Age-related differences in bitter taste and efficacy of bitter blockers

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Mennella, Julie A ^a   Reed, Danielle R ^a   Roberts, Kristi M ^a   Mathew, Phoebe S ^a   Mansfield, Corrine J ^a  

^a MONELL CHEMICAL SENSES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; DENATONIUM BENZOATE; GLUCONATE SODIUM; GLUTAMATE SODIUM; PROPYLTHIOURACIL; QUININE; UREA; G PROTEIN COUPLED RECEPTOR; GLUCONIC ACID; QUATERNARY AMMONIUM DERIVATIVE; TASTE RECEPTORS, TYPE 2;

ADULT; AGE DISTRIBUTION; ARTICLE; BITTER TASTE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHILD; CONTROLLED STUDY; ETHNICITY; FEMALE; GENETIC VARIABILITY; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PERCEPTION; PRESCHOOL CHILD; QUESTIONNAIRE; RACE DIFFERENCE; SCHOOL CHILD; SENSORY STIMULATION; TASTE; TASTE PREFERENCE; AGING; CLINICAL TRIAL; DRUG EFFECTS; GENETICS; METABOLISM; TASTE BUD;

ADULT; AGING; CAFFEINE; CHILD; CHILD, PRESCHOOL; FEMALE; GENOTYPE; GLUCONATES; HUMANS; MALE; PROPYLTHIOURACIL; QUATERNARY AMMONIUM COMPOUNDS; QUININE; RECEPTORS, G-PROTEIN-COUPLED; SODIUM GLUTAMATE; TASTE; TASTE BUDS;

EID: 84904660234     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103107     Document Type: Article

References (47)

