Effects of HIV infection on the metabolic and hormonal status of children with severe acute malnutrition

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Mody, Aaloke ^a   Bartz, Sarah ^a   Hornik, Christoph P ^a   Kiyimba, Tonny ^d   Bain, James ^a   Muehlbauer, Michael ^a   Kiboneka, Elizabeth ^d   Stevens, Robert ^a   St Peter, John V ^c   Newgard, Christopher B ^a   Bartlett, John ^b   Freemark, Michael ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PEPSICO INC   (United States)

^d MULAGO HOSPITAL   (Uganda)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; GHRELIN; LEPTIN; ADIPOQ PROTEIN, HUMAN; AMINO ACID;

ARTICLE; CD4 LYMPHOCYTE COUNT; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION PROFILING; HORMONAL REGULATION; HOSPITALIZATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; METABOLOMICS; MORTALITY; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PROSPECTIVE STUDY; ACUTE DISEASE; BLOOD; CHILD NUTRITION DISORDERS; INFANT; TREATMENT OUTCOME; VIROLOGY;

ACUTE DISEASE; ADIPONECTIN; AMINO ACIDS; CHILD NUTRITION DISORDERS; CHILD, PRESCHOOL; FEMALE; HIV INFECTIONS; HUMANS; INFANT; LEPTIN; MALE; TREATMENT OUTCOME;

EID: 84904693579     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102233     Document Type: Article

References (35)

1. Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, et al. (2008) Maternal and child undernutrition: global and regional exposures and health consequences. Lancet 371: 243-260.
2. Caulfield LE, de Onis M, Blossner M, Black RE (2004) Undernutrition as an underlying cause of child deaths associated with diarrhea, pneumonia, malaria, and measles. Am J Clin Nutr 80: 193-198.
3. Victora CG, Adair L, Fall C, Hallal PC, Martorell R, et al. (2008) Maternal and child undernutrition: consequences for adult health and human capital. Lancet 371: 340-357.
4. Fergusson P, Tomkins A (2009) HIV prevalence and mortality among children undergoing treatment for severe acute malnutrition in sub-Saharan Africa: a systematic review and meta-analysis. Transactions of the Royal Society of Tropical Medicine and Hygiene 103: 541-548.
5. Chinkhumba J, Tomkins A, Banda T, Mkangama C, Fergusson P (2008) The impact of HIV on mortality during in-patient rehabilitation of severely malnourished children in Malawi. Transactions of the Royal Society of Tropical Medicine and Hygiene 102: 639-644.
6. Bachou H, Tylleskar T, Downing R, Tumwine JK (2006) Severe malnutrition with and without HIV-1 infection in hospitalised children in Kampala, Uganda: differences in clinical features, haematological findings and CD4+ cell counts. Nutrition journal 5: 27.
7. Fergusson P, Chinkhumba J, Grijalva-Eternod C, Banda T, Mkangama C, et al. (2009) Nutritional recovery in HIV-infected and HIV-uninfected children with severe acute malnutrition. Archives of disease in childhood 94: 512-516.
8. Bartz S, Mody A, Hornik C, Bain J, Muehlbauer M, et al. (2014) Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality. J Clin Endocrinol Metab: Epub Feb 27 2014.
9. Ashworth A, Khanum S, Jackson A, Schofield C (2003) Guidelines for the inpatient treatment of severely malnourisehd children. Geneva: World Health Organization.
10. Verkauskiene R, Dollfus C, Levine M, Faye A, Deghmoun S, et al. (2006) Serum adiponectin and leptin concentrations in HIV-infected children with fat redistribution syndrome. Pediatr Res 60: 225-230. (Pubitemid 44297598)
11. Hammond E, McKinnon E, Nolan D (2010) Human immunodeficiency virus treatment-induced adipose tissue pathology and lipoatrophy: prevalence and metabolic consequences. Clin Infect Dis 51: 591-599.
12. Musoke PM, Fergusson P (2011) Severe malnutrition and metabolic complications of HIV-infected children in the antiretroviral era: clinical care and management in resource-limited settings. Am J Clin Nutr 94: 1716S-1720S.
13. Sweeney LL, Brennan AM, Mantzoros CS (2007) The role of adipokines in relation to HIV lipodystrophy. AIDS 21: 895-904. (Pubitemid 46684320)
14. Tsiodras S, Mantzoros C (2006) Leptin and Adiponectin in the HIV Associated Metabolic Syndrome: Physiologic and Therapeutic Implications. Am J Infect Dis 2: 141-152.
15. Feigerlova E, Diene G, Conte-Auriol F, Molinas C, Gennero I, et al. (2008) Hyperghrelinemia precedes obesity in Prader-Willi syndrome. J Clin Endocrinol Metab 93: 2800-2805. (Pubitemid 352008554)
16. Higgins PB, Fernandez JR, Garvey WT, Granger WM, Gower BA (2008) Entero-insular axis and postprandial insulin differences in African American and European American children. Am J Clin Nutr 88: 1277-1283.
17. Lomenick JP, Melguizo MS, Mitchell SL, Summar ML, Anderson JW (2009) Effects of meals high in carbohydrate, protein, and fat on ghrelin and peptide YY secretion in prepubertal children. J Clin Endocrinol Metab 94: 4463-4471.
18. Lomenick JP, Clasey JL, Anderson JW (2008) Meal-related changes in ghrelin, peptide YY, and appetite in normal weight and overweight children. Obesity (Silver Spring) 16: 547-552. (Pubitemid 351328004)
19. Batch BC, Shah SH, Newgard CB, Turer CB, Haynes C, et al. (2013) Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness. Metabolism 62: 961-969.
20. Warren MP (2011) Endocrine manifestations of eating disorders. The Journal of clinical endocrinology and metabolism 96: 333-343.
21. Norrelund H (2005) The metabolic role of growth hormone in humans with particular reference to fasting. Growth hormone & IGF research: official journal of the Growth Hormone Research Society and the International IGF Research Society 15: 95-122.
22. Ahima RS (2006) Adipose tissue as an endocrine organ. Obesity 14 Suppl 5: 242S-249S.
23. Nonogaki K (2008) Ghrelin and feedback systems. Vitamins and hormones 77: 149-170.
24. Soliman AT, ElZalabany MM, Salama M, Ansari BM (2000) Serum leptin concentrations during severe protein-energy malnutrition: correlation with growth parameters and endocrine function. Metabolism: clinical and experimental 49: 819-825. (Pubitemid 30483431)
25. Manary MJ, Muglia LJ, Vogt SK, Yarasheski KE (2006) Cortisol and its action on the glucocorticoid receptor in malnutrition and acute infection. Metabolism: clinical and experimental 55: 550-554.
26. Villarroya J, Diaz-Delfin J, Hyink D, Domingo P, Giralt M, et al. (2010) HIV type-1 transgene expression in mice alters adipose tissue and adipokine levels: towards a rodent model of HIV type-1 lipodystrophy. Antivir Ther 15: 1021-1028.
27. Giralt M, Domingo P, Guallar JP, Rodriguez de la Concepcion ML, Alegre M, et al. (2006) HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV- 1/HAART-associated lipodystrophy. Antivir Ther 11: 729-740. (Pubitemid 44497168)
28. Azzoni L, Crowther NJ, Firnhaber C, Foulkes AS, Yin X, et al. (2010) Association between HIV replication and serum leptin levels: an observational study of a cohort of HIV-1-infected South African women. J Int AIDS Soc 13: 33.
29. Turer AT, Scherer PE (2012) Adiponectin: mechanistic insights and clinical implications. Diabetologia 55: 2319-2326.
30. Carbone F, La Rocca C, Matarese G (2012) Immunological functions of leptin and adiponectin. Biochimie 94: 2082-2088.
31. Procaccini C, Jirillo E, Matarese G (2012) Leptin as an immunomodulator. Mol Aspects Med 33: 35-45.
32. Liu E, Spiegelman D, Semu H, Hawkins C, Chalamilla G, et al. (2011) Nutritional status and mortality among HIV-infected patients receiving antiretroviral therapy in Tanzania. The Journal of infectious diseases 204: 282-290.
33. Prendergast A, Bwakura-Dangarembizi MF, Cook AD, Bakeera-Kitaka S, Natukunda E, et al. (2011) Hospitalization for severe malnutrition among HIV-infected children starting antiretroviral therapy. AIDS 25: 951-956.
34. Heikens GT, Bunn J, Amadi B, Manary M, Chhagan M, et al. (2008) Case management of HIV-infected severely malnourished children: challenges in the area of highest prevalence. Lancet 371: 1305-1307. (Pubitemid 351491320)
35. Kim MH, Cox C, Dave A, Draper HR, Kabue M, et al. (2012) Prompt initiation of ART With therapeutic food is associated with improved outcomes in HIV-infected Malawian children with malnutrition. J Acquir Immune Defic Syndr 59: 173-176.