Phloroglucinol induces apoptosis through the regulation of insulin-like growth factor 1 receptor signaling pathways in human colon cancer HT-29 cells

International Journal of Oncology

Volumn 45, Issue 3, 2014, Pages 1036-1042

  Kang, Mi Hye ^a   Kim, In Hye ^a   Nam, Taek Jeong ^a  

^a Pukyong National University   (South Korea)

Author keywords

Cell cycle; Insulin like growth factor 1 receptor signaling pathway; Phloroglucinol; PI3K Akt mTOR signaling pathway; Ras ERK MAPK signaling pathway

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; CASPASE INHIBITOR; CYCLIN D; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; ENZYME; FAS LIGAND; INITIATION FACTOR; INITIATION FACTOR 4B; INITIATION FACTOR RPS6; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; P70S6 KINASE; PHLOROGLUCINOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; PROTEIN P21; PROTEIN P27; RAF PROTEIN; RAS PROTEIN; RETINOBLASTOMA PROTEIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER GROWTH; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CHROMATIN; COLON CANCER; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HT 29 CELL LINE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL CYCLE; CELL PROLIFERATION; COLONIC NEOPLASMS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HT29 CELLS; HUMANS; PHLOROGLUCINOL; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION;

EID: 84904390048     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2521     Document Type: Article

References (34)

