A novel role of exogenous carbon monoxide on protecting cardiac function and improving survival against sepsis via mitochondrial energetic metabolism pathway

International Journal of Biological Sciences

Volumn 10, Issue 7, 2014, Pages 777-788

  Wang, Xu ^a   Qin, Weiting ^a   Qiu, Xuefeng ^a   Cao, Jie ^a   Liu, Dadong ^a   Sun, Bingwei ^a  

^a JIANGSU UNIVERSITY   (China)

Author keywords

Carbon monoxide; Cardiac function; Energy metabolism; Gene expression; Sepsis

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBON MONOXIDE; DNA BINDING PROTEIN; GLUCOSE; LACTIC ACID; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NRF1 PROTEIN, MOUSE; NUCLEAR RESPIRATORY FACTOR 1; PPARGC1A PROTEIN, MOUSE; PROTECTIVE AGENT; TRANSCRIPTION FACTOR;

ANIMAL; C57BL MOUSE; DRUG EFFECTS; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; HEART; MALE; METABOLISM; MITOCHONDRION; PHYSIOLOGY; SEPSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARBON MONOXIDE; DNA-BINDING PROTEINS; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GLUCOSE; HEART; LACTIC ACID; MALE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NUCLEAR RESPIRATORY FACTOR 1; PROTECTIVE AGENTS; SEPSIS; TRANSCRIPTION FACTORS;

EID: 84904683743     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.9220     Document Type: Article

References (52)

