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Volumn 57, Issue 1, 2014, Pages 53-66

Salutary effects of melatonin combined with treadmill exercise on cartilage damage

Author keywords

cartilage degeneration; exercise; melatonin; MMP 13; type II collagen

Indexed keywords

AGGRECANASE 1; CASPASE 3; COLLAGENASE; COLLAGENASE 3; EPAS 1 PROTEIN; INTERLEUKIN 6; MELATONIN; MESSENGER RNA; PROTEIN; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; COLLAGEN TYPE 2;

EID: 84904511802     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12143     Document Type: Article
Times cited : (36)

References (62)
  • 1
    • 77950659332 scopus 로고    scopus 로고
    • Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
    • Goldring MB, Goldring SR,. Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann N Y Acad Sci 2010; 1192: 230-237.
    • (2010) Ann N y Acad Sci , vol.1192 , pp. 230-237
    • Goldring, M.B.1    Goldring, S.R.2
  • 2
    • 77955812504 scopus 로고    scopus 로고
    • Is osteoarthritis a disease involving only cartilage or other articular tissues?
    • Martel-Pelletier J, Pelletier JP,. Is osteoarthritis a disease involving only cartilage or other articular tissues? Eklem Hastalik Cerrahisi 2010; 21: 2-14.
    • (2010) Eklem Hastalik Cerrahisi , vol.21 , pp. 2-14
    • Martel-Pelletier, J.1    Pelletier, J.P.2
  • 3
    • 79960975877 scopus 로고    scopus 로고
    • Roles of inflammatory and anabolic cytokines in cartilage metabolism: Signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis
    • Goldring MB, Otero M, Plumb DA, et al. Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. Eur Cell Mater 2011; 21: 202-220.
    • (2011) Eur Cell Mater , vol.21 , pp. 202-220
    • Goldring, M.B.1    Otero, M.2    Plumb, D.A.3
  • 4
    • 56749175339 scopus 로고    scopus 로고
    • Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism
    • Goldring MB, Otero M, Tsuchimochi K, et al. Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis 2008; 67: iii75-iii82.
    • (2008) Ann Rheum Dis , vol.67
    • Goldring, M.B.1    Otero, M.2    Tsuchimochi, K.3
  • 5
    • 3142722961 scopus 로고    scopus 로고
    • Chondroptosis: A variant of apoptotic cell death in chondrocytes?
    • Roach HI, Aigner T, Kouri JB,. Chondroptosis: a variant of apoptotic cell death in chondrocytes? Apoptosis 2004; 9: 265-277.
    • (2004) Apoptosis , vol.9 , pp. 265-277
    • Roach, H.I.1    Aigner, T.2    Kouri, J.B.3
  • 6
    • 34447119750 scopus 로고    scopus 로고
    • Mechanisms of disease: Role of chondrocytes in the pathogenesis of osteoarthritis-structure, chaos and senescence
    • Aigner T, Söder S, Gebhard PM, et al. Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis-structure, chaos and senescence. Nat Clin Pract Rheumatol 2007; 3: 391-399.
    • (2007) Nat Clin Pract Rheumatol , vol.3 , pp. 391-399
    • Aigner, T.1    Söder, S.2    Gebhard, P.M.3
  • 7
    • 12344252610 scopus 로고    scopus 로고
    • Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage
    • Kobayashi M, Squires GR, Mousa A, et al. Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum 2005; 52: 128-135.
    • (2005) Arthritis Rheum , vol.52 , pp. 128-135
    • Kobayashi, M.1    Squires, G.R.2    Mousa, A.3
  • 8
    • 0034564348 scopus 로고    scopus 로고
    • Osteoarthritis and cartilage: The role of cytokines
    • Goldring MB,. Osteoarthritis and cartilage: the role of cytokines. Curr Rheumatol Rep 2000; 2: 459-465.
    • (2000) Curr Rheumatol Rep , vol.2 , pp. 459-465
    • Goldring, M.B.1
  • 9
    • 84892640329 scopus 로고    scopus 로고
    • Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases
    • Liu X, Xu Y, Chen S, et al. Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases. Free Radic Biol Med 2014; 68: 234-246.
    • (2014) Free Radic Biol Med , vol.68 , pp. 234-246
    • Liu, X.1    Xu, Y.2    Chen, S.3
  • 10
    • 79960360982 scopus 로고    scopus 로고
    • A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases
    • Stehle JH, Saade A, Rawashdeh O, et al. A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases. J Pineal Res 2011; 51: 17-43.
