Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Aldrin Kirk, Patrick ^a   Davidsson, Marcus ^a   Holmqvist, Staffan ^a   Li, Jia Yi ^a   Björklund, Tomas ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; APOMORPHINE; CHOLINE ACETYLTRANSFERASE; PARVOVIRUS VECTOR; DOPAMINE RECEPTOR STIMULATING AGENT;

ALPHA SYNUCLEIN GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; BRAIN DISEASE; CELL LOSS; CELL NUCLEUS INCLUSION BODY; CELL STRUCTURE; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATIONAL STUDY; CORTICAL SYNUCLEINOPATHY; DIFFUSE LEWY BODY DISEASE; EXPERIMENTAL HYPERACTIVITY; EXPLORATORY BEHAVIOR; FEMALE; FOREBRAIN; GENE OVEREXPRESSION; INTERNEURON; MEMORY DISORDER; MICROGLIA; MOLECULAR PATHOLOGY; NERVE FIBER DEGENERATION; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; RAT MODEL; SYNAPSE; VIRAL GENE DELIVERY SYSTEM; WILD TYPE; ANIMAL; CELL NUCLEUS; DEPENDOPARVOVIRUS; DISEASE COURSE; DISEASE MODEL; DRUG EFFECTS; GENE VECTOR; GENETICS; HUMAN; METABOLISM; MOTOR ACTIVITY; NEOSTRIATUM; NERVE FIBER; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PREGNANCY; PROTEIN TRANSPORT; SPRAGUE DAWLEY RAT;

ALPHA-SYNUCLEIN; ANIMALS; ANIMALS, NEWBORN; AXONS; CELL NUCLEUS; CHOLINERGIC NEURONS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOPAMINE AGONISTS; EXPLORATORY BEHAVIOR; FEMALE; GENETIC VECTORS; HUMANS; INTERNEURONS; LEWY BODY DISEASE; MICROGLIA; MOTOR ACTIVITY; NEOSTRIATUM; PHENOTYPE; PREGNANCY; PROSENCEPHALON; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; SYNAPSES;

EID: 84904400256     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100869     Document Type: Article

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