메뉴 건너뛰기




Volumn 2, Issue 1, 2014, Pages

CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CD123 ANTIGEN; DIPHTHERIA TOXIN; INTERLEUKIN 3 RECEPTOR;

EID: 84904460162     PISSN: None     EISSN: 20507771     Source Type: Journal    
DOI: 10.1186/2050-7771-2-4     Document Type: Review
Times cited : (201)

References (74)
  • 3
    • 84867421584 scopus 로고    scopus 로고
    • The GM-CSF/IL-3/GM-CSF cytokine receptor family: from ligand recognition to initiation of signaling
    • 10.1111/j.1600-065X.2012.01164.x, 23046136
    • Braughton S, Dhagat U, Hercus TR, Nero T, Grinbaldeston M, Bonder C, Lopez AF, Parker MW. The GM-CSF/IL-3/GM-CSF cytokine receptor family: from ligand recognition to initiation of signaling. Immunol Rev 2012, 250(1):277-302. 10.1111/j.1600-065X.2012.01164.x, 23046136.
    • (2012) Immunol Rev , vol.250 , Issue.1 , pp. 277-302
    • Braughton, S.1    Dhagat, U.2    Hercus, T.R.3    Nero, T.4    Grinbaldeston, M.5    Bonder, C.6    Lopez, A.F.7    Parker, M.W.8
  • 5
    • 0026555097 scopus 로고
    • Interleukin-3 and hematopoiesis
    • Ihle JN. Interleukin-3 and hematopoiesis. Chem Immunol 1992, 51:65-106.
    • (1992) Chem Immunol , vol.51 , pp. 65-106
    • Ihle, J.N.1
  • 7
    • 0023882364 scopus 로고
    • Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3
    • 10.1172/JCI113547, 442652, 3133397
    • Rothenberg ME, Oxen WF, Siberstein DS, Woods J, Soberman RJ, Austen KF, Stevens RL. Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3. J Clin Invest 1988, 81(6):1986-1992. 10.1172/JCI113547, 442652, 3133397.
    • (1988) J Clin Invest , vol.81 , Issue.6 , pp. 1986-1992
    • Rothenberg, M.E.1    Oxen, W.F.2    Siberstein, D.S.3    Woods, J.4    Soberman, R.J.5    Austen, K.F.6    Stevens, R.L.7
  • 8
    • 0027319681 scopus 로고
    • Interleukin 3 stimulates proliferation and triggers endothelial leukocyte adhesion molecule 1 gene activation of human endothelial cells
    • 10.1172/JCI116534, 443359, 7685775
    • Brizzi MF, Garbarino G, Rossi PR, Pagliardi GL, Arduino C, Avanzi GC, Pegoraro L. Interleukin 3 stimulates proliferation and triggers endothelial leukocyte adhesion molecule 1 gene activation of human endothelial cells. J Clin Invest 1993, 91(6):2887-2892. 10.1172/JCI116534, 443359, 7685775.
    • (1993) J Clin Invest , vol.91 , Issue.6 , pp. 2887-2892
    • Brizzi, M.F.1    Garbarino, G.2    Rossi, P.R.3    Pagliardi, G.L.4    Arduino, C.5    Avanzi, G.C.6    Pegoraro, L.7
  • 9
    • 0029860206 scopus 로고    scopus 로고
    • A single tyrosine residue in the membrane-proximal domain of the GM-CSF, IL-3 and IL-5 receptor common beta chain is necessary and sufficient for high affinity binding and signalling by all three ligands
    • 10.1074/jbc.271.42.25999, 8824238
    • Woodcock JM, Bagely CJ, Zacharakis B, Lopez AF. A single tyrosine residue in the membrane-proximal domain of the GM-CSF, IL-3 and IL-5 receptor common beta chain is necessary and sufficient for high affinity binding and signalling by all three ligands. J Biol Chem 1996, 271(42):25999-26006. 10.1074/jbc.271.42.25999, 8824238.
    • (1996) J Biol Chem , vol.271 , Issue.42 , pp. 25999-26006
    • Woodcock, J.M.1    Bagely, C.J.2    Zacharakis, B.3    Lopez, A.F.4
  • 11
    • 17744386517 scopus 로고    scopus 로고
    • Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, IL-5 receptors reveals a novel dimer configuration
    • Carr PD, Gustin SE, Church AP, Murphy JM, Ford SC, Mann DA, Woltring DM, Walker I, Ollis DL, Young IG. Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, IL-5 receptors reveals a novel dimer configuration. Cell 2011, 104(2):291-300.
