Comparative analysis of protein glycosylation pathways in humans and the fungal pathogen candida albicans

International Journal of Microbiology

Volumn 2014, Issue , 2014, Pages

  Martínez Duncker, Iván ^a   Díaz Jímenez, Diana F ^b   Mora Montes, Héctor M ^c  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c UNIVERSITY OF GUANAJUATO   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84904634623     PISSN: 1687918X     EISSN: 16879198     Source Type: Journal    
DOI: 10.1155/2014/267497     Document Type: Review

References (154)

1. Modrzewska B., Kurnatowski P., Selected pathogenic characteristics of fungi from the genus Candida. Annals of Parasitology 2013 59 2 57 66
2. Lehle L., Strahl S., Tanner W., Protein glycosylation, conserved from yeast to man: A model organism helps elucidate congenital human diseases. Angewandte Chemie-International Edition 2006 45 41 6802 6818 10.1002/anie.200601645 2-s2.0-33750468309 (Pubitemid 44654465)
3. Aebi M., Hennet T., Congenital disorders of glycosylation: genetic model systems lead the way. Trends in Cell Biology 2001 11 3 136 141 10.1016/S0962-8924(01)01925-0 2-s2.0-0035279221 (Pubitemid 32289444)
4. Mora-Montes H. M., Ponce-Noyola P., Villagómez-Castro J. C., Gow N. A. R., Flores-Carreón A., López-Romero E., Protein glycosylation in Candida. Future Microbiology 2009 4 9 1167 1183 10.2217/fmb.09.88 2-s2.0-73649115275
5. Parodi A. J., N -glycosylation in trypanosomatid protozoa. Glycobiology 1993 3 3 193 199 10.1093/glycob/3.3.193 2-s2.0-0027282621
6. Samuelson J., Banerjee S., Magnelli P., Cui J., Kelleher D. J., Gilmore R., Robbins P. W., The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets glycosyltranferases. Proceedings of the National Academy of Sciences of the United States of America 2005 102 5 1548 1553 10.1073/pnas.0409460102 2-s2.0-13444281918 (Pubitemid 40209206)
7. Quellhorst G. J. Jr., Piotrowski J. S., Steffen S. E., Krag S. S., Identification of Schizosaccharomyces pombe prenol as dolichol-16,17. Biochemical and Biophysical Research Communications 1998 244 2 546 550 10.1006/bbrc.1998.8098 2-s2.0-0344074010 (Pubitemid 28414118)
8. Rip J. W., Rupar C. A., Ravi K., Carroll K. K., Distribution, metabolism and function of dolichol and polyprenols. Progress in Lipid Research 1985 24 4 269 309 10.1016/0163-7827(85)90008-6 2-s2.0-0022166093
9. 2-P-P-dolichol in sealed microsomes from yeast. Journal of Biological Chemistry 2009 284 30 19835 19842 10.1074/jbc.M109.000893 2-s2.0-67749089456
10. Haeuptle M. A., Pujol F. M., Neupert C., Winchester B., Kastaniotis A., Aebi M., Hennet T., Human RFT1 deficiency leads to a disorder of N-linked glycosylation. The American Journal of Human Genetics 2008 82 3 600 606 10.1016/j.ajhg.2007.12.021 2-s2.0-41149119929
11. Jelk J., Gao N., Serricchio M., Signorell A., Schmidt R. S., Bangs J. D., Acosta-Serrano A., Lehrman M. A., Bütikofer P., Menon A. K., Glycoprotein biosynthesis in a eukaryote lacking the membrane protein Rft1. Journal of Biological Chemistry 2013 288 28 20616 20623 10.1074/jbc.M113.479642 2-s2.0-84880056818
12. Kornfeld R., Kornfeld S., Assembly of asparagine-linked oligosaccharides. Annual Review of Biochemistry 1985 54 631 664 10.1146/annurev.bi.54.070185. 003215 2-s2.0-0021891884 (Pubitemid 15073660)
13. Karaoglu D., Kelleher D. J., Gilmore R., The highly conserved Stt3 protein is a subunit of the yeast oligosaccharyltransferase and forms a subcomplex with Ost3p and Ost4p. The Journal of Biological Chemistry 1997 272 51 32513 32520 10.1074/jbc.272.51.32513 2-s2.0-0031437891 (Pubitemid 28011937)
14. Kelleher D. J., Gilmore R., DAD1: the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase. Proceedings of the National Academy of Sciences of the United States of America 1997 94 10 4994 4999 10.1073/pnas.94.10.4994 2-s2.0-0030922695 (Pubitemid 27214724)
15. Kelleher D. J., Karaoglu D., Mandon E. C., Gilmore R., Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. Molecular Cell 2003 12 1 101 111 10.1016/S1097-2765(03)00243-0 2-s2.0-0038294237 (Pubitemid 36945039)
16. Shibatani T., David L. L., McCormack A. L., Frueh K., Skach W. R., Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. Biochemistry 2005 44 16 5982 5992 10.1021/bi047328f 2-s2.0-17644366824 (Pubitemid 40570692)
17. McBride K., Baron C., Picard S., Martin S., Boismenu D., Bell A., Bergeron J., Perreault C., The model B6dom1 minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene. Immunogenetics 2002 54 8 562 569 10.1007/s00251-002-0502-4 2-s2.0-18744376856 (Pubitemid 35435515)
18. Hong G., Deleersnijder W., Kozak C. A., van Marck E., Tylzanowski P., Merregaert J., Molecular cloning of a highly conserved mouse and human integral membrane protein (ltm1) and genetic mapping to mouse chromosome 9. Genomics 1996 31 3 295 300 10.1006/geno.1996.0051 2-s2.0-0030024638
19. Ruiz-Canada C., Kelleher D. J., Gilmore R., Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. Cell 2009 136 2 272 283 10.1016/j.cell.2008.11.047 2-s2.0-58249093866
20. Roboti P., High S., Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase. Journal of Cell Science 2012 125 1 220 232 10.1242/jcs.094599 2-s2.0-84858148321