    • (2011) J Pineal Res , vol.51 , pp. 17-43
    • Stehle, J.H.1    Saade, A.2    Rawashdeh, O.3
  • 11
    • 84872685423 scopus 로고    scopus 로고
    • A review of the molecular aspects of melatonin's anti-inflammatory actions: Recent insights and new perspectives
    • Mauriz JL, Collado PS, Veneroso C, et al. A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives. J Pineal Res 2013; 54: 1-14.
    • (2013) J Pineal Res , vol.54 , pp. 1-14
    • Mauriz, J.L.1    Collado, P.S.2    Veneroso, C.3
  • 12
    • 84876850102 scopus 로고    scopus 로고
    • The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives
    • Reiter RJ, Tan DX, Rosales-Corral S, et al. The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives. Mini Rev Med Chem 2013; 13: 373-384.
    • (2013) Mini Rev Med Chem , vol.13 , pp. 373-384
    • Reiter, R.J.1    Tan, D.X.2    Rosales-Corral, S.3
  • 14
    • 78049451374 scopus 로고    scopus 로고
    • Melatonin: A pleiotropic molecule regulating inflammation
    • Radogna F, Diederich M, Ghibelli L,. Melatonin: a pleiotropic molecule regulating inflammation. Biochem Pharmacol 2010; 80: 1844-1852.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1844-1852
    • Radogna, F.1    Diederich, M.2    Ghibelli, L.3
  • 15
    • 59149097227 scopus 로고    scopus 로고
    • Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes
    • Pei M, He F, Wei L, et al. Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes. J Pineal Res 2009; 46: 181-187.
    • (2009) J Pineal Res , vol.46 , pp. 181-187
    • Pei, M.1    He, F.2    Wei, L.3
  • 16
    • 84866264061 scopus 로고    scopus 로고
    • Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway
    • Lim HD, Kim YS, Ko SH, et al. Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway. J Pineal Res 2012; 53: 225-237.
    • (2012) J Pineal Res , vol.53 , pp. 225-237
    • Lim, H.D.1    Kim, Y.S.2    Ko, S.H.3
  • 17
    • 79952115371 scopus 로고    scopus 로고
    • Effects of melatonin on expression of bone morphogenetic protein 2 and IL-1ß in articular cartilage of rat with osteoarthritis
    • Huang C, Liu J, Xia C, et al. Effects of melatonin on expression of bone morphogenetic protein 2 and IL-1ß in articular cartilage of rat with osteoarthritis. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2010; 24: 1082-1087.
    • (2010) Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi , vol.24 , pp. 1082-1087
    • Huang, C.1    Liu, J.2    Xia, C.3
  • 18
    • 0041777778 scopus 로고    scopus 로고
    • Moderate-impact exercise is associated with decreased severity of experimental osteoarthritis in rats
    • Galois L, Etienne S, Grossin L, et al. Moderate-impact exercise is associated with decreased severity of experimental osteoarthritis in rats. Rheumatology 2003; 42: 692-693.
    • (2003) Rheumatology , vol.42 , pp. 692-693
    • Galois, L.1    Etienne, S.2    Grossin, L.3
  • 19
    • 27744581290 scopus 로고    scopus 로고
    • Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: A four-month, randomized, controlled trial in patients at risk of osteoarthritis
    • Roos EM, Dahlberg L,. Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis. Arthritis Rheum 2005; 52: 3507-3514.
    • (2005) Arthritis Rheum , vol.52 , pp. 3507-3514
    • Roos, E.M.1    Dahlberg, L.2
  • 20
    • 59449098995 scopus 로고    scopus 로고
    • Changes of articular cartilage after immobilization in a rat knee contracture model
    • Hagiwara Y, Ando A, Chimoto E, et al. Changes of articular cartilage after immobilization in a rat knee contracture model. J Orthop Res 2009; 27: 236-242.
    • (2009) J Orthop Res , vol.27 , pp. 236-242
    • Hagiwara, Y.1    Ando, A.2    Chimoto, E.3
  • 21
    • 0031765517 scopus 로고    scopus 로고
    • Exercise protects against articular cartilage degeneration in the hamster
    • Otterness IG, Eskra JD, Bliven ML, et al. Exercise protects against articular cartilage degeneration in the hamster. Arthritis Rheum 1998; 41: 2068-2076.
