Polymeric micelles as drug carriers: Their lights and shadows

Journal of Drug Targeting

Volumn 22, Issue 7, 2014, Pages 576-583

  Yokoyama, Masayuki ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Biodistribution; Controlled release; Drug targeting; Immune response; Nanoparticles; Polymer; Solid tumor; Targeting; Tumor targeting

Indexed keywords

DRUG CARRIER; LIPOSOME; NANOSPHERE; POLYMER; DRUG; MICELLE;

DRUG RELEASE; DRUG RETENTION; DRUG TARGETING; IMMUNOGENICITY; MICELLE; PARTICLE SIZE; PERMEABILITY; PHYSICAL CHEMISTRY; POLYMERIZATION; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; REVIEW; SUSTAINED DRUG RELEASE; ANIMAL; BLOOD; CHEMISTRY; DRUG FORMULATION; DRUG STABILITY; HUMAN; SURFACE PROPERTY; TISSUE DISTRIBUTION; TOXICITY;

ANIMALS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG LIBERATION; DRUG STABILITY; HUMANS; MICELLES; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; POLYMERS; SURFACE PROPERTIES; TISSUE DISTRIBUTION;

EID: 84904299687     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2014.934688     Document Type: Review

References (57)

1. Tuzar Z, Kratochvíl P. Block and graft copolymer micelles in solution. Adv Coll Interface Sci 1976;6:201-32
2. Weber SE. Polymer micelles: An example of self-Assembling polymers. J Phys Chem B 1998;102:2618-26
3. Bader H, Ringsdorf H, Schmidt B. Watersoluble polymers in medicine. Angew Chem 1984;123/124:457-85
4. Pratten MK, Lloyd JB, Ringsdorf H. Micelle-forming block copolymers: Pinocytosis by macrophages and interaction with model membranes. Makromol Chem 1985;186:725-33
5. Kabanov AV, Chekhonin VP, Alakhov VYu, et al. The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles: Micelles as microcontainers for drug targeting. FEBS Lett 1989;258:343-5
6. Kabanov AV, Batrakova EV, Alakhov VY. Pluronic block copolymers for overcoming drug resistance in cancer. Adv Drug Deliv Rev 2002;54:759-79
7. Yokoyama M, Inoue S, Kataoka K, et al. Preparation of adriamycinconjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. A new type of polymeric anticancer agent. Makromol Chem Rapid Commun 1987;8:431-5
8. Yokoyama M, Inoue S, Kataoka K, et al. Molecular design for missile drug: Synthesis of adriamycin conjugated with IgG using poly(ethylene glycol)-poly(aspartic acid) block copolymer as intermediate carrier. Makromol Chem 1989;190:2041-54
9. Yokoyama M, Miyauchi M, Yamada N, et al. Characterization and anti-cancer activity of micelle-forming polymeric anti-cancer drug, adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res 1990;50:1693-700
10. Yokoyama M, Okano T, Sakurai Y, et al. Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res 1991;51:3229-36
11. Yokoyama M, Okano T, Sakurai Y, Fukushima S, Okamoto K, Kataoka K. Selective delivery of adriamycin to a solid tumor using a polymeric micelle carrier system. J Drug Targeting 1999;7: 171-86
12. Adams ML, Lavasanifar A, Kwon GS. Amphiphilic block copolymers for drug delivery. J Pharm Sci 2003;92:1343-55
13. Aliabadi M, Lavasanifar A. Polymeric micelles for drug delivery. Expert Opin Drug Deliv 2006;3:139-62
14. Aw MS, Kurian M, Losic D. Polymeric micelles for multidrug delivery and combination therapy. Chemistry Eur J 2013;19: 12586-601
15. Kwon GS. Polymeric micelles for delivery of poorly watersoluble compounds. Crit Rev Ther Drug Carrier Syst 2003;20: 357-403
16. Yokoyama M. Block copolymers as drug carriers. Crit Rev Ther Drug Carrier Syst 1992;9:213-48
17. Yokoyama M. Polymeric micelles as nano-sized drug carrier systems. In: Tabata Y, ed. Nanoparticles for pharmaceutical applications. Stevenson Ranch: American Scientific Publishers; 2007
18. Yokoyama M. Clinical applications of polymeric micelle carrier systems in chemotherapy and image diagnosis of solid tumors. J Exp Clin Med 2011;3;151-8
19. Yamamoto T, Yokoyama M, Opanasopit P, et al. What are determining factors for stable drug incorporation into polymeric micelle carriers?. Consideration on physical and chemical characters of the micelle inner core. J Contr Rel 2007;123:11-18
20. Kwon GS, Naito M, Yokoyama M, et al. Physical entrapment of adriamycin in AB block copolymer micelles. Pharm Res 1995;12: 192-5
21. Johnson RP, Jeong YI, John JV, et al. Dual stimuli-responsive poly(N-isopropylacrylamide)-b-poly(L-histidine) chimeric materials for the controlled delivery of doxorubicin into liver carcinoma. Biomacromol 2013;14:1434-43
22. Ma P, Mumper RJ. Anthracycline nano-delivery systems to overcome multiple drug resistance: A comprehensive review. Nano Today 2013;8:313-31
23. Ishida I, Maruyama K, Sasaki K, Iwatsuru M. Size-dependent extravasation and interstitial localization of polyethyleneglycol liposomes in solid tumor-bearing mice. Int J Pharm 1999;190: 49-56
24. Litzinger DC, Buiting AM, van Rooijen N, Huang L. Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes. Biochim Biophys Acta 1994;1190:99-107
25. Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986;46:6387-92
26. Maeda H. Macromolecular therapeutics in cancer treatment: The EPR effect and beyond. J Contr Rel 2012;164:138-44
27. Maeda H. The link between infection and cancer: Tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect. Cancer Sci 2013;104:779-89
28. Maeda H, Seymour LW, Miyamoto Y. Conjugates of anticancer agents and polymers: Advantages of macromolecular therapeutics in vivo. Bioconjugate Chem 1992;3:351-62
29. Hamad E, Qutubuddin S. Theory of micelle formation by amphiphilic side-chain polymers. Macromolecules 1990;23: 4185-91
30. Munch MR, Gast AP. Block copolymers at interfaces. 1. Micelle formation. Macromolecules 1988;21:1360-6
31. Xu R, Winnik MA, Riess G, et al. Micellization of polystyrenepoly(ethylene oxide) block copolymers in water. 5. A test of the star and mean-field models. Macromolecules 1992;25:644-52
32. Yuan F, Dellian M, Fukumura D, et al. Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size. Cancer Res 1995;55:3752-6
33. Cabral H, Matsumoto Y, Mizuno K, et al. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol 2011;6:815-23
34. Li Y, Kwon GS. Methotrexate esters of poly(ethylene oxide)-blockpoly( 2-hydroxyethyl-L-Aspartamide). Part I: Effects of the level of methotrexate conjugation on the stability of micelles and on drug release. Pharm Res 2000;17:607-11
35. Koizumi F, Kitagawa M, Negishi T, et al. Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors. Cancer Res 2006; 66:10048-56
36. Yokoyama M, Kwon GS, Okano T, et al. Influencing factors on in vitro micelle stability of adriamycin-block copolymer conjugates. J Contr Rel 1994;28:59-65
37. Akiba I, Terada N, Hashida S, et al. Encapsulation of a hydrophobic drug into a polymer-micelle core explored with synchrotron SAXS. Langmuir 2010;26:7544-51
38. Sanada Y, Akiba I, Hashida S, et al. Composition dependence of the micellar architecture made from poly(ethylene glycol)-block-poly(partially benzyl-esterified aspartic acid). J Phys Chem 2012;116:8241-50
39. Sanada Y, Akiba I, Sakurai K, et al. Hydrophobic molecules infiltrating into the poly(ethylene glycol) domain of the core/ shell interface of a polymeric micelle: Evidence obtained with anomalous small-Angle X-ray scattering. J Am Chem Soc 2013;135: 2574-82
40. De Duve C, De Barsy T, Poole B, et al. Commentary. Lysosomotropic agents. Biochem Pharmacol 1974;23:2495-531
41. Griffiths JR. Are cancer cells acidič. Br J Cancer 1991;64:425-7
42. Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res 1989;49:6449-65
43. Zhang X, Lin Y, Gillies RJ. Tumor pH and its measurement. J Nucl Med 2010;51:1167-70
44. Rodrigues TB, Serrao EM, Kennedy BW, et al. Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose. Nat Med 2014;20:93-7
45. Yasunaga M, Manabe S, Matsumura Y. New concept of cytotoxic immunoconjugate therapy targeting cancer-induced fibrin clots. Cancer Sci 2011;102:1396-402
46. Hisada Y, Yasunaga M, Hanaoka S, et al. Discovery of an uncovered region in fibrin clots and its clinical significance. Sci Rep 2013;3:2604. doi: 10.1038/srep02604
47. Hamaguchi T, Kato K, Yasui H, et al. A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation. Br J Cancer 2007;97:170-6
48. Matsumura Y, Hamaguchi T, Ura T, et al. Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin. Br J Cancer 2004;91:1775-81
49. Kawaguchi T, Honda T, Nishihara M, et al. Histological study on side effects and tumor targeting of a block copolymer micelle on rats. J Contr Rel 2009;136:240-6
50. Dams ET, Laverman P, Oyen WJ, et al. Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes. J Pharmacol Exp Ther 2000;292: 1071-9
51. Ishida T, Kiwada H. Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes. Int J Pharm 2008;354:56-62
52. Laverman P, Carstens MG, Boerman OC, et al. 2001. Factors affecting the accelerated blood clearance of polyethylene glycolliposomes upon repeated injection. J Pharmacol Exp Ther 2001; 298:607-12
53. Gabizon A, Isacson R, Rosengarten O, et al. An open-label study to evaluate dose and cycle dependence of the pharmacokinetics of pegylated liposomal doxorubicin. Cancer Chemother Pharmacol 2008;61:695-702
54. Koide H, Asai T, Kato H, et al. Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles. Int J Pharm 2012;432:75-9
55. Ma H, Shiraishi K, Minowa T, et al. Accelerated blood clearance was not induced for a gadolinium-containing PEGpoly(L-lysine)-based polymeric micelle in mice. Pharm Res 2010; 27:296-302
56. Shiraishi K, Yokoyama M. Polymeric micelles possessing polyethyleneglycol as outer shell and their unique behaviors in accelerated blood clearance phenomenon. Biol Pharm Bull 2013; 36:878-82
57. Shiraishi K, Hamano M, Ma H, et al. Hydrophobic blocks of PEGconjugates play a significant role in the accelerated blood clearance (ABC) phenomenon. J Contr Rel 2013;165:183-90.