21. Mora-Montes H. M., Bates S., Netea M. G., Díaz-Jiménez D. F., López-Romero E., Zinker S., Ponce-Noyola P., Kullberg B. J., Brown A. J. P., Odds F. C., Flores-Carreón A., Gow N. A. R., Endoplasmic reticulum alpha-glycosidases of Candida albicans are required for N -glycosylation, cell wall integrity, and normal host-fungus interaction. Eukaryotic Cell 2007 6 12 2184 2193 10.1128/EC.00350-07 2-s2.0-37549020379
22. Herrero A. B., Magnelli P., Mansour M. K., Levitz S. M., Bussey H., Abeijon C., KRE5 gene null mutant strains of Candida albicans are avirulent and have altered cell wall composition and hypha formation properties. Eukaryotic Cell 2004 3 6 1423 1432 10.1128/EC.3.6.1423-1432.2004 2-s2.0-11144312405 (Pubitemid 40025101)
23. Ellgaard L., Helenius A., Quality control in the endoplasmic reticulum. Nature Reviews Molecular Cell Biology 2003 4 3 181 191 10.1038/nrm1052 2-s2.0-0037336295 (Pubitemid 36288040)
24. Chui D., Oh-Eda M., Liao Y., Panneerselvam K., Lal A., Marek K. W., Freeze H. H., Moremen K. W., Fukuda M. N., Marth J. D., Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis. Cell 1997 90 1 157 167 10.1016/S0092-8674(00) 80322-0 2-s2.0-0031455984 (Pubitemid 28009427)
25. Oh-Eda M., Nakagawa H., Akama T. O., Lowitz K., Misago M., Moremen K. W., Fukuda M. N., Overexpression of the Golgi-localized enzyme α -mannosidase IIx in Chinese hamster ovary cells results in the conversion of hexamannosyl-N-acetylchitobiose to tetramannosyl-N-acetylchitobiose in the N-glycan-processing pathway. European Journal of Biochemistry 2001 268 5 1280 1288 10.1046/j.1432-1327.2001.01992.x 2-s2.0-0035082787 (Pubitemid 32231880)
26. Fukuda M. N., Akama T. O., In vivo role of α -mannosidase IIx: ineffective spermatogenesis resulting from targeted disruption of the Man2a2 in the mouse. Biochimica et Biophysica Acta-General Subjects 2002 1573 3 382 387 10.1016/S0304-4165(02)00407-5 2-s2.0-0037137475 (Pubitemid 35335448)
27. Varki A., Essentials of Glycobiology 2009 2nd New York, NY, USA Cold Spring Harbor Laboratory Press
28. Gabius H. J., Gabius S., Glycosciences: Status and Perspectives 2002 John Wiley & Sons
29. Varki A., Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins. Nature 2007 446 7139 1023 1029 10.1038/nature05816 2-s2.0-34247565506 (Pubitemid 46676064)
30. Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R., The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Glycobiology 2005 15 8 805 817 10.1093/glycob/cwi063 2-s2.0-25144501600 (Pubitemid 41417983)
31. Schauer R., Biosynthesis and function of N- and O-substituted sialic acids. Glycobiology 1991 1 5 449 452 10.1093/glycob/1.5.449 2-s2.0-0026069647
32. Varki N. M., Varki A., Diversity in cell surface sialic acid presentations: implications for biology and disease. Laboratory Investigation 2007 87 9 851 857 10.1038/labinvest.3700656 2-s2.0-34547929295 (Pubitemid 47267816)
33. López-Ribot J. L., Martínez J. P., Monteagudo C., Alloush H. M., Mattioli N. V., Chaffin W. L., Evidence for the presence of complex carbohydrates in Candida albicans cell wall glycoproteins. Revista Iberoamericana de Micologia 1999 16 1 23 26 2-s2.0-0032894341 (Pubitemid 29166853)
34. Soares R. M., de A. Soares R. M., Alviano D. S., Angluster J., Alviano C. S., Travassos L. R., Identification of sialic acids on the cell surface of Candida albicans. Biochimica et Biophysica Acta 2000 1474 2 262 268 10.1016/S0304-4165(00)00003-9 2-s2.0-0034611799 (Pubitemid 30165712)
35. Masuoka J., Surface glycans of Candida albicans and other pathogenic fungi: physiological roles, clinical uses, and experimental challenges. Clinical Microbiology Reviews 2004 17 2 281 310 10.1128/CMR.17.2.281-310.2004 2-s2.0-2042489656 (Pubitemid 38534031)
36. Wasylnka J. A., Simmer M. I., Moore M. M., Differences in sialic acid density in pathogenic and non-pathogenic Aspergillus species. Microbiology 2001 147, part 4 869 877 2-s2.0-0035043468 (Pubitemid 32401327)
37. Rodrigues M. L., Dobroff A. S. S., Couceiro J. N. D. S. S., Alviano C. S., Schauer R., Travassos L. R., Sialylglycoconjugates and sialyltransferase activity in the fungus Cryptococcus neoformans. Glycoconjugate Journal 2003 19 3 165 173 10.1023/A:1024245606607 2-s2.0-0038499721
38. Oriol R., Mollicone R., Cailleau A., Balanzino L., Breton C., Divergent evolution of fucosyltransferase genes from vertebrates, invertebrates, and bacteria. Glycobiology 1999 9 4 323 334 10.1093/glycob/9.4.323 2-s2.0-0032906430 (Pubitemid 29182148)
39. Lima-Neto R. G., Beltrão E. I. C., Oliveira P. C., Neves R. P., Adherence of Candida albicans and Candida parapsilosis to epithelial cells correlates with fungal cell surface carbohydrates. Mycoses 2011 54 1 23 29 10.1111/j.1439-0507.2009.01757.x 2-s2.0-78649882655
40. Grass J., Pabst M., Kolarich D., Pöltl G., Léonard R., Brecker L., Altmann F., Discovery and structural characterization of fucosylated oligomannosidic N -glycans in mushrooms. The Journal of Biological Chemistry 2011 286 8 5977 5984 10.1074/jbc.M110.191304 2-s2.0-79953211111
41. Coutinho M. F., Prata M. J., Alves S., Mannose-6-phosphate pathway: a review on its role in lysosomal function and dysfunction. Molecular Genetics and Metabolism 2012 105 4 542 550 10.1016/j.ymgme.2011.12.012 2-s2.0-84858698808
