Local irradiation alters bone morphology and increases bone fragility in a mouse model

Journal of Biomechanics

Volumn 43, Issue 14, 2010, Pages 2738-2746

  Wernle, James D ^a   Damron, Timothy A ^a   Allen, Matthew J ^b   Mann, Kenneth A ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Animal model; Bone mechanics; Bone morphology; Finite element analysis; Irradiation; Radiation therapy

Indexed keywords

ANIMAL MODEL; BONE MECHANICS; BONE MORPHOLOGY; FINITE ELEMENT ANALYSIS; RADIATION THERAPY;

ANIMALS; COMPRESSION TESTING; COMPUTERIZED TOMOGRAPHY; FINITE ELEMENT METHOD; FRACTURE; IRRADIATION; MECHANICS; MORPHOLOGY; PHYSIOLOGICAL MODELS; QUALITY ASSURANCE; RADIATION; RADIOTHERAPY; STRUCTURAL ANALYSIS;

BONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BIOMECHANICS; BONE DENSITY; BONE FRAGILITY; BONE STRENGTH; BONE STRUCTURE; COMPRESSION; CONTROLLED STUDY; CORTICAL BONE; FEMALE; FEMUR; FINITE ELEMENT ANALYSIS; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; TRABECULAR BONE; X IRRADIATION;

ANIMALS; BIOMECHANICS; BONE AND BONES; BONE DENSITY; DISEASE MODELS, ANIMAL; FEMALE; FEMUR; FINITE ELEMENT ANALYSIS; FRACTURES, STRESS; HINDLIMB; HUMANS; MICE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; RADIATION INJURIES, EXPERIMENTAL; STRESS, MECHANICAL; X-RAY MICROTOMOGRAPHY;

EID: 77958153963     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2010.06.017     Document Type: Article

References (29)

