-
1
-
-
78751638853
-
Challenges to effective research in acute trauma resuscitation: Consent and endpoints
-
Holcomb, J.B. et al. Challenges to effective research in acute trauma resuscitation: consent and endpoints. Shock 35, 107-113 (2011).
-
(2011)
Shock
, vol.35
, pp. 107-113
-
-
Holcomb, J.B.1
-
2
-
-
39549101440
-
Hypertonic resuscitation of hypovolemic shock after blunt trauma: A randomized controlled trial
-
Bulger, E.M. et al. Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial. Arch. Surg. 143, 139-148 (2008).
-
(2008)
Arch. Surg.
, vol.143
, pp. 139-148
-
-
Bulger, E.M.1
-
3
-
-
43349094278
-
Early events in the recognition of danger signals after tissue injury
-
Kaczorowski, D.J., Mollen, K.P., Edmonds, R. & Billiar, T.R. Early events in the recognition of danger signals after tissue injury. J. Leukoc. Biol. 83, 546-552 (2008).
-
(2008)
J. Leukoc. Biol.
, vol.83
, pp. 546-552
-
-
Kaczorowski, D.J.1
Mollen, K.P.2
Edmonds, R.3
Billiar, T.R.4
-
4
-
-
34247338128
-
Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003
-
Dombrovskiy, V.Y., Martin, A.A., Sunderram, J. & Paz, H.L. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit. Care Med. 35, 1244-1250 (2007).
-
(2007)
Crit. Care Med.
, vol.35
, pp. 1244-1250
-
-
Dombrovskiy, V.Y.1
Martin, A.A.2
Sunderram, J.3
Paz, H.L.4
-
5
-
-
84872407093
-
New approaches to the study of sepsis
-
Ward, P.A. New approaches to the study of sepsis. EMBO Mol. Med. 4, 1234-1243 (2012).
-
(2012)
EMBO Mol. Med.
, vol.4
, pp. 1234-1243
-
-
Ward, P.A.1
-
6
-
-
47949099098
-
Origin and physiological roles of inflammation
-
Medzhitov, R. Origin and physiological roles of inflammation. Nature 454, 428-435 (2008).
-
(2008)
Nature
, vol.454
, pp. 428-435
-
-
Medzhitov, R.1
-
7
-
-
20544442905
-
Alarmins: Chemotactic activators of immune responses
-
Oppenheim, J.J. & Yang, D. Alarmins: chemotactic activators of immune responses. Curr. Opin. Immunol. 17, 359-365 (2005).
-
(2005)
Curr. Opin. Immunol.
, vol.17
, pp. 359-365
-
-
Oppenheim, J.J.1
Yang, D.2
-
8
-
-
38549136572
-
Macrophage activation by endogenous danger signals
-
Zhang, X. & Mosser, D.M. Macrophage activation by endogenous danger signals. J. Pathol. 214, 161-178 (2008).
-
(2008)
J. Pathol.
, vol.214
, pp. 161-178
-
-
Zhang, X.1
Mosser, D.M.2
-
9
-
-
61849170035
-
TLRs and innate immunity
-
Beutler, B.A. TLRs and innate immunity. Blood 113, 1399-1407 (2009).
-
(2009)
Blood
, vol.113
, pp. 1399-1407
-
-
Beutler, B.A.1
-
10
-
-
66749166421
-
The sepsis seesaw: Seeking a heart salve
-
Ward, P.A. The sepsis seesaw: seeking a heart salve. Nat. Med. 15, 497-498 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 497-498
-
-
Ward, P.A.1
-
11
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
-
Kawai, T. & Akira, S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
12
-
-
63149171602
-
CD24 and Siglec-10 selectively repress tissue damage-induced immune responses
-
Chen, G.Y., Tang, J., Zheng, P. & Liu, Y. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science 323, 1722-1725 (2009).
-
(2009)
Science
, vol.323
, pp. 1722-1725
-
-
Chen, G.Y.1
Tang, J.2
Zheng, P.3
Liu, Y.4
-
13
-
-
0033538467
-
HMG-1 as a late mediator of endotoxin lethality in mice
-
Wang, H. et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285, 248-251 (1999).
-
(1999)
Science
, vol.285
, pp. 248-251
-
-
Wang, H.1
-
14
-
-
20244373939
-
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
-
Tsung, A. et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J. Exp. Med. 201, 1135-1143 (2005).