42. Lee W., Payne B. J., Gelfman C. M., Vogel P., Kornfeld S., Murine UDP-GlcNAc:Lysosomal enzyme N-acetylglucosamine-1-phosphotransferase lacking the γ -subunit retains substantial activity toward acid hydrolases. Journal of Biological Chemistry 2007 282 37 27198 27203 10.1074/jbc.M704067200 2-s2.0-34848903008 (Pubitemid 47501940)
43. Whyte J. R. C., Munro S., A yeast homolog of the mammalian mannose 6-phosphate receptors contributes to the sorting of vacuolar hydrolases. Current Biology 2001 11 13 1074 1078 10.1016/S0960-9822(01)00273-1 2-s2.0-0035838461 (Pubitemid 32632725)
44. Bates S., Hughes H. B., Munro C. A., Thomas W. P. H., MacCallum D. M., Bertram G., Atrih A., Ferguson M. A. J., Brown A. J. P., Odds F. C., Gow N. A. R., Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans. The Journal of Biological Chemistry 2006 281 1 90 98 10.1074/jbc.M510360200 2-s2.0-33644867152 (Pubitemid 43671166)
45. Rodionov D., Romero P. A., Berghuis A. M., Herscovics A., Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity. Protein Expression and Purification 2009 66 1 1 6 10.1016/j.pep.2009.02.013 2-s2.0-63649117587
46. Jungmann J., Munro S., Multi-protein complexes in the cis Golgi of Saccharomyces cerevisiae with α -1,6-mannosyltransferase activity. The EMBO Journal 1998 17 2 423 434 10.1093/emboj/17.2.423 2-s2.0-0032518685 (Pubitemid 28045483)
47. Jungmann J., Rayner J. C., Munro S., The Saccharomyces cerevisiae protein Mnn10p/Bed1p is a subunit of a Golgi mannosyltransferase complex. The Journal of Biological Chemistry 1999 274 10 6579 6585 10.1074/jbc.274.10.6579 2-s2.0-0033525512 (Pubitemid 29111075)
48. Southard S. B., Specht C. A., Mishra C., Chen-Weiner J., Robbins P. W., Molecular analysis of the Candida albicans homolog of Saccharomyces cerevisiae MNN9, required for glycosylation of cell wall mannoproteins. Journal of Bacteriology 1999 181 24 7439 7448 2-s2.0-0032786422
49. Rayner J. C., Munro S., Identification of the MNN2 and MNN5 mannosyltransferases required for forming and extending the mannose branches of the outer chain mannans of Saccharomyces cerevisiae. Journal of Biological Chemistry 1998 273 41 26836 26843 10.1074/jbc.273.41.26836 2-s2.0-0032500541 (Pubitemid 28471701)
50. Bai C., Xu X., Chan F., Lee R. T. H., Wang Y., MNN5 encodes an iron-regulated α -1,2-mannosyltransferase important for protein glycosylation, cell wall integrity, morphogenesis, and virulence in Candida albicans. Eukaryotic Cell 2006 5 2 238 247 10.1128/EC.5.2.238-247.2006 2-s2.0-32944479485 (Pubitemid 43262011)
51. Mora-Montes H. M., Bates S., Netea M. G., Castillo L., Brand A., Buurman E. T., Díaz-Jiménez D. F., Kullberg B. J., Brown A. J. P., Odds F. C., Gow N. A. R., A multifunctional mannosyltransferase family in candida albicans determines cell wall mannan structure and host-fungus interactions. Journal of Biological Chemistry 2010 285 16 12087 12095 10.1074/jbc.M109.081513 2-s2.0-77951244325
52. Hall R. A., Bates S., Lenardon M. D., MacCallum D. M., Wagener J., Lowman D. W., Kruppa M. D., Williams D. L., Odds F. C., Brown A. J. P., Gow N. A. R., The Mnn2 mannosyltransferase family modulates mannoprotein fibril length, immune recognition and virulence of Candida albicans. PLoS Pathogens 2013 9 4 e1003276 10.1371/journal.ppat.1003276 2-s2.0-84876849076
53. Lussier M., Sdicu A., Bussey H., The KTR and MNN1 mannosyltransferase families of Saccharomyces cerevisiae. Biochimica et Biophysica Acta 1999 1426 2 323 334 10.1016/S0304-4165(98)00133-0 2-s2.0-0032959442 (Pubitemid 29027948)
54. Bates S., Hall R. A., Cheetham J., Netea M. G., Maccallum D. M., Brown A. J., Odds F. C., Gow N. A., Role of the Candida albicans MNN1 gene family in cell wall structure and virulence. BMC Research Notes 2013 6 1, article 294 10.1186/1756-0500-6-294 2-s2.0-84880877849
55. Shibata N., Arai M., Haga E., Kikuchi T., Najima M., Satoh T., Kobayashi H., Suzuki S., Structural identification of an epitope of antigenic factor 5 in mannans of Candida albicans NIH B-792 (serotype B) and J-1012 (serotype A) as β -1,2- linked oligomannosyl residues. Infection and Immunity 1992 60 10 4100 4110 2-s2.0-0026723084
56. Mille C., Bobrowicz P., Trinel P., Li H., Maes E., Guerardel Y., Fradin C., Martínez-Esparza M., Davidson R. C., Janbon G., Poulain D., Wildt S., Identification of a new family of genes involved in β -1,2- mannosylation of glycans in Pichia pastoris and Candida albicans. Journal of Biological Chemistry 2008 283 15 9724 9736 10.1074/jbc.M708825200 2-s2.0-44349164573
57. Hobson R. P., Munro C. A., Bates S., MacCallum D. M., Cutler J. E., Heinsbroek S. E. M., Brown G. D., Odds F. C., Gow N. A. R., Loss of cell wall mannosylphosphate in Candida albicans does not influence macrophage recognition. Journal of Biological Chemistry 2004 279 38 39628 39635 10.1074/jbc.M405003200 2-s2.0-4544309392 (Pubitemid 39258230)
