Over-pressurized bioreactors: Application to microbial cell cultures

Biotechnology Progress

Volumn 30, Issue 4, 2014, Pages 767-775

  Lopes, Marlene ^a   Belo, Isabel ^a   Mota, Manuel ^a  

^a UNIVERSITY OF MINHO   (Portugal)

Author keywords

Antioxidant enzymes; Cellular growth; Oxygen mass transfer rate; Pressurized bioreactors; Product formation; Reactive oxygen species

Indexed keywords

ANTIOXIDANTS; ATMOSPHERIC PRESSURE; BIOREACTORS; CARBON DIOXIDE; CELL CULTURE; CULTIVATION; OXYGEN;

ANTIOXIDANT ENZYME; CELLULAR GROWTH; OXYGEN MASS TRANSFER; PRODUCT FORMATION; REACTIVE OXYGEN SPECIES;

BIOCONVERSION;

BACTERIA; BIOREACTOR; BIOTECHNOLOGY; CULTURE TECHNIQUE; FERMENTATION; GROWTH, DEVELOPMENT AND AGING; PRESSURE; PROCEDURES;

BACTERIA; BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; FERMENTATION; PRESSURE;

EID: 84904620322     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1917     Document Type: Article

References (75)

1. Belo I, Pinheiro R, Mota M. Response of the thermophile Thermus sp. RQ-1 to hyperbaric air in batch and fed-batch cultivation. Appl Microbiol Biotechnol. 2000;53:517-524.
2. Charoenrat T, Ketudat-Cairns M, Jahic M, Veide A, Enfors S-O. Increased total air pressure versus oxygen limitation for enhanced oxygen transfer and product formation in a Pichia pastoris recombinant protein process. Biochem Eng J. 2006;30:205-211.
3. Knoll A, Maier B, Tscherrig H, Buchs J. The oxygen mass transfer, carbon dioxide inhibition, heat removal, and the energy and cost efficiencies of high pressure fermentation. Adv Biochem Eng Biotechnol. 2005;92:77-99.
4. Lopes M, Gomes N, Gonçalves C, Coelho MAZ, Mota M, Belo I. Yarrowia lipolytica lipase production enhanced by increased air pressure. Lett Appl Microbiol. 2008;46:255-260.
5. Pinheiro R, Belo I, Mota M. Growth and β-galactosidase activity in cultures of Kluyveromyces marxianus under increased air pressure. Lett Appl Microbiol. 2003;37:438-442.
6. Onken U, Liefke E. Effect of total and partial pressure (oxygen and carbon dioxide) on aerobic microbial processes. Adv Biochem Eng Biotechnol. 1989;40:137-169.
7. Bliem R, Katinger H. Scale-up engineering in animal cell technology. Part II. Trends Biotechnol. 1988;6:224-230.
8. Knoll A, Bartsch S, Husemann B, Engel P, Schroer K, Ribeiro B, Stöckmann C, Seletzky J, Büchs J. High cell density cultivation of recombinant yeasts and bacteria under non-pressurized and pressurized conditions in stirred tank bioreactors. J Biotechnol. 2007;132:167-179.
9. Gogate PR, Pandit AB. Survey of measurement technique for gas-liquid mass transfer coefficient in bioreactors. Biochem Eng J. 1999;4:7-15.
10. Gupta A, Rao GA. Study of oxygen transfer in shake flasks using a non-invasive oxygen sensor. Biotechnol Bioeng. 2003;84:351-358.
11. Pan JG, Rhee JS, Lebeault JM. Physiological constraints in increasing biomass concentration of Escherichia coli B in fed-batch culture. Biotechnol Lett. 1987;9:89-94.
12. Adlercreutz P, Mattiasson B. Oxygen supply to immobilized cells: 1. Oxygen production by immobilized Chlorella pyrenoidosa. Enzyme Microb Technol. 1982;4:332-336.
13. Khang YH, Shankar H, Senatore F. Enhanced β-lactam antibiotic production by coimmobilization of fungus and alga. Biotechnol Lett. 1988;10:867-872.
14. 2 added continually to buffer solutions. Biotechnol Bioeng. 1980;22:1895-1906.