-
(2005)
J. Exp. Med.
, vol.201
, pp. 1135-1143
-
-
Tsung, A.1
-
15
-
-
23844482773
-
Heat shock proteins as endogenous adjuvants in sterile and septic inflammation
-
Quintana, F.J. & Cohen, I.R. Heat shock proteins as endogenous adjuvants in sterile and septic inflammation. J. Immunol. 175, 2777-2782 (2005).
-
(2005)
J. Immunol.
, vol.175
, pp. 2777-2782
-
-
Quintana, F.J.1
Cohen, I.R.2
-
16
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241 (2006).
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
Pétrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
17
-
-
34948900275
-
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
-
Vogl, T. et al. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat. Med. 13, 1042-1049 (2007).
-
(2007)
Nat. Med.
, vol.13
, pp. 1042-1049
-
-
Vogl, T.1
-
18
-
-
70449107044
-
Extracellular histones are major mediators of death in sepsis
-
Xu, J. et al. Extracellular histones are major mediators of death in sepsis. Nat. Med. 15, 1318-1321 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 1318-1321
-
-
Xu, J.1
-
19
-
-
77950275298
-
Circulating mitochondrial DAMPs cause inflammatory responses to injury
-
Zhang, Q. et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464, 104-107 (2010).
-
(2010)
Nature
, vol.464
, pp. 104-107
-
-
Zhang, Q.1
-
20
-
-
0031578903
-
Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene
-
Nishiyama, H. et al. Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene. Gene 204, 115-120 (1997).
-
(1997)
Gene
, vol.204
, pp. 115-120
-
-
Nishiyama, H.1
-
21
-
-
0030975108
-
A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth
-
Nishiyama, H. et al. A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth. J. Cell Biol. 137, 899-908 (1997).
-
(1997)
J. Cell Biol.
, vol.137
, pp. 899-908
-
-
Nishiyama, H.1
-
22
-
-
0033233147
-
Effects of ischemia and H2O2 on the cold stress protein CIRP expression in rat neuronal cells
-
Xue, J.H. et al. Effects of ischemia and H2O2 on the cold stress protein CIRP expression in rat neuronal cells. Free Radic. Biol. Med. 27, 1238-1244 (1999).
-
(1999)
Free Radic. Biol. Med.
, vol.27
, pp. 1238-1244
-
-
Xue, J.H.1
-
23
-
-
0031984249
-
Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature
-
Nishiyama, H. et al. Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature. Am. J. Pathol. 152, 289-296 (1998).
-
(1998)
Am. J. Pathol.
, vol.152
, pp. 289-296
-
-
Nishiyama, H.1
-
24
-
-
0032540102
-
Diurnal change of the cold-inducible RNA-binding protein (Cirp) expression in mouse brain
-
Nishiyama, H. et al. Diurnal change of the cold-inducible RNA-binding protein (Cirp) expression in mouse brain. Biochem. Biophys. Res. Commun. 245, 534-538 (1998).
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.245
, pp. 534-538
-
-
Nishiyama, H.1
-
25
-
-
0030726447
-
Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein
-
Sheikh, M.S. et al. Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein. J. Biol. Chem. 272, 26720-26726 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 26720-26726
-
-
Sheikh, M.S.1
-
26
-
-
2342427775
-
Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism
-
Wellmann, S. et al. Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. J. Cell Sci. 117, 1785-1794 (2004).
-
(2004)
J. Cell Sci.
, vol.117
, pp. 1785-1794
-
-
Wellmann, S.1
-
27
-
-
67349108796
-
P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways
-
Qu, Y. & Dubyak, G.R. P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways. Purinergic Signal. 5, 163-173 (2009).
-
(2009)
Purinergic Signal.
, vol.5
, pp. 163-173
-
-
Qu, Y.1
Dubyak, G.R.2
-
28
-
-
0024997246
-
Removal of endotoxin from protein solutions by phase separation using Triton X-114
-
Aida, Y. & Pabst, M.J. Removal of endotoxin from protein solutions by phase separation using Triton X-114. J. Immunol. Methods 132, 191-195 (1990).
