CCL2 modulates cytokine production in cultured mouse astrocytes

Journal of Neuroinflammation

Volumn 7, Issue , 2010, Pages

  Semple, Bridgette D ^a   Frugier, Tony ^a,b   Morganti Kossmann, M Cristina ^a  

^a NATIONAL TRAUMA RESEARCH INSTITUTE   (Australia)

^b ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE EXPRESSION; IMMUNOMODULATION; IN VITRO STUDY; MOUSE; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE; ANALYSIS OF VARIANCE; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; GENETICS; METABOLISM; MOUSE MUTANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANALYSIS OF VARIANCE; ANIMALS; ASTROCYTES; CELLS, CULTURED; CHEMOKINE CCL2; CYTOKINES; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77957798179     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-7-67     Document Type: Article

References (61)

1. Rollins BJ. Monocyte chemoattractant protein-1: a potential regulator of monocyte recruitment in inflammatory disease. Molecular Medicine Today 1996, 198-204. 10.1016/1357-4310(96)88772-7, 8796888.
2. Bell MD, Taub DD, Perry VH. Overriding the brain's intrinsic resistance to leukocyte recruitment with intraparenchymal injections of recombinant chemokines. Neuroscience 1996, 74:283-292. 10.1016/0306-4522(96)00083-8, 8843093.
3. Semple BD, Kossmann T, Morganti-Kossmann MC. Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks. Journal of Cerebral Blood Flow and Metabolism 2010, 30:459-473. 10.1038/jcbfm.2009.240, 19904283.
4. Rollins BJ. JE/MCP-1: an early-response gene encodes a monocyte-specific cytokine. Cancer Cells 1991, 3:517-524.
5. Fuentes ME, Durham SK, Swedel MR, Lewin AC, Barton DS, Megill JR, Bravo R, Lira SA. Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of Monocyte Chemoattractant Protein-1. The Journal of Immunology 1995, 155:5769-5776.
6. Wang CX, Shuaib A. Involvement of inflammatory cytokines in central nervous system injury. Progress in Neurobiology 2002, 67:161-172. 10.1016/S0301-0082(02)00010-2, 12126659.
7. Hughes PM, Allegrini PR, Rudin M, Perry HV, Mir AK, Weissner C. Monocyte Chemoattractant Protein-1 deficiency is protective in a murine stroke model. Journal of Cerebral Blood Flow and Metabolism 2002, 22:308-317.
8. Ma M, Wei T, Boring L, Charo IF, Ransohoff RM, Jakeman LB. Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion. Journal of Neuroscience Research 2002, 68:691-702. 10.1002/jnr.10269, 12111830.
9. Semple BD, Bye N, Rancan M, Ziebell JM, Morganti-Kossmann MC. Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice. Journal of Cerebral Blood Flow and Metabolism 2010, 30:769-782. 10.1038/jcbfm.2009.262, 20029451.
10. Rhodes J, Sharkey J, Andrews P. Serum IL-8 and MCP-1 concentration do not identify patients with enlarging contusions after traumatic brain injury. Journal of Trauma 2009, 66:1591-1597. 10.1097/TA.0b013e31819a0344, 19509619.
11. Berman JW, Guida MP, Warren J, Amat J, Brosnan CF. Localisation of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat. The Journal of Immunology 1996, 156:3017-3023.
12. Glabinski AR, Balasingam V, Tani M, Kunkel SL, Strieter RM, Wee Yong V, Ransohoff RM. Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain. The Journal of Immunology 1996, 156:4363-4368.
13. Van Der Voorn P, Tekstra J, Beelen RHJ, Tensen CP, Van Der Valk P, De Groot CJA. Expression of MCP-1 by reactive astrocytes in demyelinating Multiple Sclerosis lesions. American Journal of Pathology 1999, 154:45-51. 1853444, 9916917.
14. Rezaie P, Trillo-Pazos G, Everall IP, Male DK. Expression of beta-chemokines and chemokine receptors in human fetal astrocyte and microglial co-cultures: potential role of chemokines in the developing CNS. GLIA 2002, 37:64-75. 10.1002/glia.1128, 11746784.