    • (1998) Arthritis Rheum , vol.41 , pp. 2068-2076
    • Otterness, I.G.1    Eskra, J.D.2    Bliven, M.L.3
  • 22
    • 33645869542 scopus 로고    scopus 로고
    • The effects of exercise on human articular cartilage
    • Eckstein F, Hudelmaier M, Putz R,. The effects of exercise on human articular cartilage. J Anat 2006; 208: 491-512.
    • (2006) J Anat , vol.208 , pp. 491-512
    • Eckstein, F.1    Hudelmaier, M.2    Putz, R.3
  • 23
    • 55949118714 scopus 로고    scopus 로고
    • Exercise-induced oxidative stress: Cellular mechanisms and impact on muscle force production
    • Powers SK, Jackson MJ,. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 2008; 88: 1243-1276.
    • (2008) Physiol Rev , vol.88 , pp. 1243-1276
    • Powers, S.K.1    Jackson, M.J.2
  • 24
    • 50349096522 scopus 로고    scopus 로고
    • Primary culture and phenotyping of murine chondrocytes
    • Gosset M, Berenbaum F, Thirion S, et al. Primary culture and phenotyping of murine chondrocytes. Nat Protoc 2008; 3: 1253-1260.
    • (2008) Nat Protoc , vol.3 , pp. 1253-1260
    • Gosset, M.1    Berenbaum, F.2    Thirion, S.3
  • 25
    • 41149084706 scopus 로고    scopus 로고
    • Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis
    • Botter SM, Van Osch GJ, Waarsing JH, et al. Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis. Osteoarthritis Cartilage 2008; 16: 506-514.
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 506-514
    • Botter, S.M.1    Van Osch, G.J.2    Waarsing, J.H.3
  • 26
    • 33846333129 scopus 로고    scopus 로고
    • Markedly different effects of hyaluronic acid and chondroitin sulfate-A on the differentiation of human articular chondrocytes in micromass and 3-D honeycomb rotation cultures
    • Banu N, Tsuchiya T,. Markedly different effects of hyaluronic acid and chondroitin sulfate-A on the differentiation of human articular chondrocytes in micromass and 3-D honeycomb rotation cultures. J Biomed Mater Res A 2007; 80: 257-267.
    • (2007) J Biomed Mater Res A , vol.80 , pp. 257-267
    • Banu, N.1    Tsuchiya, T.2
  • 27
    • 4644262396 scopus 로고    scopus 로고
    • Dose-response relationship for exercise on severity of experimental osteoarthritis in rats: A pilot study
    • Galois L, Etienne S, Grossin L, et al. Dose-response relationship for exercise on severity of experimental osteoarthritis in rats: a pilot study. Osteoarthritis Cartilage 2004; 12: 779-786.
    • (2004) Osteoarthritis Cartilage , vol.12 , pp. 779-786
    • Galois, L.1    Etienne, S.2    Grossin, L.3
  • 28
    • 38149064496 scopus 로고    scopus 로고
    • Involvement of LTB4 in zymosan-induced joint nociception in mice: Participation of neutrophils and PGE2
    • Guerrero AT, Verri WA Jr, Cunha TM, et al. Involvement of LTB4 in zymosan-induced joint nociception in mice: participation of neutrophils and PGE2. J Leukoc Biol 2008; 83: 122-130.
    • (2008) J Leukoc Biol , vol.83 , pp. 122-130
    • Guerrero, A.T.1    Verri Jr., W.A.2    Cunha, T.M.3
  • 29
    • 67650079427 scopus 로고    scopus 로고
    • Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo
    • Buttgereit F, Zhou H, Kalak R, et al. Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo. Arthritis Rheum 2009; 60: 1998-2007.
    • (2009) Arthritis Rheum , vol.60 , pp. 1998-2007
    • Buttgereit, F.1    Zhou, H.2    Kalak, R.3
  • 30
    • 0027744510 scopus 로고
    • Effects of calcium deficiency on chondrocyte hypertrophy and type X collagen expression in chick embryonic sternum
    • Reginato AM, Tuan RS, Ono T, et al. Effects of calcium deficiency on chondrocyte hypertrophy and type X collagen expression in chick embryonic sternum. Dev Dyn 1993; 198: 284-295.
    • (1993) Dev Dyn , vol.198 , pp. 284-295
    • Reginato, A.M.1    Tuan, R.S.2    Ono, T.3
  • 31
    • 39449128920 scopus 로고    scopus 로고
    • Joint diseases and matrix metalloproteinases: A role for MMP-13
    • Takaishi H, Kimura T, Dalal S, et al. Joint diseases and matrix metalloproteinases: a role for MMP-13. Curr Pharm Biotechnol 2008; 9: 47-54.