15. Schlegel HG. Aeration without air: oxygen supply by hydrogen peroxide. Biotechnol Bioeng. 1977;19:413-424.
16. Amaral PFF, Rocha-Leão MHM, Marrucho IM, Coutinho JAP, Coelho MAZ. Improving lipase production using a perfluorocarbon as oxygen carrier. J Chem Technol Biotechnol. 2006;81:1368-1374.
17. Yang J-D, Wang NS. Oxygen mass transfer enhancement via fermentor headspace pressurization. Biotechnol Prog. 1992;8:244-251.
18. Belo I, Pinheiro R, Mota M. Fed-batch cultivation of Saccharomyces cerevisiae in a hyperbaric bioreactor. Biotechnol Prog. 2003;19:665-671.
19. Follonier S, Henes B, Panke S, Zinn M. Putting cells under pressure: a simple and efficient way to enhance the productivity of medium-chain-length polyhydroxyalkanoate in processes with Pseudomonas putida KT2440. Biotechnol Bioeng. 2012;109:451-461.
20. Lopes M, Mota M, Belo I. Batch and fed-batch growth of Pichia pastoris under increased air pressure. Bioprocess Biosyst Eng 2013;36:1267-1275.
21. Garcia-Ochoa F, Gomez E. Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview. Biotechnol Adv. 2009;27:153-176.
22. Lopes M, Mota M, Belo I. Oxygen mass transfer rate in a pressurized lab-scale stirred bioreactor. Chem Eng Technol. 2013;36:1779-1784.
23. Sato S, Mukataka S, Kataoka H, Takahashi J. Oxygen absorption rate in an aerated stirred tank under increasing pressure. J Ferment Technol. 1981;59:221-225.
24. Heinzle E, Dunn IJ. Methods and instruments in fermentation gas analysis. In: Rehm HJ, Reed G, Pühler A, Stadler P, editors. Biotechnology. A Multi-Volume Comprehensive Treatise, 2nd ed., Vol., Measuring, Modelling and Control (Schügerl K, editor). Weinheim: VCH 1993:27-74.
25. Doelle HW, Ewings KN, Hollywood NW. Regulation of glucose metabolism in bacterial systems. Adv Biochem Eng Biotechnol. 1982;23:1-36.
26. Futatsugi M, Ogawa T, Fukuda H. Scale-up of glucoamylase production by Saccharomycopsis fibuligera. J Ferment Bioeng. 1993;76:419-422.
27. Belo I, Mota M. Batch and fed-batch cultures of E. coli TB1 at different oxygen transfer rates. Bioprocess Eng. 1998;18:451-455.
28. Knabben I, Regestein L, Marquering F, Steinbusch S, Lara AR, Büchs J. High cell-density processes in batch mode of a genetically engineered Escherichia coli strain with minimized overflow metabolism using a pressurized bioreactor. J Biotechnol. 2010;150:73-79.
29. Onken U. Batch and continuous cultivation of Pseudomonas fluorescens at increased pressure. Biotechnol Bioeng. 1990;35:983-989.
30. Liefke E, Kaiser D, Onken U. Growth and product formation of actinomycetes cultivated at increased total pressure and oxygen partial pressure. Appl Microbiol Biotechnol. 1990;32:674-679.
31. Pinheiro R, Lopes M, Belo I, Mota M. Candida utilis metabolism and morphology under increased air pressure up to 12 bar [published online December 4, 2013]. Process Biochem. DOI: 10.1016/j.procbio.2013.11.014.
32. Coelho MAZ, Belo I, Pinheiro R, Amaral AL, Mota M, Coutinho JAP, Ferreira EC. Effect of hyperbaric stress on yeast morphology: study by automated image analysis. Appl Microbiol Biotechnol. 2004;66:318-324.
33. Belo I, Pinheiro R, Mota M. Morphological and physiological changes in Saccharomyces cerevisiae by oxidative stress from hyperbaric air. J Biotechnol. 2005;115:397-404.
34. Dong Y, Yang Q, Jia S, Qiao C. Effects of high pressure on the accumulation of trehalose and glutathione in the Saccharomyces cerevisiae cells. Biochem Eng J. 2007;37:226-230.
