Fibrin-genipin adhesive hydrogel for annulus fibrosus repair: Performance evaluation with large animal organ culture, in situ biomechanics, and in vivo degradation tests

European Cells and Materials

Volumn 28, Issue , 2014, Pages 25-38

  Likhitpanichkul, M ^a,b   Dreischarf, M ^c   Illien Junger, S ^a,b   Walter, B A ^a   Nukaga, T ^b,d   Long, R G ^a,b   Sakai, D ^b,d   Hecht, A C ^a   Iatridis, James C ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b AO FOUNDATION   (Switzerland)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adhesive biomaterial; Annulus fibrosus repair; Discectomy; Fibrin genipin; Herniation; In vivo degradation; Injectable hydrogel; Intervertebral disc; Motion segment testing; Organ culture

Indexed keywords

FIBRIN GLUE; GENIPIN; NITRIC OXIDE; HYDROGEL; IRIDOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANNULUS FIBROSUS; ARTICLE; BIOCOMPATIBILITY; BIOMECHANICS; BONE REMODELING; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; EX VIVO STUDY; IN VIVO STUDY; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISKECTOMY; LONGEVITY; NONHUMAN; ORGAN CULTURE; RAT; SUBCUTANEOUS IMPLANTATION; TISSUE REGENERATION; ANIMAL; BIOREACTOR; BOVINAE; CHONDROGENESIS; COMPRESSIVE STRENGTH; DEVICES; DRUG EFFECTS; EVALUATION STUDY; HYDROGEL; INTERVERTEBRAL DISC DEGENERATION; INTERVERTEBRAL DISK; MECHANICAL STRESS; METABOLISM; ORGAN CULTURE TECHNIQUE; PHARMACOLOGY; PHYSIOLOGY; PROCEDURES; REGENERATION; SPRAGUE DAWLEY RAT; TENSILE STRENGTH; THERAPEUTIC USE; TORQUE;

ANIMALS; BIOREACTORS; CATTLE; CHONDROGENESIS; COMPRESSIVE STRENGTH; FIBRIN TISSUE ADHESIVE; HYDROGELS; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; IRIDOIDS; NITRIC OXIDE; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION; STRESS, MECHANICAL; TENSILE STRENGTH; TORQUE;

EID: 84904581166     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: 10.22203/eCM.v028a03     Document Type: Article

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