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Volumn 51, Issue 3, 2014, Pages 168-176

Microenvironmental Interactions in Chronic Lymphocytic Leukemia: The Master Role of CD49d

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; B LYMPHOCYTE RECEPTOR; BRUTON TYROSINE KINASE INHIBITOR; CD38 ANTIGEN;

EID: 84904429269     PISSN: 00371963     EISSN: 15328686     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2014.05.002     Document Type: Article
Times cited : (33)

References (95)
  • 2
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin G.A., Dumitru C.D., Shimizu M., et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002, 99:15524-15529.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3
  • 3
    • 73649116987 scopus 로고    scopus 로고
    • The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia
    • Klein U., Lia M., Crespo M., et al. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 2010, 17:28-40.
    • (2010) Cancer Cell , vol.17 , pp. 28-40
    • Klein, U.1    Lia, M.2    Crespo, M.3
  • 4
    • 0042971643 scopus 로고    scopus 로고
    • B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor
    • Chiorazzi N., Ferrarini M. B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Annu Rev Immunol 2003, 21:841-894.
    • (2003) Annu Rev Immunol , vol.21 , pp. 841-894
    • Chiorazzi, N.1    Ferrarini, M.2
  • 5
    • 79951498701 scopus 로고    scopus 로고
    • Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities
    • Chiorazzi N., Ferrarini M. Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood 2011, 117:1781-1791.
    • (2011) Blood , vol.117 , pp. 1781-1791
    • Chiorazzi, N.1    Ferrarini, M.2
  • 6
    • 84899742457 scopus 로고    scopus 로고
    • CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia
    • Bulian P., Shanafelt T.D., Fegan C., et al. CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia. J Clin Oncol 2014, 32:897-904.
    • (2014) J Clin Oncol , vol.32 , pp. 897-904
    • Bulian, P.1    Shanafelt, T.D.2    Fegan, C.3
  • 7
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle R.N., Wasil T., Fais F., et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999, 94:1840-1847.
    • (1999) Blood , vol.94 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 8
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Dohner H., Stilgenbauer S., Benner A., et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000, 343:1910-1916.
    • (2000) N Engl J Med , vol.343 , pp. 1910-1916
    • Dohner, H.1    Stilgenbauer, S.2    Benner, A.3
  • 9
    • 38349084386 scopus 로고    scopus 로고
    • Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia
    • Gattei V., Bulian P., Del Principe M.I., et al. Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia. Blood 2008, 111:865-873.
    • (2008) Blood , vol.111 , pp. 865-873
    • Gattei, V.1    Bulian, P.2    Del Principe, M.I.3
  • 10
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) Genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin T.J., Davis Z., Gardiner A., Oscier D.G., Stevenson F.K., Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999, 94:1848-1854.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 11
    • 61549089361 scopus 로고    scopus 로고
    • The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness
    • Rossi D., Cerri M., Deambrogi C., et al. The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness. Clin Cancer Res 2009, 15:995-1004.
    • (2009) Clin Cancer Res , vol.15 , pp. 995-1004
    • Rossi, D.1    Cerri, M.2    Deambrogi, C.3
  • 12
    • 79551504914 scopus 로고    scopus 로고
    • TP53 mutation and survival in chronic lymphocytic leukemia
    • Zenz T., Eichhorst B., Busch R., et al. TP53 mutation and survival in chronic lymphocytic leukemia. J Clin Oncol 2010, 28:4473-4479.
    • (2010) J Clin Oncol , vol.28 , pp. 4473-4479
    • Zenz, T.1    Eichhorst, B.2    Busch, R.3
  • 13
    • 84863527866 scopus 로고    scopus 로고
    • Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapy
    • Dal B.o.M., Bomben R., Zucchetto A., et al. Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapy. Curr Pharm Des 2012, 18:3323-3334.
    • (2012) Curr Pharm Des , vol.18 , pp. 3323-3334
    • Dal, B.1    Bomben, R.2    Zucchetto, A.3
  • 14
    • 78751549662 scopus 로고    scopus 로고
    • The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
    • Herishanu Y., Perez-Galan P., Liu D., et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood 2011, 117:563-574.
    • (2011) Blood , vol.117 , pp. 563-574
    • Herishanu, Y.1    Perez-Galan, P.2    Liu, D.3
  • 15
    • 84891373281 scopus 로고    scopus 로고
    • Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial
    • O'Brien S., Furman R.R., Coutre S.E., et al. Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial. Lancet Oncol 2014, 15:48-58.
