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Volumn 13, Issue 6, 2014, Pages 551-560

Delivery of interleukin-15 to B16 melanoma by electroporation leads to tumor regression and long-term survival

Author keywords

Electroporation; Interleukin 15; Melanoma

Indexed keywords

INTERLEUKIN 15;

EID: 84904359653     PISSN: 15330346     EISSN: None     Source Type: Journal    
DOI: 10.7785/tcrt.2013.600252     Document Type: Article
Times cited : (42)

References (52)
  • 1
    • 0020339802 scopus 로고
    • Gene transfer into mouse lyoma cells by electroporation in high electric fields
    • DOI: 0261-4189/82/0107-0841
    • Neumann E, Schaefer-Ridder M, Wang Y & Hofschneider PH. Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J 1, 841-845 (1982). DOI: 0261-4189/82/0107-0841
    • (1982) EMBO J , vol.1 , pp. 841-845
    • Neumann, E.1    Schaefer-Ridder, M.2    Wang, Y.3    Hofschneider, P.H.4
  • 3
    • 0035102821 scopus 로고    scopus 로고
    • Gene therapy of cancer
    • DOI: 2001/01/smw-09649
    • Rochlitz CF. Gene therapy of cancer. Swiss Med Wkly 131, 4-9 (2001). DOI: 2001/01/smw-09649
    • (2001) Swiss Med Wkly , vol.131 , pp. 4-9
    • Rochlitz, C.F.1
  • 4
    • 33750626735 scopus 로고    scopus 로고
    • In vivo electroporation for gene therapy
    • DOI: 10.1089/hum.2006.17.890
    • Heller LC & Heller R. In vivo electroporation for gene therapy. Hum Gene Ther 17, 890-897 (2006). DOI: 10.1089/hum.2006.17.890
    • (2006) Hum Gene Ther , vol.17 , pp. 890-897
    • Heller, L.C.1    Heller, R.2
  • 5
    • 33646254412 scopus 로고    scopus 로고
    • Strategies for the development of more effective adjuvant therapy of melanoma: Current and future explorations of antibodies cytokines vaccines and combinations
    • DOI: 10.1158/1078-0432.CCR-05-2538
    • Kirkwood JM, Moschos S & Wang W. Strategies for the development of more effective adjuvant therapy of melanoma: current and future explorations of antibodies cytokines vaccines and combinations. Clin Cancer Res 12, 2331s-2336s (2006). DOI: 10.1158/1078-0432.CCR-05-2538
    • (2006) Clin Cancer Res , vol.12
    • Kirkwood, J.M.1    Moschos, S.2    Wang, W.3
  • 6
    • 5444270495 scopus 로고    scopus 로고
    • DNA electrotransfer: Its principles and an updated review of its therapeutic applications
    • DOI: 10.1038/sj.gt.3302367
    • Andre F & Mir LM. DNA electrotransfer: its principles and an updated review of its therapeutic applications. Gene Ther 11(Suppl. 1), S33-42 (2004). DOI: 10.1038/sj.gt.3302367
    • (2004) Gene Ther , vol.11 , Issue.SUPPL. 1
    • Andre, F.1    Mir, L.M.2
  • 7
    • 0343069846 scopus 로고    scopus 로고
    • The importance of electric field distribution for effective in vivo electroporation of tissues
    • DOI: 10.1016/S0006-3495(98)77924-X
    • Miklavcic D, Beravs K, Semrov D, Cemazar M, Demsar F & Sersa G. The importance of electric field distribution for effective in vivo electroporation of tissues. Biophys J 74, 2152-2158 (1998). DOI: 10.1016/S0006-3495(98)77924-X
    • (1998) Biophys J , vol.74 , pp. 2152-2158
    • Miklavcic, D.1    Beravs, K.2    Semrov, D.3    Cemazar, M.4    Demsar, F.5    Sersa, G.6
  • 8
    • 77958027181 scopus 로고    scopus 로고
    • Electroporation gene therapy preclinical and clinical trials for melanoma
    • DOI: ABS-39