    • (2011) Cell , vol.104 , Issue.2 , pp. 291-300
    • Carr, P.D.1    Gustin, S.E.2    Church, A.P.3    Murphy, J.M.4    Ford, S.C.5    Mann, D.A.6    Woltring, D.M.7    Walker, I.8    Ollis, D.L.9    Young, I.G.10
  • 12
    • 0030744972 scopus 로고    scopus 로고
    • The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed complex that can be activated by GM-CSF, interleukin-3 or interleukin-5
    • Woodcock JM, McClure BJ, Stomski FC, Eliott MJ, Bagley CJ, Lopez AF. The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed complex that can be activated by GM-CSF, interleukin-3 or interleukin-5. Blood 1997, 90(8):3005-3017.
    • (1997) Blood , vol.90 , Issue.8 , pp. 3005-3017
    • Woodcock, J.M.1    McClure, B.J.2    Stomski, F.C.3    Eliott, M.J.4    Bagley, C.J.5    Lopez, A.F.6
  • 13
    • 0027327477 scopus 로고
    • Expression and factor-dependent modulation of the interleukin-3 receptor subunits on human hematopoietic cells
    • Sato N, Caux C, Kitamura T, Watanabe Y, Arai K, Banchereau J, Miyajima A, et al. Expression and factor-dependent modulation of the interleukin-3 receptor subunits on human hematopoietic cells. Blood 1993, 82(3):752-761.
    • (1993) Blood , vol.82 , Issue.3 , pp. 752-761
    • Sato, N.1    Caux, C.2    Kitamura, T.3    Watanabe, Y.4    Arai, K.5    Banchereau, J.6    Miyajima, A.7
  • 14
    • 0030476966 scopus 로고    scopus 로고
    • Differential expression of receptors for hemopoietic growth factors on subsets of CD34+ hemopoietic cells
    • Wognum AR, de Jong MO, Wagemaker G. Differential expression of receptors for hemopoietic growth factors on subsets of CD34+ hemopoietic cells. Leuk Lymphoma 1996, 24(1-2):11-25.
    • (1996) Leuk Lymphoma , vol.24 , Issue.1-2 , pp. 11-25
    • Wognum, A.R.1    de Jong, M.O.2    Wagemaker, G.3
  • 15
    • 0032722187 scopus 로고    scopus 로고
    • Correlation between IL-3 receptor expression and growth potential of human CD34+ hematopoietic cells from different tissues
    • 10.1002/stem.170265, 10527461
    • Huang S, Chen Z, Yu JF, Young D, Bashey A, Ho AD, Law P. Correlation between IL-3 receptor expression and growth potential of human CD34+ hematopoietic cells from different tissues. Stem Cells 1999, 17(5):265-272. 10.1002/stem.170265, 10527461.
    • (1999) Stem Cells , vol.17 , Issue.5 , pp. 265-272
    • Huang, S.1    Chen, Z.2    Yu, J.F.3    Young, D.4    Bashey, A.5    Ho, A.D.6    Law, P.7
  • 16
    • 0037015069 scopus 로고    scopus 로고
    • Prospective isolation of human clonogenic common myeloid progenitors
    • 10.1073/pnas.172384399, 129361, 12193648
    • Manz MG, Miyamoto T, Akashi K, Weissman IL. Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci U S A 2002, 99(18):11872-11877. 10.1073/pnas.172384399, 129361, 12193648.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.18 , pp. 11872-11877
    • Manz, M.G.1    Miyamoto, T.2    Akashi, K.3    Weissman, I.L.4
  • 18
    • 85018062084 scopus 로고    scopus 로고
    • Expression of interleukin 3 and granulocyte-macrophage colony stimulating receptor common chain beta C, beta IT in normal hematopoiesis: lineage specificity and proliferation-independent induction
    • Militi S, Riccioni R, Parolini I, Sposi NM, Samoggia P, Pelosi E, Testa U, Peschle C. Expression of interleukin 3 and granulocyte-macrophage colony stimulating receptor common chain beta C, beta IT in normal hematopoiesis: lineage specificity and proliferation-independent induction. Brit J Haematol 2000, 111(2):441-451.