35. Lopes M, Gomes N, Mota M, Belo I. Yarrowia lipolytica growth under increased air pressure: influence on enzymes production. Appl Biochem Biotechnol. 2009;159:46-53.
36. Ko Y-F, Bentley WE, Weigand WA. An integrated metabolic modelling approach to describe the energy efficiency of Escherichia coli fermentations under oxygen-limited conditions: cellular energetics, carbon flux, and acetate production. Biotechnol Bioeng. 1993;42:843-853.
37. Karim A, Kaderbhai N, Evans A, Harding V, Kaderbhai MA. Efficient bacterial export of a eukaryotic cytoplasmic cytochrome. Nat Biotechnol. 1993;11:612-618.
38. Lara AR, Knabben I, Regestein L, Sassi J, Caspeta L, Ramírez OT, Büchs J. Comparison of oxygen enriched air vs. pressure cultivation to increase oxygen transfer and to scale-up plasmid DNA production fermentations. Eng Life Sci. 2011;11:382-386.
39. Ma X, Fan D, Shang LA, Cai Q, Chi L, Zhu C, Mi Y, Luo YE. Oxygen transfer rate control in the production of human-like collagen by recombinant Escherichia coli. Biotechnol Appl Biochem. 2010;55:169-174.
40. Puhar E, Lorencez I, Fiechter A. influence of partial pressure of oxygen and carbon dioxide on Methylomonas clara in continuous cultura. Eur J Appl Microbiol Biotechnol. 1983;18:131-134.
41. Cometta S, Sonnleitner B, Fiechter A. The growth behavior of Thermus aquaticus in continuous cultivation. Eur J Appl Microbiol Biotechnol. 1982;15:69-74.
42. Campelo AF, Belo I. Fermentative capacity of baker's yeast exposed to hyperbaric stress. Biotechnol Lett. 2004;26:1237-1240.
43. Pinheiro R, Belo I, Mota M. Physiological behaviour of Saccharomyces cerevisiae under increased air and oxygen pressures. Biotechnol Lett. 1997;19:703-708.
44. Coelho MAZ, Coutinho JAP, Ferreira EC, Mota M, Belo I. Analysis of the effects of hyperbaric gases on S. cerevisiae cell cycle through a morphological approach. Process Biochem. 2007;42:1378-1383.
45. Pinheiro R, Belo I, Mota M. Air pressure effects on biomass yield of two different Kluyveromyces strains. Enzyme Microb Technol. 2000;26:756-762.
46. 2 transfer rates. Biotechnol Lett. 2005;27:1617-1621.
47. 2 at low temperature. Biotechnol Bioeng. 2003;82:118-125.
48. 2 on the production of thermostable α-amylase and Neutral protease by Bacillus caldolyticus. Appl Biochem Microbiol. 2012;48:182-187.
49. Baez A, Flores N, Bolívar, Ramírez OT. Metabolic and transcriptional response of recombinant Escherichia coli to elevated dissolved carbon dioxide concentrations. Biotechnol Bioeng. 2009;104:102-110.
50. Castan A, Näsman A, Enfors S-O. Oxygen enriched air supply in Escherichia coli processes: production of biomass and recombinant human growth hormone. Enzyme Microb Technol. 2002;30:847-854.
51. Bäumchen C, Knoll A, Husemann B, Seletzky J, Maier B, Dietrich C, Amoabediny G, Büchs J. Effect of elevated dissolved carbon dioxide concentrations on growth of Corynebacterium glutamicum on D-glucose and L-lactate. J Biotechnol. 2007;128:868-874.
52. Morano KA, Grant CM, Moye-Rowley WS. The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics 2012;190:1157-1195.
53. Li Q, Bai Z, O'Donnell A, Harvey LM, Hoskisson PA, McNeil B. Oxidative stress in fungal fermentation processes: the roles of alternative respiration. Biotechnol Lett. 2011;33:457-467.
54. Lushchak VI. Adaptive response to oxidative stress: Bacteria, fungi, plants and animals. Comp Biochem Phys C. 2011;153:175-190.
