IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses

Clinical and Experimental Allergy

Volumn 44, Issue 7, 2014, Pages 976-985

  Lajoie, S ^a   Lewkowich, I ^b   Herman, N S ^b   Sproles, A ^b   Pesce, J T ^c   Wynn, T A ^c   Grusby, M J ^d   Hamid, Q ^e   Wills Karp, M ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

Airway hyperresponsiveness; Asthma; IL 21; IL 21R; Tregs

Indexed keywords

ALLERGEN; CYTOKINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 13; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 4; PREDNISONE; STEROID;

AIRWAY; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATOPHAGOIDES; FEMALE; HOUSE DUST ALLERGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; LUNG; MALE; MEDIATOR; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; STEROID THERAPY; TH2 CELL; WILD TYPE; ANIMAL; BRONCHUS HYPERREACTIVITY; DEFICIENCY; DISEASE MODEL; GENETICS; HYPERSENSITIVITY; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM;

ALLERGENS; ANIMALS; BRONCHIAL HYPERREACTIVITY; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; HYPERSENSITIVITY; IMMUNOGLOBULIN E; MALE; MICE; MICE, KNOCKOUT; RECEPTORS, INTERLEUKIN-21; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TH2 CELLS;

EID: 84904703790     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12341     Document Type: Article

References (35)

1. Frohlich A, Marsland BJ, Sonderegger I et al. IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood 2007; 109:2023-31.
2. Pesce J, Kaviratne M, Ramalingam TR et al. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest 2006; 116:2044-55.
3. Wurster AL, Rodgers VL, Satoskar AR et al. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J Exp Med 2002; 196:969-77.
4. Korn T, Bettelli E, Gao W et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007; 448:484-7.
5. Nurieva R, Yang XO, Martinez G et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007; 448:480-3.
6. Zhou L, Ivanov II, Spolski R et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007; 8:967-74.
7. Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008; 29:127-37.
8. Li Y, Yee C. IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes. Blood 2008; 111:229-35.
9. Peluso I, Fantini MC, Fina D et al. IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes. J Immunol 2007; 178:732-9.
10. Pene J, Gauchat JF, Lecart S et al. Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells. J Immunol 2004; 172:5154-7.
11. Ozaki K, Spolski R, Feng CG et al. A critical role for IL-21 in regulating immunoglobulin production. Science 2002; 298:1630-4.
12. Kasaian MT, Whitters MJ, Carter LL et al. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 2002; 16:559-69.
13. Parrish-Novak J, Dillon SR, Nelson A et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000; 408:57-63.
14. Coquet JM, Kyparissoudis K, Pellicci DG et al. IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol 2007; 178:2827-34.
15. Leonard WJ, Spolski R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat Rev Immunol 2005; 5:688-98.
16. Brandt K, Bulfone-Paus S, Foster DC, Ruckert R. Interleukin-21 inhibits dendritic cell activation and maturation. Blood 2003; 102:4090-8.
17. Ostiguy V, Allard EL, Marquis M, Leignadier J, Labrecque N. IL-21 promotes T lymphocyte survival by activating the phosphatidylinositol-3 kinase signaling cascade. J Leukoc Biol 2007; 82:645-56.
18. Monteleone G, Caruso R, Fina D et al. Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut 2006; 55:1774-80.
19. Jungel A, Distler JH, Kurowska-Stolarska M et al. Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis Rheum 2004; 50:1468-76.
20. Distler JH, Jungel A, Kowal-Bielecka O et al. Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis. Arthritis Rheum 2005; 52:856-64.
21. Miller SD, Shevach EM. Immunoregulation of experimental autoimmune encephalomyelitis: editorial overview. Res Immunol 1998; 149:753-9.
22. American Thoracic Society. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med 2000; 162:2341-51.
23. Lewkowich IP, Herman NS, Schleifer KW et al. CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J Exp Med 2005; 202:1549-61.
24. Takahashi T, Kuniyasu Y, Toda M et al. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998; 10:1969-80.
25. Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998; 188:287-96.
26. Suto A, Nakajima H, Hirose K et al. Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells. Blood 2002; 100:4565-73.
27. Hiromura Y, Kishida T, Nakano H et al. IL-21 administration into the nostril alleviates murine allergic rhinitis. J Immunol 2007; 179:7157-65.
28. Hamelmann E, Oshiba A, Schwarze J et al. Allergen-specific IgE and IL-5 are essential for the development of airway hyperresponsiveness. Am J Respir Cell Mol Biol 1997; 16:674-82.
29. Oshiba A, Hamelmann E, Takeda K et al. Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice. J Clin Invest 1996; 97:1398-408.
30. Mehlhop PD, van de Rijn M, Goldberg AB et al. Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc Natl Acad Sci U S A 1997; 94:1344-9.
31. Zeng R, Spolski R, Finkelstein SE et al. Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J Exp Med 2005; 201:139-48.
32. Onoda T, Rahman M, Nara H et al. Human CD4+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4+ T cell subsets. Int Immunol 2007; 19:1191-9.
33. Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol 2007; 8:1353-62.
34. Zeng R, Spolski R, Casas E, Zhu W, Levy DE, Leonard WJ. The molecular basis of IL-21-mediated proliferation. Blood 2007; 109:4135-42.
35. Wohlfert EA, Clark RB. 'Vive la Resistance!'-the PI3K-Akt pathway can determine target sensitivity to regulatory T cell suppression. Trends Immunol 2007; 28:154-60.