    • Heller LC & Heller R. Electroporation gene therapy preclinical and clinical trials for melanoma. Curr Gene Ther 10, 312-317 (2010). DOI: ABS-39
    • (2010) Curr Gene Ther , vol.10 , pp. 312-317
    • Heller, L.C.1    Heller, R.2
  • 10
    • 78349306040 scopus 로고    scopus 로고
    • Plasmid injection and application of electric pulses alter endogenous mRNA and protein expression in B16. F10 mouse melanomas
    • DOI: 10.1038/cgt.2010.43
    • Heller LC, Cruz YL, Ferraro B, Yang H & Heller R. Plasmid injection and application of electric pulses alter endogenous mRNA and protein expression in B16. F10 mouse melanomas. Cancer Gene Ther 17, 864-871 (2010). DOI: 10.1038/cgt.2010.43
    • (2010) Cancer Gene Ther , vol.17 , pp. 864-871
    • Heller, L.C.1    Cruz, Y.L.2    Ferraro, B.3    Yang, H.4    Heller, R.5
  • 11
    • 0036791461 scopus 로고    scopus 로고
    • Electrically mediated delivery of vector plasmid DNA elicits an antitumor effect
    • DOI: 10.1038/sj.gt.3301802
    • Heller LC & Coppola D. Electrically mediated delivery of vector plasmid DNA elicits an antitumor effect. Gene Ther 9, 1321-1325 (2002). DOI: 10.1038/sj.gt.3301802
    • (2002) Gene Ther , vol.9 , pp. 1321-1325
    • Heller, L.C.1    Coppola, D.2
  • 12
    • 0141920659 scopus 로고    scopus 로고
    • Electroporation enables plasmid vaccines to elicit CD81 T cell responses in the absence of CD41 T cells
    • DOI: 0022-1767/03
    • Dayball K, Millar J, Miller M, Wan YH & Bramson J. Electroporation enables plasmid vaccines to elicit CD81 T cell responses in the absence of CD41 T cells. J Immunol 171, 3379-3384 (2003). DOI: 0022-1767/03
    • (2003) J Immunol , vol.171 , pp. 3379-3384
    • Dayball, K.1    Millar, J.2    Miller, M.3    Wan, Y.H.4    Bramson, J.5
  • 13
    • 0029946063 scopus 로고    scopus 로고
    • IL-15: A pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels
    • DOI: 10.1016/S1074-7613(00)80246-0
    • Tagaya Y, Bamford RN, DeFilippis AP & Waldmann TA. IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity 4, 329-336 (1996). DOI: 10.1016/S1074-7613(00)80246-0
    • (1996) Immunity , vol.4 , pp. 329-336
    • Tagaya, Y.1    Bamford, R.N.2    DeFilippis, A.P.3    Waldmann, T.A.4
  • 15
    • 0036888855 scopus 로고    scopus 로고
    • Regulation of lymphoid homeostasis by interleukin-15
    • DOI: 10.1016/S1359-6101(02)00029-1
    • Lodolce JP, Burkett PR, Koka RM, Boone DL & Ma A. Regulation of lymphoid homeostasis by interleukin-15. Cytokine Growth Factor Rev 13, 429-439 (2002). DOI: 10.1016/S1359-6101(02)00029-1
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 429-439
    • Lodolce, J.P.1    Burkett, P.R.2    Koka, R.M.3    Boone, D.L.4    Ma, A.5
  • 18
    • 33745812074 scopus 로고    scopus 로고
    • IL-15/IL-15 receptor biology: A guided tour through an expanding universe
    • DOI: 10.1016/j.cytogfr.2006.05.001
    • Budagian V, Bulanova E, Paus R & Bulfone-Paus S. IL-15/IL-15 receptor biology: a guided tour through an expanding universe. Cytokine Growth Factor Rev 17, 259-280 (2006). DOI: 10.1016/j.cytogfr.2006.05.001
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 259-280
    • Budagian, V.1    Bulanova, E.2    Paus, R.3    Bulfone-Paus, S.4
  • 19
    • 13444257757 scopus 로고    scopus 로고
    • Interleukin-2, interleukin-15, and their roles in human natural killer cells