15. Edman LC, Mira H, Erices A, Malmersjö S, Andersson E, Uhlen P, Arenas E. Alpha-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres. Stem Cells 2008, 26:1891-1900. 10.1634/stemcells.2007-0753, 18436867.
16. Guyon A, Skrzydelski D, De Giry I, Rovere C, Conductier G, Trocello JM, Dauge V, Kitabgi P, Rostene W, Nahon JL, Melik-Parsadaniantz S. Long term exposure to the chemokine CCL2 activates the nigrostriatal dopamine system: a novel mechanism for the control of dopamine release. Neuroscience 2009, 162:1072-1080. 10.1016/j.neuroscience.2009.05.048, 19477239.
17. Bruno V, Copani A, Besong G, Scoto G, Nicoletti F. Neuroprotective activity of chemokines against N-methyl-D-aspartate or β-amyloid-induced toxicity in culture. European Journal of Pharmacology 2000, 399:117-121. 10.1016/S0014-2999(00)00367-8, 10884510.
18. Eugenin EA, D'Aversa TG, Lopez L, Calderon TM, Berman JW. MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. Journal of Neurochemistry 2003, 85:1299-1311. 10.1046/j.1471-4159.2003.01775.x, 12753088.
19. Magrigal JL, Leza JC, Polak P, Kalinin S, Feinstein DL. Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline. Journal of Neuroscience 2009, 29:263-267. 10.1523/JNEUROSCI.4926-08.2009, 19129402.
20. Morganti-Kossmann MC, Kossmann T, Brandes ME, Mergenhagen SE, Wahl SM. Autocrine and paracrine regulation of astrocyte function by transforming growth factor-β. Journal of Neuroimmunology 1992, 39:163-174. 10.1016/0165-5728(92)90185-N, 1320057.
21. Otto V, Gloor S, Frentzel S, Gilli U, Ammann E, Hein A, Folkers G, Kossmann T, Morganti-Kossmann M. The production of macrophage inflammatory protein-2 induced by soluble intercellular adhesion molecule-1 in mouse astrocytes is mediated by src tyrosine kinases and p42/44 mitogen-activated protein kinase. Journal of Neurochemistry 2002, 80:824-834. 10.1046/j.0022-3042.2001.00748.x, 11948246.
22. Aloisi F, Care A, Borsellino G, Gallo P, Rosa S, Bassani A, Cabibbo A, Testa U, Levi G, Peschle C. Production of haemolymphopoietic cytokines (IL-6, IL-8 and colony-stimulating factors) by normal human astrocytes in response to IL-1β and tumor necrosis factor-α. The Journal of Immunology 1992, 149:2358-2366.
23. Bolin LM, Zhaung A, Strychkarska-Orczyk I, Nelson E, Huang I, Malit M, Nguyen Q. Differential inflammatory activation of IL-6 (-/-) astrocytes. Cytokine 2005, 30:47-55. 10.1016/j.cyto.2004.11.007, 15804595.
24. Croitoru-Lamoury J, Guillemin GJ, Boussin FD, Mognetti B, Gigout LI, Cheret A, Vaslin B, Le Grand R, Brew BJ, Dormont D. Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNFα and IFNγ in CXCR4 and CCR2 modulation. GLIA 2003, 41:354-370. 10.1002/glia.10181, 12555203.
25. Guo H, Jin YX, Ishikawa M, Huang YM, Van der Meide PH, Link H, Xiao BG. Regulation of β-chemokine mRNA expression in adult rat astrocytes by lipopolysaccharide, proinflammatory and immunoregulatory cytokines. Scandinavian Journal of Immunology 1998, 48:502-508. 10.1046/j.1365-3083.1998.00422.x, 9822259.
26. Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW. Cytokine production by human fetal microglia and astrocytes. The Journal of Immunology 1993, 150:2659-2667.
27. Lieberman AP, Pitha PM, Shin HS, Shin ML. Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proceedings of the National Academy of Sciences 1989, 86:6348-6352.
28. Pang Y, Cai Z, Rhodes PG. Analysis of genes differentially expressed in astrocytes stimulated with lipopolysaccharide using cDNA arrays. Brain Research 2001, 914:15-22. 10.1016/S0006-8993(01)02766-4, 11578593.
