Rola receptorów Toll-podobnych (TLR) w patogenezie schorzeń alergicznych - Gdzie lezy prawda?;The role of Toll-like receptors in the pathogenesis of allergic diseases - Where is the truth?

Postepy Higieny i Medycyny Doswiadczalnej

Volumn 68, Issue , 2014, Pages 230-237

  Dębińska, Anna ^a   Boznański, Andrzej ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Allergy; Asthma; Innate immunity; Toll like receptors (TLR)

Indexed keywords

TOLL LIKE RECEPTOR;

ANTIGEN PRESENTING CELL; ASTHMA; EOSINOPHIL; HUMAN; HYPERSENSITIVITY; IMMUNOLOGY; MAST CELL; REGULATORY T LYMPHOCYTE; REVIEW;

ANTIGEN-PRESENTING CELLS; ASTHMA; EOSINOPHILS; HUMANS; HYPERSENSITIVITY; MAST CELLS; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTORS;

EID: 84904551810     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: 10.5604/17322693.1093202     Document Type: Review

References (64)

1. Ashino S., Wakita D., Zhang Y., Chamoto K., Kitamura H., Nishimura T.: CpG-ODN inhibits airway inflammation at effector phase through down-regulation of antigen-specific Th2-cell migration into lung. Int. Immunol., 2008; 20: 259-266
2. Bartlett N.W., Walton R.P., Edwards M.R., Aniscenko J., Caramori G., Zhu J., Glanville N., Choy K.J., Jourdan P., Burnet J., Tuthill T.J., Pedrick M.S., Hurle M.J., Plumpton C., Sharp N.A. i wsp.: Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat. Med., 2008; 14: 199-204
3. Bauer S., Hangel D., Yu P.: Immunobiology of toll-like receptors in allergic disease. Immunobiology, 2007; 212: 521-533
4. Belderbos M., Levy O., Bont L.: Neonatal innate immunity in allergy development. Curr. Opin. Pediatr., 2009; 21: 762-769
5. Bloomfield S.F., Stanwell-Smith R., Crevel R.W., Pickup J.: Too clean, or not too clean: the hygiene hypothesis and home hygiene. Clin. Exp. Allergy, 2006; 36: 402-425
6. Busse W.W., Lemanske R.F. Jr., Gern J.E.: Role of viral respiratory infections in asthma and asthma exacerbations. Lancet, 2010; 376: 826-834
7. Conrad M.L., Ferstl R., Teich R., Brand S., Blümer N., Yildirim A.O., Patrascan C.C., Hanuszkiewicz A., Akira S., Wagner H., Holst O., von Mutius E., Pfefferle P.I., Kirschning C.J., Garn H., Renz H.: Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffi F78. J. Exp. Med., 2009; 206: 2869-2877
8. Creticos P.S., Schroeder J.T., Hamilton R.G., Balcer-Whaley S.L., Khattignavong A.P., Lindblad R., Li H., Coffman R., Seyfert V., Eiden J.J., Broide D., Immune Tolerance Network Group: Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N. Engl. J. Med., 2006; 355: 1445-1455
9. Dahl M.E., Dabbagh K., Liggitt D., Kim S., Lewis D.B.: Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells. Nat. Immunol., 2004; 5: 337-343
10. Debarry J., Garn H., Hanuszkiewicz A., Dickgreber N., Blümer N., von Mutius E., Bufe A., Gatermann S., Renz H., Holst O., Heine H.: Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties. J. Allergy Clin. Immunol., 2007; 119: 1514-1521
11. Debarry J., Hanuszkiewicz A., Stein K., Holst O., Heine H.: The allergy-protecive properties of Acinetobacter lwoffii F78 are imparted by its lipopolysaccharide. Allergy, 2010; 65: 690-697
12. Eisenbarth S.C., Piggott D.A., Huleatt J.W., Visintin I., Herrick C.A., Bottomly K.: Lipopolysaccharide-enhanced Toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med., 2002; 196: 1645-1651
