IL-12-induced tumor regression correlates with in situ activity of IFN- γ produced by tumor-infiltrating cells and its secondary induction of anti- tumor pathways

Journal of Leukocyte Biology

Volumn 62, Issue 4, 1997, Pages 450-457

  Yu, Wen Gong ^a   Ogawa, Makoto ^a   Mu, Jie ^a   Umehara, Kazunari ^a   Tsujimura, Takahiro ^b   Fujiwara, Hiromi ^a   Hamaoka, Toshiyuki ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b SUMITOMO HOSPITAL   (Japan)

Author keywords

Inducible nitric oxide synthase; Tumor immunity

Indexed keywords

GAMMA INTERFERON; INTERFERON ANTIBODY; INTERFERON INDUCING AGENT; MESSENGER RNA; MONOCLONAL ANTIBODY; NITRIC OXIDE SYNTHASE; RECOMBINANT INTERLEUKIN 12;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FIBROSARCOMA; LYMPHOID CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR REGRESSION;

EID: 0030727981     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.62.4.450     Document Type: Article

References (32)

1. Trinchieri, G. (1994) Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84, 4008-4027.
2. Brunda M. J. (1994) Interleukin-12. J. Leukoc. Biol. 55, 280-288.
3. Kobayashi, M., Fits, L., Ryan, M., Hewick, R. M., Clark, S. C., Chan, S., Loudon, R., Sherman, F., Perussia, B., Trinchieri, G. (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170, 827-845.
4. Chan, S. H., Perussia, B., Gupta, J. W., Kobayashi, M., Pospisil, M., Young, H. A., Wolf, S. F., Young, D., Clark, S. C., Trinchieri, G. (1991) Induction of interferon γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173, 869-879.
5. Brunda, M. J., Luistro, L., Warrier, R. R., Wright, R. B., Hubbard, B. R., Murphy, M., Wolf, S. F. Gately, M. K. (1993) Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J. Exp. Med. 178,1223-1230.
6. Nastala, C. L., Edington, H. D., McKinney, T. G., Tahara, H., Nalesnik, M. A., Brunda, M. J., Gately, M. K., Wolf, S. F., Schreiber, R. D., Storkus, W. J., Lotze, M. T. (1994) Recombinant IL-12 administration induces tumor regression in association with IFN-γ production. J. Immunol. 153, 1697-1706.
7. Zou, J. P. Yamamoto, N., Fujii, T., Takenaka, H., Kobayashi, M., Herrmann, S. H., Wolf, S. F., Fujiwara, H., Hamaoka, T. (1995) Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells. Int. Immunol. 7, 1135-1145.
8. Brunda, M. J., Luistro, L., Hendrzak, J. A., Fountoulakis, M., Garotta, G., Gately, M. K. (1995) Role of interferon-γ in mediating the antitumor efficacy of interleukin-12. J. Immunother. 17, 71-77.
9. Yu, W.-G., Yamamoto, N., Takenaka, H., Mu, J., Tai, X.-G., Zou, J.-P., Ogawa, M., Tsutsui, T., Wijesuria, R., Yoshida, R., Herrmann, S., Fujiwara, H., Hamaoka, T. (1996) Molecular mechanisms underlying IFN-γ-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12. Int. Immunol. 8, 855-865.
10. Yoshida, T. O., Haraguchi, S., Miyamoto, H., Matsuo, T. (1979) Recognition of RSV-induced tumor cells in syngeneic mice and semisyngeneic reciprocal hybrid mice. Gann. Monograph Cancer Res. 23, 201-212.
11. Xie, Q. W., Cho, H. J., Calaycay, J., Mumford, R. A., Swiderek, K. M., Lee, T. D., Ding, A., Troso, T., Nathan, C. (1992) Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256, 225-228.
12. Vanguri, P., Farber, J. M. (1990) Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine. J. Biol. Chem. 265, 15049-15057.
13. Marchuk, D., Drumm, M., Saulino, A., Collins, F. S. (1991) Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products. Nucleic Acids. Res. 19, 1154.
