A murine model for bone loss from therapeutic and space-relevant sources of radiation

Journal of Applied Physiology

Volumn 101, Issue 3, 2006, Pages 789-793

  Hamilton, S A ^a   Pecaut, M J ^b   Gridley, D S ^b   Travis, N D ^a   Bandstra, E R ^a   Willey, J S ^a   Nelson, G A ^b   Bateman, T A ^a  

^a AMRL   (United States)

^b LOMA LINDA UNIVERSITY   (United States)

Author keywords

Cancer; Heavy ion; Microarchitecture; Microcomputed tomography; Osteoporosis

Indexed keywords

CARBON; IRON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAPHYSIS; FEMALE; FEMUR; GAMMA RADIATION; IRRADIATION; MOUSE; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; PROTON RADIATION; RADIATION; RADIATION DOSE; RADIATION EXPOSURE; SKELETON; SPACE FLIGHT; TIBIA; TRABECULAR BONE;

ANIMALS; CALCIFICATION, PHYSIOLOGIC; COSMIC RADIATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; FEMALE; HEAVY IONS; MICE; MICE, INBRED C57BL; OSTEOPOROSIS; OSTEORADIONECROSIS; RADIATION DOSAGE; RADIATION INJURIES, EXPERIMENTAL; RADIOTHERAPY; RISK ASSESSMENT; RISK FACTORS;

EID: 33748473854     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01078.2005     Document Type: Article

References (36)