    • (2000) Brit J Haematol , vol.111 , Issue.2 , pp. 441-451
    • Militi, S.1    Riccioni, R.2    Parolini, I.3    Sposi, N.M.4    Samoggia, P.5    Pelosi, E.6    Testa, U.7    Peschle, C.8
  • 19
    • 28844456971 scopus 로고    scopus 로고
    • Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia
    • 10.1182/blood-2005-03-1072, 1895250, 16131573
    • Taussig DC, Pearce DJ, Simpson C, Rohatiner AZ, Lister TA, Kelly G, Luongo JL, Danet-Desnoyers GA, Bonnet D. Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood 2005, 106(13):4086-4092. 10.1182/blood-2005-03-1072, 1895250, 16131573.
    • (2005) Blood , vol.106 , Issue.13 , pp. 4086-4092
    • Taussig, D.C.1    Pearce, D.J.2    Simpson, C.3    Rohatiner, A.Z.4    Lister, T.A.5    Kelly, G.6    Luongo, J.L.7    Danet-Desnoyers, G.A.8    Bonnet, D.9
  • 22
    • 0037114743 scopus 로고    scopus 로고
    • Characterization of human blood dendritic cell subsets
    • 10.1182/blood-2001-11-0097, 12393628
    • MacDonald KP, Mauster DJ, Clark GJ, Dzionek A, Schmitz J, Hart DN. Characterization of human blood dendritic cell subsets. Blood 2002, 100(13):4512-4520. 10.1182/blood-2001-11-0097, 12393628.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4512-4520
    • MacDonald, K.P.1    Mauster, D.J.2    Clark, G.J.3    Dzionek, A.4    Schmitz, J.5    Hart, D.N.6
  • 26
    • 0036464603 scopus 로고    scopus 로고
    • Interleukin-3 and interferon beta cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties
    • 10.1182/blood.V99.3.993, 11807004
    • Buelens C, Bartholome EJ, Amraoui Z, Boutriaux M, Salmon I, Thielemans K, Willems F, Goldman M. Interleukin-3 and interferon beta cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties. Blood 2002, 99(3):993-998. 10.1182/blood.V99.3.993, 11807004.
    • (2002) Blood , vol.99 , Issue.3 , pp. 993-998
    • Buelens, C.1    Bartholome, E.J.2    Amraoui, Z.3    Boutriaux, M.4    Salmon, I.5    Thielemans, K.6    Willems, F.7    Goldman, M.8
  • 27
    • 84858302173 scopus 로고    scopus 로고
    • Production of large numbers of plasmocytoid dendritic cells with functional activities from CD34+ hematopoietic progenitor cells: use of interleukin-3
    • Demoulin S, Roncarati P, Delvenn P, Hubert P. Production of large numbers of plasmocytoid dendritic cells with functional activities from CD34+ hematopoietic progenitor cells: use of interleukin-3. Exp Hematol 2012, 40(2):268-278.
    • (2012) Exp Hematol , vol.40 , Issue.2 , pp. 268-278
    • Demoulin, S.1    Roncarati, P.2    Delvenn, P.3    Hubert, P.4
  • 28
    • 84872470209 scopus 로고    scopus 로고
    • Stem cell tramsplantation can provide durable disease control in blastic plasmocytoid dendritic cell neoplasm: a retrospective study from the European Group and blood marrow transplantation
    • 10.1182/blood-2012-08-448613, 23203822, European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties
    • Roos-Weil D, Dietrich S, Boumendil A, Polge E, Bron D, Carreras E, Iriondo Atienza A, Arcese W, Beelen DW, Cornelissen JJ, Kröger N, Milone G, Rossi G, Jardin F, Peters C, Rocha V, Sureda A, Mohty M, Dreger P, . European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties Stem cell tramsplantation can provide durable disease control in blastic plasmocytoid dendritic cell neoplasm: a retrospective study from the European Group and blood marrow transplantation. Blood 2013, 121(3):440-446. 10.1182/blood-2012-08-448613, 23203822, European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties.
