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Volumn 23, Issue 15, 2014, Pages 1777-1787

IPSC-derived forebrain neurons from FXS individuals show defects in initial neurite outgrowth

Author keywords

[No Author keywords available]

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN;

EID: 84904608102     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2014.0030     Document Type: Article
Times cited : (139)

References (66)
  • 2
    • 23944490213 scopus 로고    scopus 로고
    • Recent advances in fragile X: A model for autism and neurodegeneration
    • Hagerman RJ, MY Ono and PJ Hagerman. (2005). Recent advances in fragile X: A model for autism and neurodegeneration. Curr Opin Psychiatry 18:490-496.
    • (2005) Curr Opin Psychiatry , vol.18 , pp. 490-496
    • Hagerman, R.J.1    Ono, M.Y.2    Hagerman, P.J.3
  • 3
    • 0032905253 scopus 로고    scopus 로고
    • Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells
    • Coffee B, F Zhang, ST Warren and D Reines. (1999). Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells. Nat Genet 22:98-101.
    • (1999) Nat Genet , vol.22 , pp. 98-101
    • Coffee, B.1    Zhang, F.2    Warren, S.T.3    Reines, D.4
  • 4
    • 0025905795 scopus 로고
    • Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
    • Verkerk AJ, M Pieretti, JS Sutcliffe, YH Fu, DP Kuhl, A Pizzuti, O Reiner, S Richards, MF Victoria and FP Zhang. (1991). Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell 65:905-914.
    • (1991) Cell , vol.65 , pp. 905-914
    • Verkerk, A.J.1    Pieretti, M.2    Sutcliffe, J.S.3    Fu, Y.H.4    Kuhl, D.P.5    Pizzuti, A.6    Reiner, O.7    Richards, S.8    Victoria, M.F.9    Zhang, F.P.10
  • 7
    • 0036782129 scopus 로고    scopus 로고
    • Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome
    • Coffee B, F Zhang, S Ceman, ST Warren and D Reines. (2002). Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome. Am J Hum Genet 71:923-932.
    • (2002) Am J Hum Genet , vol.71 , pp. 923-932
    • Coffee, B.1    Zhang, F.2    Ceman, S.3    Warren, S.T.4    Reines, D.5
  • 8
    • 0027176361 scopus 로고
    • The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation
    • Devys D, Y Lutz, N Rouyer, JP Bellocq and JL Mandel. (1993). The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation. Nat Genet 4:335-340.
    • (1993) Nat Genet , vol.4 , pp. 335-340
    • Devys, D.1    Lutz, Y.2    Rouyer, N.3    Bellocq, J.P.4    Mandel, J.L.5
  • 9
    • 0029816723 scopus 로고    scopus 로고
    • The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals
    • Eberhart DE, HE Malter, Y Feng and ST Warren. (1996). The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals. Hum Mol Genet 5:1083-1091.
    • (1996) Hum Mol Genet , vol.5 , pp. 1083-1091
    • Eberhart, D.E.1    Malter, H.E.2    Feng, Y.3    Warren, S.T.4
  • 10
    • 0031046778 scopus 로고    scopus 로고
    • Fragile X mental retardation protein: Nucleocytoplasmic shuttling and association with somatodendritic ribosomes
    • Feng Y, CA Gutekunst, DE Eberhart, H Yi, ST Warren and SM Hersch. (1997). Fragile X mental retardation protein: Nucleocytoplasmic shuttling and association with somatodendritic ribosomes. J Neurosci 17:1539-1547.
    • (1997) J Neurosci , vol.17 , pp. 1539-1547
    • Feng, Y.1    Gutekunst, C.A.2    Eberhart, D.E.3    Yi, H.4    Warren, S.T.5    Hersch, S.M.6
  • 12
    • 84875850679 scopus 로고    scopus 로고
    • Fragile X mental retardation protein and synaptic plasticity
    • Sidorov MS, BD Auerbach and MF Bear. (2013). Fragile X mental retardation protein and synaptic plasticity. Mol brain 6:15.
    • (2013) Mol Brain , vol.6 , pp. 15
    • Sidorov, M.S.1    Auerbach, B.D.2    Bear, M.F.3
  • 13
    • 0027377580 scopus 로고
    • FMR1 protein: Conserved RNP family domains and selective RNA binding
    • Ashley CT, Jr., KD Wilkinson, D Reines and ST Warren. (1993). FMR1 protein: Conserved RNP family domains and selective RNA binding. Science 262:563-566.
    • (1993) Science , vol.262 , pp. 563-566
    • Ashley Jr., C.T.1    Wilkinson, K.D.2    Reines, D.3    Warren, S.T.4
  • 14
    • 18044379515 scopus 로고    scopus 로고
    • Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