    • (2014) Lancet Oncol , vol.15 , pp. 48-58
    • O'Brien, S.1    Furman, R.R.2    Coutre, S.E.3
  • 16
    • 77951002653 scopus 로고    scopus 로고
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
    • Friedberg J.W., Sharman J., Sweetenham J., et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood 2010, 115:2578-2585.
    • (2010) Blood , vol.115 , pp. 2578-2585
    • Friedberg, J.W.1    Sharman, J.2    Sweetenham, J.3
  • 17
    • 80053345977 scopus 로고    scopus 로고
    • The phosphoinositide 3[U+05F3]-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
    • Hoellenriegel J., Meadows S.A., Sivina M., et al. The phosphoinositide 3[U+05F3]-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood 2011, 118:3603-3612.
    • (2011) Blood , vol.118 , pp. 3603-3612
    • Hoellenriegel, J.1    Meadows, S.A.2    Sivina, M.3
  • 18
    • 66149112944 scopus 로고    scopus 로고
    • Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow
    • Hartmann T.N., Grabovsky V., Wang W., et al. Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow. Cancer Res 2009, 69:3121-3130.
    • (2009) Cancer Res , vol.69 , pp. 3121-3130
    • Hartmann, T.N.1    Grabovsky, V.2    Wang, W.3
  • 19
    • 0030048565 scopus 로고    scopus 로고
    • Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro
    • Panayiotidis P., Jones D., Ganeshaguru K., Foroni L., Hoffbrand A.V. Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. Br J Haematol 1996, 92:97-103.
    • (1996) Br J Haematol , vol.92 , pp. 97-103
    • Panayiotidis, P.1    Jones, D.2    Ganeshaguru, K.3    Foroni, L.4    Hoffbrand, A.V.5
  • 20
    • 0032055818 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells
    • Lagneaux L., Delforge A., Bron D., De Bruyn C., Stryckmans P. Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells. Blood 1998, 91:2387-2396.
    • (1998) Blood , vol.91 , pp. 2387-2396
    • Lagneaux, L.1    Delforge, A.2    Bron, D.3    De Bruyn, C.4    Stryckmans, P.5
  • 21
    • 0242298176 scopus 로고    scopus 로고
    • Role of the microenvironment in chronic lymphocytic leukaemia
    • Caligaris-Cappio F. Role of the microenvironment in chronic lymphocytic leukaemia. Br J Haematol 2003, 123:380-388.
    • (2003) Br J Haematol , vol.123 , pp. 380-388
    • Caligaris-Cappio, F.1
  • 22
    • 27144549307 scopus 로고    scopus 로고
    • Differential effects on CLL cell survival exerted by different microenvironmental elements
    • Ghia P., Circosta P., Scielzo C., et al. Differential effects on CLL cell survival exerted by different microenvironmental elements. Curr Top Microbiol Immunol 2005, 294:135-145.
    • (2005) Curr Top Microbiol Immunol , vol.294 , pp. 135-145
    • Ghia, P.1    Circosta, P.2    Scielzo, C.3
  • 23
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B-cell malignancies: a target for new treatment strategies
    • Burger J.A., Ghia P., Rosenwald A., Caligaris-Cappio F. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 2009, 114:3367-3375.
    • (2009) Blood , vol.114 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3    Caligaris-Cappio, F.4
  • 24
    • 0036489442 scopus 로고    scopus 로고
    • Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine
    • de la Fuente M.T., Casanova B., Moyano J.V., et al. Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine. J Leukoc Biol 2002, 71:495-502.
    • (2002) J Leukoc Biol , vol.71 , pp. 495-502
    • de la Fuente, M.T.1    Casanova, B.2    Moyano, J.V.3
  • 25
    • 0036696904 scopus 로고    scopus 로고
    • Alpha4 integrins and the immune response
    • Rose D.M., Han J., Ginsberg M.H. Alpha4 integrins and the immune response. Immunol Rev 2002, 186:118-124.
    • (2002) Immunol Rev , vol.186 , pp. 118-124
    • Rose, D.M.1    Han, J.2    Ginsberg, M.H.3
  • 27
    • 80054086710 scopus 로고    scopus 로고
    • EMILIN1-alpha4/alpha9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation
    • Danussi C., Petrucco A., Wassermann B., et al. EMILIN1-alpha4/alpha9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation. J Cell Biol 2011, 195:131-145.