58. Butler G., Rasmussen M. D., Lin M. F., Santos M. A. S., Sakthikumar S., Munro C. A., Rheinbay E., Grabherr M., Forche A., Reedy J. L., Agrafioti I., Arnaud M. B., Bates S., Brown A. J. P., Brunke S., Costanzo M. C., Fitzpatrick D. A., De Groot P. W. J., Harris D., Hoyer L. L., Hube B., Klis F. M., Kodira C., Lennard N., Logue M. E., Martin R., Neiman A. M., Nikolaou E., Quail M. A., Quinn J., Santos M. C., Schmitzberger F. F., Sherlock G., Shah P., Silverstein K. A. T., Skrzypek M. S., Soll D., Staggs R., Stansfield I., Stumpf M. P. H., Sudbery P. E., Srikantha T., Zeng Q., Berman J., Berriman M., Heitman J., Gow N. A. R., Lorenz M. C., Birren B. W., Kellis M., Cuomo C. A., Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature 2009 459 7247 657 662 10.1038/nature08064 2-s2.0-66649105285
59. Trinel P. A., Lepage G., Jouault T., Strecker G., Poulain D., Definitive chemical evidence for the constitutive ability of Candida albicans serotype A strains to synthesize β -1,2 linked oligomannosides containing up to 14 mannose residues. FEBS Letters 1997 416 2 203 206 10.1016/S0014-5793(97)01205-2 2-s2.0-0030734676 (Pubitemid 27462789)
60. Aebi M., Bernasconi R., Clerc S., Molinari M., N-glycan structures: recognition and processing in the ER. Trends in Biochemical Sciences 2010 35 2 74 82 10.1016/j.tibs.2009.10.001 2-s2.0-75749134145
61. Jaeken J., Congenital disorders of glycosylation (CDG): it's (nearly) all in it! Journal of Inherited Metabolic Disease 2011 34 4 853 858 10.1007/s10545-011-9299-3 2-s2.0-79961167779
62. Chaffin W. L., Effect of tunicamycin on germ tube and yeast bud formation in Candida albicans. Journal of General Microbiology 1985 131 8 1853 1861 2-s2.0-0022364861 (Pubitemid 16239924)
63. 2+-ATPase, is required for glycosylation and virulence. The Journal of Biological Chemistry 2005 280 24 23408 23415 10.1074/jbc.M502162200 2-s2.0-20744455345 (Pubitemid 40853255)
64. Pierce C. G., Thomas D. P., López-Ribot J. L., Effect of tunicamycin on Candida albicans biofilm formation and maintenance. Journal of Antimicrobial Chemotherapy 2009 63 3 473 479 10.1093/jac/dkn515 2-s2.0-60649094307
65. Li R.-K., Cutler J. E., Chemical definition of an epitope/adhesin molecule on Candida albicans. The Journal of Biological Chemistry 1993 268 24 18293 18299 2-s2.0-0027290863 (Pubitemid 23260356)
66. Sundstrom P., Adhesins in Candida albicans. Current Opinion in Microbiology 1999 2 4 353 357 10.1016/S1369-5274(99)80062-9 2-s2.0-0033178457 (Pubitemid 29366954)
67. Hoyer L. L., The ALS gene family of Candida albicans. Trends in Microbiology 2001 9 4 176 180 10.1016/S0966-842X(01)01984-9 2-s2.0-0035313659 (Pubitemid 32247378)
68. Sundstrom P., Adhesion in Candida spp. Cellular Microbiology 2002 4 8 461 469 10.1046/j.1462-5822.2002.00206.x 2-s2.0-0036670881 (Pubitemid 34993745)
69. Poulain D., Jouault T., Candida albicans cell wall glycans, host receptors and responses: elements for a decisive crosstalk. Current Opinion in Microbiology 2004 7 4 342 349 10.1016/j.mib.2004.06.011 2-s2.0-4143145195 (Pubitemid 39091117)
70. Finne J., Krusius T., Margolis R. K., Margolis R. U., Novel mannitol-containing oligosaccharides obtained by mild alkaline borohydride treatment of a chondroitin sulfate proteoglycan from brain. Journal of Biological Chemistry 1979 254 20 10295 10300 2-s2.0-0018801488
71. Munro C. A., Bates S., Buurman E. T., Hughes H. B., MacCallum D. M., Bertram G., Atrih A., Ferguson M. A. J., Bain J. M., Brand A., Hamilton S., Westwater C., Thomson L. M., Brown A. J. P., Odds F. C., Gow N. A. R., Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2- mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence. Journal of Biological Chemistry 2005 280 2 1051 1060 10.1074/jbc.M411413200 2-s2.0-19944431369
72. Chai W., Yuen C., Kogelberg H., Carruthers R. A., Margolis R. U., Feizi T., Lawson A. M., High prevalence of 2-mono- and 2,6-di-substituted manol-terminating sequences among O-glycans released from brain glycopeptides by reductive alkaline hydrolysis. European Journal of Biochemistry 1999 263 3 879 888 10.1046/j.1432-1327.1999.00572.x 2-s2.0-0033179169 (Pubitemid 29361963)
73. Jurado L. A., Coloma A., Cruces J., Identification of a human homolog of the Drosophila rotated abdomen gene (POMT1) encoding a putative protein O-mannosyl-transferase, and assignment to human chromosome 9q34.1. Genomics 1999 58 2 171 180 10.1006/geno.1999.5819 2-s2.0-0033152809 (Pubitemid 29275762)
74. Willer T., Amselgruber W., Deutzmann R., Strahl S., Characterization of POMT2, a novel member of the PMT protein O-mannosyltransferase family specifically localized to the acrosome of mammalian spermatids. Glycobiology 2002 12 11 771 783 10.1093/glycob/cwf086 2-s2.0-0036869334 (Pubitemid 36041481)
75. Akasaka-Manya K., Manya H., Nakajima A., Kawakita M., Endo T., Physical and functional association of human protein O-mannosyltransferases 1 and 2. Journal of Biological Chemistry 2006 281 28 19339 19345 10.1074/jbc.M601091200 2-s2.0-33745817404 (Pubitemid 44035439)
76. Takahashi S., Sasaki T., Manya H., Chiba Y., Yoshida A., Mizuno M., Ishida H., Ito F., Inazu T., Kotani N., Takasaki S., Takeuchi M., Endo T., A new β -1,2-N-acetylglucosaminyltransferase that may play a role in the biosynthesis of mammalian O-mannosyl glycans. Glycobiology 2001 11 1 37 45 10.1093/glycob/11.1.37 2-s2.0-0035095886 (Pubitemid 32201335)
77. Yoshida-Moriguchi T., Yu L., Stalnaker S., Sarah Davis S. H., Kunz S., Madson M., Oldstone M. B. A., Schachter H., Wells L., Campbell K. P., O -Mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding. Science 2010 327 5961 88 92 10.1126/science.1180512 2-s2.0-74849131820
