Molecular modeling study on the structural basis of binding mechanism of C6-substituted phthalides with monoamine oxidases

Medicinal Chemistry Research

Volumn 23, Issue 8, 2014, Pages 3624-3631

  Li, Pei Zhen ^a   Tian, Yue Li ^a   Zhai, Hong Lin ^a   Deng, Fang Fang ^a   Xie, Mei Hong ^a   Zhang, Xiao Yun ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Binding mode; Molecular docking; Monoamine oxidase; Phthalide

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; MONOAMINE OXIDASE INHIBITOR; PHTHALIDE DERIVATIVE;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; DEGENERATIVE DISEASE; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; PARKINSON DISEASE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 84904444325     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-014-0941-0     Document Type: Article

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