    • (2013) Blood , vol.121 , Issue.3 , pp. 440-446
    • Roos-Weil, D.1    Dietrich, S.2    Boumendil, A.3    Polge, E.4    Bron, D.5    Carreras, E.6    Iriondo Atienza, A.7    Arcese, W.8    Beelen, D.W.9    Cornelissen, J.J.10    Kröger, N.11    Milone, G.12    Rossi, G.13    Jardin, F.14    Peters, C.15    Rocha, V.16    Sureda, A.17    Mohty, M.18    Dreger, P.19
  • 30
    • 84907598651 scopus 로고    scopus 로고
    • An update on the robust clinical activity of SL-401, a targeted therapy directed to the interleukin-3 receptor on cancer stem cells and tumor bulk, in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN)
    • 64672
    • Frankel AE, Woo JH, Mauldin JP, Carraway HE, Frankfurt O, Forman SJ, et al. An update on the robust clinical activity of SL-401, a targeted therapy directed to the interleukin-3 receptor on cancer stem cells and tumor bulk, in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). Blood 2013, 122(21):abstract nr 64672.
    • (2013) Blood , vol.122 , Issue.21
    • Frankel, A.E.1    Woo, J.H.2    Mauldin, J.P.3    Carraway, H.E.4    Frankfurt, O.5    Forman, S.J.6
  • 33
    • 84875382111 scopus 로고    scopus 로고
    • Distinguishing hairy cell leukemia variant from hairy cell leukemia: development and validation of diagnostic criteria
    • 10.1016/j.leukres.2012.11.021, 23347903
    • Shao K, Calvo KR, Grouborg M, Temhore PR, Kreitman RJ, Stetler-Stevenson M, Yuan CM. Distinguishing hairy cell leukemia variant from hairy cell leukemia: development and validation of diagnostic criteria. Leuk Res 2013, 37(4):401-409. 10.1016/j.leukres.2012.11.021, 23347903.
    • (2013) Leuk Res , vol.37 , Issue.4 , pp. 401-409
    • Shao, K.1    Calvo, K.R.2    Grouborg, M.3    Temhore, P.R.4    Kreitman, R.J.5    Stetler-Stevenson, M.6    Yuan, C.M.7
  • 34
    • 80053532947 scopus 로고    scopus 로고
    • Characteristic CD103 and CD123 expression pattern defines hairy cell leukemia
    • 10.1309/AJCPKUM9J4IXCWEU, 21917686
    • Venkataram G, Aguhar C, Kretiman R, Yuan C, Stetler-Stevenson M. Characteristic CD103 and CD123 expression pattern defines hairy cell leukemia. Am J Clin Pathol 2011, 136(4):625-630. 10.1309/AJCPKUM9J4IXCWEU, 21917686.
    • (2011) Am J Clin Pathol , vol.136 , Issue.4 , pp. 625-630
    • Venkataram, G.1    Aguhar, C.2    Kretiman, R.3    Yuan, C.4    Stetler-Stevenson, M.5
  • 35
    • 0037108559 scopus 로고    scopus 로고
    • Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced bast proliferation, increased cellularity and poor prognosis
    • 10.1182/blood-2002-03-0852, 12351411
    • Testa U, Riccioni R, Coccia E, Stellacci E, Samoggia P, Latagliata R, Latagliata R, Mariani G, Rossini A, Battistini A, Lo-Coco F, Peschle C. Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced bast proliferation, increased cellularity and poor prognosis. Blood 2002, 100(8):2980-2988. 10.1182/blood-2002-03-0852, 12351411.
    • (2002) Blood , vol.100 , Issue.8 , pp. 2980-2988
    • Testa, U.1    Riccioni, R.2    Coccia, E.3    Stellacci, E.4    Samoggia, P.5    Latagliata, R.6    Latagliata, R.7    Mariani, G.8    Rossini, A.9    Battistini, A.10    Lo-Coco, F.11    Peschle, C.12
  • 36
    • 67650718769 scopus 로고    scopus 로고
    • Overexpression of CD123 correlates with hyperdiploid genotype in acute lymphoblastic leukemia
    • 10.3324/haematol.2008.000299, 2704314, 19454491
    • Djokic M, Bjorklund E, Blennow E, Mazur J, Soderhall S, Powirt A. Overexpression of CD123 correlates with hyperdiploid genotype in acute lymphoblastic leukemia. Haematologica 2009, 94(7):1016-1019. 10.3324/haematol.2008.000299, 2704314, 19454491.