    • (2011) J Cell Biol , vol.195 , pp. 131-145
    • Danussi, C.1    Petrucco, A.2    Wassermann, B.3
  • 28
    • 84886996913 scopus 로고    scopus 로고
    • EMILIN1/alpha9beta1 integrin interaction is crucial in lymphatic valve formation and maintenance
    • Danussi C., Del Bel B.L., Pivetta E., et al. EMILIN1/alpha9beta1 integrin interaction is crucial in lymphatic valve formation and maintenance. Mol Cell Biol 2013, 33:4381-4394.
    • (2013) Mol Cell Biol , vol.33 , pp. 4381-4394
    • Danussi, C.1    Del Bel, B.L.2    Pivetta, E.3
  • 29
    • 0037089334 scopus 로고    scopus 로고
    • The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes
    • Till K.J., Lin K., Zuzel M., Cawley J.C. The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes. Blood 2002, 99:2977-2984.
    • (2002) Blood , vol.99 , pp. 2977-2984
    • Till, K.J.1    Lin, K.2    Zuzel, M.3    Cawley, J.C.4
  • 30
    • 20444366561 scopus 로고    scopus 로고
    • But not normal, B cells are dependent on autocrine VEGF and alpha4beta1 integrin for chemokine-induced motility on and through endothelium
    • Till K.J., Spiller D.G., Harris R.J., Chen H., Zuzel M., CLL Cawley JC. but not normal, B cells are dependent on autocrine VEGF and alpha4beta1 integrin for chemokine-induced motility on and through endothelium. Blood 2005, 105:4813-4819.
    • (2005) Blood , vol.105 , pp. 4813-4819
    • Till, K.J.1    Spiller, D.G.2    Harris, R.J.3    Chen, H.4    Zuzel, M.5
  • 31
    • 76249124026 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain
    • Redondo-Munoz J., Ugarte-Berzal E., Terol M.J., et al. Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain. Cancer Cell 2010, 17:160-172.
    • (2010) Cancer Cell , vol.17 , pp. 160-172
    • Redondo-Munoz, J.1    Ugarte-Berzal, E.2    Terol, M.J.3
  • 32
    • 0036105592 scopus 로고    scopus 로고
    • Production of matrix metalloproteinase-9 in early stage B-CLL: suppression by interferons
    • Bauvois B., Dumont J., Mathiot C., Kolb J.P. Production of matrix metalloproteinase-9 in early stage B-CLL: suppression by interferons. Leukemia 2002, 16:791-798.
    • (2002) Leukemia , vol.16 , pp. 791-798
    • Bauvois, B.1    Dumont, J.2    Mathiot, C.3    Kolb, J.P.4
  • 33
    • 2042545418 scopus 로고    scopus 로고
    • The role of matrix metalloproteinase 9 in the pathogenesis of chronic lymphocytic leukaemia
    • Kamiguti A.S., Lee E.S., Till K.J., et al. The role of matrix metalloproteinase 9 in the pathogenesis of chronic lymphocytic leukaemia. Br J Haematol 2004, 125:128-140.
    • (2004) Br J Haematol , vol.125 , pp. 128-140
    • Kamiguti, A.S.1    Lee, E.S.2    Till, K.J.3
  • 34
    • 33750017080 scopus 로고    scopus 로고
    • MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration
    • Redondo-Munoz J., Escobar-Diaz E., Samaniego R., Terol M.J., Garcia-Marco J.A., Garcia-Pardo A. MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration. Blood 2006, 108:3143-3151.
    • (2006) Blood , vol.108 , pp. 3143-3151
    • Redondo-Munoz, J.1    Escobar-Diaz, E.2    Samaniego, R.3    Terol, M.J.4    Garcia-Marco, J.A.5    Garcia-Pardo, A.6
  • 35
    • 47249093296 scopus 로고    scopus 로고
    • Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells
    • Redondo-Munoz J., Ugarte-Berzal E., Garcia-Marco J.A., et al. Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells. Blood 2008, 112:169-178.
    • (2008) Blood , vol.112 , pp. 169-178
    • Redondo-Munoz, J.1    Ugarte-Berzal, E.2    Garcia-Marco, J.A.3
  • 36
    • 79955601718 scopus 로고    scopus 로고
    • CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL
    • Majid A., Lin T.T., Best G., et al. CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL. Leuk Res 2011, 35:750-756.