55. Nathan C, Cunningham-Bussel A. Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol. 2013;13:349-361.
56. Berlett BS, Stadtman ER. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem. 1997;272:20313-20316.
57. Storz G, Christman MF, Sies H, Ames BN. Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium. Proc Natl Acad Sci USA. 1987;84:8917-8921.
58. Wolff SP, Garner A, Dean RT. Free radicals, lipids and protein degradation. Trends Biochem Sci. 1986;11:27-31.
59. Jamieson DJ. Oxidative stress response of the yeast Saccharomyces cerevisiae. Yeast 1998;14:1511-1527.
60. Oliver AE, Leprince O, Wolkers WF, Hincha DK, Heyer AG, Crowe JH. Non-disaccharide-based mechanisms of protection during drying. Cryobiology 2001;43:151-167.
61. Marchler G, Schuller C, Adam G, Ruis H. A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. EMBO J. 1993;12:1997-2003.
62. Dellomonaco C, Amaretti A, Zanoni S, Pompei A, Matteuzzi D, Rossi M. Fermentative production of superoxide dismutase with Kluyveromyces marxianus. J Ind Microbiol Biotechnol. 2007;34:27-34.
63. Angelova MB, Pashova SB, Spasova BK, Vassilev SV, Slokoska LS. Oxidative stress response of filamentous fungi induced by hydrogen peroxide and paraquat. Mycol Res. 2005;109:150-158.
64. Grant CM, MacIver FH, Dawes IW. Glutathione is an essential metabolite required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae. Curr Genet. 1996;29:511-515.
65. Schellhorn HE, Hassan HM. Response of hydroperoxidase and superoxide dismutase deficient mutants of Escherichia coli K-12 to oxidative stress. Can J Microbiol. 1988;34:1171-1176.
66. Gregory EM, Fridovich I. Induction of superoxide dismutase by molecular oxygen. J Bacteriol. 1973;114:543-548.
67. Taniguchi M, Hoshino K, Itoh T. Production of superoxide dismutase in Streptococcus lactis by a combination of use of hyperbaric oxygen and fermentation with cross-flow filtration. Biotechnol Bioeng. 1992;39:886-890.
68. Lee F-JS, Hassan HM. Effect of oxygen tension on stability and expression of a killer toxin chimeric plasmid in a chemostat culture of Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 1987;27:72-74.
69. Lopes M, Mota M, Belo I. Comparison of Yarrowia lipolytica and Pichia pastoris cellular response to different agents of oxidative stress. Appl Biochem Biotechnol. 2013;170:448-458.
70. Follonier S, Escapa IF, Fonseca PM, Henes B, Panke S, Zinn M, Prieto MA. New insights on the reorganization of gene transcription in Pseudomonas putida KT2440 at elevated pressure. Microb Cell Fact. 2013;12:30-47.
71. Vogel C, Silva GM, Marcotte EM. Protein expression regulation under oxidative stress. Mol Cell Proteomics 2011;10:M111.009217.
72. Cabiscol E, Tamarit J, Ros J. Oxidative stress in bacteria and protein damage by reactive oxygen species. Int Microbiol. 2000;3:3-8.
73. Groves MR, Lucana DOO. Adaptation to oxidative stress by Gram-positive bacteria: the redox sensing system HbpS-SenS-SenR from Streptomyces reticuli. Appl Microbiol Microb Biotechnol. 2010;1:33-42.
74. Pereira MD, Eleutherio ECA, Panek AD. Acquisition of tolerance against oxidative damage in Saccharomyces cerevisiae. BMC Microbiol. 2001;1:11-20.
75. Okada N, Ogawa J, Shima J. Comprehensive analysis of genes involved in the oxidative stress tolerance using yeast heterozygous deletion collection. FEMS Yeast Res. 2014;14:425-434.