    • (2009) Haematologica , vol.94 , Issue.7 , pp. 1016-1019
    • Djokic, M.1    Bjorklund, E.2    Blennow, E.3    Mazur, J.4    Soderhall, S.5    Powirt, A.6
  • 37
    • 70349572488 scopus 로고    scopus 로고
    • Distinct expression patterns of CD123 and CD 34 on normal bone marrow B-cell precursors (" hematogenes" ) and B lymphoblastic leukemia blasts
    • 10.1309/AJCPO4DS0GTLSOEI, 19762535
    • Hassanein N, Alcancia F, Perkinson K, Buckley P, Lagoo A. Distinct expression patterns of CD123 and CD 34 on normal bone marrow B-cell precursors (" hematogenes" ) and B lymphoblastic leukemia blasts. Am J Clin Pathol 2009, 132(4):573-580. 10.1309/AJCPO4DS0GTLSOEI, 19762535.
    • (2009) Am J Clin Pathol , vol.132 , Issue.4 , pp. 573-580
    • Hassanein, N.1    Alcancia, F.2    Perkinson, K.3    Buckley, P.4    Lagoo, A.5
  • 40
    • 1242307379 scopus 로고    scopus 로고
    • Interleukin 3 receptor in acute leukemia
    • 10.1038/sj.leu.2403224, 14671644
    • Testa U, Riccioni R, Diverio D, Rossini A, Lo-Coco F, Peschle C. Interleukin 3 receptor in acute leukemia. Leukemia 2004, 18(2):219-226. 10.1038/sj.leu.2403224, 14671644.
    • (2004) Leukemia , vol.18 , Issue.2 , pp. 219-226
    • Testa, U.1    Riccioni, R.2    Diverio, D.3    Rossini, A.4    Lo-Coco, F.5    Peschle, C.6
  • 41
    • 58449106592 scopus 로고    scopus 로고
    • Interleukin (IL)-3/granulocyte macrophage-colony stimulating factor/IL-5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukemias with mutated FMS-related tyrosine kinase 3 receptor
    • Riccioni R, Diverio D, Riti V, Buffolino S, Mariani G, Boe A, Cedrone M, Ottone T, Foà R, Testa U. Interleukin (IL)-3/granulocyte macrophage-colony stimulating factor/IL-5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukemias with mutated FMS-related tyrosine kinase 3 receptor. Brit J Haematol 2009, 144(3):376-387.
    • (2009) Brit J Haematol , vol.144 , Issue.3 , pp. 376-387
    • Riccioni, R.1    Diverio, D.2    Riti, V.3    Buffolino, S.4    Mariani, G.5    Boe, A.6    Cedrone, M.7    Ottone, T.8    Foà, R.9    Testa, U.10
  • 42
    • 79952590045 scopus 로고    scopus 로고
    • Immunophenotypic features of acute myeloid leukemia patients exhibiting high Flt3 expression not associated with mutations
    • Riccioni R, Pelosi E, Riti V, Castelli G, Lo-Coco F, Testa U. Immunophenotypic features of acute myeloid leukemia patients exhibiting high Flt3 expression not associated with mutations. Brit J Haematol 2011, 153:33-42.
    • (2011) Brit J Haematol , vol.153 , pp. 33-42
    • Riccioni, R.1    Pelosi, E.2    Riti, V.3    Castelli, G.4    Lo-Coco, F.5    Testa, U.6
  • 46
    • 84867336583 scopus 로고    scopus 로고
    • Flow cytometric quantification and immunophenotyping of leukemic stem cells in acute myeloid leukemia
    • 10.1007/s00277-012-1501-7, 22669506
    • Hwang K, Park CJ, Jang S, Chi HS, Kim DY, Lee JH, Im HJ, Seo JJ. Flow cytometric quantification and immunophenotyping of leukemic stem cells in acute myeloid leukemia. Ann Hematol 2012, 91(10):1541-1546. 10.1007/s00277-012-1501-7, 22669506.
    • (2012) Ann Hematol , vol.91 , Issue.10 , pp. 1541-1546
    • Hwang, K.1    Park, C.J.2    Jang, S.3    Chi, H.S.4    Kim, D.Y.5    Lee, J.H.6    Im, H.J.7    Seo, J.J.8
  • 48
    • 79955952683 scopus 로고    scopus 로고
    • Overexpression of IL-3Ralpha on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML
    • 10.1182/blood-2010-09-309179, 3087476, 21330473
    • Du W, Li XE, Sipple J, Pang Q. Overexpression of IL-3Ralpha on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML. Blood 2011, 117(16):4243-4252. 10.1182/blood-2010-09-309179, 3087476, 21330473.