    • DOI: 10.1016/S0065-2776(04)86006-1
    • Becknell B & Caligiuri MA. Interleukin-2, interleukin-15, and their roles in human natural killer cells. Adv Immunol 86, 209-239 (2005). DOI: 10.1016/S0065-2776(04)86006-1
    • (2005) Adv Immunol , vol.86 , pp. 209-239
    • Becknell, B.1    Caligiuri, M.A.2
  • 20
    • 33646580769 scopus 로고    scopus 로고
    • The structure of the interleukin-15 alpha receptor and its implications for ligand binding
    • DOI: 10.1074/jbc.M513118200
    • Lorenzen I, Dingley AJ, Jacques Y & Grotzinger J. The structure of the interleukin-15 alpha receptor and its implications for ligand binding. J Biol Chem 281, 6642-6647 (2006). DOI: 10.1074/jbc.M513118200
    • (2006) J Biol Chem , vol.281 , pp. 6642-6647
    • Lorenzen, I.1    Dingley, A.J.2    Jacques, Y.3    Grotzinger, J.4
  • 21
    • 71649100833 scopus 로고    scopus 로고
    • Trans-presentation: A novel mechanism regulating IL-15 delivery and responses
    • DOI: 10.1016/j.imlet.2009.09.009
    • Stonier SW & Schluns KS. Trans-presentation: a novel mechanism regulating IL-15 delivery and responses. Immunol Lett 127, 85-92 (2010). DOI: 10.1016/j.imlet.2009.09.009
    • (2010) Immunol Lett , vol.127 , pp. 85-92
    • Stonier, S.W.1    Schluns, K.S.2
  • 22
    • 77957108904 scopus 로고    scopus 로고
    • IL-15 has innate anti-tumor activity independent of NK and CD8 T cells
    • DOI:10.1189/jlb.0909648
    • Davies E, Reid S, Medina MF, Lichty B & Ashkar AA. IL-15 has innate anti-tumor activity independent of NK and CD8 T cells. J Leukoc Biol 88, 529-536 (2010). DOI:10.1189/jlb.0909648
    • (2010) J Leukoc Biol , vol.88 , pp. 529-536
    • Davies, E.1    Reid, S.2    Medina, M.F.3    Lichty, B.4    Ashkar, A.A.5
  • 23
    • 0036625927 scopus 로고    scopus 로고
    • Critical role for IL-15 in innate immunity
    • DOI: 1012174/1566524023362519
    • Ohteki T. Critical role for IL-15 in innate immunity. Curr Mol Med 2, 371-380 (2002). DOI: 1012174/1566524023362519
    • (2002) Curr Mol Med , vol.2 , pp. 371-380
    • Ohteki, T.1
  • 25
    • 19544362066 scopus 로고    scopus 로고
    • Adhesion migration and communication in melanocytes and melanoma
    • DOI: 10.1111/j.1600-0749.2005.00235.x
    • Haass NK, Smalley KS, Li L & Herlyn M. Adhesion migration and communication in melanocytes and melanoma. Pigment Cell Res 18, 150-159 (2005). DOI: 10.1111/j.1600-0749.2005.00235.x
    • (2005) Pigment Cell Res , vol.18 , pp. 150-159
    • Haass, N.K.1    Smalley, K.S.2    Li, L.3    Herlyn, M.4
  • 26
    • 0035077793 scopus 로고    scopus 로고
    • Intramuscular electroporation delivery of IFN-alpha gene therapy for inhibition of tumor growth located at a distant site
    • DOI: 10.1038/sj.gt.3301418
    • Li S, Zhang X, Xia X, Zhou L, Breau R, Suen J & Hanna E. Intramuscular electroporation delivery of IFN-alpha gene therapy for inhibition of tumor growth located at a distant site. Gene Ther 8, 400-407 (2001). DOI: 10.1038/sj.gt.3301418
    • (2001) Gene Ther , vol.8 , pp. 400-407
    • Li, S.1    Zhang, X.2    Xia, X.3    Zhou, L.4    Breau, R.5    Suen, J.6    Hanna, E.7
  • 27
    • 0036627876 scopus 로고    scopus 로고
    • Effect of electrically mediated intratumor and intramuscular delivery of a plasmid encoding IFN alpha on visible B16 mouse melanomas
    • DOI: 53007&c54058&p510979&do5detail [pii]
