Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology

American Journal of Pathology

Volumn 165, Issue 4, 2004, Pages 1175-1185

  Griffin, Sian V ^a   Hiromura, Keiju ^a   Pippin, Jeffrey ^a   Petermann, Arndt T ^a   Blonski, Mary J ^a   Krofft, Ron ^a   Takahashi, Satoru ^b   Kulkarni, Ashok B ^b   Shankland, Stuart J ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 5; ENZYME ACTIVATOR; GLOMERULUS BASEMENT MEMBRANE ANTIBODY; PROTEIN P35; REGULATOR PROTEIN; SMALL INTERFERING RNA;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL ELONGATION; CELL FRACTIONATION; CELL FUNCTION; CELL IMMORTALIZATION; CELL LEVEL; CELL MEMBRANE; CELL PROLIFERATION; CELL SHAPE; CELL STRUCTURE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME LOCALIZATION; GLOMERULONEPHRITIS; GLOMERULUS; HISTOPATHOLOGY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KIDNEY DEVELOPMENT; MOUSE; NONHUMAN; PHENOTYPE; PODOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEINURIA; RAT; REGULATORY MECHANISM; TRANSGENIC MOUSE; WESTERN BLOTTING;

EID: 4644273096     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63378-0     Document Type: Article

References (35)

1. Pavenstadt H, Kriz W, Kretzler M: Cell biology of the glomerular podocyte. Physiol Rev 2003, 83:253-307
2. Kriz W: Podocyte is the major culprit accounting for the progression of chronic renal disease. Microsc Res Tech 2002, 57:189-195
3. Kreidberg JA: Podocyte development and glomerulogenesis. J Am Soc Nephrol 2003, 14:806-814
4. Kobayashi N: Mechanism of the process formation; podocytes vs. neurons. Microsc Res Tech 2002, 57:217-223
5. Combs HL, Shankland SJ, Setzer SV, Hudkins KL, Alpers CE: Expression of the cyclin kinase inhibitor p27kip1 in developing and mature human kidney. Kidney Int 1998, 53:892-896
6. Nagata M, Shibata S, Shigeta M, Yu-Ming S, Watanabe T: Cyclin-dependent kinase inhibitors: p27kip1 and p57kip2 expression during human podocyte differentiation. Nephrol Dial Transplant 1999, 14:48-51
7. Mundel P, Shankland SJ: Podocyte biology and response to injury. J Am Soc Nephrol 2002, 13:3005-3015
8. Barisoni L, Kriz W, Mundel P, D'Agati V: The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 1999, 10:51-61
9. Shirato I: Podocyte process effacement in vivo. Microsc Res Tech 2002, 57:241-246
10. Kriz W, Kretzler M, Provoost AP, Shirato I: Stability and leakiness: opposing challenges to the glomerulus. Kidney Int 1996, 49:1570-1574
11. Griffin SV, Pichler R, Wada T, Vaughan M, Durvasula R, Shankland SJ: The role of cell cycle proteins in glomerular disease. Semin Nephrol 2003, 23:569-582
12. Dhavan R, Tsai LH: A decade of cdk5. Nat Rev Mol Cell Biol 2001, 2:749-759
13. Tsai LH, Takahashi T, Caviness Jr VS, Harlow E: Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 1993, 119:1029-1040
14. Lew J, Huang QQ, Qi Z, Winkfein RJ, Aebersold R, Hunt T, Wang JH: A brain-specific activator of cyclin-dependent kinase 5. Nature 1994, 371:423-426
15. Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH: Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 1999, 402:615-622
16. Nguyen MD, Lariviere RC, Julien JP: Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron 2001, 30:135-147
17. Mundel P, Reiser J, Zuniga Mejia Borja A, Pavenstadt H, Davidson GR, Kriz W, Zeller R: Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte lines. Exp Cell Res 1997, 236:248-258
18. Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N, Inagaki M, Delcros JG, Moulinoux JP: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 243:527-536
19. Leost M, Schultz C, Link A, Wu YZ, Biernat J, Mandelkow EM, Bibb JA, Snyder GL, Greengard P, Zaharevitz DW, Gussio R, Senderowicz AM, Sausville EA, Kunick C, Meijer L: Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. Eur J Biochem 2000, 267:5983-5994
20. Hiromura K, Haseley LA, Zhang P, Monkawa T, Durvasula R, Petermann AT, Alpers CE, Mundel P, Shankland SJ: Podocyte expression of the CDK-inhibitor p57 during development and disease. Kidney Int 2001, 60:2235-2246
21. Ohshima T, Ward JM, Huh CG, Longenecker G, Veeranna, Pant HC, Brady RO, Martin LJ, Kulkarni AB: Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci USA 1996, 93:11173-11178
22. Kim YG, Alpers CE, Brugarolas J, Johnson RJ, Couser WG, Shankland SJ: The cyclin kinase inhibitor p21CIP1/WAF1 limits glomerular epithelial cell proliferation in experimental glomerulonephritis. Kidney Int 1999, 55:2349-2361
23. Kopp JB, Klotman ME, Adler SH, Bruggeman LA, Dickie P, Marinos NJ, Eckhaus M, Bryant JL, Notkins AL, Klotman PE: Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. Proc Natl Acad Sci USA 1992, 89:1577-1581
24. Nakao N, Hiraiwa N, Yoshiki A, Ike F, Kusakabe M: Tenascin-C promotes healing of Habu-snake venom-induced glomerulonephritis: studies in knockout congenic mice and in culture. Am J Pathol 1998, 152:1237-1245
25. Shankland SJ, Hugo C, Coats SR, Nangaku M, Pichler RH, Gordon KL, Pippin J, Roberts JM, Couser WG, Johnson RJ: Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis. Kidney Int 1996, 50:1230-1239
26. Nikolic M, Tsai LH: Activity and regulation of p35/Cdk5 kinase complex. Methods Enzymol 2000, 325:200-213
27. Nikolic M, Chou MM, Lu W, Mayer BJ, Tsai LH: The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nature 1998, 395:194-198
28. Hiromura K, Pippin JW, Fero ML, Roberts JM, Shankland SJ: Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1). J Clin Invest 1999, 103:597-604
29. Barisoni L, Mokrzycki M, Sablay L, Nagata M, Yamase H, Mundel P: Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. Kidney Int 2000, 58:137-143
30. Bradfield JW, Cattell V, Smith J: The mesangial cell in glomerulonephritis. II. Mesangial proliferation caused by Habu snake venom in the rat. Lab Invest 1977, 36:487-492
31. Lazaro JB, Kitzmann M, Poul MA, Vandromme M, Lamb NJ, Fernandez A: Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells. J Cell Sci 1997, 110:1251-1260
32. Gao CY, Zakeri Z, Zhu Y, He H, Zelenka PS: Expression of Cdk5, p35, and Cdk5-associated kinase activity in the developing rat lens. Dev Genet 1997, 20:267-275
33. Chen F, Studzinski GP: Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation. Blood 2001, 97:3763-3767
34. Zhang Q, Ahuja HS, Zakeri ZF, Wolgemuth DJ: Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling. Dev Biol 1997, 183:222-233
35. Barisoni L, Bruggeman LA, Mundel P, D'Agati VD, Klotman PE: HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. Kidney Int 2000, 58:173-181