14. Wilson, K. C., Finbloom, D. S. (1992) Interferon γ rapidly induces in human monocytes a DNA-binding factor that recognizes the γ response region within the promoter of the gene for the high-affinity Fcγ receptor. Proc. Natl. Acad. Sci. USA 89, 11964-11968.
15. Mu, J., Zou, J. P., Yamamoto, N., Tsutsui, T., Tai, X. G., Kobayashi, M., Herrmann, S., Fujiwara, H., Hamaoka, T. (1995) Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes. Cancer Res. 55, 4404-4408.
16. Fujiwara, H., Clark, S., Hamaoka, T. (1996) Cellular and molecular mechanisms underlying IL-12-induced tumor regression. Ann. NY Acad. Sci. 795, 294-309.
17. Ogawa, M., Tsutsui, T., Zou, J-P., Mu, J., Wijesuriya, R., Yu, W-G., Herrmann, S., Kubo, T. Fujiwara, H., Hamaoka, T. (1997) Enhanced induction of VLA-4/LFA-1-dependent T cell migration to tumor sites following administration of IL-12. Cancer Res. 57, 2216-2222.
18. Martinotti, A., Stoppacciaro, A., Vagliani, M., Melani, C., Spreafico, F. Wysocka, M., Parmiani, G., Trinchieri, G., Colombo, M. P. (1995) CD4 T cells inhibit in vivo the CD8-mediated immune response against murine colon carcinoma cells transduced with interleukin-12 genes. Eur. J. Immunol. 25, 137-146.
19. Staeheli, P. (1990) Interferon-induced proteins and the antiviral state. Adv. Virus Res. 38, 147-200.
20. Luster, A. D., Unkeless, J. C., Ravetch, J. V. (1985) γ-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315, 672-676.
21. Yoshida, R., Imanishi, J., Oku, T., Kishida, T., Hayaishi, O. (1981) Induction of pulmonary indoleamine 2,3-dioxygenase by interferon. Proc. Natl. Acad. Sci. USA 78, 129-132.
22. Nathan, C. (1992) Nitric oxide as a secretory product of mammalian cells. FASEB J. 6, 3051-3064.
23. Rosa, F. M., Cochet, M. M., Fellous, M. (1986) Interferon and major histocompatibility complex genes: a model to analyse eukaryotic gene regulation? Interferon 7, 47-87.
24. Ozaki, Y., Edelstein, M. P., Duch, D. S. (1988) Induction of indoleamine 2.3-dioxygenase: a mechanism of the antitumor activity of interferon γ. Proc. Natl. Acad. Sci. USA 85, 1242-1246.
25. Angiolillo, A. L., Sgadari, C., Tosato, G. (1996) A role for the interferon-inducible protein-10 in inhibition of angiogenesis by interleukin-12. Ann. NY Acad. Sci. 795, 158-167.
26. Taub, D. D., Lloyd, A. R., Conlon, K., Wang, J. M., Ortaldo, J. R., Harada, A., Matsushima, K., Kelvin, D. J., Oppenheim, J. J. (1993) Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells. J. Exp. Med. 177, 1809-1814.
27. Nathan, C. F., Hibbs, J., Jr. (1991) Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Op. Immunol. 3, 65-70.
28. Moncada, S., Palmer, R. M., Higgs, E. A. (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109-142.
29. Asano, K., Chee, C. B., Gaston, B., Lilly, C. M., Gerard, C., Drazen, J. M., Stamler, J. S. (1994) Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc. Natl. Acad. Sci. USA 91, 10089-10093.
30. Farias-Eisner, R., Sherman, M. P., Aeberhard, E., Chaudhuri, G. (1994) Nitric oxide is an important mediator for tumoricidal activity in vivo. Proc. Natl. Acad. Sci. USA 91, 9407-9411.
31. Chen, L. K., Tourvieille, B., Burns, G. F, Bach, F. H., Mathieu-Mahul, D., Sasportes, M., Bensussan, A. (1986) Interferon: a cytotoxic T lymphocyte differentiation signal. Eur. J. Immunol. 16, 767-770.
32. Maraskovsky, E., Chen, W. F. Shortman, K. (1989) IL-2 and IFN-γ are two necessary lymphokines in the development of cytolytic T cells. J. Immunol. 143, 1210-1214.