    • Heller LC, Ingram SF, Lucas ML, Gilbert RA & Heller R. Effect of electrically mediated intratumor and intramuscular delivery of a plasmid encoding IFN alpha on visible B16 mouse melanomas. Technol Cancer Res Treat 1, 205-209 (2002). DOI: 53007&c54058&p510979&do5detail [pii]
    • (2002) Technol Cancer Res Treat , vol.1 , pp. 205-209
    • Heller, L.C.1    Ingram, S.F.2    Lucas, M.L.3    Gilbert, R.A.4    Heller, R.5
  • 29
    • 0032127362 scopus 로고    scopus 로고
    • Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin
    • DOI: 10.1002/(SICI)1097-0142(19980701)83:1,148::AID-CNCR20.3.0.CO;2-W
    • Heller R, Jaroszeski MJ, Reintgen DS, Puleo CA, DeConti RC, Gilbert RA & Glass LF. Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin. Cancer 83, 148-157 (1998). DOI: 10.1002/(SICI)1097-0142(19980701)83:1,148::AID-CNCR20.3.0.CO;2-W
    • (1998) Cancer , vol.83 , pp. 148-157
    • Heller, R.1    Jaroszeski, M.J.2    Reintgen, D.S.3    Puleo, C.A.4    DeConti, R.C.5    Gilbert, R.A.6    Glass, L.F.7
  • 30
    • 0036594813 scopus 로고    scopus 로고
    • IL-12 plasmid delivery by in vivo electroporation for the successful treatment of established subcutaneous B16. F10 melanoma
    • DOI: 10.1006/mthe.2002.0601
    • Lucas ML, Heller L, Coppola D & Heller R. IL-12 plasmid delivery by in vivo electroporation for the successful treatment of established subcutaneous B16. F10 melanoma. Molecular Therapy 5, 668-675 (2002). DOI: 10.1006/mthe.2002.0601
    • (2002) Molecular Therapy , vol.5 , pp. 668-675
    • Lucas, M.L.1    Heller, L.2    Coppola, D.3    Heller, R.4
  • 31
    • 33748571952 scopus 로고    scopus 로고
    • Regression of subcutaneous B16 melanoma tumors after intratumoral delivery of an IL-15-expressing plasmid followed by in vivo electroporation
    • DOI: 10.1038/sj.cgt.7700973
    • Ugen KE, Kutzler MA, Marrero B, Westover J, Coppola D, Weiner DB & Heller R. Regression of subcutaneous B16 melanoma tumors after intratumoral delivery of an IL-15-expressing plasmid followed by in vivo electroporation. Cancer Gene Ther 13, 969-974 (2006). DOI: 10.1038/sj.cgt.7700973
    • (2006) Cancer Gene Ther , vol.13 , pp. 969-974
    • Ugen, K.E.1    Kutzler, M.A.2    Marrero, B.3    Westover, J.4    Coppola, D.5    Weiner, D.B.6    Heller, R.7
  • 32
    • 0346732375 scopus 로고    scopus 로고
    • IL-12 gene therapy using an electrically mediated nonviral approach reduces metastatic growth of melanoma
    • DOI: 10.1089/104454903322624966
    • Lucas ML & Heller R. IL-12 gene therapy using an electrically mediated nonviral approach reduces metastatic growth of melanoma. DNA Cell Biol 22, 755-763 (2003). DOI: 10.1089/104454903322624966
    • (2003) DNA Cell Biol , vol.22 , pp. 755-763
    • Lucas, M.L.1    Heller, R.2
  • 35
    • 0024354304 scopus 로고
    • Determination of subcutaneous tumor size in athymic (nude) mice
    • DOI: 10.1007/BF00300234
    • Tomayko MM & Reynolds CP. Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharmacol 24, 148-154 (1989). DOI: 10.1007/BF00300234
    • (1989) Cancer Chemother Pharmacol , vol.24 , pp. 148-154
    • Tomayko, M.M.1    Reynolds, C.P.2
  • 36
    • 0030727981 scopus 로고    scopus 로고
    • IL-12-induced tumor regression correlates with in situ activity of IFN-gamma produced by tumor-infiltrating cells and its secondary induction of anti-tumor pathways