78. Yoshida-Moriguchi T., Willer T., Anderson M. E., Venzke D., Whyte T., Muntoni F., Lee H., Nelson S. F., Yu L., Campbell K. P., SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. Science 2013 341 6148 896 899 10.1126/science.1239951 2-s2.0-84882923644
79. Hewitt J. E., LARGE enzyme activity deciphered: a new therapeutic target for muscular dystrophies. Genome Medicine 2012 4 3, article 23 10.1186/gm322 2-s2.0-84858712285
80. Inamori K., Hara Y., Willer T., Anderson M. E., Zhu Z., Yoshida-Moriguchi T., Campbell K. P., Xylosyl- and glucuronyltransferase functions of LARGE in α -dystroglycan modification are conserved in LARGE2. Glycobiology 2013 23 3 295 302 10.1093/glycob/cws152 2-s2.0-84874834197
81. Prill S. K., Klinkert B., Timpel C., Gale C. A., Schröppel K., Ernst J. F., PMT family of Candida albicans: Five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance. Molecular Microbiology 2005 55 2 546 560 10.1111/j.1365-2958.2004.04401.x 2-s2.0-13144261712 (Pubitemid 40179386)
82. Lengeler K. B., Tielker D., Ernst J. F., Protein-O-mannosyltransferases in virulence and development. Cellular and Molecular Life Sciences 2008 65 4 528 544 10.1007/s00018-007-7409-z 2-s2.0-39749162836
83. Cantero P. D., Lengsfeld C., Prill S. K.-., Subanović M., Román E., Pla J., Ernst J. F., Transcriptional and physiological adaptation to defective protein-O-mannosylation in Candida albicans. Molecular Microbiology 2007 64 4 1115 1128 10.1111/j.1365-2958.2007.05723.x 2-s2.0-34248376466 (Pubitemid 46743975)
84. Girrbach V., Strahl S., Members of the evolutionarily conserved PMT family of protein O -mannosyltransferases form distinct protein complexes among themselves. The Journal of Biological Chemistry 2003 278 14 12554 12562 10.1074/jbc.M212582200 2-s2.0-0038823596 (Pubitemid 36800245)
85. Díaz-Jiménez D. F., Mora-Montes H. M., Hernández- Cervantes A., Luna-Arias J. P., Gow N. A. R., Flores-Carreón A., Biochemical characterization of recombinant Candida albicans mannosyltransferases Mnt1, Mnt2 and Mnt5 reveals new functions in O- and N-mannan biosynthesis. Biochemical and Biophysical Research Communications 2012 419 1 77 82 10.1016/j.bbrc.2012.01.131 2-s2.0-84857646146
86. Endo T., Dystroglycan glycosylation and its role in α -dystroglycanopathies. Acta Myologica 2007 26 3 165 170 2-s2.0-43449084044 (Pubitemid 351668924)
87. Godfrey C., Foley A. R., Clement E., Muntoni F., Dystroglycanopathies: coming into focus. Current Opinion in Genetics and Development 2011 21 3 278 285 10.1016/j.gde.2011.02.001 2-s2.0-79957622998
88. Netea M. G., Gow N. A. R., Munro C. A., Bates S., Collins C., Ferwerda G., Hobson R. P., Bertram G., Hughes H. B., Jansen T., Jacobs L., Buurman E. T., Gijzen K., Williams D. L., Torensma R., McKinnon A., MacCallum D. M., Odds F. C., Van Der Meer J. W. M., Brown A. J. P., Kullberg B. J., Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. Journal of Clinical Investigation 2006 116 6 1642 1650 10.1172/JCI27114 2-s2.0-33745207594
89. Rouabhia M., Schaller M., Corbucci C., Vecchiarelli A., Prill S. K.-., Giasson L., Ernst J. F., Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases. Infection and Immunity 2005 73 8 4571 4580 10.1128/IAI.73.8.4571-4580.2005 2-s2.0-23344450808 (Pubitemid 41105611)
90. Timpel C., Zink S., Strahl-Bolsinger S., Schröppel K., Ernst J., Morphogenesis, adhesive properties, and antifungal resistance depend on the Pmt6 protein mannosyltransferase in the fungal pathogen Candida albicans. Journal of Bacteriology 2000 182 11 3063 3071 10.1128/JB.182.11.3063-3071.2000 2-s2.0-0034109113 (Pubitemid 30326919)
91. Peltroche-Llacsahuanga H., Goyard S., D'Enfert C., Prill S. K., Ernst J. F., Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans. Antimicrobial Agents and Chemotherapy 2006 50 10 3488 3491 10.1128/AAC.00606-06 2-s2.0-33749512972 (Pubitemid 44527534)
92. Murciano C., Moyes D. L., Runglall M., Islam A., Mille C., Fradin C., Poulain D., Gow N. A. R., Naglik J. R., Candida albicans cell wall glycosylation may be indirectly required for activation of epithelial cell proinflammatory responses. Infection and Immunity 2011 79 12 4902 4911 10.1128/IAI.05591-11 2-s2.0-84855747363
93. Sheth C. C., Hall R., Lewis L., Brown A. J. P., Odds F. C., Erwig L. P., Gow N. A. R., Glycosylation status of the C. albicans cell wall affects the efficiency of neutrophil phagocytosis and killing but not cytokine signaling. Medical Mycology 2011 49 5 513 524 10.3109/13693786.2010.551425 2-s2.0-79959212041
94. Netea M. G., Van der Graaf C. A. A., Vonk A. G., Verschueren I., Van der Meet J. W. M., Kullberg B. J., The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. Journal of Infectious Diseases 2002 185 10 1483 1489 10.1086/340511 2-s2.0-0037094116 (Pubitemid 34507972)
95. Gasparoto T. H., Tessarolli V., Garlet T. P., Torres S. A., Garlet G. P., Da Silva J. S., Campanelli A. P., Absence of functional TLR4 impairs response of macrophages after Candida albicans infection. Medical Mycology 2010 48 8 1009 1017 10.3109/13693786.2010.481292 2-s2.0-77958490746