    • (2011) Blood , vol.117 , Issue.16 , pp. 4243-4252
    • Du, W.1    Li, X.E.2    Sipple, J.3    Pang, Q.4
  • 49
    • 84881478666 scopus 로고    scopus 로고
    • Minimal residual disease in acute myeloid leukemia
    • 10.1038/nrclinonc.2013.100, 23799371
    • Hourigan CS, Karp JE. Minimal residual disease in acute myeloid leukemia. Nat Rev Clin Oncol 2013, 10(8):460-471. 10.1038/nrclinonc.2013.100, 23799371.
    • (2013) Nat Rev Clin Oncol , vol.10 , Issue.8 , pp. 460-471
    • Hourigan, C.S.1    Karp, J.E.2
  • 50
    • 84155172363 scopus 로고    scopus 로고
    • Expression of the hMICL in acute myeloid leukemia-a highly reliable disease marker at diagnosis and during follow-up
    • Larsen HO, Roug AS, Just J, Brown GD, Hokland P. Expression of the hMICL in acute myeloid leukemia-a highly reliable disease marker at diagnosis and during follow-up. Cytometry 2012, 82(1):3-8.
    • (2012) Cytometry , vol.82 , Issue.1 , pp. 3-8
    • Larsen, H.O.1    Roug, A.S.2    Just, J.3    Brown, G.D.4    Hokland, P.5
  • 51
    • 84891624172 scopus 로고    scopus 로고
    • HMICL and CD123 in combination with a CD45/CD34/CD117 backbone - a universal marker combination for the detection of minimal residual disease in acute myeloid leukemia
    • Roug AS, Larsen HO, Nedeiby L, Just T, Brown G, Nyvold C, Ommen H, Hokland P. hMICL and CD123 in combination with a CD45/CD34/CD117 backbone - a universal marker combination for the detection of minimal residual disease in acute myeloid leukemia. Brit J Haematol 2014, 164(1):212-222.
    • (2014) Brit J Haematol , vol.164 , Issue.1 , pp. 212-222
    • Roug, A.S.1    Larsen, H.O.2    Nedeiby, L.3    Just, T.4    Brown, G.5    Nyvold, C.6    Ommen, H.7    Hokland, P.8
  • 52
    • 84943565318 scopus 로고    scopus 로고
    • Unraveling the leukemic nature of hMICL and CD123 expressing cells in acute myeloid leukemia
    • Abstract 2626
    • Nederby L, Hokland P, Brown G, Hansen M, Nyvold CG, Roug AS. Unraveling the leukemic nature of hMICL and CD123 expressing cells in acute myeloid leukemia. Blood 2013, 122:Abstract 2626.
    • (2013) Blood , vol.122
    • Nederby, L.1    Hokland, P.2    Brown, G.3    Hansen, M.4    Nyvold, C.G.5    Roug, A.S.6
  • 55
    • 3042813426 scopus 로고    scopus 로고
    • Toxicology and pharmacokinetics of DT388IL3, a fusion protein consisting of a truncated diphteria toxin (DT388) linked to human interleukin 3 (IL3) in cymolgous monkeys
    • Cohen KA, Liu TF, Cline JM, Wagner JD, Hall PD, Frankel AE. Toxicology and pharmacokinetics of DT388IL3, a fusion protein consisting of a truncated diphteria toxin (DT388) linked to human interleukin 3 (IL3) in cymolgous monkeys. Leuk Lymphoma 2004, 45(9):1647-1656.
    • (2004) Leuk Lymphoma , vol.45 , Issue.9 , pp. 1647-1656
    • Cohen, K.A.1    Liu, T.F.2    Cline, J.M.3    Wagner, J.D.4    Hall, P.D.5    Frankel, A.E.6
  • 56
    • 22144433750 scopus 로고    scopus 로고
    • Safety evaluation of DT388IL3, a diphteria toxin/interleukin 3 fusion protein, in the cynomolgus monkey
    • Cohen KA, Liu TF, Cline JM, Wagner JD, Hall PD, Frankel AE. Safety evaluation of DT388IL3, a diphteria toxin/interleukin 3 fusion protein, in the cynomolgus monkey. Cancer Immunol Immunother 2005, 54(5):799-806.