    • DOI: 9335314
    • Yu WG, Ogawa M, Mu J, Umehara K, Tsujimura T, Fujiwara H & Hamaoka T. IL-12-induced tumor regression correlates with in situ activity of IFN-gamma produced by tumor-infiltrating cells and its secondary induction of anti-tumor pathways. J Leukoc Biol 62, 450-457 (1997). DOI: 9335314
    • (1997) J Leukoc Biol , vol.62 , pp. 450-457
    • Yu, W.G.1    Ogawa, M.2    Mu, J.3    Umehara, K.4    Tsujimura, T.5    Fujiwara, H.6    Hamaoka, T.7
  • 39
    • 34447619379 scopus 로고    scopus 로고
    • In situ expression of IFN-gamma-inducible T cell alpha chemoattractant in breast cancer mounts an enhanced specific anti-tumor immunity which leads to tumor regression
    • DOI: 10.1007/s00262-007-0296-1
    • Chu Y, Yang X, Xu W, Wang Y, Guo Q & Xiong S. In situ expression of IFN-gamma-inducible T cell alpha chemoattractant in breast cancer mounts an enhanced specific anti-tumor immunity which leads to tumor regression. Cancer Immunol Immunother 56, 1539-1549 (2007). DOI: 10.1007/s00262-007-0296-1
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 1539-1549
    • Chu, Y.1    Yang, X.2    Xu, W.3    Wang, Y.4    Guo, Q.5    Xiong, S.6
  • 40
    • 70349240430 scopus 로고    scopus 로고
    • Secretion and biological activity of short signal peptide IL-15 is chaperoned by IL-15 receptor alpha in vivo
    • DOI: 10.4049/jimmunol.0900693
    • Bergamaschi C, Jalah R, Kulkarni V, Rosati M, Zhang GM, Alicea C, Zolotukhin AS, Felber BK & Pavlakis GN. Secretion and biological activity of short signal peptide IL-15 is chaperoned by IL-15 receptor alpha in vivo. J Immunol 183, 3064-3072 (2009). DOI: 10.4049/jimmunol.0900693
    • (2009) J Immunol , vol.183 , pp. 3064-3072
    • Bergamaschi, C.1    Jalah, R.2    Kulkarni, V.3    Rosati, M.4    Zhang, G.M.5    Alicea, C.6    Zolotukhin, A.S.7    Felber, B.K.8    Pavlakis, G.N.9
  • 41
    • 84864983867 scopus 로고    scopus 로고
    • Regulating the immune system via IL-15 transpresentation
    • DOI: 10.1016/j.cyto.2012.06.017
    • Castillo EF & Schluns KS. Regulating the immune system via IL-15 transpresentation. Cytokine 59, 479-490 (2012). DOI: 10.1016/j.cyto.2012.06.017
    • (2012) Cytokine , vol.59 , pp. 479-490
    • Castillo, E.F.1    Schluns, K.S.2
  • 42
    • 0033046593 scopus 로고    scopus 로고
    • The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
    • DOI: 10.1146/annurev.immunol.17.1.19
    • Waldmann TA & Tagaya Y. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol 17, 19-49 (1999). DOI: 10.1146/annurev.immunol.17.1.19
    • (1999) Annu Rev Immunol , vol.17 , pp. 19-49
    • Waldmann, T.A.1    Tagaya, Y.2
  • 43
    • 0036436131 scopus 로고    scopus 로고
    • Interleukin-15 interactions with interleukin-15 receptor complexes: Characterization and species specificity
    • DOI: 10.1006/cyto.2002.1989
    • Eisenman J, Ahdieh M, Beers C, Brasel K, Kennedy MK, Le T, Bonnert TP, Paxton RJ & Park LS. Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity. Cytokine 20, 121-129 (2002). DOI: 10.1006/cyto.2002.1989
    • (2002) Cytokine , vol.20 , pp. 121-129
    • Eisenman, J.1    Ahdieh, M.2    Beers, C.3    Brasel, K.4    Kennedy, M.K.5    Le, T.6    Bonnert, T.P.7    Paxton, R.J.8    Park, L.S.9
  • 45
    • 0034984652 scopus 로고    scopus 로고
