Total-body irradiation of postpubertal mice with 137Cs acutely compromises the microarchitecture of cancellous bone and increases osteoclasts

Radiation Research

Volumn 171, Issue 3, 2009, Pages 283-289

  Kondo, Hisataka ^a,b   Searby, Nancy D ^b   Mojarrab, Rose ^b   Phillips, Jonathan ^b   Alwood, Joshua ^b,c   Yumoto, Kenji ^a,b   Almeida, Eduardo A C ^b   Limoli, Charles L ^a   Globus, Ruth K ^b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NASA AMES RESEARCH CENTER   (United States)

^c Department of Aeronautics and Astronautics Department of Mechanical Engineering and Industrial for Computational and Mathematical Engineering   (United States)

^d NASA HEADQUARTERS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CESIUM 137;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE REMODELING; CANCELLOUS BONE; CONTROLLED STUDY; LUMBAR VERTEBRA; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; RADIATION DOSE; TRABECULAR BONE; WHOLE BODY RADIATION;

AGING; ANIMALS; BODY WEIGHT; BONE AND BONES; BONE DENSITY; BONE RESORPTION; CESIUM RADIOISOTOPES; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; MALE; MICE; ORGAN SIZE; OSTEOCLASTS; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; WHOLE-BODY IRRADIATION;

MUS;

EID: 61849179241     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1463.1     Document Type: Article

References (38)

