Severe malnutrition with and without HIV-1 infection in hospitalised children in Kampala, Uganda: Differences in clinical features, haematological findings and CD4+ cell counts

Nutrition Journal

Volumn 5, Issue 1, 2006, Pages

  Bachou, Hanifa ^a,b   Tylleskär, Thorkild ^b   Downing, Robert ^c   Tumwine, James K ^a  

^a MAKERERE UNIVERSITY MEDICAL SCHOOL   (Uganda)

^b UNIVERSITY OF BERGEN   (Norway)

^c UGANDA VIRUS RESEARCH INSTITUTE   (Uganda)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN;

ARTICLE; BLOOD ANALYSIS; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HOSPITAL PATIENT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; LABORATORY TEST; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; NEWBORN; PRESCHOOL CHILD; UGANDA;

BODY HEIGHT; BODY WEIGHT; CD4 LYMPHOCYTE COUNT; CD4-CD8 RATIO; CHILD, PRESCHOOL; EDEMA; FEMALE; HEMOGLOBINS; HIV INFECTIONS; HIV-1; HUMANS; INFANT; INFECTION; KWASHIORKOR; LEUKOCYTE COUNT; LOGISTIC MODELS; MALE; MALNUTRITION; PROTEIN-ENERGY MALNUTRITION; UGANDA;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33750842367     PISSN: 14752891     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-5-27     Document Type: Article

References (22)

1. Chandra RK: Nutrition and immunology: from the clinic to cellular biology and back again. Proc Nutr Soc 1999, 58:681-683.
2. Scrimshaw NS SanGiovanni JP: Synergism of nutrition, infection, and immunity: an overview. Am J Clin Nutr 1997, 66:464S-477S.
3. Najera O Gonzalez C, Toledo G, Lopez L, Ortiz R: Flow cytometry study of lymphocyte subsets in malnourished and well-nourished children with bacterial infections. Clin Diagn Lab Immunol 2004, 11:577-580.
4. Rikimaru T Taniguchi K, Yartey JE, Kennedy DO, Nkrumah FK: Humoral and cell-mediated immunity in malnourished children in Ghana. Eur J Clin Nutr 1998, 52:344-350.
5. Bakaki P Kayita J, Machado MJE, Coulter JB, Tindyebwa D, Ndugwa CM, Hart CA: Epidemiologic and clinical features of HIV-infected and HIV-uninfected Ugandan children younger than 18 months. J Acquir Immune Defic Syndr 2001, 28:35-42.
6. Ticklay IM Nathoo KJ, Siziya S, Brady JP: HIV infection in malnourished children in Harare, Zimbabwe. East Afr Med J 1997, 74:217-220.
7. Ndugwa CM Friesen H: Uganda: paediatric AIDS. AIDS Action 1988:5.
8. Bhuta UM, Ulstein H: Evaluation of the Beckman Coulter AcT 5 diff AL hematology analyzer in a hospital setting. Lab Hematol 2003, 9:167-174.
9. World Health Organization: Management of severe malnutrition: a manual for physicians and other senior health workers. In Management of severe malnutrition 1999 edition. Edited by: WHO . Geneva, WHO; 1999.
10. World Health Organization: Guidelines for the Clinical Management of HIV infection in children. In WHO/GPA/IDS/HCS/933 Edited by: Document WHO. Geneva, WHO; 1993.
11. Lugada ES Mermin J, Kaharuza F, Ulvestad E, Were W, Langeland N, Asjo B, Malamba S, Downing R: Population-based hematologic and immunologic reference values for a healthy Ugandan population. Clin Diagn Lab Immunol 2004, 11:29-34.
12. Fakhir S Ahmad P, Faridi MA, Rattan A: Cell-mediated immune responses in malnourished host. J Trop Pediatr 1989, 35:175-178.
13. Carney JM Warner MS, Borut , Byrne W, Ament M, Cherry JD, Stichm ER: Cell Mediated defects and infection, A study of malnourished hospitalized children. Am J Dis Child 1980, 134:824-827.
14. Borelli P Blatt SL, Rogero MM, Fock, RA: Haematological alterations in protein malnutrition. Rev bras hematol hemoter 2004, 26:49-56.
15. Keusch GT: The history of nutrition: malnutrition, infection and immunity. J Nutr 2003, 133:336S-340S.
16. Savino W: The Thymus. European Journal of Clinical Nutrition 2002, 56:546-549.
17. Chevalier P Sevilla R, Zalles L, Sejas E, Belmonte G, Parent G, Jambon B: Immuno-nutritional recovery of children of children with severe malnutrition. Sante 1996, 6:201-208.
18. Zaman K Baqui AH, Yunus M, Sack RB, Chowdhury HR, Black RE: Malnutrition, cell-mediated immune deficiency and acute upper respiratory infections in rural Bangladeshi children. Acta Paediatr 1997, 86:923-927.
19. Prazuck T Tall F, Nacro B, Rochereau A, Traore A, Sanou T, Malkin JF, Apaire-Marchais V, Masson D, Dublanchet A et al: HIV infection and severe malnutrition: a clinical and epidemiological study in Burkina Faso. AIDS 1993, 7:103-108.
20. Macallan DC: Nutrition and immune function in human immunodeficiency virus infection. 1999, 58:743-748.
21. Kessler L Daley H, Malenga G, Graham S: The impact of the human immunodeficiency virus type 1 on the management of severe malnutrition in Malawi. Ann Trop Paediatr 2000, 20:50-56.
22. Embree J Bwayo J, Nagelkerke N, Njenga S, Nyange P, Ndinya-Achola, Pamba H, Plummer F: Lymphocyte subsets in human immunodeficiency virus type 1-infected and uninfected children in Nairobi. Pediatr Infect Dis J 2001, 20:397-403.