    • Immunomodulation by electrically enhanced delivery of plasmid DNA encoding IL-12 to murine skeletal muscle
    • DOI: 0.1006/mthe.2000.0233
    • Lucas ML & Heller R. Immunomodulation by electrically enhanced delivery of plasmid DNA encoding IL-12 to murine skeletal muscle. Mol Ther 3, 47-53 (2001). DOI: 0.1006/mthe.2000.0233
    • (2001) Mol Ther , vol.3 , pp. 47-53
    • Lucas, M.L.1    Heller, R.2
  • 47
    • 0030955249 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
    • DOI: 10.1073/pnas.94.20.10833
    • Weiner GJ, Liu HM, Wooldridge JE, Dahle CE & Krieg AM. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci U S A 94, 10833-10837 (1997). DOI: 10.1073/pnas.94.20.10833
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10833-10837
    • Weiner, G.J.1    Liu, H.M.2    Wooldridge, J.E.3    Dahle, C.E.4    Krieg, A.M.5
  • 48
    • 0032533269 scopus 로고    scopus 로고
    • Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor
    • DOI: 006-4971/98/9210-0023
    • Liu HM, Newbrough SE, Bhatia SK, Dahle CE, Krieg AM & Weiner GJ. Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor. Blood 92, 3730-3736 (1998). DOI: 006-4971/98/9210-0023
    • (1998) Blood , vol.92 , pp. 3730-3736
    • Liu, H.M.1    Newbrough, S.E.2    Bhatia, S.K.3    Dahle, C.E.4    Krieg, A.M.5    Weiner, G.J.6
  • 49
    • 0035992782 scopus 로고    scopus 로고
    • Antitumor mechanisms of oligodeoxynucleotides with CpG and polyG motifs in murine prostate cancer cells: Decrease of NF-kappaB and AP-1 binding activities and induction of apoptosis
    • DOI: 10.1089/108729002760220752
    • Shen W, Waldschmidt M, Zhao X, Ratliff T & Krieg AM. Antitumor mechanisms of oligodeoxynucleotides with CpG and polyG motifs in murine prostate cancer cells: decrease of NF-kappaB and AP-1 binding activities and induction of apoptosis. Antisense Nucleic Acid Drug Dev 12, 155-164 (2002). DOI: 10.1089/108729002760220752
    • (2002) Antisense Nucleic Acid Drug Dev , vol.12 , pp. 155-164
    • Shen, W.1    Waldschmidt, M.2    Zhao, X.3    Ratliff, T.4    Krieg, A.M.5
  • 50
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • DOI: 10.1038/nrd2059
    • Krieg AM. Therapeutic potential of Toll-like receptor 9 activation Nat Rev Drug Discov 5, 471-484 (2006). DOI: 10.1038/nrd2059
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 471-484
    • Krieg, A.M.1
  • 51
    • 33846859783 scopus 로고    scopus 로고
    • Electric pulses applied prior to intramuscular DNA vaccination greatly improve the vaccine immunogenicity
    • DOI: 10.1016/j.vaccine.2006.11.042
    • Peng B, Zhao Y, Xu L & Xu Y. Electric pulses applied prior to intramuscular DNA vaccination greatly improve the vaccine immunogenicity. Vaccine 25, 2064-2073 (2007). DOI: 10.1016/j.vaccine.2006.11.042
    • (2007) Vaccine , vol.25 , pp. 2064-2073
    • Peng, B.1    Zhao, Y.2    Xu, L.3    Xu, Y.4
  • 52
    • 43949114521 scopus 로고    scopus 로고
    • Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation
    • DOI: 10.1128/JVI.02564-07
    • Liu J, Kjeken R, Mathiesen I & Barouch DH. Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation. J Virol 82, 5643-5649 (2008). DOI: 10.1128/JVI.02564-07
    • (2008) J Virol , vol.82 , pp. 5643-5649
    • Liu, J.1    Kjeken, R.2    Mathiesen, I.3    Barouch, D.H.4


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