Pharmacodynamic change in plasma angiogenic proteins: A dose-escalation phase 1 study of the multi-kinase inhibitor lenvatinib

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Koyama, Noriyuki ^a   Saito, Kenichi ^a   Nishioka, Yuki ^a   Yusa, Wataru ^a   Yamamoto, Noboru ^b   Yamada, Yasuhide ^b   Nokihara, Hiroshi ^b   Koizumi, Fumiaki ^b   Nishio, Kazuto ^c   Tamura, Tomohide ^b  

^a EISAI CO LTD   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL   (Japan)

^c KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiogenesis; Lenvatinib; Maximum tumor shrinkage; Pharmacodynamic biomarkers; SDF1 ; sVEGFR2; VEGF

Indexed keywords

ANGIOGENIC PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; LENVATINIB; PLATELET DERIVED GROWTH FACTOR BB; SCATTER FACTOR; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1ALPHA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; CARBANILAMIDE DERIVATIVE; PHARMACOLOGICAL BIOMARKER; PLASMA PROTEIN; PROTEIN KINASE INHIBITOR; QUINOLINE DERIVATIVE;

ADVANCED CANCER; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG EXPOSURE; DRUG RESPONSE; DRUG SAFETY; FATIGUE; HUMAN; HYPERTENSION; MULTIPLE CYCLE TREATMENT; ONCOLOGICAL PARAMETERS; OPEN STUDY; OUTCOME ASSESSMENT; PHARMACODYNAMICS; PHASE 1 CLINICAL TRIAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEINURIA; SOLID TUMOR; TUMOR SHRINKAGE; TUMOR VASCULARIZATION; BLOOD; CLINICAL TRIAL; DISEASE COURSE; DRUG ADMINISTRATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; NEOPLASMS; PATHOLOGY; TREATMENT OUTCOME;

ANGIOGENIC PROTEINS; BIOMARKERS, PHARMACOLOGICAL; BLOOD PROTEINS; DISEASE PROGRESSION; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; PHENYLUREA COMPOUNDS; PROTEIN KINASE INHIBITORS; QUINOLINES; TREATMENT OUTCOME;

EID: 84904445789     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-530     Document Type: Article

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