-
(1990)
J. Immunol. Methods
, vol.132
, pp. 191-195
-
-
Aida, Y.1
Pabst, M.J.2
-
29
-
-
14844355875
-
Identification of stimulating and inhibitory epitopes within the heat shock protein 70 molecule that modulate cytokine production and maturation of dendritic cells
-
Wang, Y. et al. Identification of stimulating and inhibitory epitopes within the heat shock protein 70 molecule that modulate cytokine production and maturation of dendritic cells. J. Immunol. 174, 3306-3316 (2005).
-
(2005)
J. Immunol.
, vol.174
, pp. 3306-3316
-
-
Wang, Y.1
-
30
-
-
77950349873
-
Caught with their PAMPs down' the extracellular signalling actions of molecular chaperones are not due to microbial contaminants
-
Henderson, B. et al. Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants. Cell Stress Chaperones 15, 123-141 (2010).
-
(2010)
Cell Stress Chaperones
, vol.15
, pp. 123-141
-
-
Henderson, B.1
-
31
-
-
0034698830
-
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
-
Andersson, U. et al. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J. Exp. Med. 192, 565-570 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 565-570
-
-
Andersson, U.1
-
32
-
-
9144241208
-
Reversing established sepsis with antagonists of endogenous high-mobility group box 1
-
Yang, H. et al. Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc. Natl. Acad. Sci. USA 101, 296-301 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 296-301
-
-
Yang, H.1
-
33
-
-
0036830201
-
Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: Role of adrenomedullin and adrenomedullin binding protein-1
-
Yang, S., Zhou, M., Chaudry, I.H. & Wang, P. Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: role of adrenomedullin and adrenomedullin binding protein-1. Ann. Surg. 236, 625-633 (2002).
-
(2002)
Ann. Surg.
, vol.236
, pp. 625-633
-
-
Yang, S.1
Zhou, M.2
Chaudry, I.H.3
Wang, P.4
-
34
-
-
0036301797
-
Essential role of MD-2 in LPS responsiveness and TLR4 distribution
-
Nagai, Y. et al. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3, 667-672 (2002).
-
(2002)
Nat. Immunol.
, vol.3
, pp. 667-672
-
-
Nagai, Y.1
-
35
-
-
9144271703
-
Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling
-
Hyakushima, N. et al. Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling. J. Immunol. 173, 6949-6954 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 6949-6954
-
-
Hyakushima, N.1
-
36
-
-
0035861655
-
The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response
-
Yang, C. & Carrier, F. The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response. J. Biol. Chem. 276, 47277-47284 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47277-47284
-
-
Yang, C.1
Carrier, F.2
-
37
-
-
56149106691
-
Post-transcriptional control of gene expression through subcellular relocalization of mRNA binding proteins
-
Cammas, A., Lewis, S.M., Vagner, S. & Holcik, M. Post-transcriptional control of gene expression through subcellular relocalization of mRNA binding proteins. Biochem. Pharmacol. 76, 1395-1403 (2008).
-
(2008)
Biochem. Pharmacol.
, vol.76
, pp. 1395-1403
-
-
Cammas, A.1
Lewis, S.M.2
Vagner, S.3
Holcik, M.4
-
38
-
-
36049032156
-
The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor
-
De Leeuw, F. et al. The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor. Exp. Cell Res. 313, 4130-4144 (2007).
-
(2007)
Exp. Cell Res.
, vol.313
, pp. 4130-4144
-
-
De Leeuw, F.1
-
39
-
-
77950561704
-
Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3?-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript
-
Yang, R. et al. Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3?-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript. J. Biol. Chem. 285, 8887-8893 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 8887-8893
-
-
Yang, R.1
-
40
-
-
34548614009
-
Nonclassical IL-1 secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages
-
Qu, Y., Franchi, L., Nunez, G. & Dubyak, G.R. Nonclassical IL-1? secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J. Immunol. 179, 1913-1925 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 1913-1925
-
-
Qu, Y.1
Franchi, L.2
Nunez, G.3
Dubyak, G.R.4
-
41
-
-
67650508030
-
Toll-like receptors 4 contribute to endothelial injury and inflammation in hemorrhagic shock in mice
-
Benhamou, Y. et al. Toll-like receptors 4 contribute to endothelial injury and inflammation in hemorrhagic shock in mice. Crit. Care Med. 37, 1724-1728 (2009).
-
(2009)
Crit. Care Med.