    • Brown V, P Jin, S Ceman, JC Darnell, WT O'Donnell, SA Tenenbaum, X Jin, Y Feng, KD Wilkinson, et al. (2001). Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 107:477-487.
    • (2001) Cell , vol.107 , pp. 477-487
    • Brown, V.1    Jin, P.2    Ceman, S.3    Darnell, J.C.4    O'Donnell, W.T.5    Tenenbaum, S.A.6    Jin, X.7    Feng, Y.8    Wilkinson, K.D.9
  • 17
    • 79960898814 scopus 로고    scopus 로고
    • Defects in translational regulation contributing to human cognitive and behavioral disease
    • Darnell J. (2011). Defects in translational regulation contributing to human cognitive and behavioral disease. Curr Opin Genet Dev 21:465-473.
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 465-473
    • Darnell, J.1
  • 18
    • 52949109182 scopus 로고    scopus 로고
    • Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory
    • Bolduc FV, K Bell, H Cox, KS Broadie and T Tully. (2008). Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory. Nat Neurosci 11:1143-1145.
    • (2008) Nat Neurosci , vol.11 , pp. 1143-1145
    • Bolduc, F.V.1    Bell, K.2    Cox, H.3    Broadie, K.S.4    Tully, T.5
  • 20
    • 33746892681 scopus 로고    scopus 로고
    • Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines
    • Grossman AW, NM Elisseou, BC McKinney and WT Greenough. (2006). Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines. Brain Res 1084:158-164.
    • (2006) Brain Res , vol.1084 , pp. 158-164
    • Grossman, A.W.1    Elisseou, N.M.2    McKinney, B.C.3    Greenough, W.T.4
  • 22
    • 6944247816 scopus 로고    scopus 로고
    • The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation
    • Pan L, YQ Zhang, E Woodruff and K Broadie. (2004). The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. Curr Biol 14: 1863-1870.
    • (2004) Curr Biol , vol.14 , pp. 1863-1870
    • Pan, L.1    Zhang, Y.Q.2    Woodruff, E.3    Broadie, K.4
  • 23
    • 33751353757 scopus 로고    scopus 로고
    • Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome
    • Tucker B, RI Richards and M Lardelli. (2006). Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome. Hum Mol Genet 15:3446-3458.
    • (2006) Hum Mol Genet , vol.15 , pp. 3446-3458
    • Tucker, B.1    Richards, R.I.2    Lardelli, M.3
  • 24
    • 0035977134 scopus 로고    scopus 로고
    • Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function
    • Zhang YQ, AM Bailey, HJ Matthies, RB Renden, MA Smith, SD Speese, GM Rubin and K Broadie. (2001). Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell 107:591-603.
    • (2001) Cell , vol.107 , pp. 591-603
    • Zhang, Y.Q.1    Bailey, A.M.2    Matthies, H.J.3    Renden, R.B.4    Smith, M.A.5    Speese, S.D.6    Rubin, G.M.7    Broadie, K.8
  • 25
    • 0344962385 scopus 로고    scopus 로고
    • Understanding fragile X syndrome: Insights from animal models
    • Bakker CE and BA Oostra. (2003). Understanding fragile X syndrome: Insights from animal models. Cytogenet Genome Res 100:111-123.
    • (2003) Cytogenet Genome Res , vol.100 , pp. 111-123
    • Bakker, C.E.1    Oostra, B.A.2
  • 27
    • 77956214743 scopus 로고    scopus 로고
    • Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells
    • Urbach A, O Bar-Nur, GQ Daley and N Benvenisty. (2010). Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell 6:407-411.
    • (2010) Cell Stem Cell , vol.6 , pp. 407-411
    • Urbach, A.1    Bar-Nur, O.2    Daley, G.Q.3    Benvenisty, N.4
  • 29
    • 80053948646 scopus 로고    scopus 로고
    • Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome
    • Sheridan SD, KM Theriault, SA Reis, F Zhou, JM Madison, L Daheron, JF Loring and SJ Haggarty. (2011). Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome. PLoS One 6:e26203.
    • (2011) PLoS One , vol.6
    • Sheridan, S.D.1    Theriault, K.M.2    Reis, S.A.3    Zhou, F.4    Madison, J.M.5    Daheron, L.6    Loring, J.F.7    Haggarty, S.J.8
  • 30
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, K Tanabe, M Ohnuki, M Narita, T Ichisaka, K Tomoda and S Yamanaka. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 32
    • 33745012950 scopus 로고    scopus 로고
    • Neural subtype specification from embryonic stem cells