    • (2008) Curr Pharm Biotechnol , vol.9 , pp. 47-54
    • Takaishi, H.1    Kimura, T.2    Dalal, S.3
  • 32
    • 39749196140 scopus 로고    scopus 로고
    • The potential role of vascular endothelial growth factor (VEGF) in cartilage: How the angiogenic factor could be involved in the pathogenesis of osteoarthritis?
    • Murata M, Yudoh K, Masuko K,. The potential role of vascular endothelial growth factor (VEGF) in cartilage: how the angiogenic factor could be involved in the pathogenesis of osteoarthritis? Osteoarthritis Cartilage 2008; 16: 279-286.
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 279-286
    • Murata, M.1    Yudoh, K.2    Masuko, K.3
  • 33
    • 84861830188 scopus 로고    scopus 로고
    • Autophagy modulates osteoarthritis-related gene expression in human chondrocytes
    • Sasaki H, Takayama K, Matsushita T, et al. Autophagy modulates osteoarthritis-related gene expression in human chondrocytes. Arthritis Rheum 2012; 64: 1920-19280.
    • (2012) Arthritis Rheum , vol.64 , pp. 1920-19280
    • Sasaki, H.1    Takayama, K.2    Matsushita, T.3
  • 34
    • 0035153590 scopus 로고    scopus 로고
    • Expression of early and late differentiation markers (proliferating cell nuclear antigen, syndecan-3, annexin VI, and alkaline phosphatase) by human osteoarthritic chondrocytes
    • Pfander D, Swoboda B, Kirsch T,. Expression of early and late differentiation markers (proliferating cell nuclear antigen, syndecan-3, annexin VI, and alkaline phosphatase) by human osteoarthritic chondrocytes. Am J Pathol 2001; 159: 1777-1783.
    • (2001) Am J Pathol , vol.159 , pp. 1777-1783
    • Pfander, D.1    Swoboda, B.2    Kirsch, T.3
  • 35
    • 1642562820 scopus 로고    scopus 로고
    • Regulation of antioxidant enzymes: A significant role for melatonin
    • Rodriguez C, Mayo JC, Sainz RM, et al. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004; 36: 1-9.
    • (2004) J Pineal Res , vol.36 , pp. 1-9
    • Rodriguez, C.1    Mayo, J.C.2    Sainz, R.M.3
  • 36
    • 33847635533 scopus 로고    scopus 로고
    • Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo
    • Satomura K, Tobiume S, Tokuyama R, et al. Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo. J Pineal Res 2007; 42: 231-239.
    • (2007) J Pineal Res , vol.42 , pp. 231-239
    • Satomura, K.1    Tobiume, S.2    Tokuyama, R.3
  • 37
    • 0036899738 scopus 로고    scopus 로고
    • Melatonin in rheumatoid arthritis: A disease-promoting and modulating hormone?
    • Maestroni GJ, Sulli A, Pizzorni C, et al. Melatonin in rheumatoid arthritis: a disease-promoting and modulating hormone? Clin Exp Rheumatol 2002; 20: 872-873.
    • (2002) Clin Exp Rheumatol , vol.20 , pp. 872-873
    • Maestroni, G.J.1    Sulli, A.2    Pizzorni, C.3
  • 39
    • 0036303799 scopus 로고    scopus 로고
    • Melatonin in rheumatoid arthritis: Synovial macrophages show melatonin receptors
    • Maestroni GJ, Sulli A, Pizzorni C, et al. Melatonin in rheumatoid arthritis: synovial macrophages show melatonin receptors. Ann N Y Acad Sci 2002; 966: 271-275.
    • (2002) Ann N y Acad Sci , vol.966 , pp. 271-275
    • Maestroni, G.J.1    Sulli, A.2    Pizzorni, C.3
  • 40
    • 0033925920 scopus 로고    scopus 로고
    • Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo
    • Reiter RJ, Tan DX, Qi W, et al. Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo. Biol Signals Recept 2000; 9: 160-171.
    • (2000) Biol Signals Recept , vol.9 , pp. 160-171
    • Reiter, R.J.1    Tan, D.X.2    Qi, W.3
  • 42
    • 0031572309 scopus 로고    scopus 로고
    • Apoptosis of chondrocytes in transgenic mice lacking collagen II
    • Yang C, Li SW, Helminen HJ, et al. Apoptosis of chondrocytes in transgenic mice lacking collagen II. Exp Cell Res 1997; 235: 370-373.