, vol.37
, pp. 1724-1728
-
-
Benhamou, Y.1
-
42
-
-
77952481566
-
Toll-like receptor 4 modulation as a strategy to treat sepsis
-
Wittebole, X., Castanares-Zapatero, D. & Laterre, P.F. Toll-like receptor 4 modulation as a strategy to treat sepsis. Mediators Inflamm. 2010, 568396 (2010).
-
(2010)
Mediators Inflamm.
, vol.2010
, pp. 568396
-
-
Wittebole, X.1
Castanares-Zapatero, D.2
Laterre, P.F.3
-
43
-
-
1542380035
-
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
-
Park, J.S. et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J. Biol. Chem. 279, 7370-7377 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7370-7377
-
-
Park, J.S.1
-
44
-
-
0034650427
-
Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
-
Ohashi, K., Burkart, V., Flohé, S. & Kolb, H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 164, 558-561 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 558-561
-
-
Ohashi, K.1
Burkart, V.2
Flohé, S.3
Kolb, H.4
-
45
-
-
0037033364
-
Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
-
Termeer, C. et al. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J. Exp. Med. 195, 99-111 (2002).
-
(2002)
J. Exp. Med.
, vol.195
, pp. 99-111
-
-
Termeer, C.1
-
46
-
-
0035971217
-
The extra domain A of fibronectin activates Toll-like receptor 4
-
Okamura, Y. et al. The extra domain A of fibronectin activates Toll-like receptor 4. J. Biol. Chem. 276, 10229-10233 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10229-10233
-
-
Okamura, Y.1
-
47
-
-
77955403878
-
A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
-
Yang, H. et al. A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. Proc. Natl. Acad. Sci. USA 107, 11942-11947 (2010).
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 11942-11947
-
-
Yang, H.1
-
48
-
-
84878408642
-
The many faces of HMGB1: Molecular structure-functional activity in inflammation, apoptosis, and chemotaxis
-
Yang, H., Antoine, D.J., Andersson, U. & Tracey, K.J. The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis. J. Leukoc. Biol. 93, 865-873 (2013).
-
(2013)
J. Leukoc. Biol.
, vol.93
, pp. 865-873
-
-
Yang, H.1
Antoine, D.J.2
Andersson, U.3
Tracey, K.J.4
-
49
-
-
35048817885
-
Kinetics of binding of LPS to recombinant CD14 TLR4 and MD-2 proteins
-
Shin, H.J. et al. Kinetics of binding of LPS to recombinant CD14, TLR4, and MD-2 proteins. Mol. Cells 24, 119-124 (2007).
-
(2007)
Mol. Cells
, vol.24
, pp. 119-124
-
-
Shin, H.J.1
-
50
-
-
0037062934
-
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
-
Scaffidi, P., Misteli, T. & Bianchi, M.E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418, 191-195 (2002).
-
(2002)
Nature
, vol.418
, pp. 191-195
-
-
Scaffidi, P.1
Misteli, T.2
Bianchi, M.E.3
-
51
-
-
84874343625
-
NF-?B-dependent role for cold-inducible RNA binding protein in regulating interleukin 1?
-
Brochu, C. et al. NF-?B-dependent role for cold-inducible RNA binding protein in regulating interleukin 1?. PLoS ONE 8, e57426 (2013).
-
(2013)
PLoS ONE
, vol.8
-
-
Brochu, C.1
-
52
-
-
33646047404
-
Cirp protects against tumor necrosis factor-?-induced apoptosis via activation of extracellular signal-regulated kinase
-
Sakurai, T. et al. Cirp protects against tumor necrosis factor-?-induced apoptosis via activation of extracellular signal-regulated kinase. Biochim. Biophys. Acta 1763, 290-295 (2006).
-
(2006)
Biochim. Biophys. Acta
, vol.1763
, pp. 290-295
-
-
Sakurai, T.1
-
53
-
-
21444456794
-
Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: The central role of adrenomedullin binding protein-1
-
Wu, R. et al. Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: the central role of adrenomedullin binding protein-1. Ann. Surg. 242, 115-123 (2005).
-
(2005)
Ann. Surg.
, vol.242
, pp. 115-123
-
-
Wu, R.1
-
54
-
-
77952094971
-
Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII
-
Miksa, M. et al. Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII. J. Immunol. 183, 5983-5990 (2009)
-
(2009)
J. Immunol.
, vol.183
, pp. 5983-5990
-
-
Miksa, M.1
|