    • (2011) Leuk Res , vol.35 , pp. 750-756
    • Majid, A.1    Lin, T.T.2    Best, G.3
  • 37
    • 0035099504 scopus 로고    scopus 로고
    • Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cells
    • Hidalgo A., Sanz-Rodriguez F., Rodriguez-Fernandez J.L., et al. Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cells. Exp Hematol 2001, 29:345-355.
    • (2001) Exp Hematol , vol.29 , pp. 345-355
    • Hidalgo, A.1    Sanz-Rodriguez, F.2    Rodriguez-Fernandez, J.L.3
  • 38
    • 0035863789 scopus 로고    scopus 로고
    • Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1
    • Sanz-Rodriguez F., Hidalgo A., Teixido J. Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1. Blood 2001, 97:346-351.
    • (2001) Blood , vol.97 , pp. 346-351
    • Sanz-Rodriguez, F.1    Hidalgo, A.2    Teixido, J.3
  • 39
    • 65949106828 scopus 로고    scopus 로고
    • CD38/CD31, the CCL3 and CCL4 chemokines, and CD49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival
    • Zucchetto A., Benedetti D., Tripodo C., et al. CD38/CD31, the CCL3 and CCL4 chemokines, and CD49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival. Cancer Res 2009, 69:4001-4009.
    • (2009) Cancer Res , vol.69 , pp. 4001-4009
    • Zucchetto, A.1    Benedetti, D.2    Tripodo, C.3
  • 41
    • 64049093376 scopus 로고    scopus 로고
    • High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation
    • Burger J.A., Quiroga M.P., Hartmann E., et al. High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation. Blood 2009, 113:3050-3058.
    • (2009) Blood , vol.113 , pp. 3050-3058
    • Burger, J.A.1    Quiroga, M.P.2    Hartmann, E.3
  • 42
    • 0034092634 scopus 로고    scopus 로고
    • International union of pharmacology. XXII. Nomenclature for chemokine receptors
    • Murphy P.M., Baggiolini M., Charo I.F., et al. International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev 2000, 52:145-176.
    • (2000) Pharmacol Rev , vol.52 , pp. 145-176
    • Murphy, P.M.1    Baggiolini, M.2    Charo, I.F.3
  • 43
    • 0035115994 scopus 로고    scopus 로고
    • Increase of CCR1 and CCR5 expression and enhanced functional response to MIP-1 alpha during differentiation of human monocytes to macrophages
    • Kaufmann A., Salentin R., Gemsa D., Sprenger H. Increase of CCR1 and CCR5 expression and enhanced functional response to MIP-1 alpha during differentiation of human monocytes to macrophages. J Leukoc Biol 2001, 69:248-252.
    • (2001) J Leukoc Biol , vol.69 , pp. 248-252
    • Kaufmann, A.1    Salentin, R.2    Gemsa, D.3    Sprenger, H.4
  • 44
    • 50949128066 scopus 로고    scopus 로고
    • BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells
    • Guarini A., Chiaretti S., Tavolaro S., et al. BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells. Blood 2008, 112:782-792.
    • (2008) Blood , vol.112 , pp. 782-792
    • Guarini, A.1    Chiaretti, S.2    Tavolaro, S.3
  • 45
    • 0034667624 scopus 로고    scopus 로고
    • Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1
    • Burger J.A., Tsukada N., Burger M., Zvaifler N.J., Dell'Aquila M., Kipps T.J. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood 2000, 96:2655-2663.
    • (2000) Blood , vol.96 , pp. 2655-2663
    • Burger, J.A.1    Tsukada, N.2    Burger, M.3    Zvaifler, N.J.4    Dell'Aquila, M.5    Kipps, T.J.6
  • 46
    • 0036464610 scopus 로고    scopus 로고
    • Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia
    • Tsukada N., Burger J.A., Zvaifler N.J., Kipps T.J. Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia. Blood 2002, 99:1030-1037.
    • (2002) Blood , vol.99 , pp. 1030-1037
    • Tsukada, N.1    Burger, J.A.2    Zvaifler, N.J.3    Kipps, T.J.4
  • 47
    • 0036099832 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22
    • Ghia P., Strola G., Granziero L., et al. Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. Eur J Immunol 2002, 32:1403-1413.
    • (2002) Eur J Immunol , vol.32 , pp. 1403-1413
    • Ghia, P.1    Strola, G.2    Granziero, L.3
  • 48
    • 0032851693 scopus 로고    scopus 로고
    • Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia
    • Kitada S., Zapata J.M., Andreeff M., Reed JC Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia. Br J Haematol 1999, 106:995-1004.