1. Matsui T, Omura K, Kawakami K, Morita S and Sakamoto J: Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer. Oncol Rep 16: 1111-1115, 2006.
2. Oehler C and Ciernik IF: Radiation therapy and combined modality treatment of gastrointestinal carcinomas. Cancer Treat Rev 32: 119-138, 2006. (Pubitemid 43362233)
3. Nagayama K, lwamura K, Shibata T, Hirayama I and Nakamura T: Bactericidal activity of phlorotannins from the brown alga Ecklonia kurom. J Antimicrob Chemother 50: 889-893, 2002. (Pubitemid 36032809)
4. Park EJ and Pezzuto JM: Botanicals in cancer chemoprevention. Cancer Metast Rev 21: 231-255, 2002. (Pubitemid 36071912)
5. Stan SD, Kar S, Stoner GD and Singh SV: Bioactive food components and cancer risk reduction. J Cell Biochem 104: 339-356, 2008.
6. Wei A, Zhou D, Xiong C, Cai Y and Ruan J: A novel non-aromatic β-ring flavonoid: isolation, structure elucidation and its induction of apoptosis in human colon HT-29 tumor cell via the reactive oxygen species-mitochondrial dysfunction and MAPK activation. Food Chem Toxicol 49: 2445-2452, 2011.
7. Hsu HF, Houng JY, Kuo CF, Tsao N and Wua YC: Glossogin, a novel phenylpropanoid from Glossogyne tenuifolia, induced apoptosis in A549 lung cancer cells. Food Chem Toxicol 46: 3785-3791, 2008.
8. Kang HS, Chung HY, Kim JY, Son BW, Jung HA and Choi JS: Inhibitory phlorotannins from the edible brown alga Ecklonia stolonifera on total reactive oxygen species (ROS) generation. Arch Pharm Res 27: 194-198, 2004.
9. Kim MM, Ta QV, Mendis E, Rajapakse N, Jung WK, Byun HG, Jeon YJ and Kim SK: Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity. Life Sci 79: 1436-1443, 2006.
10. 2+-dependent mitochondrial death pathway in human nasopharyngeal carcinoma cells. Anticancer Res 27: 3313-3322, 2007.
11. Debatin KM and Krammer PH: Death receptors in chemotherapy and cancer. Oncogene 23: 2950-2966, 2004.
12. Hu W, Lee SK, Jung MJ, Heo SI, Hur JH and Wang MH: Induction of cell cycle arrest and apoptosis by the ethyl acetate fraction of Kalopanax pictus leaves in human colon cancer cells. Bio Resour Technol 101: 9366-9372, 2010.
13. Degterev A and Yuan J: Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol 9: 378-390, 2008. (Pubitemid 351574200)
14. Tan ML, Ooi JP, Ismail N, Moad Al and Muhammad TS: Programmed cell death pathways and current antitumor targets. Pharm Res 26: 1547-1560, 2009.
15. Maddika S, Ande SR, Wiechec E, Hansen LL, Wesselborg S and Los M: Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis. J Cell Sci 121: 979-988, 2008. (Pubitemid 351639417)
16. Hengartner MO: The biochemistry of apoptosis. Nature 407: 770-776, 2000.
17. Grimm S and Brdiczka D: The permeability transition pore in cell death. Apoptosis 12: 841-855, 2007. (Pubitemid 46653295)
18. Cryns V and Yuan J: Proteases to die for. Genes Dev 12: 1551-1570, 1998. (Pubitemid 28299508)
19. Cantley LC: The phosphoinositide 3-kinase pathway. Science 296: 1655-1657, 2002.
20. Sachdev D, Li SL, Hartell JS, Fujita-Yamaguchi Y, Miller JS and Yee D: A chimeric humanized single chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-1. Cancer Res 63: 627-635, 2003. (Pubitemid 36158140)
21. Segrelles C, Moral M, Lara MF, Ruiz S, Santos M, Leis H, Garcia-Escudero R, Martinez-Cruz AB, Martinez-Palacio J, Hernandez P, Ballestin C and Paramio JM: Molecular determinants of Akt-induced keratinocyte transformation. Oncogene 25: 1174-1185, 2006.
22. Lee ER, Kim JY, Kang YJ, Ahn JY, Kim JH, Kim BW, Choi HY, Jeong MY and Cho SG: Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis. Biochim Biophys Acta 1763: 958-968, 2006.
23. Shaw RJ and Cantley LC: Ras, PI(3)K and mTOR signaling controls tumour cell growth. Nature 441: 424-430, 2006. (Pubitemid 44050136)
24. Bhandari BK, Feliers D, Duraisamy S, Stewart JL, Gingras AC, Abboud HE, Choudhury GG, Sonenberg N and Kasinath BS: Insulin regulation of protein translation repressor 4E-BP1, an elF4E-binding protein, in renal epithelial cells. Kidney Int 59: 866-875, 2001. (Pubitemid 32206849)
25. Oldham S and Hafen E: Insulin/IGF and target of rapamycin signaling: ATOR de force in growth control. Trends Cell Biol 13: 79-85, 2003. (Pubitemid 36135889)
26. Bjornsti MA and Houghton PJ: The TOR pathway: a target for cancer therapy. Nat Rev Cancer 4: 335-348, 2004. (Pubitemid 38579480)
27. White MF: The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Recent Prog Horm Res 53: 119-138, 1998.
28. Mori H, Inoki K, Opland D, Munzberg H, Villanueva EC, Faouzi M, Guan KL, et al: Critical roles for the TSC-mTOR pathway in β-cell function. Am J Physiol Endocrinol Metab 297: E1013-E1022, 2009.
29. Wan X, Harkavy B, Shen N, Grohar P and Helman L: Rapamycin induces feedback activation of Akt signaling through an IGF-1R dependent mechanism. Oncogene 26: 1932-1940, 2007. (Pubitemid 46474636)
30. O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, Lane H, Hofmann F, et al: mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 66: 1500-1508, 2006. (Pubitemid 43259931)
31. Quevedo C, Salinas M and Alcazar A: Regulation of cap-dependent translation by insulin-like growth factor-1 in neuronal cells. Biochem Biophys Res Commun 291: 560-566, 2002. (Pubitemid 34687381)
32. Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N and Blenis J: RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem 282: 14056-14064, 2007. (Pubitemid 47100467)
33. Kiaris H and Spandidos D: Mutations of ras genes in human tumors (review). Int J Oncol 7: 413-421, 1995.
34. Treisman R: Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 8: 205-215, 1996.