29. Sharif SF, Hariri RJ, Chang VA, Barie PS, Wang RS, Ghajar BG. Human astrocyte production of tumour necrosis factor-α, interleukin-1β, and interleukin-6 following exposure to lipopolysaccharide endotoxin. Neurological Research 1993, 15:109-112.
30. Weiss JM, Berman JW. Astrocyte expression of monocyte chemoattractant protein-1 is differentially regulated by transforming growth factor beta. Journal of Neuroimmunology 1998, 91:190-197. 10.1016/S0165-5728(98)00183-0, 9846835.
31. Benveniste EN, Sparacio SM, Norris JG, Grenett HE, Fuller GM. Induction and regulation of interleukin-6 gene expression in rat astrocytes. Journal of Neuroimmunology 1990, 30:201-212. 10.1016/0165-5728(90)90104-U, 2121800.
32. Hayashi M, Luo Y, Laning J, Strieter RM, Dorf ME. Production and function of monocyte chemoattractant protein-1 and other β-chemokines in murine glial cells. Journal of Neuroimmunology 1995, 60:143-150. 10.1016/0165-5728(95)00064-9, 7642742.
33. Frei K, Nohava K, Malipiero U, Schwerdel C, Fontana A. Production of macrophage colony-stimulating factor by astrocytes and brain macrophages. Journal of Neuroimmunology 1992, 40:189-195. 10.1016/0165-5728(92)90133-6, 1430151.
34. de Souza DF, Leite MC, Quincozes-Santos A, Nardin P, Tortorelli LS, Rigo MM, Gottfried C, Leal RB, Goncalves CA. S100B secretion is stimulated by IL-1beta in glial cultures and hippocampal slices of rats: Likely involvement of MAPK pathway. Journal of Neuroimmunology 2009, 206:52-57. 10.1016/j.jneuroim.2008.10.012, 19042033.
35. Hua LL, Lee SC. Distinct patterns of stimulus-inducible chemokine mRNA accumulation in human fetal astrocytes and microglia. GLIA 2000, 30:74-81. 10.1002/(SICI)1098-1136(200003)30:1<74::AID-GLIA8>3.0.CO;2-C, 10696146.
36. Mizutani N, Sakurai T, Shibata T, Uchida K, Fujita J, Kawashima R, Kawamura YI, Toyama-Sorimachi N, Imai T, Dohi T. Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. The Journal of Immunology 2007, 179:7478-7487.
37. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-delta delta CT method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262, 11846609.
38. Morganti-Kossmann MC, Satgunaseelan L, Bye N, Kossmann T. Modulation of immune response by head injury. Injury 2007, 38:1392-1400. 10.1016/j.injury.2007.10.005, 18048036.
39. Kossmann T, Hans V, Imhof HG, Trentz O, Morganti-Kossmann MC. Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes. Brain Research 1996, 713:143-152. 10.1016/0006-8993(95)01501-9, 8724985.
40. John GR, Lee SC, Song X, Rivieccio M, Brosnan CF. IL-1-regulated responses in astrocytes: relevance to injury and recovery. GLIA 2005, 49:161-176. 10.1002/glia.20109, 15472994.
41. Allan SM, Tyrrell PJ, Rothwell NJ. Interleukin-1 and neuronal injury. Nature Reviews Immunology 2005, 5:629-640. 10.1038/nri1664, 16034365.
42. Huang DR, Wang J, Kivisakk P, Rollins BJ, Ransohoff RM. Absence of monocyte chemoattractant protein-1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. The Journal of Experimental Medicine 2001, 193:713-726. 10.1084/jem.193.6.713, 2193420, 11257138.
43. Fife BT, Huffnagle GB, Kuziel WA, Karpus WJ. CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis. Journal of Experimental Medicine 2000, 192:899-805. 10.1084/jem.192.6.899, 2193286, 10993920.
44. Kumai Y, Ooboshi H, Takada J, Kamouchi M, Kitazono T, Egashira K, Ibayashi S, Iida M. Anti-Monocyte Chemoattractant Protein-1 gene therapy protects against focal brain ischemia in hypertensive rats. Journal of Cerebral Blood Flow and Metabolism 2004, 24:1359-1368. 10.1097/00004647-200412000-00005, 15625410.
45. Chiu K, Yeung SC, So KF, Chang RCC. Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma. Cellular and Molecular Immunology 2010, 7:61-68. 10.1038/cmi.2009.110, 20081877.