    • (1999) Br J Haematol , vol.106 , pp. 995-1004
    • Kitada, S.1    Zapata, J.M.2    Andreeff, M.3    Reed, J.C.4
  • 49
    • 79959856063 scopus 로고    scopus 로고
    • Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9
    • Buggins A.G., Levi A., Gohil S., et al. Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9. Br J Haematol 2011, 154:216-222.
    • (2011) Br J Haematol , vol.154 , pp. 216-222
    • Buggins, A.G.1    Levi, A.2    Gohil, S.3
  • 50
    • 34249986412 scopus 로고    scopus 로고
    • CD38/CD19: a lipid raft-dependent signaling complex in human B cells
    • Deaglio S., Vaisitti T., Billington R., et al. CD38/CD19: a lipid raft-dependent signaling complex in human B cells. Blood 2007, 109:5390-5398.
    • (2007) Blood , vol.109 , pp. 5390-5398
    • Deaglio, S.1    Vaisitti, T.2    Billington, R.3
  • 51
    • 33845901815 scopus 로고    scopus 로고
    • Lipid rafts: at a crossroad between cell biology and physics
    • Jacobson K., Mouritsen O.G., Anderson R.G. Lipid rafts: at a crossroad between cell biology and physics. Nat Cell Biol 2007, 9:7-14.
    • (2007) Nat Cell Biol , vol.9 , pp. 7-14
    • Jacobson, K.1    Mouritsen, O.G.2    Anderson, R.G.3
  • 52
    • 0031720629 scopus 로고    scopus 로고
    • Integrin associated proteins
    • Hemler M.E. Integrin associated proteins. Curr Opin Cell Biol 1998, 10:578-585.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 578-585
    • Hemler, M.E.1
  • 53
    • 84862016635 scopus 로고    scopus 로고
    • The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells
    • Zucchetto A., Vaisitti T., Benedetti D., et al. The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells. Leukemia 2012, 26:1301-1312.
    • (2012) Leukemia , vol.26 , pp. 1301-1312
    • Zucchetto, A.1    Vaisitti, T.2    Benedetti, D.3
  • 54
    • 18844457109 scopus 로고    scopus 로고
    • Vav promotes differentiation of human tumoral myeloid precursors
    • Bertagnolo V., Brugnoli F., Mischiati C., et al. Vav promotes differentiation of human tumoral myeloid precursors. Exp Cell Res 2005, 306:56-63.
    • (2005) Exp Cell Res , vol.306 , pp. 56-63
    • Bertagnolo, V.1    Brugnoli, F.2    Mischiati, C.3
  • 55
    • 0035473464 scopus 로고    scopus 로고
    • Vav proteins, adaptors and cell signaling
    • Bustelo X.R. Vav proteins, adaptors and cell signaling. Oncogene 2001, 20:6372-6381.
    • (2001) Oncogene , vol.20 , pp. 6372-6381
    • Bustelo, X.R.1
  • 56
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes C.D., Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995, 81:53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 58
    • 84858636448 scopus 로고    scopus 로고
    • The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
    • de Rooij M.F., Kuil A., Geest C.R., et al. The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. Blood 2012, 119:2590-2594.
    • (2012) Blood , vol.119 , pp. 2590-2594
    • de Rooij, M.F.1    Kuil, A.2    Geest, C.R.3
  • 59
    • 84863011553 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
    • Ponader S., Chen S.S., Buggy J.J., et al. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 2012, 119:1182-1189.
    • (2012) Blood , vol.119 , pp. 1182-1189
    • Ponader, S.1    Chen, S.S.2    Buggy, J.J.3
  • 60
    • 70349237504 scopus 로고    scopus 로고
    • B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406
    • Quiroga M.P., Balakrishnan K., Kurtova A.V., et al. B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood 2009, 114:1029-1037.
    • (2009) Blood , vol.114 , pp. 1029-1037
    • Quiroga, M.P.1    Balakrishnan, K.2    Kurtova, A.V.3
  • 61
    • 0033216389 scopus 로고    scopus 로고
    • Alpha4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo
    • Arroyo A.G., Yang J.T., Rayburn H., Hynes R.O. Alpha4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. Immunity 1999, 11:555-566.
    • (1999) Immunity , vol.11 , pp. 555-566
    • Arroyo, A.G.1    Yang, J.T.2    Rayburn, H.3    Hynes, R.O.4
  • 62
    • 0026035375 scopus 로고
    • Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis
    • Miyake K., Weissman I.L., Greenberger J.S., Kincade P.W. Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. J Exp Med 1991, 173:599-607.