96. Ferwerda G., Meyer-Wentrup F., Kullberg B., Netea M. G., Adema G. J., Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages. Cellular Microbiology 2008 10 10 2058 2066 10.1111/j.1462-5822.2008.01188.x 2-s2.0-51449087747
97. Dennehy K. M., Ferwerda G., Faro-Trindade I., Pyz E., Willment J. A., Taylor P. R., Kerrigan A., Tsoni S. V., Gordon S., Meyer-Wentrup F., Adema G. J., Kullberg B., Schweighoffer E., Tybulewicz V., Mora-Montes H. M., Gow N. A. R., Williams D. L., Netea M. G., Brown G. D., Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. European Journal of Immunology 2008 38 2 500 506 10.1002/eji. 200737741 2-s2.0-42249083091
98. Cambi A., Netea M. G., Mora-Montes H. M., Gow N. A. R., Hato S. V., Lowman D. W., Kullberg B., Torensma R., Williams D. L., Figdor C. G., Dendritic cell interaction with Candida albicans critically depends on N-linked Mannan. Journal of Biological Chemistry 2008 283 29 20590 20599 10.1074/jbc.M709334200 2-s2.0-50649113319
99. Netea M. G., Gow N. A. R., Joosten L. A. B., Verschueren I., Van Der Meer J. W. M., Kullberg B. J., Variable recognition of Candida albicans strains by TLR4 and lectin recognition receptors. Medical Mycology 2010 48 7 897 903 10.3109/13693781003621575 2-s2.0-77957737142
100. Watanabe R., Inoue N., Westfall B., Taron C. H., Orlean P., Takeda J., Kinoshita T., The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. EMBO Journal 1998 17 4 877 885 10.1093/emboj/17.4.877 2-s2.0-0032481318 (Pubitemid 28077642)
101. Leidich S. D., Kostova Z., Latek R. R., Costello L. C., Drapp D. A., Gray W., Fassler J. S., Orlean P., Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminyl phosphatidylinositol: cloning of the GPI2 gene. Journal of Biological Chemistry 1995 270 22 13029 13035 10.1074/jbc.270.22.13029 2-s2.0-0028998118
102. Inoue N., Watanabe R., Takeda J., Kinoshita T., PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2. Biochemical and Biophysical Research Communications 1996 226 1 193 199 10.1006/bbrc.1996.1332 2-s2.0-0030568835 (Pubitemid 26332185)
103. Yan B. C., Westfall B. A., Orlean P., Ynl038wp (Gpil5p) is the Saccharomyces cerevisiae homologue of human Pig-Hp and participates in the first step in glycosylphosphatidylinositol assembly. Yeast 2001 18 15 1383 1389 10.1002/yea.783 2-s2.0-0034747085 (Pubitemid 33085620)
104. Newman H. A., Romeo M. J., Lewis S. E., Yan B. C., Orlean P., Levin D. E., Gpi19: the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis. Eukaryotic Cell 2005 4 11 1801 1807 10.1128/EC.4.11.1801-1807.2005 2-s2.0-27744523571 (Pubitemid 41636872)
105. Leidich S. D., Orlean P., Gpi1, a Saccharomyces cerevisiae protein that participates in the first step in glycosylphosphatidylinositol anchor synthesis. The Journal of Biological Chemistry 1996 271 44 27829 27837 10.1074/jbc.271.44.27829 2-s2.0-0029910146 (Pubitemid 26367359)
106. Tiede A., Nischan C., Schubert J., Schmidt R. E., Characterisation of the enzymatic complex for the first step in glycosylphosphatidylinositol biosynthesis. International Journal of Biochemistry and Cell Biology 2000 32 3 339 350 10.1016/S1357-2725(99)00122-3 2-s2.0-0033972925 (Pubitemid 30069976)
107. Murakami Y., Siripanyaphinyo U., Hong Y., Tashima Y., Maeda Y., Kinoshita T., The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. Molecular Biology of the Cell 2005 16 11 5236 5246 10.1091/mbc.E05-08-0743 2-s2.0-27644514673 (Pubitemid 41566835)
108. Watanabe R., Ohishi K., Maeda Y., Nakamura N., Kinoshita T., Mammalian PIG-L and its yeast homologue Gpi12p are N- acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis. Biochemical Journal 1999 339 1 185 192 10.1042/0264-6021:3390185 2-s2.0-0033119014 (Pubitemid 29179306)
109. Murakami Y., Siripanyapinyo U., Hong Y., Kang J. Y., Ishihara S., Nakakuma H., Maeda Y., Kinoshita T., PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor. Molecular Biology of the Cell 2003 14 10 4285 4295 10.1091/mbc.E03-03-0193 2-s2.0-0141652825 (Pubitemid 37186328)
110. Umemura M., Okamoto M., Nakayama K., Sagane K., Tsukahara K., Hata K., Jigami Y., GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast. Journal of Biological Chemistry 2003 278 26 23639 23647 10.1074/jbc.M301044200 2-s2.0-0037593245 (Pubitemid 36830186)
111. Maeda Y., Watanabe R., Harris C. L., Hong Y., Ohishi K., Kinoshita K., Kinoshita T., PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER. EMBO Journal 2001 20 1-2 250 261 10.1093/emboj/20.1.250 2-s2.0-0035863209 (Pubitemid 32099121)
112. Kang J. Y., Yeongjin H., Ashida H., Shishioh N., Murakami Y., Morita Y. S., Maeda Y., Kinoshita T., PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol. Journal of Biological Chemistry 2005 280 10 9489 9497 10.1074/jbc.M413867200 2-s2.0-15744375371 (Pubitemid 40409644)
113. Fabre A., Orlean P., Taron C. H., Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly. FEBS Journal 2005 272 5 1160 1168 10.1111/j.1742-4658.2005.04551.x 2-s2.0-14644389477 (Pubitemid 40314935)
114. Takahashi M., Inoue N., Ohishi K., Maeda Y., Nakamura N., Endo Y., Fujita T., Takeda J., Kinoshita T., PIG-B: a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor. The EMBO Journal 1996 15 16 4254 4261 2-s2.0-0029782178 (Pubitemid 26278708)