1. Angus DC, van der Poll T: Severe sepsis and septic shock. The New England journal of medicine 2013, 369(9):840-851.
2. Charles PE, Gibot S: Predicting outcome in patients with sepsis: new biomarkers for old expectations. Critical care 2014, 18(1):108.
3. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Critical care medicine 2001, 29(7):1303-1310.
4. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL: Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003. Critical care medicine 2007, 35(5):1244-1250.
5. Rudiger A, Singer M: Mechanisms of sepsis-induced cardiac dysfunction. Critical care medicine 2007, 35(6):1599-1608.
6. Rudiger A, Singer M: The Heart in Sepsis: From Basic Mechanisms to Clinical Management. Curr Vasc Pharmacol 2013, 11(2):187-195.
7. Court O, Kumar A, Parrillo JE, Kumar A: Clinical review: Myocardial depression in sepsis and septic shock. Critical care 2002, 6(6):500-508.
8. Annane D, Bellissant E, Cavaillon JM: Septic shock. Lancet 2005, 365(9453):63-78.
9. Crouser ED: Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome. Mitochondrion 2004, 4(5-6):729-741.
10. Garrabou G, Moren C, Lopez S, Tobias E, Cardellach F, Miro O, Casademont J: The effects of sepsis on mitochondria. The Journal of infectious diseases 2012, 205(3):392-400.
11. Li L, Hu BC, Chen CQ, Gong SJ, Yu YH, Dai HW, Yan J: Role of mitochondrial damage during cardiac apoptosis in septic rats. Chinese Medical Journal 2013, 126(10):1860-1866.
12. Grundler K, Angstwurm M, Hilge R, Baumann P, Annecke T, Crispin A, Sohn HY, Massberg S, Kraemer BF: Platelet mitochondrial membrane depolarization reflects disease severity in patients with sepsis and correlates with clinical outcome. Critical care 2014, 18(1):R31.
13. Motterlini R, Otterbein LE: The therapeutic potential of carbon monoxide. Nature reviews Drug discovery 2010, 9(9):728-743.
14. Koulouras VP, Li R, Chen L, Hedenstierna GG: Effects of inhaled carbon monoxide and glucocorticoids in porcine endotoxin sepsis. International Journal of Clinical and Experimental Medicine 2011, 4(1):53-66.
15. Lee S, Lee SJ, Coronata AA, Fredenburgh LE, Chung SW, Perrella MA, Nakahira K, Ryter SW, Choi AM: Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. Antioxidants & redox signaling 2014, 20(3):432-442.
16. Wang X, Cao J, Sun BW, Liu DD, Liang F, Gao L: Exogenous carbon monoxide attenuates inflammatory responses in the small intestine of septic mice. World journal of gastroenterology: WJG 2012, 18(40):5719-5728.
17. Sun BW, Sun Y, Sun ZW, Chen X: CO liberated from CORM-2 modulates the inflammatory response in the liver of thermally injured mice. World journal of gastroenterology: WJG 2008, 14(4):547-553.
18. Sun B, Sun H, Liu C, Shen J, Chen Z, Chen X: Role of CO-releasing molecules liberated CO in attenuating leukocytes sequestration and inflammatory responses in the lung of thermally injured mice. The Journal of surgical research 2007, 139(1):128-135.
19. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical care medicine 2001, 29(7):1303-1310.
20. Merx MW, Weber C: Sepsis and the heart. Circulation 2007, 116(7):793-802.
21. Ruggieri AJ, Levy RJ, Deutschman CS: Mitochondrial dysfunction and resuscitation in sepsis. Critical care clinics 2010, 26(3):567-575.
22. Sayeed MM: Mitochondrial dysfunction in sepsis: a familiar song with new lyrics. Critical care medicine 2002, 30(12):2780-2781.
23. Singer M: Mitochondrial function in sepsis: acute phase versus multiple organ failure. Critical care medicine 2007, 35(9 Suppl):S441-448.
24. Song R, Kubo M, Morse D, Zhou Z, Zhang X, Dauber JH, Fabisiak J, Alber SM, Watkins SC, Zuckerbraun BS et al: Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects. The American journal of pathology 2003, 163(1):231-242.
25. Otterbein LE: Carbon monoxide: innovative anti-inflammatory properties of an age-old gas molecule. Antioxidants & redox signaling 2002, 4(2):309-319.
26. Caumartin Y, Stephen J, Deng JP, Lian D, Lan Z, Liu W, Garcia B, Jevnikar AM, Wang H, Cepinskas G et al: Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation. Kidney international 2011, 79(10):1080-1089.
27. Maruyama K, Morishita E, Yuno T, Sekiya A, Asakura H, Ohtake S, Yachie A: Carbon monoxide (CO)-releasing molecule-derived CO regulates tissue factor and plasminogen activator inhibitor type 1 in human endothelial cells. Thromb Res 2012, 130(3):e188-193.
28. Tsoyi K, Ha YM, Kim YM, Lee YS, Kim HJ, Kim HJ, Seo HG, Lee JH, Chang KC: Activation of PPAR-gamma by Carbon Monoxide from CORM-2 Leads to the Inhibition of iNOS but not COX-2 Expression in LPS-Stimulated Macrophages. Inflammation 2009, 32(6):364-371.
29. Dejager L, Pinheiro I, Dejonckheere E, Libert C: Cecal ligation and puncture: the gold standard model for polymicrobial sepsis? Trends in microbiology 2011, 19(4):198-208.
30. Bastarache JA, Matthay MA: Cecal ligation model of sepsis in mice: new insights. Critical care medicine 2013, 41(1):356-357.
31. Mitchell MD, Laird RE, Brown RD, Long CS: IL-1beta stimulates rat cardiac fibroblast migration via MAP kinase pathways. American journal of physiology Heart and circulatory physiology 2007, 292(2):H1139-1147.
32. Meador BM, Krzyszton CP, Johnson RW, Huey KA: Effects of IL-10 and age on IL-6, IL-1beta, and TNF-alpha responses in mouse skeletal and cardiac muscle to an acute inflammatory insult. J Appl Physiol 2008, 104(4):991-997.
33. Bayeva M, Gheorghiade M, Ardehali H: Mitochondria as a Therapeutic Target in Heart Failure. Journal of the American College of Cardiology 2013, 61(6):599-610.
34. Walters AM, Porter GA, Brookes PS: Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy. Circulation research 2012, 111(9):1222-1236.
35. Moslehi J, DePinho RA, Sahin E: Telomeres and Mitochondria in the Aging Heart. Circulation research 2012, 110(9):1226-1237.
36. Garrabou G, Moren C, Lopez S, Tobias E, Cardellach F, Miro O, Casademont J: The Effects of Sepsis on Mitochondria. Journal of Infectious Diseases 2012, 205(3):392-400.
37. Balestra GM, Legrand M, Ince C: Microcirculation and mitochondria in sepsis: getting out of breath. Current Opinion in Anesthesiology 2009, 22(2):184-190.
38. Singer M, Brealey D: Mitochondrial dysfunction in sepsis. Biochemical Society symposium 1999, 66:149-166.
39. Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Davies NA, Cooper CE, Singer M: Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002, 360(9328):219-223.
40. Mittra E, Quon A: Positron Emission Tomography/Computed Tomography: The Current Technology and Applications. Radiologic Clinics of North America 2009, 47(1):147.
41. Gong J, Jing L: Glutamine induces heat shock protein 70 expression via O-GlcNAc modification and subsequent increased expression and transcriptional activity of heat shock factor-1. Minerva Anestesiol 2011, 77(5):488-495.
42. Kowald A, Kirkwood TBL: Evolution of the mitochondrial fusion-fission cycle and its role in aging. Proceedings of the National Academy of Sciences of the United States of America 2011, 108(25):10237-10242.
43. MacGarvey NC, Suliman HB, Bartz RR, Fu P, Withers CM, Welty-Wolf KE, Piantadosi CA: Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis. American journal of respiratory and critical care medicine 2012, 185(8):851-861.
44. Piantadosi CA, Withers CM, Bartz RR, MacGarvey NC, Fu P, Sweeney TE, Welty-Wolf KE, Suliman HB: Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. J Biol Chem 2011, 286(18):16374-16385.
45. Scarpulla RC, Vega RB, Kelly DP: Transcriptional integration of mitochondrial biogenesis. Trends in Endocrinology and Metabolism 2012, 23(9):459-466.
46. Fernandez-Marcos PJ, Auwerx J: Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr 2011, 93(4):884S-890.
47. Scarpulla RC: Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiological reviews 2008, 88(2):611-638.
48. Fujimoto H, Ohno M, Ayabe S, Kobayashi H, Ishizaka N, Kimura H, Yoshida K, Nagai R: Carbon monoxide protects against cardiac ischemia--reperfusion injury in vivo via MAPK and Akt--eNOS pathways. Arteriosclerosis, thrombosis, and vascular biology 2004, 24(10):1848-1853.
49. Liu H, Song D, Lee SS: Role of heme oxygenase-carbon monoxide pathway in pathogenesis of cirrhotic cardiomyopathy in the rat. American journal of physiology Gastrointestinal and liver physiology 2001, 280(1):G68-74.
50. Otterbein LE, Bach FH, Alam J, Soares M, Lu HT, Wysk M, Davis RJ, Flavell RA, Choi AMK: Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nature medicine 2000, 6(4):422-428.
51. Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, Bracale R, Valerio A, Francolini M, Moncada S et al: Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 2003, 299(5608):896-899.
52. Nisoli E, Falcone S, Tonello C, Cozzi V, Palomba L, Fiorani M, Pisconti A, Brunelli S, Cardile A, Francolini M et al: Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals. Proceedings of the National Academy of Sciences of the United States of America 2004, 101(47):16507-16512.