    • (1991) J Exp Med , vol.173 , pp. 599-607
    • Miyake, K.1    Weissman, I.L.2    Greenberger, J.S.3    Kincade, P.W.4
  • 63
    • 0035911253 scopus 로고    scopus 로고
    • Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow
    • Koni P.A., Joshi S.K., Temann U.A., Olson D., Burkly L., Flavell R.A. Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med 2001, 193:741-754.
    • (2001) J Exp Med , vol.193 , pp. 741-754
    • Koni, P.A.1    Joshi, S.K.2    Temann, U.A.3    Olson, D.4    Burkly, L.5    Flavell, R.A.6
  • 64
    • 0036166387 scopus 로고    scopus 로고
    • Chemokines and the tissue-specific migration of lymphocytes
    • Kunkel E.J., Butcher E.C. Chemokines and the tissue-specific migration of lymphocytes. Immunity 2002, 16:1-4.
    • (2002) Immunity , vol.16 , pp. 1-4
    • Kunkel, E.J.1    Butcher, E.C.2
  • 65
    • 0030938144 scopus 로고    scopus 로고
    • Germinal center development
    • Liu Y.J., Arpin C. Germinal center development. Immunol Rev 1997, 156:111-126.
    • (1997) Immunol Rev , vol.156 , pp. 111-126
    • Liu, Y.J.1    Arpin, C.2
  • 66
    • 0025125351 scopus 로고
    • Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110
    • Freedman A.S., Munro J.M., Rice G.E., et al. Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110. Science 1990, 249:1030-1033.
    • (1990) Science , vol.249 , pp. 1030-1033
    • Freedman, A.S.1    Munro, J.M.2    Rice, G.E.3
  • 67
    • 0026528275 scopus 로고
    • Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro
    • Kosco M.H., Pflugfelder E., Gray D. Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro. J Immunol 1992, 148:2331-2339.
    • (1992) J Immunol , vol.148 , pp. 2331-2339
    • Kosco, M.H.1    Pflugfelder, E.2    Gray, D.3
  • 68
    • 0033010661 scopus 로고    scopus 로고
    • Genetic analysis of B cell antigen receptor signaling
    • Kurosaki T. Genetic analysis of B cell antigen receptor signaling. Annu Rev Immunol 1999, 17:555-592.
    • (1999) Annu Rev Immunol , vol.17 , pp. 555-592
    • Kurosaki, T.1
  • 69
    • 0036584284 scopus 로고    scopus 로고
    • Regulation of B-cell signal transduction by adaptor proteins
    • Kurosaki T. Regulation of B-cell signal transduction by adaptor proteins. Nat Rev Immunol 2002, 2:354-363.
    • (2002) Nat Rev Immunol , vol.2 , pp. 354-363
    • Kurosaki, T.1
  • 70
    • 0036884819 scopus 로고    scopus 로고
    • Regulation of B-cell fate by antigen-receptor signals
    • Niiro H., Clark E.A. Regulation of B-cell fate by antigen-receptor signals. Nat Rev Immunol 2002, 2:945-956.
    • (2002) Nat Rev Immunol , vol.2 , pp. 945-956
    • Niiro, H.1    Clark, E.A.2
  • 71
    • 0345016875 scopus 로고    scopus 로고
    • The B cell antigen receptor controls integrin activity through Btk and PLCgamma2
    • Spaargaren M., Beuling E.A., Rurup M.L., et al. The B cell antigen receptor controls integrin activity through Btk and PLCgamma2. J Exp Med 2003, 198:1539-1550.
    • (2003) J Exp Med , vol.198 , pp. 1539-1550
    • Spaargaren, M.1    Beuling, E.A.2    Rurup, M.L.3
  • 72
    • 84893472705 scopus 로고    scopus 로고
    • The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells
    • Fiorcari S., Brown W.S., McIntyre B.W., et al. The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells. PLoS One 2013, 8:e83830.
    • (2013) PLoS One , vol.8
    • Fiorcari, S.1    Brown, W.S.2    McIntyre, B.W.3
  • 73
    • 84891679581 scopus 로고    scopus 로고
    • CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism
    • Zucchetto A., Caldana C., Benedetti D., et al. CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism. Blood 2013, 122:3317-3321.
