PTH1-34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival

Bone

Volumn 67, Issue , 2014, Pages 33-40

  Chandra, Abhishek ^a   Lin, Tiao ^a,b   Tribble, Mary Beth ^a   Zhu, Ji ^a   Altman, Allison R ^a   Tseng, Wei Ju ^a   Zhang, Yejia ^a   Akintoye, Sunday O ^c   Cengel, Keith ^d   Liu, X Sherry ^a   Qin, Ling ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apoptosis; Image registration; Osteoblast; Parathyroid hormone; Radiotherapy; Trabecular bone

Indexed keywords

PARATHYROID HORMONE[1-34]; PARATHYROID HORMONE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE DISEASE; BONE MASS; BONE STRENGTH; CANCER RADIOTHERAPY; CELL ACTIVITY; CELL COUNT; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG INTERMITTENT THERAPY; FEMALE; IN VIVO STUDY; NONHUMAN; OSTEOBLAST; OSTEOCYTE; OSTEOLYSIS; RADIATION INDUCED BONE LOSS; RADIATION INJURY; RADIATION PROTECTION; RAT; TIBIA; TRABECULAR BONE; ADVERSE EFFECTS; ANIMAL; BONE DISEASES; CYTOLOGY; DRUG EFFECTS; METABOLISM; RADIATION RESPONSE; RADIOTHERAPY;

ANIMALS; APOPTOSIS; BONE DISEASES; OSTEOBLASTS; OSTEOCYTES; PARATHYROID HORMONE; RADIOTHERAPY; RATS; TIBIA;

EID: 84904333618     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.06.030     Document Type: Article

References (45)