    • Zhang SC. (2006). Neural subtype specification from embryonic stem cells. Brain Pathol 16:132-142.
    • (2006) Brain Pathol , vol.16 , pp. 132-142
    • Zhang, S.C.1
  • 33
    • 77953089981 scopus 로고    scopus 로고
    • Directed differentiation of neural-stem cells and subtype-specific neurons from hESCs
    • Hu BY and SC Zhang. (2010). Directed differentiation of neural-stem cells and subtype-specific neurons from hESCs. Methods Mol Biol 636:123-137.
    • (2010) Methods Mol Biol , vol.636 , pp. 123-137
    • Hu, B.Y.1    Zhang, S.C.2
  • 34
    • 77749279749 scopus 로고    scopus 로고
    • Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
    • Hu BY, JP Weick, J Yu, LX Ma, XQ Zhang, JA Thomson and SC Zhang. (2010). Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci USA 107:4335-4340.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4335-4340
    • Hu, B.Y.1    Weick, J.P.2    Yu, J.3    Ma, L.X.4    Zhang, X.Q.5    Thomson, J.A.6    Zhang, S.C.7
  • 36
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • Schmittgen TD and KJ Livak. (2008). Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3:1101-1108.
    • (2008) Nat Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 38
    • 0026469752 scopus 로고
    • GAP-43 phosphorylation is dynamically regulated in individual growth cones
    • Dent EW and KF Meiri. (1992). GAP-43 phosphorylation is dynamically regulated in individual growth cones. J Neurobiol 23:1037-1053.
    • (1992) J Neurobiol , vol.23 , pp. 1037-1053
    • Dent, E.W.1    Meiri, K.F.2
  • 42
    • 0027300283 scopus 로고
    • Nucleus basalis magnocellularis and hippocampus are the major sites of FMR-1 expression in the human fetal brain
    • Abitbol M, C Menini, AL Delezoide, T Rhyner, M Vekemans and J Mallet. (1993). Nucleus basalis magnocellularis and hippocampus are the major sites of FMR-1 expression in the human fetal brain. Nat Genet 4:147-153.
    • (1993) Nat Genet , vol.4 , pp. 147-153
    • Abitbol, M.1    Menini, C.2    Delezoide, A.L.3    Rhyner, T.4    Vekemans, M.5    Mallet, J.6
  • 43
    • 82255175070 scopus 로고    scopus 로고
    • Specification of neuronal and glial subtypes from human pluripotent stem cells
    • Liu H and SC Zhang. (2011). Specification of neuronal and glial subtypes from human pluripotent stem cells. Cell Mol Life Sci 68:3995-4008.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 3995-4008
    • Liu, H.1    Zhang, S.C.2
  • 44
    • 33744966575 scopus 로고    scopus 로고
    • Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses
    • Antar LN, C Li, H Zhang, RC Carroll and GJ Bassell. (2006). Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses. Mol Cell Neurosci 32:37-48.
    • (2006) Mol Cell Neurosci , vol.32 , pp. 37-48
    • Antar, L.N.1    Li, C.2    Zhang, H.3    Carroll, R.C.4    Bassell, G.J.5
  • 45
    • 53849110899 scopus 로고    scopus 로고
    • Fragile X syndrome: Loss of local mRNA regulation alters synaptic development and function
    • Bassell GJ and ST Warren. (2008). Fragile X syndrome: Loss of local mRNA regulation alters synaptic development and function. Neuron 60:201-214.
    • (2008) Neuron , vol.60 , pp. 201-214
    • Bassell, G.J.1    Warren, S.T.2
  • 46
    • 44449121279 scopus 로고    scopus 로고
    • A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome
    • Dictenberg JB, SA Swanger, LN Antar, RH Singer and GJ Bassell. (2008). A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Dev Cell 14:926-939.
    • (2008) Dev Cell , vol.14 , pp. 926-939
    • Dictenberg, J.B.1    Swanger, S.A.2    Antar, L.N.3    Singer, R.H.4    Bassell, G.J.5
  • 49
    • 84872370488 scopus 로고    scopus 로고
    • Neural differentiation of fragile X human embryonic stem cells reveals abnormal patterns of development despite successful neurogenesis
    • Telias M, M Segal and D Ben-Yosef. (2013). Neural differentiation of fragile X human embryonic stem cells reveals abnormal patterns of development despite successful neurogenesis. Dev Biol 374:32-45.
    • (2013) Dev Biol , vol.374 , pp. 32-45
    • Telias, M.1    Segal, M.2    Ben-Yosef, D.3
  • 53
    • 84887534693 scopus 로고    scopus 로고
    • Toward pluripotency by reprogramming: Mechanisms and application