    • (2013) Blood , vol.122 , pp. 3317-3321
    • Zucchetto, A.1    Caldana, C.2    Benedetti, D.3
  • 74
    • 44249124028 scopus 로고    scopus 로고
    • Karyotype evolution on fluorescent in situ hybridization analysis is associated with short survival in patients with chronic lymphocytic leukemia and is related to CD49d expression
    • Shanafelt T.D., Hanson C., Dewald G.W., et al. Karyotype evolution on fluorescent in situ hybridization analysis is associated with short survival in patients with chronic lymphocytic leukemia and is related to CD49d expression. J Clin Oncol 2008, 26:e5-e6.
    • (2008) J Clin Oncol , vol.26
    • Shanafelt, T.D.1    Hanson, C.2    Dewald, G.W.3
  • 75
    • 0032855068 scopus 로고    scopus 로고
    • Evaluation of trisomy 12 by fluorescence in situ hybridization in peripheral blood, bone marrow and lymph nodes of patients with B-cell chronic lymphocytic leukemia
    • Liso V., Capalbo S., Lapietra A., Pavone V., Guarini A., Specchia G. Evaluation of trisomy 12 by fluorescence in situ hybridization in peripheral blood, bone marrow and lymph nodes of patients with B-cell chronic lymphocytic leukemia. Haematologica 1999, 84:212-217.
    • (1999) Haematologica , vol.84 , pp. 212-217
    • Liso, V.1    Capalbo, S.2    Lapietra, A.3    Pavone, V.4    Guarini, A.5    Specchia, G.6
  • 76
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: biological implications and therapeutic opportunities
    • Desgrosellier J.S., Cheresh D.A. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 2010, 10:9-22.
    • (2010) Nat Rev Cancer , vol.10 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 77
    • 0032588618 scopus 로고    scopus 로고
    • Fibronectin interaction with alpha4beta1 integrin prevents apoptosis in B cell chronic lymphocytic leukemia: correlation with Bcl-2 and Bax
    • de la Fuente M.T., Casanova B., Garcia-Gila M., Silva A., Garcia-Pardo A. Fibronectin interaction with alpha4beta1 integrin prevents apoptosis in B cell chronic lymphocytic leukemia: correlation with Bcl-2 and Bax. Leukemia 1999, 13:266-274.
    • (1999) Leukemia , vol.13 , pp. 266-274
    • de la Fuente, M.T.1    Casanova, B.2    Garcia-Gila, M.3    Silva, A.4    Garcia-Pardo, A.5
  • 78
    • 0242409826 scopus 로고    scopus 로고
    • Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine
    • de la Fuente M.T., Casanova B., Cantero E., et al. Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine. Biochem Biophys Res Commun 2003, 311:708-712.
    • (2003) Biochem Biophys Res Commun , vol.311 , pp. 708-712
    • de la Fuente, M.T.1    Casanova, B.2    Cantero, E.3
  • 79
    • 77952886100 scopus 로고    scopus 로고
    • Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia
    • Buchner M., Baer C., Prinz G., et al. Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia. Blood 2010, 115:4497-4506.
    • (2010) Blood , vol.115 , pp. 4497-4506
    • Buchner, M.1    Baer, C.2    Prinz, G.3
  • 80
    • 70349284466 scopus 로고    scopus 로고
    • The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression
    • Baudot A.D., Jeandel P.Y., Mouska X., et al. The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression. Oncogene 2009, 28:3261-3273.
    • (2009) Oncogene , vol.28 , pp. 3261-3273
    • Baudot, A.D.1    Jeandel, P.Y.2    Mouska, X.3
  • 81
    • 38349107623 scopus 로고    scopus 로고
    • The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells
    • Longo P.G., Laurenti L., Gobessi S., Sica S., Leone G., Efremov D.G. The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. Blood 2008, 111:846-855.
    • (2008) Blood , vol.111 , pp. 846-855
    • Longo, P.G.1    Laurenti, L.2    Gobessi, S.3    Sica, S.4    Leone, G.5    Efremov, D.G.6
  • 82
    • 13744254802 scopus 로고    scopus 로고
    • Protein-tyrosine kinase, Syk, is required for CXCL12-induced polarization of B cells
    • Matsusaka S., Tohyama Y., He J., et al. Protein-tyrosine kinase, Syk, is required for CXCL12-induced polarization of B cells. Biochem Biophys Res Commun 2005, 328:1163-1169.
    • (2005) Biochem Biophys Res Commun , vol.328 , pp. 1163-1169
    • Matsusaka, S.1    Tohyama, Y.2    He, J.3
  • 83
    • 20444389401 scopus 로고    scopus 로고
    • Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells
    • Petlickovski A., Laurenti L., Li X., et al. Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells. Blood 2005, 105:4820-4827.
