Selenite cataracts: Activation of endoplasmic reticulum stress and loss of Nrf2/Keap1-dependent stress protection

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1842, Issue 9, 2014, Pages 1794-1805

  Palsamy, Periyasamy ^a   Bidasee, Keshore R ^a   Shinohara, Toshimichi ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Cataract; ER stress; Human lens epithelial cells; Keap1 promoter demethylation; Sodium selenite; Unfolded protein response

Indexed keywords

DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM SELENITE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; ENZYME; GLUCOSE; GLUTATHIONE; HOMOCYSTEINE; OXIDOREDUCTASE; PROTEIN; PROTEIN GCLC; PROTEIN GCLM; PROTEIN NQO1; PROTEIN SRXN1; TET1 ENZYME; THIOREDOXIN REDUCTASE 1; TUNICAMYCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CATARACT; CATARACTOGENESIS; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CPG ISLAND; DNA FRAGMENTATION; DNA METHYLATION; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; LENS EPITHELIUM; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FOLDING; RAT; UNFOLDED PROTEIN RESPONSE; APOPTOSIS; CALCIUM HOMEOSTASIS; CELL FUNCTION; CONFOCAL LASER MICROSCOPY; DEMETHYLATION; DENSITOMETRY; EPITHELIUM CELL; HUMAN CELL; HYPOXIA; LENS CAPSULE; LIQUEFACTION; NICK END LABELING; PROTEIN DEGRADATION; PROTEIN DEPLETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SELENITE CATARACT; SUCKLING ANIMAL; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

CATARACT; ER STRESS; HUMAN LENS EPITHELIAL CELLS; KEAP1 PROMOTER DEMETHYLATION; SODIUM SELENITE; UNFOLDED PROTEIN RESPONSE;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CATARACT; CELL PROLIFERATION; CELLS, CULTURED; DNA METHYLATION; ENDOPLASMIC RETICULUM STRESS; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; EPITHELIAL CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LENS, CRYSTALLINE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SODIUM SELENITE; TRACE ELEMENTS; UNFOLDED PROTEIN RESPONSE;

EID: 84904411046     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.06.028     Document Type: Article

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