    • (1997) Exp Cell Res , vol.235 , pp. 370-373
    • Yang, C.1    Li, S.W.2    Helminen, H.J.3
  • 43
    • 70449640613 scopus 로고    scopus 로고
    • TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: Modulation and integration of signaling pathways through receptor-Smads
    • Van der Kraan PM, Blaney Davidson EN, Blom A, et al. TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads. Osteoarthritis Cartilage 2009; 17: 1539-1545.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 1539-1545
    • Van Der Kraan, P.M.1    Blaney Davidson, E.N.2    Blom, A.3
  • 44
    • 33645846303 scopus 로고    scopus 로고
    • The effect of exogenous melatonin administration on trabecular width, ligament thickness and TGF-beta(1) expression in degenerated intervertebral disk tissue in the rat
    • Turgut M, Oktem G, Uslu S, et al. The effect of exogenous melatonin administration on trabecular width, ligament thickness and TGF-beta(1) expression in degenerated intervertebral disk tissue in the rat. J Clin Neurosci 2006; 13: 357-363.
    • (2006) J Clin Neurosci , vol.13 , pp. 357-363
    • Turgut, M.1    Oktem, G.2    Uslu, S.3
  • 45
    • 33745574971 scopus 로고    scopus 로고
    • Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and nuclear factor kappa B activation in rat skeletal muscle
    • Alonso M, Collado PS, González-Gallego J,. Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and nuclear factor kappa B activation in rat skeletal muscle. J Pineal Res 2006; 41: 8-14.
    • (2006) J Pineal Res , vol.41 , pp. 8-14
    • Alonso, M.1    Collado, P.S.2    González-Gallego, J.3
  • 46
    • 0036159161 scopus 로고    scopus 로고
    • Matrix metalloproteinases as therapeutic targets in arthritic diseases: Bull's-eye or missing the mark?
    • Mengshol JA, Mix KS, Brinckerhoff CE,. Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark? Arthritis Rheum 2002; 46: 13-20.
    • (2002) Arthritis Rheum , vol.46 , pp. 13-20
    • Mengshol, J.A.1    Mix, K.S.2    Brinckerhoff, C.E.3
  • 47
    • 37549010964 scopus 로고    scopus 로고
    • Characterization of an exosite binding inhibitor of matrix metalloproteinase 13
    • Gooljarsingh LT, Lakdawala A, Coppo F, et al. Characterization of an exosite binding inhibitor of matrix metalloproteinase 13. Protein Sci 2008; 17: 66-71.
    • (2008) Protein Sci , vol.17 , pp. 66-71
    • Gooljarsingh, L.T.1    Lakdawala, A.2    Coppo, F.3
  • 48
    • 34948864524 scopus 로고    scopus 로고
    • Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects
    • Johnson AR, Pavlovsky AG, Ortwine DF, et al. Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. J Biol Chem 2007; 282: 27781-27791.
    • (2007) J Biol Chem , vol.282 , pp. 27781-27791
    • Johnson, A.R.1    Pavlovsky, A.G.2    Ortwine, D.F.3
  • 49
    • 47249126749 scopus 로고    scopus 로고
    • The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes
    • Pizarro JG, Yeste-Velasco M, Esparza JL, et al. The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes. J Pineal Res 2008; 45: 8-16.
    • (2008) J Pineal Res , vol.45 , pp. 8-16
    • Pizarro, J.G.1    Yeste-Velasco, M.2    Esparza, J.L.3
  • 50
    • 53749085741 scopus 로고    scopus 로고
    • Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line
    • Martín-Renedo J, Mauriz JL, Jorquera F, et al. Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line. J Pineal Res 2008; 45: 532-540.
    • (2008) J Pineal Res , vol.45 , pp. 532-540
    • Martín-Renedo, J.1    Mauriz, J.L.2    Jorquera, F.3
  • 51
    • 33746516109 scopus 로고    scopus 로고
    • Melatonin induces apoptosis in human neuroblastoma cancer cells
    • García-Santos G, Antolín I, Herrera F, et al. Melatonin induces apoptosis in human neuroblastoma cancer cells. J Pineal Res 2006; 41: 130-135.
