Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes

Cardiovascular Research

Volumn 98, Issue 3, 2013, Pages 391-401

  Tian, Jing ^a   Guo, Xin ^b   Liu, Xue Mei ^b   Liu, Li ^b   Weng, Qi Fang ^a   Dong, Shu Juan ^b   Knowlton, Anne A ^c   Yuan, Wen Jun ^a,b   Lin, Li ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b NINGXIA MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cardiomyocyte; Heat shock protein; Inflammatory cytokine; Toll like receptor

Indexed keywords

CHAPERONIN 60; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXTRACELLULAR SPACE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; INFLAMMATION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; WESTERN BLOTTING;

CARDIOMYOCYTE; HEAT SHOCK PROTEIN; INFLAMMATORY CYTOKINE; TOLL-LIKE RECEPTOR;

ANIMALS; CELL LINE; CHAPERONIN 60; DISEASE MODELS, ANIMAL; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MITOCHONDRIAL PROTEINS; MYELOID DIFFERENTIATION FACTOR 88; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84877934501     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt047     Document Type: Article

References (33)

1. Taqueti VR, Mitchell RN, Lichtman AH. Protecting the pump: controlling myocardial inflammatory responses. Annu Rev Physiol 2005;68:67-95.
2. Coggins M, Rosenzweig A. The fire within: cardiac inflammatory signaling in health and disease. Circ Res 2012;110:116-125.
3. Prabhu SD. Cytokine-induced modulation of cardiac function. Circ Res 2004; 95:1140-1153.
4. Chao W. Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart. Am J Physiol Heart Circ Physiol 2009;296:H1-H12.
5. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124:783-801.
6. Kawai T, Akira S. TLR signaling. Semin Immunol 2007;19:24-32.
7. Boyd JH, Mathur S, Wang Y, Bateman RM, Walley KR. Toll-like receptor stimulation in cardiomyocytes decreases contractility and initiates an NF-kB dependent inflammatory response. Cardiovasc Res 2006;72:384-393.
8. Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 2003; 301:640-643.
9. Chong AJ, Shimamoto A, Hampton CR, Takayama H, Spring DJ, Rothnie CL et al. Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. J Thorac Cardi-ovasc Surg 2004;128:170-179.
10. Li Y, Si R, Feng Y, Chen HH, Zou L, Wang E et al. Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and toll-like receptor 4. J Biol Chem 2011;286:31308-31319.
11. Oyama J, Blais C Jr, Liu X, Pu M, Kobzik L, Kelly RA et al. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 2004; 109:784-789.
12. Shishido T, Nozaki N, Yamaguchi S, Shibata Y, Nitobe J, Miyamoto T et al. Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation 2003;108:2905-2910.
13. Timmers L, Sluijter JP, van Keulen JK, Hoefer IE, Nederhoff MG, Goumans MJ et al. Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction. Circ Res 2008;102:257-264.
14. Kaczorowski DJ, Mollen KP, Edmonds R, Billiar TR. Early events in the recognition of danger signals after tissue injury. J Leukoc Biol 2008;83:546-552.
15. Ohashi K, Burkart V, Flohe S, Kolb H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 2000;164:558-561.
16. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE et al. Novel signal transduc-tion pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 2002;277:15028-15034.
17. Calderwood SK, Mambula SS, Gray PJ Jr. Extracellular heat shock proteins in cell signaling and immunity. Ann NY Acad Sci 2007;1113:28-39.
18. Lin L, Kim SC, Wang Y, Gupta S, Davis B, Simon SI et al. HSP60 in heart failure: ab normal distribution and role in cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol 2007;293:H2238-H2247.
19. Kim SC, Stice JP, Chen L, Jung JS, Gupta S, Wang Y et al. Extracellular heat shock protein 60, cardiac myocytes, and apoptosis. Circ Res 2009;105:1186-1195.
20. Gobert AP, Bambou JC, Werts C, Balloy V, Chignard M, Moran AP et al. Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentiation 88-independent mechanism. J Biol Chem 2004;279:245-250.
21. Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Hacker H et al. Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 2001; 276:31332-31339.
22. Fang J, Song XW, Tian J, Chen HY, Li DF, Wang JF et al. Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes. Apoptosis 2012;17:410-423.
23. Sun L, Chang J, Kirchhoff SR, Knowlton AA. Activation of HSF and selective increase in heat shock proteins by acute dexamethasone treatment. Am J Physiol 2000; 278:H1091-H1096.
24. + overloading, trigger pH and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion. Am J Physiol Heart Circ Physiol 2006;290:H2024-H2034.
25. Peng T, Lu X, Lei M, Moe GW, Feng Q. Inhibition of p38 MAPK decreases myocardial TNF-a expression and improves myocardial function and survival in endotoxemia. Cardiovasc Res 2003;59:893-900.
26. Peng T, Zhang T, Lu X, Feng Q. JNK1/c-fos inhibits cardiomyocyte TNF-a expression via a negative crosstalk with ERK and p38 MAPK in endotoxaemia. Cardiovasc Res 2009;81:733-741.
27. Swantek JL, Cobb MH, Geppert TD. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK Mol Cell Biol 1997;17:6274-6282.
28. Comalada M, Xaus J, Valledor AF, Lopez-Lopez C, Pennington DJ, Celada A. PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages. Am J Physiol Cell Physiol 2003;285:C1235-C1245.
29. Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 2005;11:1173-1179.
30. Gupta S, Knowlton AA. HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway. Am J Physiol Heart Circ Physiol 2007;292:H3052-H3056.
31. Mandal K, Afzal AR, Brecker SJ, Poloniecki J, Xu Q, Jahangiri M. Association of serum soluble heat shock protein 60 with toll-like receptor 4 polymorphism and severity of coronary artery disease. Heart 2006;92:683-685.
32. Novo G, Cappello F, Rizzo M, Fazio G, Zambuto S, Tortorici E et al. Hsp60 and heme oxygenase-1 (Hsp32) in acute myocardial infarction. Transl Res 2011;157:285-292.
33. Frantz S, Kobzik L, Kim YD, Fukazawa R, Medzhitov R, Lee RT et al. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest 1999; 104:271-280.