1. Ries L.A.G., Eisner M.P., Kosary C.L., Hanke B.F., Miller B.A., Clegg L., et al. SEER Cancer Statistics Review, 1973-1999 2002, National Cancer Institute, Bethesda, MD.
2. Perez C.A., Halperin E.C., Brady L.W., Wazer D.E. Perez & Brady's principles and practice of radiation 2013, Philadelphia, PA, USA, Wolters Kluwer Lippincott Williams and Wilkins. 6th ed.
3. Costantino P.D., Friedman C.D., Steinberg M.J. Irradiated bone and its management. Otolaryngol Clin North Am 1995, 28:1021-1038.
4. Howland W.J., Loeffler R.K., Starchman D.E., Johnson R.G. Postirradiation atrophic changes of bone and related complications. Radiology 1975, 117:677-685.
5. Williams H.J., Davies A.M. The effect of X-rays on bone: a pictorial review. Eur Radiol 2006, 16:619-633.
6. Ergun H., Howland W.J. Postradiation atrophy of mature bone. CRC Crit Rev Diagn Imaging 1980, 12:225-243.
7. Dudziak M.E., Saadeh P.B., Mehrara B.J., Steinbrech D.S., Greenwald J.A., Gittes G.K., et al. The effects of ionizing radiation on osteoblast-like cells in vitro. Plast Reconstr Surg 2000, 106:1049-1061.
8. Gal T.J., Munoz-Antonia T., Muro-Cacho C.A., Klotch D.W. Radiation effects on osteoblasts in vitro: a potential role in osteoradionecrosis. Arch Otolaryngol Head Neck Surg 2000, 126:1124-1128.
9. Matsumura S., Jikko A., Hiranuma H., Deguchi A., Fuchihata H. Effect of X-ray irradiation on proliferation and differentiation of osteoblast. Calcif Tissue Int 1996, 59:307-308.
10. Szymczyk K.H., Shapiro I.M., Adams C.S. Ionizing radiation sensitizes bone cells to apoptosis. Bone 2004, 34:148-156.
11. Gungor T., Hedlund T., Hulth A., Johnell O. The effect of irradiation on osteoclasts with or without transplantation of hematopoietic cells. Acta Orthop Scand 1982, 53:333-337.
12. Sawajiri M., Mizoe J., Tanimoto K. Changes in osteoclasts after irradiation with carbon ion particles. Radiat Environ Biophys 2003, 42:219-223.
13. Cao X., Wu X., Frassica D., Yu B., Pang L., Xian L., et al. Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells. Proc Natl Acad Sci U S A 2011, 108:1609-1614.
14. Kondo H., Searby N.D., Mojarrab R., Phillips J., Alwood J., Yumoto K., et al. Total-body irradiation of postpubertal mice with (137)Cs acutely compromises the microarchitecture of cancellous bone and increases osteoclasts. Radiat Res 2009, 171:283-289.
15. Kondo H., Yumoto K., Alwood J.S., Mojarrab R., Wang A., Almeida E.A., et al. Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse. J Appl Physiol 2009, 108:152-161.
16. Willey J.S., Lloyd S.A., Robbins M.E., Bourland J.D., Smith-Sielicki H., Bowman L.C., et al. Early increase in osteoclast number in mice after whole-body irradiation with 2Gy X rays. Radiat Res 2008, 170:388-392.
17. Keenawinna L., Oest M.E., Mann K.A., Spadaro J., Damron T.A. Zoledronic acid prevents loss of trabecular bone after focal irradiation in mice. Radiat Res 2013, 180:89-99.
18. Willey J.S., Livingston E.W., Robbins M.E., Bourland J.D., Tirado-Lee L., Smith-Sielicki H., et al. Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations. Bone 2010, 46:101-111.
19. Margulies B., Morgan H., Allen M., Strauss J., Spadaro J., Damron T. Transiently increased bone density after irradiation and the radioprotectant drug amifostine in a rat model. Am J Clin Oncol 2003, 26:e106-e114.
20. Bellido T., Ali A.A., Plotkin L.I., Fu Q., Gubrij I., Roberson P.K., et al. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem 2003, 278:50259-50272.
21. Jilka R.L., Weinstein R.S., Bellido T., Roberson P., Parfitt A.M., Manolagas S.C. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J Clin Invest 1999, 104:439-446.
22. Motyl K.J., McCauley L.K., McCabe L.R. Amelioration of type I diabetes-induced osteoporosis by parathyroid hormone is associated with improved osteoblast survival. J Cell Physiol 2012, 227:1326-1334.
23. Weinstein R.S., Jilka R.L., Almeida M., Roberson P.K., Manolagas S.C. Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice. Endocrinology 2010, 151:2641-2649.
24. Koh A.J., Novince C.M., Li X., Wang T., Taichman R.S., McCauley L.K. An irradiation-altered bone marrow microenvironment impacts anabolic actions of PTH. Endocrinology 2011, 152:4525-4536.
25. Chandra A., Lan S., Zhu J., Zhang X., Siclari V.A., Altman A.R., et al. PTH prevents the adverse effects of focal radiation on bone architecture in young rats. Bone 2013, 55:449-457.
26. Wong J., Armour E., Kazanzides P., Iordachita I., Tryggestad E., Deng H., et al. High-resolution, small animal radiation research platform with X-ray tomographic guidance capabilities. Int J Radiat Oncol Biol Phys 2008, 71:1591-1599.
27. Lan S., Luo S., Huh B.K., Chandra A., Altman A.R., Qin L., et al. 3D image registration is critical to ensure accurate detection of longitudinal changes in trabecular bone density, microstructure, and stiffness measurements in rat tibiae by in vivo microcomputed tomography (uCT). Bone 2013, 56:83-90.
28. Collignon A., Maes F., Delaere D., Vandermeulen D., Suetens P., Marchal G. Automated multi-modality image registration based on information theory. Information processing in medical imaging 1995, 263-274. Kluwer Academic Publishers, Dordrecht, The Netherlands. Y. Bizais, C. Barillot, R. di Paola (Eds.).
29. Viola P., Wells W.M. Alignment by maximization of mutual information. Int J Comput Vis 1997, 24:137-154.
30. Ibanez L., Schroeder W., Ng L., Cates J. The ITK Software Guide 2005, Available at http://www.itk.org/ItkSoftwareGuide.pdf Accessed December 5, 2008. 2nd ed.
31. Dempster D.W., Compston J.E., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., et al. Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2013, 28:2-17.
32. Brennan T.C., Rizzoli R., Ammann P. Selective modification of bone quality by PTH, pamidronate, or raloxifene. J Bone Miner Res 2009, 24:800-808.
33. Friedl G., Turner R.T., Evans G.L., Dobnig H. Intermittent parathyroid hormone (PTH) treatment and age-dependent effects on rat cancellous bone and mineral metabolism. J Orthop Res 2007, 25:1454-1464.
34. Prisby R., Guignandon A., Vanden-Bossche A., Mac-Way F., Linossier M.T., Thomas M., et al. Intermittent PTH(1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites. J Bone Miner Res 2011, 26:2583-2596.
35. Green D.E., Adler B.J., Chan M.E., Rubin C.T. Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity. J Bone Miner Res 2012, 27:749-759.
36. Hamilton S.A., Pecaut M.J., Gridley D.S., Travis N.D., Bandstra E.R., Willey J.S., et al. A murine model for bone loss from therapeutic and space-relevant sources of radiation. J Appl Physiol 2006, 101:789-793.
37. Jia D., Gaddy D., Suva L.J., Corry P.M. Rapid loss of bone mass and strength in mice after abdominal irradiation. Radiat Res 2011, 176:624-635.
38. Wernle J.D., Damron T.A., Allen M.J., Mann K.A. Local irradiation alters bone morphology and increases bone fragility in a mouse model. J Biomech 2010, 43:2738-2746.
39. Vahle J.L., Long G.G., Sandusky G., Westmore M., Ma Y.L., Sato M. Bone neoplasms in F344 rats given teriparatide [rhPTH(1-34)] are dependent on duration of treatment and dose. Toxicol Pathol 2004, 32:426-438.
40. Vahle J.L., Sato M., Long G.G., Young J.K., Francis P.C., Engelhardt J.A., et al. Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2years and relevance to human safety. Toxicol Pathol 2002, 30:312-321.
41. Andrews E.B., Gilsenan A.W., Midkiff K., Sherrill B., Wu Y., Mann B.H., et al. The US postmarketing surveillance study of adult osteosarcoma and teriparatide: study design and findings from the first 7years. J Bone Miner Res 2012, 27:2429-2437.
42. Cipriani C., Irani D., Bilezikian J.P. Safety of osteoanabolic therapy: a decade of experience. J Bone Miner Res 2012, 27:2419-2428.
43. Cusano N.E., Rubin M.R., McMahon D.J., Zhang C., Ives R., Tulley A., et al. Therapy of hypoparathyroidism with PTH(1-84): a prospective four-year investigation of efficacy and safety. J Clin Endocrinol Metab 2013, 98:137-144.
44. Winer K.K., Sinaii N., Reynolds J., Peterson D., Dowdy K., Cutler G.B. Long-term treatment of 12 children with chronic hypoparathyroidism: a randomized trial comparing synthetic human parathyroid hormone 1-34 versus calcitriol and calcium. J Clin Endocrinol Metab 2010, 95:2680-2688.
45. Gallagher K.K., Deshpande S., Tchanque-Fossuo C.N., Donneys A., Sarhaddi D., Nelson N.S., et al. Role of parathyroid hormone therapy in reversing radiation-induced nonunion and normalization of radiomorphometrics in a murine mandibular model of distraction osteogenesis. Head Neck 2013, 17:23216.