13. Fuchs B., Knothe S., Rochlitzer S., Nassimi M., Greweling M., Lauenstein H.D., Nassenstein C., Müller M., Ebensen T., Dittrich A.M., Krug N., Guzman C.A., Braun A.: A Toll-like receptor 2/6 agonist reduces allergic airway inflammation in chronic respiratory sensitisation to Timothy grass pollen antigens. Int. Arch. Allergy Immunol., 2010; 152: 131-139
14. Garn H., Renz H.: Epidemiological and immunological evidence for hygiene hypothesis. Immunobiology, 2007; 212: 441-452
15. Gerhold K., Avagyan A., Seib C., Frei R., Steinle J., Ahrens B., Dittrich A.M., Blumchen K., Lauener R., Hamelmann E.: Prenatal initiation of endotoxin airway exposure prevents subsequent allergen-induced sensitization and airway inflammation in mice. J. Allergy Clin. Immunol., 2006; 118: 666-673
16. Goldman M.: Translational mini-review series on Toll-like receptors: Toll-like receptor ligands as novel pharmaceuticals for allergic disorders. Clin. Exp. Immunol., 2007; 147: 208-216
17. Gupta G.K., Agrawal D.K.: CpG oligodeoxynucleotides as TLR9 agonists: therapeutic application in allergy and asthma. BioDrugs, 2010; 24: 225-235
18. Hammad H., Chieppa M., Perros F., Willart M.A., Germain R.N., Lambrecht B.N.: House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat. Med., 2009; 15: 410-416
19. Hayashi T., Raz E.: TLR-9 based immunotherapy for allergic disease. Am. J. Med., 2006; 119: 897.e1-897.e6
20. Hollingsworth J.W., Whitehead G.S., Lin K.L., Nakano H., Gunn M.D., Schwartz D.A., Cook D.N.: TLR4 signaling attenuates ongoing allergic inflammetion. J. Immunol., 2006; 176: 5856-5862
21. Iwamura C., Nakayama T.: Toll-like receptors in the respiratory system: their roles in inflammation. Curr. Allergy Asthma Rep., 2008; 8: 7-13
22. Iwasaki A., Medzhitov R.: Toll-like receptor control of the adaptive immune responses. Nat. Immunol., 2004; 5: 987-995
23. Kanzler H., Barrat F.J., Hessel E.M., Coffman R.L.: Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat. Med., 2007; 13: 552-559
24. Kato A., Favoreto S. Jr., Avila P.C., Schleimer R.P.: TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells J. Immunol., 2007; 179: 1080-1087
25. Kim Y.K., Oh S.Y., Jeon S.G., Park H.W., Lee S.Y., Chun E.Y., Bang B., Lee H.S., Oh M.H., Kim Y.S., Kim J.H., Gho Y.S., Cho S.H., Min K.U., Kim Y.Y., Zhu Z.: Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J. Immunol., 2007; 178: 5375-5382
26. Klimek L., Willers J., Hammann-Haenni A., Pfaar O., Stocker H., Mueller P., Renner W.A., Bachmann M.F.: Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: a phase IIb study. Clin. Exp. Allergy, 2011; 41: 1305-1312
27. Kuo C., Lim S., King N.J., Bartlett N.W., Walton R.P., Zhu J., Glanville N., Aniscenko J., Johnston S.L., Burgess J.K., Black J.L., Oliver B.G.: Rhinovirus infection induces expression of airway remodelling factors in vitro and in vivo. Respirology, 2011; 16: 367-377
28. Lam D., Ng N., Lee S., Batzer G., Horner A.A.: Airway house dust extract exposures modify allergen-induced airway hypersensitivity responses by TLR4-dependent and independent pathways. J. Immunol., 2008; 181: 2925-2932
29. Liu Y.J.: Thymic stromal lymphopoietin: master switch for allergic inflammation. J. Exp. Med., 2006; 203: 269-273