    • (2005) Cancer Immunol Immunother , vol.54 , Issue.5 , pp. 799-806
    • Cohen, K.A.1    Liu, T.F.2    Cline, J.M.3    Wagner, J.D.4    Hall, P.D.5    Frankel, A.E.6
  • 57
    • 27144451436 scopus 로고    scopus 로고
    • Diphteria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression
    • 10.1182/blood-2005-02-0540, 1895267, 15928038
    • Testa U, Riccioni R, Biffoni M, Diverio D, Lo-Coco F, Foà R, Peschle C, Frankel A. Diphteria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression. Blood 2005, 106(7):2527-2529. 10.1182/blood-2005-02-0540, 1895267, 15928038.
    • (2005) Blood , vol.106 , Issue.7 , pp. 2527-2529
    • Testa, U.1    Riccioni, R.2    Biffoni, M.3    Diverio, D.4    Lo-Coco, F.5    Foà, R.6    Peschle, C.7    Frankel, A.8
  • 58
    • 33751174737 scopus 로고    scopus 로고
    • Expression of interleukin-3 receptor subunits on defined subpopulations of acute myeloid leukemia blasts predicts the cytotoxicity of diphteria toxin interleukin-3 fusion protein against malignant progenitors that engraft in immunodeficient mice
    • 10.1182/blood-2006-04-013813, 16882709
    • Yalcintepe L, Frankel AE, Hogge DE. Expression of interleukin-3 receptor subunits on defined subpopulations of acute myeloid leukemia blasts predicts the cytotoxicity of diphteria toxin interleukin-3 fusion protein against malignant progenitors that engraft in immunodeficient mice. Blood 2006, 108(10):3530-3537. 10.1182/blood-2006-04-013813, 16882709.
    • (2006) Blood , vol.108 , Issue.10 , pp. 3530-3537
    • Yalcintepe, L.1    Frankel, A.E.2    Hogge, D.E.3
  • 59
    • 33644755626 scopus 로고    scopus 로고
    • Variant diphteria toxin-interleukin-3 fusion proteins with increased receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors
    • 10.1158/1078-0432.CCR-05-2070, 16489085
    • Hogge DE, Yalcintepe L, Wong SH, Gerhard B, Frankel AE. Variant diphteria toxin-interleukin-3 fusion proteins with increased receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors. Clin Cancer Res 2006, 12(4):1284-1291. 10.1158/1078-0432.CCR-05-2070, 16489085.
    • (2006) Clin Cancer Res , vol.12 , Issue.4 , pp. 1284-1291
    • Hogge, D.E.1    Yalcintepe, L.2    Wong, S.H.3    Gerhard, B.4    Frankel, A.E.5
  • 61
    • 80052622425 scopus 로고    scopus 로고
    • Auger electron radioimmunotherapeutic agent specific for the CD123+/CD131- phenotype of the leukemia stem cell population
    • 10.2967/jnumed.111.087668, 21816968
    • Leyton JV, Hu M, Gao C, Turner PV, Dick JE, Minden M, Reilly RM. Auger electron radioimmunotherapeutic agent specific for the CD123+/CD131- phenotype of the leukemia stem cell population. J Nucl Med 2011, 52(9):1465-1473. 10.2967/jnumed.111.087668, 21816968.
    • (2011) J Nucl Med , vol.52 , Issue.9 , pp. 1465-1473
    • Leyton, J.V.1    Hu, M.2    Gao, C.3    Turner, P.V.4    Dick, J.E.5    Minden, M.6    Reilly, R.M.7
  • 63
    • 85062924967 scopus 로고    scopus 로고
    • Pharmacodynamic activity and preclinical safety of CSL363, a novel humanised, affinity-matured monoclonal antibody against haman interleukin 3 receptor
    • Abstract 1524
    • Herzog E, Busfield S, Biondo M, Vairo G, DeWitte M, Pragst I, Dickneite G, Nash A, Zollner S. Pharmacodynamic activity and preclinical safety of CSL363, a novel humanised, affinity-matured monoclonal antibody against haman interleukin 3 receptor. Blood 2012, 120:Abstract 1524.
    • (2012) Blood , vol.120
    • Herzog, E.1    Busfield, S.2    Biondo, M.3    Vairo, G.4    DeWitte, M.5    Pragst, I.6    Dickneite, G.7    Nash, A.8    Zollner, S.9
  • 64
    • 84902177820 scopus 로고    scopus 로고
    • A neutralizing antibody (CSL362) against the interleukin-3 receptor alpha-chain augments the efficacy of a cytabarine/daunorubicin induction-type therapy in preclinical xenograft models of acute myelogenous leukemia
    • Abstract 3599
    • Lee EM, Yee D, Busfield S, Vairo G, Lock R. A neutralizing antibody (CSL362) against the interleukin-3 receptor alpha-chain augments the efficacy of a cytabarine/daunorubicin induction-type therapy in preclinical xenograft models of acute myelogenous leukemia. Blood 2012, 120:Abstract 3599.