115. Sütterlin C., Escribano M. V., Gerold P., Maeda Y., Mazon M. J., Kinoshita T., Schwarz R. T., Riezman H., Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis. Biochemical Journal 1998 332 1 153 159 2-s2.0-0032524569 (Pubitemid 28239330)
116. Grimme S. J., Westfall B. A., Wiedman J. M., Taron C. H., Orlean P., The essential Smp3 protein is required for addition of the side-branching fourth mannose during assembly of yeast glycosylphosphatidylinositols. Journal of Biological Chemistry 2001 276 29 27731 27739 10.1074/jbc.M101986200 2-s2.0-0035920193
117. Taron B. W., Colussi P. A., Wiedman J. M., Orlean P., Taron C. H., Human Smp3p adds a fourth mannose to yeast and human glycosylphosphatidylinositol precursors in vivo. The Journal of Biological Chemistry 2004 279 34 36083 36092 10.1074/jbc.M405081200 2-s2.0-4143059365 (Pubitemid 39100616)
118. Grimme S. J., Colussi P. A., Taron C. H., Orlean P., Deficiencies in the essential Smp3 mannosyl-transferase block glycosylphosphatidylinositol assembly and lead to defects in growth and cell wall biogenesis in Candida albicans. Microbiology 2004 150, part 10 3115 3128 10.1099/mic.0.27254-0 2-s2.0-6444221182 (Pubitemid 39406184)
119. Hong Y., Maeda Y., Watanabe R., Ohishi K., Mishkind M., Riezman H., Kinoshita T., Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol. Journal of Biological Chemistry 1999 274 49 35099 35106 10.1074/jbc.274.49.35099 2-s2.0-0033521023 (Pubitemid 129509564)
120. Benachour A., Sipos G., Flury I., Reggiori F., Canivenc-Gansel E., Vionnet C., Conzelmann A., Benghezal M., Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity. Journal of Biological Chemistry 1999 274 21 15251 15261 10.1074/jbc.274.21.15251 2-s2.0-0033591254 (Pubitemid 29265919)
121. Shishioh N., Hong Y., Ohishi K., Ashida H., Maeda Y., Kinoshita T., GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. Journal of Biological Chemistry 2005 280 10 9728 9734 10.1074/jbc.M413755200 2-s2.0-15744391942 (Pubitemid 40409671)
122. Taron C. H., Wiedman J. M., Grimme S. J., Orlean P., Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p- deficient yeast suggest a branched pathway and implicate Gpi13p in phosphoethanolamine transfer to the third mannose. Molecular Biology of the Cell 2000 11 5 1611 1630 10.1091/mbc.11.5.1611 2-s2.0-0034075970 (Pubitemid 30307900)
123. Hong Y., Maeda Y., Watanabe R., Inoue N., Ohishi K., Kinoshita T., Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. The Journal of Biological Chemistry 2000 275 27 20911 20919 10.1074/jbc.M001913200 2-s2.0-0034617298 (Pubitemid 30457687)
124. Orlean P., Menon A. K., Thematic review series: lipid posttranslational modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids. Journal of Lipid Research 2007 48 5 993 1011 10.1194/jlr.R700002-JLR200 2-s2.0-34248227584 (Pubitemid 46708667)
125. Hamburger D., Egerton M., Riezman H., Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins. Journal of Cell Biology 1995 129 3 629 639 10.1083/jcb.129.3.629 2-s2.0-0028940341
126. Hong Y., Ohishi K., Kang J. Y., Tanaka S., Inoue N., Nishimura J., Maeda Y., Kinoshita T., Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. Molecular Biology of the Cell 2003 14 5 1780 1789 10.1091/mbc.E02-12-0794 2-s2.0-0038247909 (Pubitemid 36583532)
127. Tanaka S., Maeda Y., Tashima Y., Kinoshita T., Inositol Deacylation of Glycosylphosphatidylinositol-anchored Proteins Is Mediated by Mammalian PGAP1 and Yeast Bst1p. Journal of Biological Chemistry 2004 279 14 14256 14263 10.1074/jbc.M313755200 2-s2.0-1842790673 (Pubitemid 38468965)
128. Fujita M., Umemura M., Yoko-O T., Jigami Y., PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins. Molecular Biology of the Cell 2006 17 12 5253 5264 10.1091/mbc.E06-08-0715 2-s2.0-33845404854 (Pubitemid 44907366)
129. Maeda Y., Tashima Y., Houjou T., Fujita M., Yoko-o T., Jigami Y., Taguchi R., Kinoshita T., Fatty acid remodeling of GPI-anchored proteins is required for their raft association. Molecular Biology of the Cell 2007 18 4 1497 1506 10.1091/mbc.E06-10-0885 2-s2.0-34247228098 (Pubitemid 46626645)
130. Bosson R., Jaquenoud M., Conzelmann A., GUP1 of Saccharomyces cerevisiae encodes an O -acyltransferase involved in remodeling of the GPI anchor. Molecular Biology of the Cell 2006 17 6 2636 2645 10.1091/mbc.E06-02-0104 2-s2.0-33744718462 (Pubitemid 43825501)
131. Tashima Y., Taguchi R., Murata C., Ashida H., Kinoshita T., Maeda Y., PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins. Molecular Biology of the Cell 2006 17 3 1410 1420 10.1091/mbc.E05-11- 1005 2-s2.0-33644853935 (Pubitemid 43376560)
132. Pramoonjago P., Wanachiwanawin W., Chinprasertsuk S., Pattanapanyasat K., Takeda J., Kinoshita T., PIG-A gene abnormalities in Thai patients with paroxysmal nocturnal hemoglobinuria. The Southeast Asian Journal of Tropical Medicine and Public Health 1995 26 supplement 1 322 324 2-s2.0-0029437648
133. Almeida A. M., Murakami Y., Layton D. M., Hillmen P., Sellick G. S., Maeda Y., Richards S., Patterson S., Kotsianidis I., Mollica L., Crawford D. H., Baker A., Ferguson M., Roberts I., Houlston R., Kinoshita T., Karadimitris A., Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency. Nature Medicine 2006 12 7 846 851 10.1038/nm1410 2-s2.0-33745904714 (Pubitemid 44050077)