30. Lombardi V., Van Overtvelt L., Horiot S., Moussu H., Chabre H., Louise A., Balazuc A.M., Mascarell L., Moingeon P.: Toll-like receptor 2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual route. Clin. Exp. Allergy, 2008; 38: 1819-1829
31. Marsland B.J., Scanga C.B., Kopf M., Le Gros G.: Allergic airway inflammation is exacerbated during acute influenza infection and correlates with increased allergen presentation and recruitment of allergen-specific T-helper type 2 cells. Clin. Exp. Allergy, 2004; 34: 1299-1306
32. McCormack P.L., Wagstaff A.J.: Ultra-short-course seasonal allergy vaccine (Pollinex Quattro). Drugs, 2006; 66: 931-938
33. Newcomb D.C., Peebles R.S. Jr.: Bugs and asthma: a different disease? Proc. Am. Thorac. Soc., 2009; 6: 266-271
34. Nigo Y.I., Yamashita M., Hirahara K., Shinnakasu R., Inami M., Kimura M., Hasegawa A., Kohno Y., Nakayama T.: Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc. Natl. Acad. Sci. USA, 2006; 103: 2286-2291
35. Ng N., Lam D., Paulus P., Batzer G., Horner A.A.: House dust extracts have both TH2 adjuvant and tolerogenic activities. J. Allergy Clin. Immunol., 2006; 117: 1074-1081
36. Patel M., Xu D., Kewin P., Choo-Kang B., McSharry C., Thomson N.C., Liew F.Y.: TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells. J. Immunol., 2005; 174: 7558-7563
37. Phipps S., Lam C.E., Kaiko G.E., Foo S.Y., Collison A., Mattes J., Barry J., Davidson S., Oreo K., Smith L., Mansell A., Matthaei K.I., Foster P.S.: Toll/IL-1 signaling is critical for house dust mite-specific Th1 and Th2 responses. Am. J. Respir. Crit. Care Med., 2009; 179: 883-893
38. Piggott D.A., Eisenbarth S.C., Xu L., Constant S.L., Huleatt J.W., Herrick C.A., Bottomly K.: MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J. Clin. Invest., 2005; 115: 459-467
39. Redecke V., Häcker H., Datta S.K., Fermin A., Pitha P.M., Broide D.H., Raz E.: Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J. Immunol., 2004; 172: 2739-2743
40. Renner W.A., Beeh K.M., Schilder C., Wagner F., Kanniess F., Naudts I., Hammann A., Willers J., Mueller P., Bachmann M.: Novel TLR-9 agonist CYT003-QbG10 shown to improve asthma control in placebo-controlled phase II clinical trial. Am. J. Respir. Crit. Care Med., 183; 2011: A4063
41. Revets H., Pynaert G., Grooten J., De Baetselier P.: Lipoprotein I, a TLR2/4 ligand modulates Th2-driven allergic immune responses. J. Immunol., 2005; 174: 1097-1103
42. Romagnani S.: The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? Immunology, 2004; 112: 352-363
43. Sandor F., Buc M.: Toll-like receptors. II. Distribution and pathways involved in TLR signalling. Folia Biol., 2005; 51: 188-197
44. Schaub B., Liu J., Höppler S., Schleich I., Huehn J., Olek S., Wieczorek G., Illi S, von Mutius E.: Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J. Allergy Clin. Immunol., 2009; 123: 774-782.e5
45. Schröder N.W.: The role of innate immunity in the pathogenesis of asthma. Curr. Opin. Allergy Clin. Immunol., 2009; 9: 38-43
46. Schröder N.W., Crother T.R., Naiki Y., Chen S., Wong M.H., Yilmaz A., Slepenkin A., Schulte D., Alsabeh R., Doherty T.M., Peterson E., Nel A.E., Arditi M.: Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization. J. Allergy Clin. Immunol., 2008; 122: 595-602.e5
47. Sel S., Wegmann M., Sel S., Bauer S., Garn H., Alber G., Renz H.: Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10. J. Immunol., 2007; 178: 7805-7813