    • Wang T, ST Warren and P Jin. (2013). Toward pluripotency by reprogramming: Mechanisms and application. Protein Cell 4:820-832.
    • (2013) Protein Cell , vol.4 , pp. 820-832
    • Wang, T.1    Warren, S.T.2    Jin, P.3
  • 55
    • 0030795653 scopus 로고    scopus 로고
    • The effect of FMR1 CGG repeat interruptions on mutation frequency as measured by sperm typing
    • Kunst CB, EP Leeflang, JC Iber, N Arnheim and ST Warren. (1997). The effect of FMR1 CGG repeat interruptions on mutation frequency as measured by sperm typing. J Med Genet 34:627-631.
    • (1997) J Med Genet , vol.34 , pp. 627-631
    • Kunst, C.B.1    Leeflang, E.P.2    Iber, J.C.3    Arnheim, N.4    Warren, S.T.5
  • 56
    • 0034639857 scopus 로고    scopus 로고
    • Understanding the molecular basis of fragile X syndrome
    • Jin P and ST Warren. (2000). Understanding the molecular basis of fragile X syndrome. Hum Mol Genet 9:901-908.
    • (2000) Hum Mol Genet , vol.9 , pp. 901-908
    • Jin, P.1    Warren, S.T.2
  • 60
    • 84862241820 scopus 로고    scopus 로고
    • Fragile X-associated tremor/ataxia phenotype in a male carrier of unmethylated full mutation in the FMR1 gene
    • Loesch DZ, S Sherwell, G Kinsella, F Tassone, A Taylor, D Amor, S Sung and A Evans. (2012). Fragile X-associated tremor/ataxia phenotype in a male carrier of unmethylated full mutation in the FMR1 gene. Clin Genet 82:88-92.
    • (2012) Clin Genet , vol.82 , pp. 88-92
    • Loesch, D.Z.1    Sherwell, S.2    Kinsella, G.3    Tassone, F.4    Taylor, A.5    Amor, D.6    Sung, S.7    Evans, A.8
  • 61
    • 33947545733 scopus 로고    scopus 로고
    • Functional neural development from human embryonic stem cells: Accelerated synaptic activity via astrocyte coculture
    • Johnson MA, JP Weick, RA Pearce and SC Zhang. (2007). Functional neural development from human embryonic stem cells: Accelerated synaptic activity via astrocyte coculture. J Neurosci 27:3069-3077.
    • (2007) J Neurosci , vol.27 , pp. 3069-3077
    • Ma, J.1    Weick, J.P.2    Pearce, R.A.3    Zhang, S.C.4
  • 62
    • 34547102737 scopus 로고    scopus 로고
    • Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage
    • Pankratz MT, XJ Li, TM Lavaute, EA Lyons, X Chen and SC Zhang. (2007). Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells 25:1511-1520.
    • (2007) Stem Cells , vol.25 , pp. 1511-1520
    • Pankratz, M.T.1    Li, X.J.2    Lavaute, T.M.3    Lyons, E.A.4    Chen, X.5    Zhang, S.C.6
  • 63
    • 84870030633 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks
    • Shi Y, P Kirwan and FJ Livesey. (2012). Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks. Nat Protoc 7:1836-1846.
    • (2012) Nat Protoc , vol.7 , pp. 1836-1846
    • Shi, Y.1    Kirwan, P.2    Livesey, F.J.3
  • 64
    • 0026026911 scopus 로고
    • The Fra(X) syndrome: Neurological, electrophysiological, and neuropathological abnormalities
    • Wisniewski KE, SM Segan, CM Miezejeski, EA Sersen and RD Rudelli. (1991). The Fra(X) syndrome: Neurological, electrophysiological, and neuropathological abnormalities. Am J Med Genet 38:476-480.
    • (1991) Am J Med Genet , vol.38 , pp. 476-480
    • Wisniewski, K.E.1    Segan, S.M.2    Miezejeski, C.M.3    Sersen, E.A.4    Rudelli, R.D.5
  • 65
    • 0035863624 scopus 로고    scopus 로고
    • Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: A quantitative examination
    • Irwin SA, B Patel, M Idupulapati, JB Harris, RA Crisostomo, BP Larsen, F Kooy, PJ Willems, P Cras, et al. (2001). Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: A quantitative examination. Am J Med Genet 98:161-167.
    • (2001) Am J Med Genet , vol.98 , pp. 161-167
    • Irwin, S.A.1    Patel, B.2    Idupulapati, M.3    Harris, J.B.4    Crisostomo, R.A.5    Larsen, B.P.6    Kooy, F.7    Willems, P.J.8    Cras, P.9
  • 66
    • 0025720084 scopus 로고
    • Analysis of neocortex in three males with the fragile X syndrome
    • Hinton VJ, WT Brown, K Wisniewski and RD Rudelli. (1991). Analysis of neocortex in three males with the fragile X syndrome. Am J Med Genet 41:289-294.
    • (1991) Am J Med Genet , vol.41 , pp. 289-294
    • Hinton, V.J.1    Brown, W.T.2    Wisniewski, K.3    Rudelli, R.D.4


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