1. Milne CP, Bruss JB (2008) The economics of pediatric formulation development for off-patent drugs. Clin Ther 30: 2133-2145.
2. Glendinning JI (1994) Is the bitter rejection response always adaptive? Physiol Behav 56: 1217-1227.
3. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, et al. (2000) A novel family of mammalian taste receptors. Cell 100: 693-702.
4. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, et al. (2000) T2Rs function as bitter taste receptors. Cell 100: 703-711.
5. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010) The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35: 157-170.
6. Behrens M, Meyerhof W (2009) Mammalian bitter taste perception. Results Probl Cell Differ 47: 203-220.
7. Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, et al. (2003) Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299: 1221-1225. (Pubitemid 36237461)
8. Mennella JA, Pepino MY, Beauchamp GK (2003) Modification of bitter taste in children. Dev Psychobiol 43: 120-127. (Pubitemid 36999502)
9. Mennella JA, Spector AC, Reed DR, Coldwell SE (2013) The bad taste of medicines: Overview of basic research on bitter taste. Clin Ther 35: 1225-1246.
10. Palmer RK (2007) The pharmacology and signaling of bitter, sweet, and umami taste sensing. Mol Interv 7: 87-98.
11. Ley JP (2008) Masking bitter taste by molecules. Chemosensory Perception 1: 58-77.
12. Breslin PA, Beauchamp GK (1997) Salt enhances flavour by suppressing bitterness. Nature 387: 563. (Pubitemid 27248752)
13. Roy G (1997) Modifying bitterness: mechanisms, ingredients, and applications: CRC Press.
14. Keast RS, Breslin PA (2002) Modifying the bitterness of selected oral pharmaceuticals with cation and anion series of salts. Pharm Res 19: 1019-1026. (Pubitemid 34804245)
15. Keast RS, Canty TM, Breslin PA (2004) The influence of sodium salts on binary mixtures of bitter-tasting compounds. Chem Senses 29: 431-439. (Pubitemid 41289321)
16. Breslin PA, Beauchamp GK (1995) Suppression of bitterness by sodium: variation among bitter taste stimuli. Chem Senses 20: 609-623. (Pubitemid 26002794)
17. Narukawa M, Tsujitani T, Ueno Y, Nakano-Ooka K, Miyamoto-Kokubo N, et al. (2012) Evaluation of the suppressive effect on bitter taste of gluconate. Biosci Biotechnol Biochem 76: 2282-2288.
18. Delwiche JF, Buletic Z, Breslin PA (2001) Covariation in individuals' sensitivities to bitter compounds: evidence supporting multiple receptor/transduction mechanisms. Percept Psychophys 63: 761-776. (Pubitemid 33603928)
19. Bufe B, Breslin PA, Kuhn C, Reed DR, Tharp CD, et al. (2005) The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 15: 322-327. (Pubitemid 40263364)
20. Mennella JA, Pepino MY, Reed DR (2005) Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 115: e216-222. (Pubitemid 43193801)
21. Spielman AI, Pepino MY, Feldman R, Brand JG (2010) Technique to collect fungiform (taste) papillae from human tongue. J Vis Exp.
22. Mennella JA, Pepino MY, Duke FF, Reed DR (2010) Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38. BMC Genet 11: 60.
23. Anliker JA, Bartoshuk L, Ferris AM, Hooks LD (1991) Children's food preferences and genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP). Am J Clin Nutr 54: 316-320. (Pubitemid 21898936)
24. Mennella JA, Pepino MY, Duke FF, Reed DR (2011) Psychophysical dissection of genotype effects on human bitter perception. Chem Senses 36: 161-167.
25. Siegel S, Castellan NJ (1988) The case of k related samples. Nonparametric statistics for behavioral sciences 2nd edition. 2nd ed. New York: McGraw-Hill. pp. 168-189.
26. Pew Charitable Trust (2011) A city transformed: The racial and ethnic changes in Philadelphia over the last 20 years. Available: http://www.pewtrusts. org/uploadedFiles/wwwpewtrustsorg/Reports/Philadelphia-Research-Initiative/ Philadelphia-Population-Ethnic-Changes.pdf. Accessed 2014 Apr 16.
27. Mowry JB, Spyker DA, Cantilena LR, Jr., Bailey JE, Ford M (2013) 2012 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 30th Annual Report. Clin Toxicol (Phila) 51: 949-1229.
28. Sibert JR, Frude N (1991) Bittering agents in the prevention of accidental poisoning: children's reactions to denatonium benzoate (Bitrex). Arch Emerg Med 8: 1-7.
29. Rodgers GCJ, Tenenbein M (1994) The role of aversive bittering agents in the prevention of pediatric poisonings. Pediatrics 93: 68-69.
30. Lawless HT, Hammer LD, Corina MD (1982) Aversions to bitterness and accidental poisonings among preschool children. J Toxicol Clin Toxicol 19: 951-964. (Pubitemid 13063262)
31. Schiffman SS, Gatlin LA, Frey AE, Heiman SA, Stagner WC, et al. (1994) Taste perception of bitter compounds in young and elderly persons: relation to lipophilicity of bitter compounds. Neurobiol Aging 15: 743-750. (Pubitemid 24360166)
32. Cowart BJ, Yokomukai Y, Beauchamp GK (1994) Bitter taste in aging: compound-specific decline in sensitivity. Physiology and Behavior 56: 1237-1241. (Pubitemid 24374231)
33. Stevens JC (1996) Detection of tastes in mixture with other tastes: issues of masking and aging. Chem Senses 21: 211-221.
34. Mattes RD (1985) Gustation as a determinant of ingestion: methodological issues. Am J Clin Nutr 41: 672-683.
35. Stein LJ, Nagai H, Nakagawa M, Beauchamp GK (2003) Effects of repeated exposure and health-related information on hedonic evaluation and acceptance of a bitter beverage. Appetite 40: 119-129. (Pubitemid 36629298)
36. Kroeze JH, Bartoshuk LM (1985) Bitterness suppression as revealed by split-tongue taste stimulation in humans. Physiol Behav 35: 779-783. (Pubitemid 16253607)
37. Bartoshuk LM (1980) Sensory analysis of the taste of NaCl. In: Kare MR, Fregly MJ, Bernard RA, editors. Biological and behavioral aspects of salt intake. New York: Academic Press. pp. 83-98.
38. Born S, Levit A, Niv MY, Meyerhof W, Behrens M (2013) The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. J Neurosci 33: 201-213.
39. Liu W, Chun E, Thompson AA, Chubukov P, Xu F, et al. (2012) Structural basis for allosteric regulation of GPCRs by sodium ions. Science 337: 232-236.
40. Guo SW, Reed DR (2001) The genetics of phenylthiocarbamide perception. Ann Hum Biol 28: 111-142.
41. Bartoshuk LM (2000) Comparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception. Chem Senses 25: 447-460.
42. Mennella JA, Lukasewycz LD, Griffith JW, Beauchamp GK (2011) Evaluation of the Monell forced-choice, paired-comparison tracking procedure for determining sweet taste preferences across the lifespan. Chem Senses 36: 345-355.
43. Beauchamp GK, Cowart BJ (1990) Preference for high salt concentrations among children. Developmental Psychology 26: 539-545.
44. Mennella JA, Finkbeiner S, Lipchock SV, Hwang LD, Reed DR (2014) Preferences for salty and sweet tastes are elevated and related to each other during childhood. PLoS One 9: e92201.
45. Giacoia GP, Taylor-Zapata P, Zajicek A (2012) Eunice Kennedy Shriver National Institute of Child Health and Human Development Pediatrics Formulation Initiative: Proceedings from the Second Workshop on Pediatric Formulations. Clin Ther 34: S1-S10.
46. Salunke S, Brandys B, Giacoia G, Tuleu C (2013) The STEP (Safety and Toxicity of Excipients for Paediatrics) database: Part 2 - The pilot version. Int J Pharm 457: 310-322.
47. Soares S, Kohl S, Thalmann S, Mateus N, Meyerhof W, et al. (2013) Different phenolic compounds activate distinct human bitter taste receptors. J Agric Food Chem 61: 1525-1533.