48. Senti G., Johansen P., Haug S., Bull C., Gottschaller C., Müller P., Pfister T., Maurer P., Bachmann M.F., Graf N., Kündig T.M.: Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trial. Clin. Exp. Allergy, 2009; 39: 562-570
49. Sevin C.M., Peebles R.S. Jr.: Infections and asthma: new insights into old ideas. Clin. Exp. Allergy, 2010; 40: 1142-1154
50. Soumelis V., Reche P.A., Kanzler H., Yuan W., Edward G., Horney B., Gilliet M., Ho S., Antonenko S., Lauerma A., Smith K., Gorman D., Zurawski S., Abrams J., Menon S., McClanahan T., de Waal-Malefyt R., Bazan F., Kastelein R.A., Liu Y.J.: Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol., 2002; 3: 673-680
51. Strachan D.P.: Hay fever, hygiene, and household size. BMJ, 1989; 299: 1259-1260
52. Strachan D.P.: Family size, infection and atopy: the first decade of the "hygiene hypothesis". Thorax, 2000; 55 (Suppl. 1): S2-S10
53. Taylor R.C., Richmond P., Upham J.W.: Toll-like receptor 2 ligands inhibit TH2 responses to mite allergen. J. Allergy Clin. Immunol., 2006; 117: 1148-1154
54. Trompette A., Divanovic S., Visintin A., Blanchard C., Hegde R.S., Madan R., Thorne P.S., Wills-Karp M., Gioannini T.L., Weiss J.P., Karp C.L.: Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature, 2009; 457: 585-589
55. Tse K., Horner A.A.: Allergen tolerance versus the allergic march: the hygiene hypothesis revisited. Curr. Allergy Asthma Rep., 2008; 8: 475-483
56. Tulic M.K., Fiset P.O., Christodoulopoulos P., Vaillancourt P., Desrosiers M., Lavigne F., Eiden J., Hamid Q.: Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response. J. Allergy Clin. Immunol., 2004; 113: 235-241
57. Tulic M.K., Fiset P.O., Manoukian J.J., Frenkiel S., Lavigne F., Eidelman D.H., Hamid Q.: Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adults. Lancet, 2004; 363: 1689-1697
58. Velasco G., Campo M., Manrique O.J., Bellou A., He H., Arestides R.S., Schaub B., Perkins D.L., Finn P.W.: Toll-like receptor 2 or 4 agonists decrease allergic inflammation. Am. J. Respir. Cell Mol. Biol., 2005; 32: 218-224
59. Vogel K., Blümer N., Korthals M., Mittelstädt J., Garn H., Ege M., von Mutius E., Gatermann S., Bufe A., Goldmann T., Schwaiger K., Renz H., Brandau S., Bauer J., Heine H., Holst O.: Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties. J. Allergy Clin. Immunol., 2008; 122: 307-312.e8
60. von Mutius E.: Allergies, infections and the hygiene hypothesis - the epidemiological evidence. Immunobiology, 2007; 212: 433-439
61. Wang Q., Nagarkar D.R., Bowman E.R., Schneider D., Gosangi B., Lei J., Zhao Y., McHenry C.L., Burgens R.V., Miller D.J., Sajjan U., Hershenson M.B.: Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. J. Immunol., 2009; 183: 6989-6997
62. Wang Y., McCusker C.: Neonatal exposure with LPS and/or allergen prevents experimental allergic airways disease: development of tolerance using environmental antigens. J. Allergy Clin. Immunol., 2006; 118: 143-151
63. Wang Y.H., Liu Y.J.: Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses. Clin. Exp. Allergy, 2009; 39: 798-806
64. Zhou B., Comeau M.R., De Smedt T., Liggitt H.D., Dahl M.E., Lewis D.B., Gyarmati D., Aye T., Campbell D.J., Ziegler S.F.: Thymic stromal lymphopoietin as a key initiatior of allergic airway inflammation in mice. Nat. Immunol., 2005; 6: 1047-1053