1. Bandstra E.R., Pecaut M.J., Anderson E.R., Willey J.S., De Carlo F., Stock S.R., Gridley D.S., Nelson G.A., Levine H.G., Bateman T.A. Long-term dose response of trabecular bone in mice to proton radiation. Radiation Research 2008, 169:607-614.
2. Bayraktar H.H., Morgan E.F., Niebur G.L., Morris G.E., Wong E.K., Keaveny T.M. Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue. Journal of Biomechanics 2004, 37:27-35.
3. Duchemin L., Mitton D., Jolivet E., Bousson V., Laredo J.D., Skalli W. An anatomical subject-specific FE-model for hip fracture load prediction. Computer Methods in Biomechanics and Biomedical Engineering 2008, 11:105-111.
4. Fukuda, S., and Hasegawa, S. (2000). Effects of heavy ion irradiation on bone metabolism and the related organs in rats. Research project with heavy ions. Annual Report NIRS-HIMAC, pp. 82-83.
5. Griffith J.F., Genant H.K. Bone mass and architecture determination: state of the art. Best Practice and Research: Clinical Endocrinology and Metabolism 2008, 22:737-764.
6. Hamilton S.A., Pecaut M.J., Gridley D.S., Travis N.D., Bandstra E.R., Willey J.S., Nelson G.A., Bateman T.A. A murine model for bone loss from therapeutic and space-relevant sources of radiation. Journal of Applied Physiology 2006, 101:789-793.
7. Howland W.J., Loeffler R.K., Starchman D.E., Johnson R.G. Postirradiation atrophic changes of bone and related complications. Radiology 1975, 117:677-685.
8. Inoue Y., Miki C., Ojima E., Nomoto Y., Kusunoki M. Pelvic insufficiency fractures after preoperative radiotherapy for rectal carcinoma. International Journal of Clinical Oncology 2003, 8(5):336-339.
9. Keyak J.H., Rossi S.A., Jones K.A., Skinner H.B. Prediction of femoral fracture load using automated finite element modeling. Journal of Biomechanics 1998, 31:125-133.
10. King M.A., Casarett G.W., Weber D.A. A study of irradiated bone: I. Histopathologic and physiologic changes. Journal of Nuclear Medicine 1979, 20:1142-1149.
11. Konski A., Sowers M. Pelvic fractures following irradiation for endometrial carcinoma. International Journal of Radiation Oncology Biology Physics 1996, 35:361-367.
12. Kwon J.W., Huh S.J., Yoon Y.C., Choi S.H., Jung J.Y., Oh D., Choe B.K. Pelvic bone complications after radiation therapy of uterine cervical cancer: evaluation with MRI. American Journal of Roentgenology 2008, 191:987-994.
13. Lin P.P., Schupak K.D., Boland P.J., Brennan M.F., Healey J.H. Pathologic femoral fracture after periosteal excision and radiation for the treatment of soft tissue sarcoma. Cancer 1998, 82:2356-2365.
14. Lochmuller E.M., Eckstein F., Kaiser D., Zeller J.B., Landgraf J., Putz R., Steldinger R. Prediction of vertebral failure loads from spinal and femoral dual-energy X-ray absorptiometry, and calcaneal ultrasound: an in situ analysis with intact soft tissues. Bone 1998, 23:417-424.
15. Maeda M., Bryant M.H., Yamagata M., Li G., Earle J.D., Chao E.Y.S. Effects of irradiation on cortical bone and their time-related changes. A biomechanical and histomorphological study. Journal of Bone and Joint Surgery-Series A 1988, 70:392-399.
16. Mann K.A., Lee J., Arrington S.A., Damron T.A., Allen M.J. Predicting distal femur bone strength in a murine model of tumor osteolysis. Clinical Orthopaedics and Related Research 2008, 466:1271-1278.
17. Margulies B., Morgan H., Allen M., Strauss J., Spadaro J., Damron T. Transiently increased bone density after irradiation and the radioprotectant drug amifostine in a rat model. American Journal of Clinical Oncology 2003, 26:e106-e114.
18. Niebur G.L., Feldstein M.J., Yuen J.C., Chen T.J., Keaveny T.M. High-resolution finite element models with tissue strength asymmetry accurately predict failure of trabecular bone. Journal of Biomechanics 2000, 33:1575-1583.
19. Niehoff P., Wiltfang J., Springer I., Weppner N., Kimmig B., Acil Y. Increased excretion of collagen crosslinks in irradiated patients indicates destruction of collagen. International Journal of Radiation Biology 2006, 82:503-509.
20. Nyaruba M.M., Yamamoto I., Kimura H., Morita R. Bone fragility induced by X-ray irradiation in relation to cortical bone-mineral content. Acta Radiologica 1998, 39:43-46.
21. Rohrer M.D., Kim Y., Fayos J.V. The effect of cobalt-60 irradiation on monkey mandibles. Oral Surgery Oral Medicine and Oral Pathology 1979, 48:424-440.
22. Sawajiri M., Mizoe J. Changes in bone volume after irradiation with carbon ions. Radiation and Environmental Biophysics 2003, 42:101-106.
23. Siris E.S., Chen Y.T., Abbott T.A., Barrett-Connor E., Miller P.D., Wehren L.E., Berger M.L. Bone mineral density thresholds for pharmacological intervention to prevent fractures. Archives of Internal Medicine 2004, 164:1108-1112.
24. Sugimoto M., Takahashi S., Toguchida J., Kotoura Y., Shibamoto Y., Yamamuro T. Changes in bone after high-dose irradiation. Biomechanics and histomorphology. Journal of Bone and Joint Surgery-Series B 1991, 73:492-497.
25. Szulc P., Munoz F., Duboeuf F., Marchand F., Delmas P.D. Bone mineral density predicts osteoporotic fractures in elderly men: the MINOS study. Osteoporosis International 2005, 16:1184-1192.
26. Willey, J. S., Livingston, E. W., Robbins, M. E., Bourland, J. D., Tirado-Lee, L., Smith-Sielicki, H., and Bateman, T. A. (2010). Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations. Bone.
27. Willey J.S., Lloyd S.A.J., Robbins M.E., Bourland J.D., Smith-Sielicki H., Bowman L.C., Norrdin R.W., Bateman T.A. Early increase in osteoclast number in mice after whole-body irradiation with 2Gy X rays. Radiation Research 2008, 170:388-392.
28. Yerramshetty J.S., Akkus O. The associations between mineral crystallinity and the mechanical properties of human cortical bone. Bone 2008, 42:476-482.
29. Zioupos P., Currey J.D., Casinos A. Exploring the effects of hypermineralisation in bone tissue by using an extreme biological example. Connective Tissue Research 2000, 41:229-248.