1. Banfi A, Bianchi G, Galotto M, Cancedda R, and Quarto R. Bone marrow stromal damage after chemo/radiotherapy: occurrence, consequences and possibilities of treatment. Leuk Lymphoma 42: 863-870, 2001.
2. Bateman T, Abarbanel J, and Criswell M. Structural modifications to the framing system of a proposed lunar/Martian inflatable structure. Proc Int Conf Space 7: 424-430, 2000.
3. Baxter NN, Habermann EB, Tepper JE, Durham SB, and Virnig BA. Risk of pelvic fractures in older women following pelvic irradiation. JAMA 294: 2587-2593, 2005.
4. Blair JM, Zhou H, Seibel MJ, and Dunstan CR. Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Nat Clin Pract Oncol 3: 41-49, 2006.
5. Borah B, Dufresne TE, Chmielewski PA, Gross GJ, Prenger MC, and Phipps RJ. Risedronate preserves trabecular architecture and increases bone strength in vertebra of ovariectomized minipigs as measured by three-dimensional microcomputed tomography. J Bone Miner Res 17: 1139-1147, 2002.
6. Cucinotta FA, Manuel FK, Jones J, Iszard G, Murrey J, Djojonegro B, and Wear M. Space radiation and cataracts in astronauts. Radiat Res 156: 460-466, 2001.
7. Cucinotta FA, Schimmerling W, Wilson JW, Peterson LE, Badhwar GD, Saganti PB, and Dicello JF. Space Radiation Cancer Risk Projections for Exploratory Missions: Uncertainty Reduction and Mitigation. Houston, TX: Johnson Space Center, 2001.
8. Cucinotta FA, Wu H, Shavers MR, and George K. Radiation dosimetry and biophysical models of space radiation effects. Gravit Space Biol Bull 16: 11-18, 2003.
9. Darzy KH and Shalet SM. Hypopituitarism after cranial irradiation. J Endocrinol Invest 28: 78-87, 2005.
10. Dempster DW, Cosman F, Kurland ES, Zhou H, Nieves J, Woelfert L, Shane E, Plavetic K, Muller R, Bilezikian J, and Lindsay R. Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study. J Bone Miner Res 16: 1846-1853, 2001.
11. Donovan DJ, Huynh TV, Purdom EB, Johnson RE, and Sniezek JC. Osteoradionecrosis of the cervical spine resulting from radiotherapy for primary head and neck malignancies: operative and nonoperative management. Case report. J Neurosurg Spine 3: 159-164, 2005.
12. Edwards AA. RBE of radiations in space and the implications for space travel. Phys Med 17, Suppl 1: 147-152, 2001.
13. Frassica DA and Zellars R. Radiation oncology: the year in review. Curr Opin Oncol 14: 594-599, 2002.
14. Gridley DS, Pecaut MJ, Dutta-Roy R, and Nelson GA. Dose and dose rate effects of whole-body proton irradiation on leukocyte populations and lymphoid organs: part I. Immunol Lett 80: 55-66, 2002.
15. Gridley DS, Pecaut MJ, Miller GM, Moyers MF, and Nelson GA. Dose and dose rate effects of whole-body gamma-irradiation: II. Hematological variables and cytokines. In Vivo 15: 209-216, 2001.
16. Guo XE and Kim CH. Mechanical consequence of trabecular bone loss and its treatment: a three-dimensional model simulation. Bone 30: 404-411, 2002.
17. Hall EJ. Radiobiology for the Radiologist. Philadelphia, PA: Lippincott Williams & Wilkins, 2000.
18. Hopewell JW. Radiation-therapy effects on bone density. Med Pediatr Oncol 41: 208-211, 2003.
19. Kinney JH and Ladd AJ. The relationship between three-dimensional connectivity and the elastic properties of trabecular bone. J Bone Miner Res 13: 839-845, 1998.
20. Lang T, LeBlanc A, Evans H, Lu Y, Genant H, and Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res 19: 1006-1012, 2004.
21. Langlands AO, Souter WA, Samuel E, and Redpath AT. Radiation osteitis following irradiation for breast cancer. Clin Radiol 28: 93-96, 1977.
22. Matsumoto H, Takahashi A, and Ohnishi T. Radiation-induced adaptive responses and bystander effects. Biol Sci Space 18: 247-254, 2004.
23. Ott S. Histomorphometric analysis of bone remodeling. In: Principles of Bone Biology (2nd ed.), edited by Bilezikian J, Raisz L, and Rodan G. San Diego, CA: Academic, 2002, p. 303-319.
24. Parfitt AM. Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences. Calcif Tissue Int 36, Suppl 1: 123-128, 1984.
25. Parsons JL, Townsend LW. Interplanetary crew dose rates for the August 1972 solar particle event. Radiat Res 153: 729-733, 2000.
26. 2 euthanasia. Comp Med 50: 595-602, 2000.
27. Petersen PM, Giwercman A, Skakkebaek NE, and Rorth M. Gonadal function in men with testicular cancer. Semin Oncol 25: 224-233, 1998.
28. Pollack LA, Greer GE, Rowland JH, Miller A, Doneski D, Coughlin SS, Stovall E, and Ulman D. Cancer survivorship: a new challenge in comprehensive cancer control. Cancer Causes Control 16, Suppl 1: 51-59, 2005.
29. Setlow R, Dicello JF, Fry RJM, Little JB, Preston RJ, Smathers JB, and Ullrich RL. Radiation Hazards to Crews of Interplanetary Missions: Biological Issues and Research Strategies. Washington, DC: Space Studies Board, National Research Council, & National Academy Press, 1996, p. 13-34.
30. Small W Jr and Kachnic L. Postradiotherapy pelvic fractures: cause for concern or opportunity for future research? JAMA 294: 2635-2637, 2005.
31. Tilton FE, Degioanni JJ, and Schneider VS. Long-term follow-up of Skylab bone demineralization. Aviat Space Environ Med 51: 1209-1213, 1980.
32. Todd P. Space radiation health: a brief primer. Gravit Space Biol Bull 16: 1-4, 2003.
33. Vazquez ME. Neurobiological problems in long-term deep space flights. Adv Space Res 22: 171-183, 1998.
34. Vernikos J and Nicogossian AE. Strategic Program Plan for Space Radiation Health Research. Washington, DC: NASA Headquarters Space Radiation Health, 1998, p. 1-71.
35. Wall JE, Kaste SC, Greenwald CA, Jenkins JJ, Douglass EC, and Pratt CB. Fractures in children treated with radiotherapy for soft tissue sarcoma. Orthopedics 19: 657-664, 1996.
36. Wild A, Jaeger M, Haak H, and Mehdian SH. Sacral insufficiency fracture, an unsuspected cause of low-back pain in elderly women. Arch Orthop Trauma Surg 122: 58-60, 2002.