via transforming growth factor-β1 signaling pathway

Experimental Cell Research

Volumn 326, Issue 2, 2014, Pages 219-229

  Zhang, Yue ^a   Li, Hongbo ^a   Hao, Jun ^a   Zhou, Yi ^a   Liu, Wei ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Cdk; Cdk5; Diabetic nephropathy; DN; Egr; ERK; High glucose; MEK; Podocyte; SiRNA; TGF 1

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; CYCLIN DEPENDENT KINASE 5; EARLY GROWTH RESPONSE FACTOR 1; GLUCOSE; MANNITOL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P35; ROSCOVITINE; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CELL DAMAGE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; IN VITRO STUDY; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION;

RATTUS;

CDK5; DIABETIC NEPHROPATHY; HIGH GLUCOSE; PODOCYTE; TGF-Β1;

ANIMALS; APOPTOSIS; BENZAMIDES; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; DIABETIC NEPHROPATHIES; DIOXOLES; EARLY GROWTH RESPONSE PROTEIN 1; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; MICE; PHOSPHOTRANSFERASES; PODOCYTES; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PURINES; RATS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84904730677     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2014.04.014     Document Type: Article

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