    • (2005) Blood , vol.105 , pp. 4820-4827
    • Petlickovski, A.1    Laurenti, L.2    Li, X.3
  • 84
    • 77957366071 scopus 로고    scopus 로고
    • Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription
    • Buggins A.G., Pepper C., Patten P.E., et al. Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription. Cancer Res 2010, 70:7523-7533.
    • (2010) Cancer Res , vol.70 , pp. 7523-7533
    • Buggins, A.G.1    Pepper, C.2    Patten, P.E.3
  • 86
    • 80051833040 scopus 로고    scopus 로고
    • Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells
    • Brachtl G., Sahakyan K., Denk U., et al. Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells. PLoS One 2011, 6:e23758.
    • (2011) PLoS One , vol.6
    • Brachtl, G.1    Sahakyan, K.2    Denk, U.3
  • 87
    • 79955846227 scopus 로고    scopus 로고
    • IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells
    • Coscia M., Pantaleoni F., Riganti C., et al. IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells. Leukemia 2011, 25:828-837.
    • (2011) Leukemia , vol.25 , pp. 828-837
    • Coscia, M.1    Pantaleoni, F.2    Riganti, C.3
  • 88
    • 84895828705 scopus 로고    scopus 로고
    • CD49d expression identifies a chronic-lymphocytic leukemia subset with high levels of mobilized circulating CD34 hemopoietic progenitors cells
    • Rossi F.M., Zucchetto A., Tissino E., et al. CD49d expression identifies a chronic-lymphocytic leukemia subset with high levels of mobilized circulating CD34 hemopoietic progenitors cells. Leukemia 2014, 28:705-708.
    • (2014) Leukemia , vol.28 , pp. 705-708
    • Rossi, F.M.1    Zucchetto, A.2    Tissino, E.3
  • 89
    • 82855177892 scopus 로고    scopus 로고
    • Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells
    • Calissano C., Damle R.N., Marsilio S., et al. Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells. Mol Med 2011, 17:1374-1382.
    • (2011) Mol Med , vol.17 , pp. 1374-1382
    • Calissano, C.1    Damle, R.N.2    Marsilio, S.3
  • 90
    • 58549100059 scopus 로고    scopus 로고
    • Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study
    • Bomben R., Dal B.M., Capello D., et al. Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study. Br J Haematol 2009, 144:492-506.
    • (2009) Br J Haematol , vol.144 , pp. 492-506
    • Bomben, R.1    Dal, B.M.2    Capello, D.3
  • 91
    • 58549094492 scopus 로고    scopus 로고
    • Computational identification of CDR3 sequence archetypes among immunoglobulin sequences in chronic lymphocytic leukemia
    • Messmer B.T., Raphael B.J., Aerni S.J., et al. Computational identification of CDR3 sequence archetypes among immunoglobulin sequences in chronic lymphocytic leukemia. Leuk Res 2009, 33:368-376.
    • (2009) Leuk Res , vol.33 , pp. 368-376
    • Messmer, B.T.1    Raphael, B.J.2    Aerni, S.J.3
  • 92
    • 38949203770 scopus 로고    scopus 로고
    • Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis
    • Murray F., Darzentas N., Hadzidimitriou A., et al. Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood 2008, 111:1524-1533.
    • (2008) Blood , vol.111 , pp. 1524-1533
    • Murray, F.1    Darzentas, N.2    Hadzidimitriou, A.3
  • 93
    • 33846108722 scopus 로고    scopus 로고
    • Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
    • Stamatopoulos K., Belessi C., Moreno C., et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood 2007, 109:259-270.
    • (2007) Blood , vol.109 , pp. 259-270
    • Stamatopoulos, K.1    Belessi, C.2    Moreno, C.3
  • 94
    • 84881266955 scopus 로고    scopus 로고
    • Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia
    • Rossi D., Spina V., Bomben R., et al. Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia. Blood 2013, 121:4902-4905.
    • (2013) Blood , vol.121 , pp. 4902-4905
    • Rossi, D.1    Spina, V.2    Bomben, R.3
  • 95
    • 84887317173 scopus 로고    scopus 로고
    • Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2
    • Strefford J.C., Sutton L.A., Baliakas P., et al. Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2. Leukemia 2013, 27:2196-2199.
    • (2013) Leukemia , vol.27 , pp. 2196-2199
    • Strefford, J.C.1    Sutton, L.A.2    Baliakas, P.3


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