Overexpression of CD123 correlates with the hyperdiploid genotype in acute lymphoblastic leukemia

Haematologica

Volumn 94, Issue 7, 2009, Pages 1016-1019

  Djokic, Miroslav ^a,d   Björklund, Elisabet ^a   Blennow, Elisabeth ^b   Mazur, Joanna ^c   Söderhäll, Stefan ^a   Porwit, Anna ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c INSTITUTE OF MOTHER AND CHILD   (Poland)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

CD123; Hyperdiploid genotype; Overexpression

Indexed keywords

CD123 ANTIGEN; DIPHTHERIA TOXIN; DIPHTHERIA TOXIN INTERLEUKIN 3 FUSION PROTEIN; HYBRID PROTEIN; INTERLEUKIN 3; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ANTIGEN EXPRESSION; ARTICLE; BLOOD; BONE MARROW BIOPSY; CANCER CHEMOTHERAPY; CHILD; CHILDHOOD LEUKEMIA; CHROMOSOME; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DRUG TARGETING; FLUORESCENCE IN SITU HYBRIDIZATION; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENOTYPE; HUMAN; HUMAN CELL; HYPERDIPLOID GENOTYPE; IMMUNOPHENOTYPING; KARYOTYPE; LEUKEMIA CELL; LYMPH NODE BIOPSY; MAJOR CLINICAL STUDY; MINIMAL RESIDUAL DISEASE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRE B LYMPHOCYTE; PROGNOSIS;

ADOLESCENT; ADULT; AGE FACTORS; AGED; CHILD; CHILD, PRESCHOOL; DIPLOIDY; GENE EXPRESSION REGULATION, LEUKEMIC; GENOTYPE; HUMANS; INFANT; INFANT, NEWBORN; INTERLEUKIN-3 RECEPTOR ALPHA SUBUNIT; KARYOTYPING; MIDDLE AGED; PHENOTYPE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 67650718769     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2008.000299     Document Type: Article

References (18)

1. Blalock WL, Weinstein-Oppenheimer C, Chang F, Hoyle PE, Wang XY, Algate PA, et al. Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with antineoplastic drugs. Leukemia 1999;13: 1109-66.
2. Miyajima A, Kitamura T, Harada N, Yokota T, Arai K. Cytokine receptors and signal transduction. Annu Rev Immunol 1992;10:295-31.
3. Rapoport AP, Luhowskyj S, Doshi P, DiPersio JF. Mutational analysis of the α subunit of the human interleukin-3 receptor. Blood 1996;87: 112-22.
4. Kremer E, Baker E, D'Andrea RJ, Slim R, Phillips H, Moretti PA, et al. A cytokine receptor gene cluster in the X-Y pseudoautosomal region? Blood 1993;82:22-8.
5. Uckun FM, Gesner TG, Song CW, Myers DE, Mufson A. Leukemic Bcell precursors express functional receptors for human interleukin-3. Blood 1989;73:533-42.
6. Zhou M, Gu L, Holden J, Yeager AM, Findley HW. CD40 ligand upregulates expression of the IL-3 receptor and stimulates proliferation of B-lineage acute lymphoblastic leukemia cells in the presence of IL-3. Leukemia 2000;14:403-11.
7. Munoz L, Nomdedeu JF, Lopez O, Carnicer MJ, Bellido M, Aventin A, et al. Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignancies. Haematologica 2001;86:1261-9.
8. Testa U, Torelli GF, Riccioni R, Muta AO, Militi S, Annino L, et al. Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors. Blood 2002;99:4634-7.
9. Brunning R. B precursor leukemia/ lymphoma. In: Jaffe E Harris N, Stein H, Vardiman J, editors. Pathology and Genetics: Tumors of Haematopoietic system. Lyon, France: IARC Press; 2001. p.111-4.
10. Bene MC. Immunophenotyping of acute leukaemias. Immunol Lett 2005;98:9-21.
11. Kuchinskaya E, Heyman M, Grander D, Linderholm M, Soderhall S, Zaritskey A, et al. Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles. Eur J Haematol 2005; 74:466-80.
12. Lucio P, Parreira A, van den Beemd MW, van Lochem EG, van Wering ER, Baars E, et al. Flow cytometric analysis of normal B cell differentiation: a frame of reference for the detection of minimal residual disease in precursor-B-ALL. Leukemia 1999; 13:419-27.
13. Bjorklund E, Mazur J, Soderhall S, Porwit-MacDonald A. Flow cytometric follow-up of minimal residual disease in bone marrow gives prognostic information in children with acute lymphoblastic leukemia. Leukemia 2003;17:138-48.
14. Lhermitte L, de LA, Dupret C, Lapillonne H, Millien C, Landman-Parker J, et al. Most immature TALLs express Ra-IL3 (CD123): possible target for DT-IL3 therapy. Leukemia 2006;20:1908-10.
15. Gaipa G, Basso G, Maglia O, Leoni V, Faini A, Cazzaniga G, et al. I-BFMALL-FCM-MRD Study Group. Druginduced immunophenotypic modulation in childhood ALL: implications for minimal residual disease detection. Leukemia 2005;19:49-56.
16. Testa U, Riccioni R, Diverio D, Rossini A, Lo CF, Peschle C. Interleukin-3 receptor in acute leukemia. Leukemia 2004;18:219-26.
17. Heinonen K, Mahlamäki E, Riikonen P, Meltoranta RL, Rahiala J, Perkkiö M. Acquired X-chromosome aneuploidy in children with acute lymphoblastic leukemia. Med Pediatr Oncol 1999;32:360-5.
18. Testa U, Riccioni R, Biffoni M, Diverio D, Lo-Coco F, Foa R, et al. Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression. Blood 2005;106:2527-9.