134. Freeze H. H., Chong J. X., Bamshad M. J., Ng B. G., Solving glycosylation disorders: fundamental approaches reveal complicated pathways. The American Journal of Human Genetics 2014 94 2 161 175 10.1016/j.ajhg.2013.10.024
135. Leidich S. D., Drapp D. A., Orlean P., A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis. Journal of Biological Chemistry 1994 269 14 10193 10196 2-s2.0-0028361106 (Pubitemid 24198203)
136. Plaine A., Walker L., Da Costa G., Mora-Montes H. M., McKinnon A., Gow N. A. R., Gaillardin C., Munro C. A., Richard M. L., Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivity. Fungal Genetics and Biology 2008 45 10 1404 1414 10.1016/j.fgb.2008.08.003 2-s2.0-53049099570
137. Richard M., de Groot P., Courtin O., Poulain D., Klis F., Gaillardin C., GP17 affects cell-wall protein anchorage in Saccharomyces cerevisiae and Candida albicans. Microbiology 2002 148, part 7 2125 2133 2-s2.0-0035983824 (Pubitemid 34785296)
138. Victoria G. S., Kumar P., Komath S. S., The Candida albicans homologue of PIG-P, CaGpi19p: gene dosage and role in growth and filamentation. Microbiology 2010 156 10 3041 3051 10.1099/mic.0.039628-0 2-s2.0-77957867115
139. Yadav B., Bhatnagar S., Ahmad M. F., First step of glycosylphosphatidylinositol (GPI) biosynthesis cross-talks with ergosterol biosynthesis and Ras signaling in Candida albicans. The Journal of Biological Chemistry 2014 289 6 3365 3382
140. Sheppard D. C., Yeaman M. R., Welch W. H., Phan Q. T., Fu Y., Ibrahim A. S., Filler S. G., Zhang M., Waring A. J., Edwards J. E. Jr., Functional and structural diversity in the Als protein family of Candida albicans. The Journal of Biological Chemistry 2004 279 29 30480 30489 10.1074/jbc.M401929200 2-s2.0-3142677978 (Pubitemid 38937978)
141. Patsos G., Hebbe-Viton V., San Martin R., Paraskeva C., Gallagher T., Corfield A., Action of a library of O-glycosylation inhibitors on the growth of human colorectal cancer cells in culture. Biochemical Society Transactions 2005 33 4 721 723 10.1042/BST0330721 2-s2.0-23844476132 (Pubitemid 41160849)
142. Dwarakanath B. S., Cytotoxicity, radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucose in vitro. Journal of cancer research and therapeutics 2009 5 supplement 1 S27 S31 10.4103/0973-1482.55137 2-s2.0-77951235938
143. Díaz-Jiménez D., Pérez-García L. A., Martínez-Álvarez J. A., Mora-Montes H. M., Role of the fungal cell wall in pathogenesis and antifungal resistance. Current Fungal Infection Reports 2012 6 4 275 282
144. Price N. P. J., Tsvetanova B., Biosynthesis of the tunicamycins: a review. Journal of Antibiotics 2007 60 8 485 491 10.1038/ja.2007.62 2-s2.0-36049024081
145. Lim S. P., Wang Q. Y., Noble C. G., Ten years of dengue drug discovery: progress and prospects. Antiviral Research 2013 100 2 500 519
146. Chang J., Block T. M., Guo J. T., Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions. Antiviral Research 2013 99 3 251 260 10.1016/j.antiviral.2013.06.011
147. Chang J., Warren T. K., Zhao X., Gill T., Guo F., Wang L., Comunale M. A., Du Y., Alonzi D. S., Yu W., Ye H., Liu F., Guo J., Mehta A., Cuconati A., Butters T. D., Bavari S., Xu X., Block T. M., Small molecule inhibitors of ER α -glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Research 2013 98 3 432 440 10.1016/j.antiviral.2013.03.023 2-s2.0-84877100308
148. Howe J. D., Smith N., Lee M. J., Ardes-Guisot N., Vauzeilles B., Désiré J., Baron A., Blériot Y., Sollogoub M., Alonzi D. S., Butters T. D., Novel imino sugar alpha-glucosidase inhibitors as antiviral compounds. Bioorganic and Medicinal Chemistry 2013 21 16 4831 4838 10.1016/j.bmc.2013.03.014 2-s2.0-84880571652
149. Qu X., Pan X., Weidner J., Yu W., Alonzi D., Xu X., Butters T., Block T., Guo J., Chang J., Inhibitors of endoplasmic reticulum α -glucosidases potently suppress hepatitis C virus virion assembly and release. Antimicrobial Agents and Chemotherapy 2011 55 3 1036 1044 10.1128/AAC.01319-10 2-s2.0-79952322370
150. Durantel D., Celgosivir, an α -glucosidase I inhibitor for the potential treatment of HCV infection. Current Opinion in Investigational Drugs 2009 10 8 860 870 2-s2.0-68649083959
151. Arroyo J., Hutzler J., Bermejo C., Ragni E., García-Cantalejo J., Botías P., Piberger H., Schott A., Sanz A. B., Strahl S., Functional and genomic analyses of blocked protein O-mannosylation in baker's yeast. Molecular Microbiology 2011 79 6 1529 1546 10.1111/j.1365-2958.2011.07537.x 2-s2.0-79952453315
152. McLellan C. A., Whitesell L., King O. D., Lancaster A. K., Mazitschek R., Lindquist S., Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity. ACS Chemical Biology 2012 7 9 1520 1528 10.1021/cb300235m 2-s2.0-84868159204
153. McLellan C. A., Whitesell L., King O. D., Lancaster A. K., Mazitschek R., Lindquist S., Correction to inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity. ACS Chemical Biology 2014 9 4 1061 10.1021/cb5000339 2-s2.0-84868159204
154. Watanabe N., Miyazaki M., Horii T., Sagane K., Tsukahara K., Hata K., E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis. Antimicrobial Agents and Chemotherapy 2012 56 2 960 971 10.1128/AAC.00731-11 2-s2.0-84856073587