The inhibition of Rho kinase blocks cell migration and accumulation possibly by challenging inflammatory cytokines and chemokines on astrocytes

Journal of the Neurological Sciences

Volumn 343, Issue 1-2, 2014, Pages 69-75

  Guo, Min Fang ^a   Meng, Jian ^a   Li, Yan Hua ^a   Yu, Jie Zhong ^a   Liu, Chun Yun ^a   Feng, Ling ^a   Yang, Wan Fang ^c   Li, Jun Lian ^c   Feng, Qian Jin ^c   Xiao, Bao Guo ^b   Ma, Cun Gen ^a,c  

^a SHANXI DATONG UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c SHANXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Astrocytes; Chemokines; Cytokines; Experimental autoimmune encephalomyelitis; Fasudil; Rho kinase inhibitor

Indexed keywords

CHEMOKINE; CYTOKINE; FASUDIL; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; GLIAL FIBRILLARY ACIDIC PROTEIN; LIPOPOLYSACCHARIDE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); NITRITE; PEPTIDE FRAGMENT; PROTEIN KINASE INHIBITOR; RHO KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CD4+ T LYMPHOCYTE; CELL ADHESION; CELL FUNCTION; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE MIGRATION; LYMPHOCYTIC INFILTRATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; CELL MOTION; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEWBORN; PATHOLOGY; PHYSIOLOGY; TOXICITY;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; NITRITES; PEPTIDE FRAGMENTS; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; RHO-ASSOCIATED KINASES;

EID: 84904265106     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2014.05.034     Document Type: Article

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