46. Hu S, Chao CC, Ehrlich LC, Sheng WS, Sutton RL, Rockswold GL, Peterson PK. Inhibition of microglial cell RANTES production by IL-10 and TGF-β. Journal of Leukocyte Biology 1999, 65:815-821.
47. Kremlev SG, Roberts RL, Palmer C. Differential expression of chemokines and chemokine receptors during microglial activation and inhibition. Journal of Neuroimmunology 2004, 149:1-9. 10.1016/j.jneuroim.2003.11.012, 15020059.
48. Hariri RJ, Chang VA, Barie PS, Wang RS, Sharif SF, Ghajar JBG. Traumatic injury induces interleukin-6 production by human astrocytes. Brain Research 1994, 636:139-142. 10.1016/0006-8993(94)90188-0, 8156401.
49. Lau LT, Yu ACH. Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury. Journal of Neurotrauma 2001, 18:351-359. 10.1089/08977150151071035, 11284554.
50. Rankine EL, Hughes PM, Botham MS, Perry VH, Felton LM. Brain cytokine synthesis induced by an intraparenchymal injection of LPS is reduced in MCP-1-deficient mice prior to leukocyte recruitment. European Journal of Neuroscience 2006, 24:77-86. 10.1111/j.1460-9568.2006.04891.x, 16882009.
51. Thompson WL, Karpus WJ, Van Eldik LJ. MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult. Journal of Neuroinflammation 2008, 5:1-13. 10.1186/1742-2094-5-35, 2235846, 18171484.
52. Felton LM, Cunningham C, Rankine EL, Waters S, Boche D, Perry VH. MCP-1 and murine prion disease: Separation of early behavioural dysfunction from overt clinical disease. Neurobiology of Disease 2005, 20:283-295. 10.1016/j.nbd.2005.03.008, 15886005.
53. Zisman DA, Kunkel SL, Strieter RM, Tsai WC, Bucknell K, Wilkowski J, Standiford TJ. MCP-1 protects mice in lethal endotoxemia. The Journal of Clinical Investigation 1997, 99:2832-2836. 10.1172/JCI119475, 508132, 9185504.
54. Andjelkovic AV, Kerkovich D, Shanley J, Pulliam L, Pachter JS. Expression of binding sites for β-chemokines on human astrocytes. GLIA 1999, 28:225-235. 10.1002/(SICI)1098-1136(199912)28:3<225::AID-GLIA6>3.0.CO;2-6, 10559781.
55. Andjelkovic AV, Song L, Dzenko KA, Cong H, Pachter JS. Functional expression of CCR2 by human fetal astrocytes. Journal of Neuroscience Research 2002, 70:219-231. 10.1002/jnr.10372, 12271471.
56. Heesen M, Tanabe S, Berman I, Yoshizawa Y, Luo Y, Kim RJ, Post TW, Gerald C, Dorf ME. Mouse astrocytes respond to the chemoknies MCP-1 and KC, but reverse transcriptase polymerase chain reaction does not detect mRNA for the KC and new MCP-1 receptor. Journal of Neuroscience Research 1996, 45:382-391. 10.1002/(SICI)1097-4547(19960815)45:4<382::AID-JNR7>3.0.CO;2-5, 8872898.
57. McKimmie CS, Graham GJ. Astrocytes modulate the chemokine network in a pathogen-specific manner. Biochemical and Biophysical Research Communications 2010, 394:1006-1011. 10.1016/j.bbrc.2010.03.111, 20331977.
58. Quinones MP, Kalkonde Y, Estrada CA, Jimenez F, Ramirez R, Mahimainathan L, Mummidi S, Choudhury GG, Martinez H, Adams L, et al. Role of astrocytes and chemokine systems in acute TNFa induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kB and Akt. Molecular Cell Neuroscience 2008, 37:96-109.
59. Ge S, Murugesan N, Pachter JS. Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation. Journal of Molecular Neuroscience 2009, 39:269-283. 10.1007/s12031-009-9197-4, 2903863, 19340610.
60. Shohami E, Bass R, Wallach D, Yamin A, Gallily R. Inhibition of tumor necrosis factor alpha (TNFalpha) activity in rat brain is associated with cerebroprotection after closed head injury. Journal of Cerebral Blood Flow and Metabolism 1996, 16:378-384.
61. Scherbel U, Raghupathi R, Nakamura M, Saatman KE, Trojanowski JQ, Neugebauer E, Marino MW, McIntosh TK. Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:8721-8726. 10.1073/pnas.96.15.8721, 17583, 10411942.