    • (2012) Blood , vol.120
    • Lee, E.M.1    Yee, D.2    Busfield, S.3    Vairo, G.4    Lock, R.5
  • 66
    • 84866996937 scopus 로고    scopus 로고
    • Engineering of a CD123xCD3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells
    • Kuo SR, Wong L, Liu JS. Engineering of a CD123xCD3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells. Protein Eng Des Sel 2012, 25(7):561-569.
    • (2012) Protein Eng Des Sel , vol.25 , Issue.7 , pp. 561-569
    • Kuo, S.R.1    Wong, L.2    Liu, J.S.3
  • 68
    • 77649225962 scopus 로고    scopus 로고
    • Novel conjugates of single chain Fv antibody fragments specific for stem cell antigen CD123 mediate potent death of acute myeloid leukemia cells
    • Stein C, Kellner C, Kugler M, Reiff N, Mentz K, Schwenkert M, Stockmeyer B, Mackensen A, Fey GH. Novel conjugates of single chain Fv antibody fragments specific for stem cell antigen CD123 mediate potent death of acute myeloid leukemia cells. Brit J Haematol 2010, 148(6):879-889.
    • (2010) Brit J Haematol , vol.148 , Issue.6 , pp. 879-889
    • Stein, C.1    Kellner, C.2    Kugler, M.3    Reiff, N.4    Mentz, K.5    Schwenkert, M.6    Stockmeyer, B.7    Mackensen, A.8    Fey, G.H.9
  • 72
    • 84902585692 scopus 로고    scopus 로고
    • Anti-CD123 chimeric antigen receptor T cells (CART-123) provide a novel myeloablative conditioning regimen that eradicates human acute myeloid leukemia in preclinical models
    • Abstract 143
    • Gill S, Tasian S, Ruella M, Shestova O, Li Y, Porter DL, Carroll M, Danet-Desoyers G, Scholler J, Grupp SA, June CH, Kalos M. Anti-CD123 chimeric antigen receptor T cells (CART-123) provide a novel myeloablative conditioning regimen that eradicates human acute myeloid leukemia in preclinical models. Blood 2013, 122:Abstract 143.
    • (2013) Blood , vol.122
    • Gill, S.1    Tasian, S.2    Ruella, M.3    Shestova, O.4    Li, Y.5    Porter, D.L.6    Carroll, M.7    Danet-Desoyers, G.8    Scholler, J.9    Grupp, S.A.10    June, C.H.11    Kalos, M.12
  • 73
    • 84904505489 scopus 로고    scopus 로고
    • Activity and tolerability of SL-401, a targeted therapy directed to the interleukin-3 receptor on cancer stem cells and tumor bulk, as a single agent in patients with advanced hematologic malignancies
    • 7029
    • Frankel AE, Konopleva M, Hogge D, Rizzieri D, Brooks C, Cirrito T, et al. Activity and tolerability of SL-401, a targeted therapy directed to the interleukin-3 receptor on cancer stem cells and tumor bulk, as a single agent in patients with advanced hematologic malignancies. J Clin Oncol 2013, 31(suppl):abstract nr 7029.
    • (2013) J Clin Oncol , vol.31
    • Frankel, A.E.1    Konopleva, M.2    Hogge, D.3    Rizzieri, D.4    Brooks, C.5    Cirrito, T.6
  • 74
    • 85011732970 scopus 로고    scopus 로고
    • A phase I study of anti-CD123 monoclonal antibody (CD123) CSL360 targeting leukemia stem cells (LSC) in AML
    • e13012
    • Roberts AW, He S, Ritchie D, Hertzberg MS, Kerridge I, et al. A phase I study of anti-CD123 monoclonal antibody (CD123) CSL360 targeting leukemia stem cells (LSC) in AML. J Clin Oncol 2010, 28:abstract nr e13012.
    • (2010) J Clin Oncol , vol.28
    • Roberts, A.W.1    He, S.2    Ritchie, D.3    Hertzberg, M.S.4    Kerridge, I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.