    • (2006) J Pineal Res , vol.41 , pp. 130-135
    • García-Santos, G.1    Antolín, I.2    Herrera, F.3
  • 52
    • 78349247846 scopus 로고    scopus 로고
    • Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression
    • Zhang L, Su P, Xu C, et al. Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression. J Pineal Res 2010; 49: 364-372.
    • (2010) J Pineal Res , vol.49 , pp. 364-372
    • Zhang, L.1    Su, P.2    Xu, C.3
  • 53
    • 33747105835 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase II in human articular chondrocytes
    • Shimazaki A, Wright MO, Elliot K, et al. Calcium/calmodulin-dependent protein kinase II in human articular chondrocytes. Biorheology 2006; 43: 223-233.
    • (2006) Biorheology , vol.43 , pp. 223-233
    • Shimazaki, A.1    Wright, M.O.2    Elliot, K.3
  • 54
    • 30044441003 scopus 로고    scopus 로고
    • Calcium/calmodulin signaling controls osteoblast growth and differentiation
    • Zayzafoon M,. Calcium/calmodulin signaling controls osteoblast growth and differentiation. J Cell Biochem 2006; 97: 56-70.
    • (2006) J Cell Biochem , vol.97 , pp. 56-70
    • Zayzafoon, M.1
  • 55
    • 0033868210 scopus 로고    scopus 로고
    • Parathyroid hormone induces rat interstitial collagenase mRNA through Ets-1 facilitated by cyclic AMP response element-binding protein and Ca(2+)/calmodulin-dependent protein kinase II in osteoblastic cells
    • Quinn CO, Rajakumar RA, Agapova OA,. Parathyroid hormone induces rat interstitial collagenase mRNA through Ets-1 facilitated by cyclic AMP response element-binding protein and Ca(2+)/calmodulin-dependent protein kinase II in osteoblastic cells. J Mol Endocrinol 2000; 25: 73-84.
    • (2000) J Mol Endocrinol , vol.25 , pp. 73-84
    • Quinn, C.O.1    Rajakumar, R.A.2    Agapova, O.A.3
  • 57
    • 77955353960 scopus 로고    scopus 로고
    • Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors
    • Borzí RM, Olivotto E, Pagani S, et al. Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors. Arthritis Rheum 2010; 62: 2370-2381.
    • (2010) Arthritis Rheum , vol.62 , pp. 2370-2381
    • Borzí, R.M.1    Olivotto, E.2    Pagani, S.3
  • 58
    • 84865237162 scopus 로고    scopus 로고
    • Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance
    • Tang SY, Herber RP, Ho SP, et al. Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance. J Bone Miner Res 2012; 27: 1936-1950.
    • (2012) J Bone Miner Res , vol.27 , pp. 1936-1950
    • Tang, S.Y.1    Herber, R.P.2    Ho, S.P.3
  • 59
    • 33845766871 scopus 로고    scopus 로고
    • Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts
    • Toriseva MJ, Ala-Aho R, Karvinen J, et al. Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts. J Invest Dermatol 2007; 127: 49-59.
    • (2007) J Invest Dermatol , vol.127 , pp. 49-59
    • Toriseva, M.J.1    Ala-Aho, R.2    Karvinen, J.3
  • 60
    • 0034242788 scopus 로고    scopus 로고
    • Normal and pathological adaptations of articular cartilage to joint loading
    • Arokoski JP, Jurvelin JS, Väätäinen U, et al. Normal and pathological adaptations of articular cartilage to joint loading. Scand J Med Sci Sports 2000; 10: 186-198.
    • (2000) Scand J Med Sci Sports , vol.10 , pp. 186-198
    • Arokoski, J.P.1    Jurvelin, J.S.2    Väätäinen, U.3
  • 61
    • 81255160693 scopus 로고    scopus 로고
    • Mechanical loading: Bone remodeling and cartilage maintenance
    • Yokota H, Leong DJ, Sun HB,. Mechanical loading: bone remodeling and cartilage maintenance. Curr Osteoporos Rep 2011; 9: 237-242.
    • (2011) Curr Osteoporos Rep , vol.9 , pp. 237-242
    • Yokota, H.1    Leong, D.J.2    Sun, H.B.3
  • 62
    • 80052030405 scopus 로고    scopus 로고
    • Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
    • Pickarski M, Hayami T, Zhuo Y, et al. Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. BMC Musculoskelet Disord 2011; 12: 197.
    • (2011) BMC Musculoskelet Disord , vol.12 , pp. 197
    • Pickarski, M.1    Hayami, T.2    Zhuo, Y.3


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