1. R. J. White and M. Averner, Humans in space. Nature 409, 1115-1118 (2001).
2. F. A. Cucinotta, F. K. Manuel, J. Jones, G. Iszard, J. Murrey, B. Djojonegro and M. Wear, Space radiation and cataracts in astronauts. Radiat. Res. 156, 460-466 (2001).
3. J. A. Jones, M. McCarten, K. Manuel, B. Djojonegro, J. Murray, A. Feiversen and M. Wear, Cataract formation mechanisms and risk in aviation and space crews. Aviat. Space Environ. Med. 78, A56-A66 (2007).
4. T. Lang, A. LeBlanc, H. Evans, Y. Lu, H. Genant and A. Yu, Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J. Bone Miner. Res. 19, 1006-1012 (2004).
5. T. F. Lang, A. D. Leblanc, H. J. Evans and Y. Lu, Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight. J. Bone Miner. Res. 21, 1224-1230 (2006).
6. J. D. Sibonga, H. J. Evans, H. G. Sung, E. R. Spector, T F. Lang, V. S. Oganov, A. V. Bakulin, L. C. Shackelford and A. D. Leblanc, Recovery of spaceflight-induced bone loss: Bone mineral density after long-duration missions as fitted with an exponential function. Bone 41, 973-978 (2007).
7. R. D. Lloyd, G. N. Taylor and S. C. Miller, Fracture occurrence from radionuclides in the skeleton. Health Phys. 78, 687-692 (2000).
8. N. N. Baxter, E. B. Habermann, J. E. Tepper, S. B. Durham and B. A. Virnig, Risk of pelvic fractures in older women following pelvic irradiation. J. Am. Med. Assoc. 294, 2587-2593 (2005).
9. K. Nishiyama, F. Inaba, T. Higashihara, K. Kitatani and T. Kozuka, Radiation osteoporosis - an assessment using single energy quantitative computed tomography. Eur. Radiol. 2, 322-325 (1992).
10. + bone marrow mesenchymal stem cells induced by total body irradiation and its contribution to long-term bone and hematopoietic injury. Haematologica 92, 889-896 (2007).
11. S. A. Hamilton, M. J. Pecaut, D. S. Gridley, N. D. Travis, E. R. Bandstra, J. S. Willey, G. A. Nelson and T. A. Bateman, A murine model for bone loss from therapeutic and space-relevant sources of radiation. J. Appl. Physiol. 101, 789-793 (2006).
12. E. R. Bandstra, M. J. Pecaut, E. R. Anderson, J. S. Willey, F. De Carlo, S. R. Stock, D. S. Gridley, G. A. Nelson, H. G. Levine and T. A. Bateman, Long-term dose response of trabecular bone in mice to proton radiation. Radiat. Res. 169, 607-614 (2008).
13. W. G. Beamer, L. R. Donahue, C. J. Rosen and D. J. Baylink, Genetic variability in adult bone density among inbred strains of mice. Bone 18, 397-403 (1996).
14. R. F. Klein, S. R. Mitchell, T. J. Phillips, J. K. Belknap and E. S. Orwoll, Quantitative trait loci affecting peak bone mineral density in mice. J. Bone Miner. Res. 13, 1648-1656 (1998).
15. B. P. Halloran, V. L. Ferguson, S. J. Simske, A. Burghardt, L. L. Venton and S. Majumdar, Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J. Bone Miner. Res. 17, 1044-1050 (2002).
16. R. K. Globus, D. D. Bikle and E. Morey-Holton, The temporal response of bone to unloading. Endocrinology 118, 733-742 (1986).
17. U. T. Iwaniec, T. J. Wronski, D. Amblard, Y. Nishimura, M. C. van der Meulen, C. E. Wade, M. A. Bourgeois, C. D. Damsky and R. K. Globus, Effects of disrupted beta1-integrin function on the skeletal response to short-term hindlimb unloading in mice. J. Appl. Physiol. 98, 690-696 (2005).
18. H. Ha, J. H. Lee, H. N. Kim, H. M. Kim, H. B. Kwak, S. Lee, H. H. Kim and Z. H. Lee, α-Lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis. J. Immunol. 176, 111-117 (2006).
19. M. Nakamura, N. Udagawa, S. Matsuura, M. Mogi, H. Nakamura, H. Horiuchi, N. Saito, B. Y. Hiraoka, Y. Kobayashi and N. Takahashi, Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption. Endocrinology 144, 5441-5449 (2003).
20. T. Suda, E. Jimi, I. Nakamura and N. Takahashi, Role of 1 α,25-dihydroxyvitamin D3 in osteoclast differentiation and function. Methods Enzymol. 282, 223-235 (1997).
21. S. M. Tommasini, T. G. Morgan, M. van der Meulen and K. J. Jepsen, Genetic variation in structure-function relationships for the inbred mouse lumbar vertebral body. J. Bone Miner. Res. 20, 817-827 (2005).
22. M. J. Pecaut, G. A. Nelson and D. S. Gridley, Dose and dose rate effects of whole-body gamma-irradiation: I. Lymphocytes and lymphoid organs. In Vivo 15, 195-208 (2001).
23. Y. Gao, F. Grassi, M. R. Ryan, M. Terauchi, K. Page, X. Yang, M. N. Weitzmann and R. Pacifici, IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J. Clin. Invest. 117, 122-132 (2007).
24. J. S. Willey, S. A. Lloyd, M. E. Robbins, J. D. Bourland, H. Smith-Sielicki, L. C. Bowman, R. W. Norrdin and T. A. Bateman, Early increase in osteoclast number in mice after whole-body irradiation with 2 Gy X rays. Radiat. Res. 170, 388-392 (2008).
25. M. Sawajiri, J. Mizoe and K. Tanimoto, Changes in osteoclasts after irradiation with carbon ion particles. Radiat. Environ. Biophys. 42, 219-223 (2003).
26. Y. Hosokawa, Y. Sakakura, L. Tanaka, K. Okumura, T. Yajima and M. Kaneko, Effects of local and whole body irradiation on appearance of osteoclasts during wound healing of tooth extraction sockets in rats. J. Radiat. Res. (Tokyo) 48, 273-280 (2007).
27. B. A. Scheven, E. H. Burger, E. W. Kawilarang-de Haas, A. M. Wassenaar and P. J. Nijweide, Effects of ionizing irradiation on formation and resorbing activity of osteoclasts in vitro. Lab. Invest. 53, 72-79 (1985).
28. B. A. Scheven, A. M. Wassenaar, E. W. Kawilarang-de Haas and P. J. Nijweide, Direct and indirect radiation effects on osteoclast formation in vitro. Bone Miner. 2, 291-300 (1987).
29. M. Sawajiri and J. Mizoe, Changes in bone volume after irradiation with carbon ions. Radiat. Environ. Biophys. 42, 101-106 (2003).
30. M. Maeda, M. H. Bryant, M. Yamagata, G. Li, J. D. Earle and E. Y. Chao, Effects of irradiation on cortical bone and their time-related changes. A biomechanical and histomorphological study. J. Bone Joint Surg. Am. 70, 392-399 (1988).
31. M. Sugimoto, S. Takahashi, J. Toguchida, Y. Kotoura, Y. Shibamoto and T. Yamamuro, Changes in bone after high-dose irradiation. Biomechanics and histomorphology. J. Bone Joint Surg. Br. 73, 492-497 (1991).
32. M. J. Silva and L. J. Gibson, Modeling the mechanical behavior of vertebral trabecular bone: effects of age-related changes in micro-structure. Bone 21, 191-199 (1997).
33. W. Most, L. van der Wee-Pals, A. Ederveen, S. Papapoulos and C. Lowik, Ovariectomy and orchidectomy induce a transient increase in the osteoclastogenic potential of bone marrow cells in the mouse. Bone 20, 27-30 (1997).
34. Y. Onoe, C. Miyaura, M. Ito, H. Ohta, S. Nozawa and T. Suda, Comparative effects of estrogen and raloxifene on B lymphopoiesis and bone loss induced by sex steroid deficiency in mice. J. Bone Miner. Res. 15, 541-549 (2000).
35. 60Co gamma-ray on male reproductive endocrine damages induced by subsequent high-dose irradiation. Int. J. Androl. 29, 592-596 (2006).
36. R. P. Vergouwen, R. Huiskamp, R. J. Bas, H. L. Roepers-Gajadien, F. H. de Jong, F. J. van Eerdenburg, J. A. Davids and D. G. de Rooij, Radiosensitivity of testicular cells in the prepubertal mouse. Radiat. Res. 139, 316-326 (1994).
37. J. K. Kim, J. H. Kim and Y. D. Yoon, Evaluation of caffeine as a radioprotector in whole-body irradiated male mice. In Vivo 17, 197-200 (2003).
38. 60Co irradiation. Reprod. Nutr. Dev. 25, 355-366 (1985).